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1. 发明申请

WO2010129337A2 NEW ORAL FORMULATIONS FOR TETRAPYRROLE DERIVATIVES 审中-公开
标题翻译：新的口服制剂用于四环素衍生物
公开(公告)号：WO2010129337A2
公开(公告)日：2010-11-11
申请号：PCT/US2010032766
申请日：2010-04-28
申请人： CERAMOPTEC IND INC , GRAEFE SUSANNA , NIFANTIEV NIKOLAY , ALBRECHT VOLKER , NEUBERGER WOLFGANG , SCHEGLMANN DIETRICH , GERHARD WIELAND , WIEHE ARNO , FAHR ALBERT
发明人： GRAEFE SUSANNA , NIFANTIEV NIKOLAY , ALBRECHT VOLKER , NEUBERGER WOLFGANG , SCHEGLMANN DIETRICH , GERHARD WIELAND , WIEHE ARNO , FAHR ALBERT
IPC分类号： A61K9/16 , A61K9/20 , A61K31/122 , A61K31/495 , A61P31/04 , A61P35/00
CPC分类号： A61K31/409 , A61K9/0065 , A61K9/127 , A61K9/1271 , A61K31/498
摘要： Oral formulations and method of formulating photosensitive agents for oral administration during photodynamic therapy (PDT) and Antimicrobial photodynamic therapy (APDT) treatment are presented. The oral formulated photosensitizers show increased solubility and permeability, thus improving the bioavailability of photosensitizers at the treatment site. An orally administered photosensitizer is suitably formulated for mucosal adhesion and absorption via gastrointestinal mucosal membranes. Oral formulation provided herein use lipids and known proteins as carriers for photosensitizers by oral route. Carriers for encapsulating preselected photosensitizers include conventional liposomes, pegylated liposomes, nanoemulsions, nanocrystrals, nanoparticles, fatty emulsions, lipidic formulations, hydrosols, SMEDDS, Alpha-Feto protein (AFP), and Bovine-Serum-Albumin (BSA), fatty emulsions, hot-melt-extrudates and nanoparticles. The oral formulation, in case of a hydrophobic photosensitizer in the present invention, is stabilized using suitable surfactants/solubilizers thus preventing aggregation of the drug in the stomach and until it is absorbed in the duodenum and the small intestine. Oral formulations can be administered in the form of liquid, capsule, tablet, powder, paste or gel. Formulated drugs can be administered orally as one single dose or in multiple doses before administering PDT. In one embodiment Temoporfin (m-THPC) is used as a photosensitizer in the oral formulations. Temoporfin like many hydrophobic photosensitizers are especially suitable to be administered orally because there is no known enzyme system in the mammalian body which can metabolize Temoporfin or similar photosensitizers. Temoporfin can reach the blood system unchanged and fully active after absorption of the formulation in the gastrointestinal tract.
摘要翻译：提出了在光动力治疗（PDT）和抗微生物光动力疗法（APDT）治疗中配制口服光敏剂的口服制剂和方法。口服配制的光敏剂显示增加的溶解度和渗透性，从而提高光敏剂在治疗部位的生物利用度。口服给药的光敏剂适于配制用于通过胃肠粘膜进行粘膜粘附和吸收。本文提供的口服制剂通过口服途径使用脂质和已知蛋白质作为光敏剂的载体。用于封装预选光敏剂的载体包括常规脂质体，聚乙二醇化脂质体，纳米乳剂，纳米胶体，纳米颗粒，脂肪乳剂，脂质制剂，水溶胶，SMEDDS，α-铁蛋白（AFP）和牛血清白蛋白（BSA），脂肪乳剂，热熔融挤出物和纳米颗粒。在本发明的疏水性光敏剂的情况下，使用合适的表面活性剂/增溶剂稳定口服制剂，从而防止药物在胃中的聚集，直到其被吸收到十二指肠和小肠中。口服制剂可以以液体，胶囊，片剂，粉末，糊剂或凝胶的形式施用。配制药物可以在给予PDT之前以一次剂量或多次剂量口服给药。在一个实施方案中，Temoporfin（m-THPC）用作口服制剂中的光敏剂。类似于许多疏水性光敏剂的Temoporfin特别适合于口服给药，因为哺乳动物体内没有已知的可以代谢Temoporfin或类似光敏剂的酶系统。 Temoporfin可以在胃肠道吸收制剂后达到血液系统不变和充分活性。

