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1. 发明申请

WO2008069960A3 SEPARABLE SOLID DOSAGE FORM ADMINISTRATION SYSTEM 审中-公开
标题翻译：可分开的固定剂量表格管理系统
公开(公告)号：WO2008069960A3
公开(公告)日：2008-08-07
申请号：PCT/US2007024614
申请日：2007-11-30
申请人： CEPHALON INC , HAGUE BRIAN , MALAND LYNN J
发明人： HAGUE BRIAN , MALAND LYNN J
IPC分类号： A61J7/00 , A23G3/56 , A61K9/44 , A61K31/465 , A61P25/34
CPC分类号： A61K31/465 , A61J7/003 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： The invention described herein provides a solid dosage form administration system comprising: an oral solid dosage form containing an active ingredient; and a hand-held applicator; wherein the hand-held applicator is removably coupled to the dosage form. The system includes a reversible coupling structure permitting repeated engagement and disengagement of the dosage form component from the hand-held applicator component of the system. In one embodiment, the applicator is composed of a soft durometer flexible polymeric material. The invention can be used to administer various medicaments, and is especially useful in treatment of nicotine addiction.
摘要翻译：本文所述的发明提供了固体剂型给药系统，其包含：含有活性成分的口服固体剂型; 和一个手持式涂药器; 其中手持式施用器可移除地连接到剂型。该系统包括允许剂型部件从系统的手持式施用部件反复接合和脱离的可逆连接结构。在一个实施例中，涂药器由软硬度柔性聚合物材料组成。本发明可以用于给药各种药物，并且特别用于治疗尼古丁成瘾。

2. 发明申请

WO2004069198A2 SUGAR-FREE ORAL TRANSMUCOSAL SOLID DOSAGE FORMS AND USES THEREOF 审中-公开
标题翻译：无糖口腔透皮固体剂型及其用途
公开(公告)号：WO2004069198A2
公开(公告)日：2004-08-19
申请号：PCT/US2004003055
申请日：2004-02-04
申请人： CEPHALON INC , HAGUE BRIAN , MALAND LYNN J
发明人： HAGUE BRIAN , MALAND LYNN J
IPC分类号： A61K9/00 , A61K9/20 , A61K31/4468 , A61K
CPC分类号： A61K31/4468 , A61K9/0056 , A61K9/2018 , A61K9/2031
摘要： The present invention is directed to oral solid dosage forms. The solid dosage forms are sugar-free, and comprise a pharmaceutical agent and a suitable pharmaceutically acceptable excipient. Preferably, the solid dosage forms of the present invention are bioequivalent to a sugar-containing solid dosage form. Bioequivalence is preferably obtained by incorporating an ionizing agent, more preferably in the form of a buffer system, into the solid dosage forms, in an amount sufficient to maintain a portion of the pharmaceutical agent, upon dissolution of said composition in saliva, in an ionized state.
摘要翻译：本发明涉及口服固体剂型。固体剂型是无糖的，并且包含药剂和合适的药学上可接受的赋形剂。优选地，本发明的固体剂型与含糖固体剂型是生物等效的。生物等效性优选通过将离子化试剂，更优选以缓冲体系的形式并入固体剂型中，其量足以维持一部分药剂，在所述组合物在唾液中溶解时，以离子化州。

3. 发明申请

WO2008069921A2 ORAL TRANSMUCOSAL NICOTINE DOSAGE FORM 审中-公开
标题翻译：口腔转运尼古丁剂量形式
公开(公告)号：WO2008069921A2
公开(公告)日：2008-06-12
申请号：PCT/US2007024218
申请日：2007-11-20
申请人： CIMA LABS INC , CEPHALON INC , AGARWAL VIKAS , HAGUE BRIAN , KHANKARI RAJENDRA K
发明人： AGARWAL VIKAS , HAGUE BRIAN , KHANKARI RAJENDRA K
IPC分类号： A61K9/46 , A61K31/465
CPC分类号： A61K31/465 , A61K9/0007 , A61K9/0056
摘要： The invention described herein relates to an oral transmucosal solid dosage form useful in treating nicotine addiction or as a nicotine substitute or replacement. By virtue of the formulation in combination with nicotine, the invention transmucosally delivers an effective amount of nicotine to the recipient while permitting the accomplishing of such, and manufacture of such, using a relatively small, convenient and orally comfortable dosage form (e.g., tablet) size.
摘要翻译：本文所述的发明涉及可用于治疗尼古丁成瘾或作为尼古丁替代物或替代物的口腔粘膜固体剂型。通过与尼古丁的组合，本发明将有效量的尼古丁经粘膜递送至接受者，同时允许使用相对较小，方便和口服舒适的剂型（例如片剂）来实现和制造，尺寸。

