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4. 发明申请

WO2021089821A1 IRON-SCORE AND IN VITRO METHOD FOR IDENTIFYING MANTLE CELL LYMPHOMA (MCL) SUBJECTS AND THERAPEUTIC USES AND METHODS 审中-公开
公开(公告)号：WO2021089821A1
公开(公告)日：2021-05-14
申请号：PCT/EP2020/081352
申请日：2020-11-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE MONTPELLIER , INSTITUT CURIE
发明人： MOREAUX, Jérôme , RODRIGUEZ, Raphaël , DEVIN, Julie , BRET, Caroline , CANEQUE COBO, Tatiana
IPC分类号： C12Q1/6886
摘要： The invention relates to the use of an iron-score based on the expression level of at least 1 gene, in particular at least 3, preferably at least 5, and even preferably 8 genes selected in the group consisting of APEX1, TFRC, HIF1A, ABCG2, SCARA3, IREB2, SFXN4 and SLC39A14 involved in the iron metabolism, as a prognosis marker in subjects having MCL, in particular for identifying subjects with a poor outcome such as a relapse and/or death.

5. 发明申请

WO2022234040A1 NITROGEN-CONTAINING ANALOGS OF SALINOMYCIN FOR USE IN MULTIPLE MYELOMA (MM) 审中-公开
公开(公告)号：WO2022234040A1
公开(公告)日：2022-11-10
申请号：PCT/EP2022/062202
申请日：2022-05-05
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT CURIE , UNIVERSITE DE MONTPELLIER
发明人： RODRIGUEZ, Raphaël , MOREAUX, Jérôme , BRET, Caroline , DEVIN, Julie , CANEQUE COBO, Tatiana
IPC分类号： A61K31/198 , A61K31/35 , A61K31/454 , A61K38/07 , A61P35/02
摘要： The invention relates compound of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diastereoisomers thereof: (F), wherein W, X, Y and Z are as defined, for use in the treatment of Multiple Myeloma (MM).

6. 发明申请

WO2021089819A1 IRON-SCORE AND IN VITRO METHOD FOR IDENTIFYING HIGH RISK DLBCL SUBJECTS AND THERAPEUTIC USES AND METHODS 审中-公开
公开(公告)号：WO2021089819A1
公开(公告)日：2021-05-14
申请号：PCT/EP2020/081349
申请日：2020-11-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE MONTPELLIER , INSTITUT CURIE
发明人： MOREAUX, Jérôme , RODRIGUEZ, Raphaël , DEVIN, Julie , BRET, Caroline , CANEQUE COBO, Tatiana
IPC分类号： C12Q1/6886
摘要： The invention relates to the use of an iron-score based on the expression level of at least 2 genes, in particular at least 5, preferably at least 10, and even preferably 11 genes selected in the group consisting of ALAS1, HIF1A, LRP2, HMOX1, HMOX2, HFE, ISCA1, SLC25A37, PPOX, STEAP1 and TMPRSS6 involved in the iron metabolism, as a prognosis marker in subjects having DLBCL, in particular for identifying subjects with a poor outcome such as a relapse and/or death.