2. 发明申请

WO2010129340A3 NOVEL PHOTOSENSITIZER FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的新型光敏剂配方
公开(公告)号：WO2010129340A3
公开(公告)日：2011-04-07
申请号：PCT/US2010032780
申请日：2010-04-28
申请人： CERAMOPTEC IND INC , FARMER GERARD , NIFANTIEV NIKOLAY , ALBRECHT VOLKER , NEUBERGER WOLFGANG , SCHEGLMANN DIETRICH , GERHARD WIELAND , WIEHE ARNO , GRAEFE SUSANNA
发明人： FARMER GERARD , NIFANTIEV NIKOLAY , ALBRECHT VOLKER , NEUBERGER WOLFGANG , SCHEGLMANN DIETRICH , GERHARD WIELAND , WIEHE ARNO , GRAEFE SUSANNA
IPC分类号： A61K31/498 , A61K31/122 , A61K31/40 , A61P31/04 , A61P35/00
CPC分类号： A61K31/122 , A61K31/40 , A61K31/498 , A61K41/0071
摘要： The present invention provides novel drug formulations for oral administration for diverse medical applications including anticancer, antimetastatic, antibacterial, antifungal, antiprotozoic, antiviral, antiprionic and PDT treatments for diagnostic and therapeutic purposes. In a preferred embodiment the oral drug formulation comprises a photosensitizer and suitable excipients and may be administered in multiple doses over an extended period of time with exposure to activating radiation occurring generally between individual doses or in a light-independent manner. In another preferred embodiment PDT methods for treating hyperplasia and neoplasia, for localizing hyperplasic and neoplasic tissues and pathogen bacteria by fluorescence, for treating infections caused by pathogen bacteria in complex body fluids and for fat reduction, skin disorders and vascular diseases are provided.
摘要翻译：本发明提供用于口服给药以用于各种医学应用的新型药物制剂，包括用于诊断和治疗目的的抗癌，抗转移，抗细菌，抗真菌，抗原生动脉，抗病毒，止痒和PDT治疗。在优选的实施方案中，口服药物制剂包含光敏剂和合适的赋形剂，并且可以在延长的时间段内以多个剂量施用，暴露于通常在单独剂量之间或以轻轻独立的方式发生的活化辐射。在另一个优选实施方案中，提供了用于治疗增生和瘤形成的PDT方法，用于通过荧光定位超基质和新生组织和病原体细菌，用于治疗复杂体液中由病原体引起的感染和用于减脂，皮肤病和血管疾病。