4. 发明专利

JP2003047644A Method and system for disposing of oral dosage form medicine 有权
标题翻译：口服剂型药物治疗方法与系统
公开(公告)号：JP2003047644A
公开(公告)日：2003-02-18
申请号：JP2002139186
申请日：2002-05-14
申请人： Cephalon Inc , セファロン・インコーポレイテッド
发明人： HAGUE BRIAN
IPC分类号： A61J7/00
CPC分类号： A61J7/003 , A61J7/0046
摘要： PROBLEM TO BE SOLVED: To provide a disposal system for disposing oral administration type medicine.
SOLUTION: This disposing system comprises 1) a vessel having a top part, a bottom part and a side wall, which has a single or more openings arranged therein; 2) a means for surely retaining an oral dosage form medicine in the vessel, which allows the easy insertion of the oral dosage form medicine but preventing the medicine from being removed from the vessel in order to surely retain the medicine in the vessel; and 3) a fluid propulsion device for disposing of the medicine, which advances a fluid or liquid into the vessel through the openings to dissolve and dispose of the medicine in the fluid, in which the fluid can easily get in and out of the vessel.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种处置口服药物的处理系统。解决方案：该处理系统包括：1）具有顶部，底部和侧壁的容器，其具有布置在其中的单个或多个开口; 2）一种用于将口服剂型药物确保地保留在容器中的方法，其允许容易地插入口服剂型药物，但是防止药物从容器中移出以确保将药物保留在容器中; 以及3）用于处理药物的流体推进装置，其通过所述开口将流体或液体推进到所述容器中，以将所述药物溶解并处理在所述流体中，所述流体可容易地进入和流出所述容器。

5. 发明授权

US6286698B2 Methods and apparatus for the interim storage of medicated oral dosage forms 有权
标题翻译：药物口服剂型临时储存的方法和装置
公开(公告)号：US6286698B2
公开(公告)日：2001-09-11
申请号：US73208000
申请日：2000-12-07
申请人： CEPHALON INC
发明人： HAGUE BRIAN , SHOEMAKER STEVE
IPC分类号： A61J1/00 , A61J1/14 , A61J7/00 , B65D50/06 , B65D50/00
CPC分类号： A61J7/003 , A61J1/1437 , A61J7/0046 , B65D50/061 , Y02W30/807
摘要： An apparatus for the reusable interim storage of partially consumed medicated oral dosage forms and methods for employing such an apparatus in order to use medicated oral dosage forms in the safest possible manner. The apparatus of the present invention in its broadest terms comprises (1) a container sized to hold a medicated oral dosage form, (2) means for allowing a medicated oral dosage form easy access into the container but substantially preventing the medicated oral dosage form from passing out of the container, and (3) a child resistant means for allowing an adult to remove a medicated oral dosage form from within the container despite the one-way access means. The preferred embodiment comprises an opaque container having one opening, a child resistant closure with an aperture there through that extends over said opening, and a plastic slitted membrane covering said aperture. The method of the present invention comprises providing a patient with the apparatus of the present invention, administering to the patient a medicated oral dosage form, and when the patient has received sufficient medication, inserting the partially consumed medicated oral dosage form into the apparatus via the one-way access means.
摘要翻译：用于可重复使用的部分消耗的药物口服剂型的临时储存的装置和使用这种装置的方法，以便以最安全的方式使用药物口服剂型。本发明的最广泛的装置包括（1）容纳大量药物口服剂型的容器，（2）允许药物口服剂型容易进入容器但基本上防止药物口服剂型从容器中流出，以及（3）使用成年人从儿童容器内取出药物口服剂型的儿童抵抗手段，尽管是单向通道。优选实施例包括具有一个开口的不透明容器，具有穿过所述开口延伸的孔的儿童防护盖，以及覆盖所述孔的塑料切割膜。本发明的方法包括向患者提供本发明的装置，向患者施用药物口服剂型，并且当患者已经接受足够的药物时，将部分消耗的药物口服剂型通过经由单向接入方式。

