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    • 1. 发明申请
      WO2006023194A3 IMPROVED PHOTOSENSITIZER FORMULATIONS AND THEIR USE 审中-公开
    • IMPROVED PHOTOSENSITIZER FORMULATIONS AND THEIR USE
    • WO2006023194A3
    • 2006-03-02
    • PCT/US2005/026051
    • 2005-07-22
    • CERAMOPTEC INDUSTRIES, INC. , NIKOLAY, Nifantiev , VOLKER, Albrecht
    • NIKOLAY, Nifantiev , VOLKER, Albrecht
    • A61K31/555
    • A low concentration formulation for hydrophobic photosensitizers (PS) and improved method for photodynamic therapy ("PDT"). It was found that PDT treatments using the disclosed low concentration formulations provide for more accurate, more efficient and more convenient dosing. It was found that the inventive formulation (1) reduces the time for a therapeutically effective level of photosensitizer to accumulate in diseased tissue and (2) reduces the time for achieving a sufficient ratio of photosensitizer in diseased tissue vs. healthy tissue. As a result, the formulation of the invention reduces the time interval between PS application/administration and irradiation (the drug-light interval or "DLI") and can provide for a "same day" PDT treatment option. The inventive formulation can be used for PDT treatment regimes where photosensitizers are administered in at least one preselected dose, including a low concentration therapy for PDT. In particular, when meta Tetra-Hydroxy-Phenyl Chlorin (m-THPC) is the photosensitizer then a concentration of 0.8 mg/ml to 0.04 mg/ml in a mixture of pure propylene glycol and ethanol in a 3:2 volume ratio accumulates in diseased tissue and differentiates between diseased tissue and normal tissue sufficiently quickly for `one day' or overnight administration and activation treatment procedures to be possible.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 2. 发明公开
      EP1786431A2 IMPROVED PHOTOSENSITIZER FORMULATIONS AND THEIR USE 有权 转让
    • IMPROVED PHOTOSENSITIZER FORMULATIONS AND THEIR USE
    • 改进的光敏剂制剂及其用途
    • EP1786431A2
    • 2007-05-23
    • EP05803753.2
    • 2005-07-22
    • Ceramoptec Industries, Inc.
    • NIKOLAY, Nifantiev , VOLKER, Albrecht
    • A61K31/555
    • A61K31/195 , A61K31/366 , A61K31/409 , A61K41/0057 , A61K41/0061 , A61K41/0071
    • A low concentration formulation for hydrophobic photosensitizers (PS) and improved method for photodynamic therapy ('PDT'). It was found that PDT treatments using the disclosed low concentration formulations provide for more accurate, more efficient and more convenient dosing. It was found that the inventive formulation (1) reduces the time for a therapeutically effective level of photosensitizer to accumulate in diseased tissue and (2) reduces the time for achieving a sufficient ratio of photosensitizer in diseased tissue vs. healthy tissue. As a result, the formulation of the invention reduces the time interval between PS application/administration and irradiation (the drug-light interval or 'DLI') and can provide for a 'same day' PDT treatment option. The inventive formulation can be used for PDT treatment regimes where photosensitizers are administered in at least one preselected dose, including a low concentration therapy for PDT. In particular, when meta Tetra-Hydroxy-Phenyl Chlorin (m-THPC) is the photosensitizer then a concentration of 0.8 mg/ml to 0.04 mg/ml in a mixture of pure propylene glycol and ethanol in a 3:2 volume ratio accumulates in diseased tissue and differentiates between diseased tissue and normal tissue sufficiently quickly for `one day' or overnight administration and activation treatment procedures to be possible.
    • 用于疏水性光敏剂（PS）的低浓度制剂和用于光动力疗法（“PDT”）的改进方法。 发现使用所公开的低浓度制剂的PDT治疗提供更准确，更有效和更方便的给药。 发现本发明的制剂（1）减少了治疗有效水平的光敏剂积聚在患病组织中的时间，并且（2）减少了在患病组织中与光敏剂在健康组织中达到足够比例的光敏剂的时间。 结果，本发明的制剂减少了PS施用/施用和照射之间的时间间隔（药物 - 光间隔或“DLI”），并且可以提供“同一天”的PDT治疗选择。 本发明的制剂可用于PDT治疗方案，其中光敏剂以至少一种预选剂量施用，包括PDT的低浓度疗法。 特别是当间四羟基 - 苯基二氢卟酚（m-THPC）是光敏剂时，则在纯丙二醇和乙醇的体积比为3:2的混合物中的浓度为0.8mg / ml至0.04mg / ml积聚在 患病组织并在疾病组织和正常组织之间充分快速地分化一天或过夜施用和激活治疗程序是可能的。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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