3. 发明申请

WO2008088810A3 FORMULATIONS FOR COSMETIC AND WOUND CARE TREATMENTS WITH PHOTOSENSITIZERS AS FLUORESCENT MARKERS 审中-公开
标题翻译：用光敏剂作为荧光标记的化妆品和伤口护理制剂的配方
公开(公告)号：WO2008088810A3
公开(公告)日：2008-12-18
申请号：PCT/US2008000537
申请日：2008-01-16
申请人： CERAMOPTEC IND INC , NEUBERGER WOLFGANG , GRAFE SUSANNA , NIFANTIEV NIKOLAY
发明人： NEUBERGER WOLFGANG , GRAFE SUSANNA , NIFANTIEV NIKOLAY
IPC分类号： A61F13/00 , A61B5/055 , A61K9/127
CPC分类号： A61K31/715 , A61K8/02 , A61K8/494 , A61K8/64 , A61K8/735 , A61K9/0019 , A61K9/127 , A61K2800/434 , A61K2800/91 , A61Q19/08
摘要： Photoactive materials, such as photosensitizers, are used as fluorescent markers for in vivo detection of the distribution of the injected filler material during cosmetic treatments. In one preferred embodiment, liposomal formulated temoporfin is used, as the photoactive component, in very small concentrations along with fillers for cosmetic and wound healing applications. Fillers, which can be used in the invention, include collagen, hyaluronic acids and other synthetic or natural products which are generally used in wound healing, scar reduction and other such medical applications. In a preferred embodiment, the formulated photosensitizer is coupled to the filler so that tracking is possible over longer periods of time A liposomal formulated photosensitizer is injected with the fillers into the treatment area, and is irradiated with laser light shortly after injection. The emitted fluorescence is measured by a special non-invasive device. Thereby it is possible to monitor the injection site and the distribution of the injected solution around the injection site. When irradiated with laser or other light source, the fluorescence of the photosensitizer is detected using a fluorescence detector, which permits tracking the filler at injection site and in the injection volume.
摘要翻译：光敏材料如光敏剂被用作荧光标记，用于在美容处理期间体内检测注入的填充材料的分布。在一个优选的实施方案中，使用脂质体配制的temoporfin作为光敏成分，与用于美容和伤口愈合应用的填充剂一起以非常小的浓度。可用于本发明的填充剂包括胶原蛋白，透明质酸和通常用于伤口愈合，疤痕减少和其它这类医疗应用的其他合成或天然产物。在一个优选的实施方案中，配制的光敏剂与填充剂偶联，使得可以在更长的时间段内追踪。将脂质体配制的光敏剂与填充剂一起注入治疗区域，并在注射后不久用激光照射。发射的荧光通过特殊的无创设备进行测量。因此可以监测注射部位和注射部位周围注射溶液的分布。当用激光或其他光源照射时，使用荧光检测器检测光敏剂的荧光，该荧光检测器允许在注射部位和注射体积中跟踪填充物。

4. 发明申请

WO2011090885A3 ENHANCED ANTI-MICROBIAL PDT 审中-公开
标题翻译：增强抗微生物PDT
公开(公告)号：WO2011090885A3
公开(公告)日：2011-11-17
申请号：PCT/US2011021179
申请日：2011-01-13
申请人： CERAMOPTEC IND INC , ALBRECHT VOLKER , WIELAND GERHARD , GITTER BURKHARD , NEUBERGER WOLFGANG
发明人： ALBRECHT VOLKER , WIELAND GERHARD , GITTER BURKHARD , NEUBERGER WOLFGANG
IPC分类号： A61N5/00 , A61K31/407 , A61N5/06 , A61P31/04
CPC分类号： A61N5/062 , A61L2/0029 , A61L2/0052 , A61L2202/21 , A61M1/3681 , A61M1/3686 , A61N5/0624 , A61N2005/063 , A61N2005/0652
摘要： Present invention provides enhanced methods and improved devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids. In preferred embodiments, present invention provides an antimicrobial PDT treatment and devices that effectively inactivates, reduces and/or destroys both Gram (-) and Gram (+) bacteria in complex body fluids. Preferred device embodiments comprise guiding channels and at least one electromagnetic radiation source, arranged separately or in sequence. Preferably, laser device or LED-panels are used to deliver electromagnetic radiation to activate the photosensilizer. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. When used with preferred photosensitizer composition based on Safranin O, preferred laser radiation wavelength is in the range of 500-580nm. Additionally, present invention diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.
摘要翻译：本发明提供增强的方法和改进的装置，以消除，减少，破坏和/或抑制不期望的体液物质，例如病原体微生物和复杂环境如血液，血清和其它体液中的恶化或恶性细胞。在优选的实施方案中，本发明提供了抗微生物PDT治疗和在复杂体液中有效灭活，减少和/或破坏革兰氏（ - ）和革兰氏阴性（+）细菌的装置。优选的装置实施例包括分开或依次布置的引导通道和至少一个电磁辐射源。优选地，激光装置或LED面板用于传送电磁辐射以激活光敏剂。基于治疗参数，电磁辐射优选间歇地以脉冲宽度递送。当与基于Safranin O的优选光敏剂组合物一起使用时，优选的激光辐射波长在500-580nm的范围内。此外，本发明通过中和病原微生物片段的生物活性来减少不良宿主的炎症反应，还原和/或除去负责其的病原微生物片段。