6. 发明专利

BRPI0406996A 未知
公开(公告)号：BRPI0406996A
公开(公告)日：2006-01-10
申请号：BRPI0406996
申请日：2004-02-04
申请人： CEPHALON INC
发明人： HAGUE BRIAN , MALAND LYNN J
IPC分类号： A61K9/00 , A61K9/20 , A61K31/4468
摘要： The present invention is directed to oral solid dosage forms. The solid dosage forms are sugar-free, and comprise a pharmaceutical agent and a suitable pharmaceutically acceptable excipient. Preferably, the solid dosage forms of the present invention are bioequivalent to a sugar-containing solid dosage form. Bioequivalence is preferably obtained by incorporating an ionizing agent, more preferably in the form of a buffer system, into the solid dosage forms, in an amount sufficient to maintain a portion of the pharmaceutical agent, upon dissolution of said composition in saliva, in an ionized state.

7. 发明专利

AU2007328373A1 Oral transmucosal nicotine dosage form 未知
公开(公告)号：AU2007328373A1
公开(公告)日：2008-06-12
申请号：AU2007328373
申请日：2007-11-20
申请人： CIMA LABS INC , CEPHALON INC
发明人： KHANKARI RAJENDRA K , AGARWAL VIKAS , HAGUE BRIAN
IPC分类号： A61K9/46 , A61K31/465
摘要： The invention described herein relates to an oral transmucosal solid dosage form useful in treating nicotine addiction or as a nicotine substitute or replacement. By virtue of the formulation in combination with nicotine, the invention transmucosally delivers an effective amount of nicotine to the recipient while permitting the accomplishing of such, and manufacture of such, using a relatively small, convenient and orally comfortable dosage form (e.g., tablet) size.

8. 发明专利

AR043019A1 FORMAS DE DOSIFICACION SOLIDA TRANSMUCOSAL ORAL LIBRES DE AZUCAR Y SUS USOS 未知
公开(公告)号：AR043019A1
公开(公告)日：2005-07-13
申请号：ARP040100337
申请日：2004-02-04
申请人： CEPHALON INC
发明人： HAGUE BRIAN , MALAND LYNN J
IPC分类号： A61K9/20 , A61K31/4468 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/34 , A61P25/04
摘要： Formas de dosificación sólida transmucosal oral. Las formas de dosificación sólida son libres de azúcar siendo adecuadas para pacientes diabéticos y comprenden un agente farmacéutico fentanilo, entre otros y un excipiente farmacéuticamente aceptable apropiado. Preferentemente, las formas de dosificación sólida son bioequivalentes a formas de dosificación sólida que contienen azúcar. La bioequivalencia es obtenida preferentemente incorporando un agente ionizante, más preferentemente con la forma de un sistema buffer, a las formas de dosificación sólida, en una cantidad suficiente para mantener una porción del agente farmacéutico en estado ionizado cuando dicha composición se disuelve en la saliva. Método para la administración transmucosa 1.

9. 发明专利

AU2004208827A1 Sugar-free oral transmucosal solid dosage forms and uses thereof 未知
公开(公告)号：AU2004208827A1
公开(公告)日：2004-08-19
申请号：AU2004208827
申请日：2004-02-04
申请人： CEPHALON INC
发明人： HAGUE BRIAN , MALAND LYNN J
IPC分类号： A61K9/00 , A61K9/20 , A61K31/4468
摘要： The present invention is directed to oral solid dosage forms. The solid dosage forms are sugar-free, and comprise a pharmaceutical agent and a suitable pharmaceutically acceptable excipient. Preferably, the solid dosage forms of the present invention are bioequivalent to a sugar-containing solid dosage form. Bioequivalence is preferably obtained by incorporating an ionizing agent, more preferably in the form of a buffer system, into the solid dosage forms, in an amount sufficient to maintain a portion of the pharmaceutical agent, upon dissolution of said composition in saliva, in an ionized state.

10. 发明专利

ZA200506833B Sugar-free oral transmucosal solid dosage forms and uses thereof 未知
公开(公告)号：ZA200506833B
公开(公告)日：2006-05-31
申请号：ZA200506833
申请日：2005-08-25
申请人： CEPHALON INC
发明人： HAGUE BRIAN , MALAND LYNN J
IPC分类号： A61K20060101

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