5. 发明申请

WO2007084468A3 PHOTODYNAMIC COSMETIC PROCEDURE AND HEALING METHOD 审中-公开
标题翻译：光化学疗法和治疗方法
公开(公告)号：WO2007084468A3
公开(公告)日：2007-11-22
申请号：PCT/US2007001051
申请日：2007-01-16
申请人： CERAMOPTEC IND INC , NEUBERGER WOLFGANG , CASTRO DANILO , ALBRECHT VOLKER
发明人： NEUBERGER WOLFGANG , CASTRO DANILO , ALBRECHT VOLKER
IPC分类号： A61K9/127 , A61K31/355
CPC分类号： A61K8/65 , A61K8/4946 , A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071 , A61K2800/434 , A61K2800/81 , A61L27/24 , A61L27/54 , A61L2300/414 , A61L2300/604 , A61Q19/06 , A61Q19/08
摘要： Non-surgical methods and compositions for administering PDT to promote tissue regeneration or augmentation in afflicted epidermal and connective tissue layers with applications for the treatment of acute and chronic wounds or cosmetic surgery/treatments and minimize scarring and risk of infection Said methods make use of a suitable biodegradable supporting matpx which is embedded with a liposomal loaded photosensitizer that can be injected at the site followed by collagen implantation and PDT treatment In another embodiment a liposomal photosensitizer is incorporated in the collagen wherein light activation is earned out 30 minutes after incorporation The matrix may also carry growth factors and cytokines to the wound site and infection at the wound site can also be controlled by antibacterial PDT.
摘要翻译：用于施用PDT以促进受影响的表皮和结缔组织层中的组织再生或增加的非手术方法和组合物，其用于治疗急性和慢性伤口或整容手术/治疗并使瘢痕形成和感染风险最小化所述方法利用适合的可生物降解的支撑垫，其嵌入可以在该部位注射的脂质体加载的光敏剂，然后进行胶原植入和PDT处理。在另一个实施方案中，在胶原中掺入脂质体光敏剂，其中在引入后30分钟内获得光活化。还对伤口部位携带生长因子和细胞因子，伤口部位的感染也可以通过抗菌PDT控制。

6. 发明申请

WO2008002340A3 BENIGN PROSTATIC HYPERPLASIA TREATMENT DEVICE AND METHOD 审中-公开
标题翻译： BENIGN PROSTATIC HYPERPLASIA治疗装置及方法
公开(公告)号：WO2008002340A3
公开(公告)日：2015-10-22
申请号：PCT/US2007006659
申请日：2007-03-16
申请人： CERAMOPTEC IND INC , NEUBERGER WOLFGANG
发明人： NEUBERGER WOLFGANG
IPC分类号： A61N5/06
CPC分类号： A61B18/24 , A61B2017/00274 , A61B2018/00547 , A61B2018/2005 , A61B2018/207 , A61B2018/2272 , A61N2005/0659
摘要： A device and method are provided which achieve tissue ablation as well as tissue coagulation substantially simultaneously during the treatment of BPH by utilizing at least two wavelengths of light. The device and method improve urinary flow and minimize post-treatment blood loss and edema while maintaining a nearly blood-free operating field during treatment by irradiating substantially simultaneously with at least two different wavelengths of light. The present device and method uses optical fibers including in preferred embodiments special side emitting optical fibers to provide a practical, minimally invasive treatment of enlarged prostates. According to the present invention, tissue ablation is affected by having one wavelength that is highly absorbed in the prostatic tissue while another less highly absorbed wavelength coagulates surrounding hyperplasic tissues while maintaining minimal thermal damage to normal tissue, surrounding the hyperplasia. This combination can aid the practitioner by maintaining a substantially blood-free area during treatment.
摘要翻译：提供了一种通过利用至少两个波长的光来在BPH治疗期间基本上同时实现组织消融以及组织凝固的装置和方法。该装置和方法改善尿流量并且使治疗后的失血和水肿最小化，同时通过基本同时照射至少两种不同波长的光而在治疗期间保持几乎无血液的操作区域。本发明的装置和方法使用光纤，包括优选实施例中的特殊侧发射光纤，以提供对扩大的前列腺的实用的微创治疗。根据本发明，组织消融受到在前列腺组织中高度吸收的一种波长的影响，而另一种较不高吸收的波长凝结周围的超基质组织，同时保持围绕增生的正常组织的最小热损伤。这种组合可以在治疗期间通过维持基本上无血液的区域来帮助从业者。

7. 发明申请

WO2011085299A3 DEVICE AND METHOD FOR UNDERSKIN RADIATION TREATMENT OF ADIPOSE TISSUE 审中-公开
标题翻译： ADIPOSE组织的辐射治疗的装置和方法
公开(公告)号：WO2011085299A3
公开(公告)日：2011-12-22
申请号：PCT/US2011020657
申请日：2011-01-10
申请人： CERAMOPTEC IND INC , NEUBERGER WOLFGANG
发明人： NEUBERGER WOLFGANG
IPC分类号： A61N5/06 , A61B18/18 , A61N5/067
CPC分类号： A61B18/22 , A61B2018/0019 , A61B2018/00994 , A61B2018/2005 , A61B2018/2272
摘要： A method and device for underskin treatment and removal of adipose tissue by means of a radiation energy source is disclosed. The method consists of inserting a part of a device below the skin, emitting radiation, and moving the device within tissue area to reach all parts. The intensity level of the radiation is low enough to minimize carbonization in the main tissue and connective tissue but sufficient to enable coagulation of smaller blood vessels. The device consists of a handpiece with a part that can be inserted below the skin and a part that can be held and manipulated outside the body. The part inserted below the skin can he vibrated or oscillated to aid in distributing the radiation. In a preferred embodiment, the handpiece consists in a hollow cannula incorporating at least one channel for suction and/or irrigation and a light guiding means in its body/wall section.
摘要翻译：公开了一种用于通过辐射能量源处理和去除脂肪组织的方法和装置。该方法包括将一部分设备插入皮肤下方，发射辐射，以及在组织区域内移动设备以达到所有部位。辐射的强度水平足够低以使主要组织和结缔组织中的碳化最小化，但足以使较小血管凝结。该装置包括具有可以插入皮肤下方的部分的手柄和可以在身体外部被保持和操纵的部分。插入皮肤下方的部分可以振动或振荡，以帮助分散辐射。在优选实施例中，手持件包括一个中空套管，其中包括用于抽吸和/或冲洗的至少一个通道和在其主体/壁部分中的导光装置。

8. 发明申请

WO2010138747A3 PRECISELY-SHAPED CORE FIBERS AND METHOD OF MANUFACTURE 审中-公开
标题翻译：精密芯芯纤维和制造方法
公开(公告)号：WO2010138747A3
公开(公告)日：2011-02-24
申请号：PCT/US2010036451
申请日：2010-05-27
申请人： CERAMOPTEC IND INC , NEUBERGER WOLFGANG
发明人： NEUBERGER WOLFGANG
IPC分类号： G02B6/028
CPC分类号： G02B6/02 , H01S3/06729
摘要： Non-circular core optical preforms are provided whose core-cladding interface edge has a sharpness that can be accurately controlled according to application- specific needs. Preform design and fiber fabrication is handled such that precisely edged fiber cores are maintained in the drawn fibers. This provides for markedly improved fiber functions, which rely on the non-circular structure of the core. In short, optical fibers having non-circular wave-guiding regions with precise, controlled edges are provided. By using selected manufacturing techniques that employ lower temperatures than commonly used, prior art techniques and by choosing proper materials with appropriate viscosities for core and cladding, the rounding of the edges of the wave-guiding region is precisely maintained in the final optical fibers.
摘要翻译：提供非圆形光学预制棒，其芯 - 包层界面边缘具有可根据应用特定需要精确控制的清晰度。处理预成型设计和纤维制造，使得在拉伸的纤维中保持精密边缘的纤维芯。这提供了显着改进的纤维功能，其依赖于芯的非圆形结构。简而言之，提供具有精确控制边缘的非圆形波导区域的光纤。通过使用采用比通常使用的较低温度的选定制造技术，现有技术和通过选择具有适当的粘度用于芯和包层的合适的材料，波导区域的边缘的倒圆被精确地保持在最终的光纤中。

9. 发明申请

WO2007016287A3 PDT TREATMENT METHOD FOR CELLULITES AND COSMETIC USE 审中-公开
标题翻译：用于细胞和化妆品用途的PDT处理方法
公开(公告)号：WO2007016287A3
公开(公告)日：2008-12-18
申请号：PCT/US2006029284
申请日：2006-07-27
申请人： CERAMOPTEC IND INC , CASTRO DANILO SUAREZ , NEUBERGER WOLFGANG
发明人： CASTRO DANILO SUAREZ , NEUBERGER WOLFGANG
IPC分类号： A61K35/32 , A61K35/36
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： A photosensitizer mixture and a method of treating cellulites by means of a percutaneous application of the mixture into the area of cellulite buildup followed by light illumination are presented. The photosensitizer can be combined with one or more cellular products including adipose cells and/or collagen that have been previously removed by liposuction. This mixture can also include other compounds such as Lipofundin MCT 10 % to improve the photosensitizer's diffusion or to dilute it Varying concentrations are used depending on the area of treatment as well as the stage of the cellulites and whether the cellulites present a depressed area in the skin or an elevated area. The cosmetic treatment method substantially reduces or removes localized lipodystrophies and/or flaccidity and/or cellulite by localized laser, LED or other light irradiation of the area of treatment having a photosensitizer applied therein. The light energy is applied to destroy the "fat" cells by a combination of chemical reactions, primarily, and temperature wherein the cell walls break releasing the cell fluid. The light radiation is generally applied through devices to guide the radiation to the area of treatment. One or more light sources such as laser diodes or LEDs may be coupled into one or more optical fibers to increase the area of coverage as well as increase the amount of radiation in that area of coverage. Optical fibers can be introduced percutaneously or possibly interstitially into the area of treatment. Cell fluid in the area of treatment is removed by a combination of techniques. Quick and lasting cosmetic changes in areas having prior untreatable cellulite fat tissues are achieved while minimizing trauma.
摘要翻译：提供了一种光敏剂混合物和通过将混合物经皮施用到脂肪团累积区域中随后进行光照射处理脂肪团的方法。光敏剂可以与一种或多种细胞产品组合，包括脂肪细胞和/或胶原蛋白，其先前通过吸脂除去。该混合物还可以包括其他化合物，例如Lipofundin MCT 10％，以改善光敏剂的扩散或稀释。根据治疗面积和脂肪团的阶段以及脂肪团是否存在凹陷区域，使用不同的浓度皮肤或高架区域。美容治疗方法通过局部激光，LED或其它应用光敏剂的治疗区域的其它光照射，显着地减少或去除局部的脂肪营养不良和/或脂肪酸和/或脂肪团。施加光能以通过化学反应（主要是）和细胞壁破坏释放细胞液体的温度的组合来破坏“脂肪”细胞。光辐射通常通过装置施加以将辐射引导到治疗区域。可以将一个或多个光源（例如激光二极管或LED）耦合到一个或多个光纤中，以增加覆盖区域以及增加覆盖区域中的辐射量。光纤经皮或间隙引入治疗区域。通过技术的组合去除处理区域中的细胞液。在具有先前不可治愈的脂肪脂肪组织的区域中实现快速和持久的化妆品变化，同时最小化创伤。

10. 发明申请

WO2007016287A9 PDT TREATMENT METHOD FOR CELLULITES AND COSMETIC USE 审中-公开
标题翻译：光敏剂和化妆品用PDT处理方法
公开(公告)号：WO2007016287A9
公开(公告)日：2008-10-30
申请号：PCT/US2006029284
申请日：2006-07-27
申请人： CERAMOPTEC IND INC , CASTRO DANILO SUAREZ , NEUBERGER WOLFGANG
发明人： CASTRO DANILO SUAREZ , NEUBERGER WOLFGANG
IPC分类号： A61K31/555 , A61K9/127 , A61K31/409
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： A photosensitizer mixture and a method of treating cellulites by means of a percutaneous application of the mixture into the area of cellulite buildup followed by light illumination are presented. The photosensitizer can be combined with one or more cellular products including adipose cells and/or collagen that have been previously removed by liposuction. This mixture can also include other compounds such as Lipofundin MCT 10 % to improve the photosensitizer's diffusion or to dilute it Varying concentrations are used depending on the area of treatment as well as the stage of the cellulites and whether the cellulites present a depressed area in the skin or an elevated area. The cosmetic treatment method substantially reduces or removes localized lipodystrophies and/or flaccidity and/or cellulite by localized laser, LED or other light irradiation of the area of treatment having a photosensitizer applied therein. The light energy is applied to destroy the "fat" cells by a combination of chemical reactions, primarily, and temperature wherein the cell walls break releasing the cell fluid. The light radiation is generally applied through devices to guide the radiation to the area of treatment. One or more light sources such as laser diodes or LEDs may be coupled into one or more optical fibers to increase the area of coverage as well as increase the amount of radiation in that area of coverage. Optical fibers can be introduced percutaneously or possibly interstitially into the area of treatment. Cell fluid in the area of treatment is removed by a combination of techniques. Quick and lasting cosmetic changes in areas having prior untreatable cellulite fat tissues are achieved while minimizing trauma.
摘要翻译：提出了一种光敏剂混合物和一种通过将该混合物经皮施用于脂肪团积聚区域然后进行光照治疗蜂窝组织的方法。光敏剂可以与一种或多种细胞产物结合，所述细胞产物包括脂肪细胞和/或先前已通过吸脂去除的胶原蛋白。这种混合物还可以包括其他化合物如10％的Lipofundin MCT以改善光敏剂的扩散或稀释它。根据处理区域以及脂肪团的阶段和蜂窝组织是否存在凹陷区域，使用不同的浓度皮肤或高架地区。该美容治疗方法通过局部激光，LED或其中应用了光敏剂的治疗区域的其他光照射来显着降低或消除局部脂肪营养不良和/或眩晕和/或脂肪团。通过化学反应，主要是细胞壁破裂释放细胞液的温度，施加光能以破坏“脂肪”细胞。光辐射通常通过装置施加以将辐射引导至治疗区域。诸如激光二极管或LED之类的一个或多个光源可耦合到一个或多个光纤中以增加覆盖区域并增加该覆盖区域中的辐射量。光纤可以经皮或可能间质地引入治疗区域。处理区域中的细胞液通过技术组合被去除。在具有以前不可治疗的脂肪团脂肪组织的区域中实现快速且持久的美容改变，同时使创伤最小化。

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