7. 发明申请

WO2016012630A1 METHODS FOR PREDICTING RESPONSE TO DNA REPAIR PATHWAY INHIBITORS IN DIFFUSE LARGE B-CELL LYMPHOMA 审中-公开
标题翻译：用于预测大量B细胞淋巴瘤中DNA修复途径抑制剂的反应方法
公开(公告)号：WO2016012630A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/067174
申请日：2015-07-27
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE MONTPELLIER , CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： MOREAUX, Jérôme , CARTRON, Guillaume , BRET, Caroline , CONSTANTINOU, Angelos , PASERO, Philippe
IPC分类号： C12Q1/68 , G06F19/18 , G06F19/20 , G06F19/24
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G06F19/00 , G06F19/18 , G06F19/20 , G06F19/24 , G16H50/30
摘要： The present invention relates to a method of testing whether a patient suffering from arge B-cell lymphoma will respond or not to a DNA repair pathway inhibitor comprising: i) determining the expression level (ELi) of several genes Gi-Gn selected from table A in a biological sample obtained from said patient comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii) calculating the DNA repair score trough the following formula (I), wherein βi represent the regression β coefficient reference value for the gene Gi and C i = 1 if the expression of the gene Gi (ELi) is higher than the predetermined reference level (ELRi) or Ci = -1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) iv) comparing the score DNARS determined at step iii) with a predetermined reference value DNARS R v) and concluding that the patient will respond to the treatment when the DNARS score is higher than the predetermined reference value DNARS R or concluding that the patient will not respond to the treatment when the DNARS score is lower than the predetermined reference value DNARS R .
摘要翻译：本发明涉及一种检测是否患有弓形B细胞淋巴瘤的患者是否对DNA修复途径抑制剂有反应的方法，包括：i）确定从表A中选出的若干基因Gi-Gn的表达水平（ELi）在从所述患者获得的生物样品中比较在步骤i）确定的表达水平（ELi）与预定参考水平（ELRi）iii）通过下式（I）计算DNA修复评分，其中βi表示回归β系数如果基因Gi（ELi）的表达高于预定参考水平（ELRi），则基因Gi和Ci = 1的参考值，如果基因（ELi）的表达低于或等于预定参考水平（ELRi）iv）将在步骤iii）确定的分数DNARS与预定参考值DNARSR v）进行比较，并得出当DNARS评分高于预测值时患者将对治疗作出响应开采参考值DNARSR或结论当DNARS评分低于预定参考值DNARSR时患者不会对治疗作出反应。

8. 发明授权

EP2898091B1 METHODS FOR PREDICTING MULTIPLE MYELOMA TREATMENT RESPONSE 有权
公开(公告)号：EP2898091B1
公开(公告)日：2019-10-02
申请号：EP13766076.7
申请日：2013-09-23
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Montpellier I , Centre Hospitalier Universitaire de Montpellier
发明人： MOREAUX, Jérôme , KLEIN, Bernard
IPC分类号： C12Q1/6886 , A61K31/7068

10. 发明公开

EP2898091A1 METHODS FOR PREDICTING MULTIPLE MYELOMA TREATMENT RESPONSE 有权
标题翻译：预测多发性骨髓瘤治疗反应的方法
公开(公告)号：EP2898091A1
公开(公告)日：2015-07-29
申请号：EP13766076.7
申请日：2013-09-23
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Montpellier I , Centre Hospitalier Universitaire de Montpellier
发明人： MOREAUX, Jérôme , KLEIN, Bernard
IPC分类号： C12Q1/68 , A61K31/7068
CPC分类号： C12Q1/6886 , A61K31/706 , A61K31/7068 , C12Q2600/106 , C12Q2600/158 , G06F19/3456 , G16B25/00
摘要： The present invention relates to a method of testing whether a patient suffering of multiple myeloma will respond or not to a DNA methyltransferase inhibitor (DNMTi) comprising: i. determining the expression level (ELi) of several genes G1-Gn selected from table A in a biological sample obtained from said patient ii. comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii. calculating the DMS score trough the following formula (I) wherein &bgr;1 represent the regression &bgr; coefficient reference value for the gene Gi and Ci=1 if the expression of the gene Gi (ELi) is higher than the predetermined reference level (ELRi) or Ci=−1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) comparing the score DMS determined at step iii) with a predetermined reference value DMSR and concluding that the patient will respond to the DNMTi when the DMS score is higher than the predetermined reference value DMSR or concluding that the patient will not respond to the DNMTi when the DMS score is lower than the predetermined reference value DMSR. DMS = ∑ i = 1 n  &bgr;  i × Ci ( I )
摘要翻译：本发明涉及一种测试患有多发性骨髓瘤的患者是否会对DNA甲基转移酶抑制剂（DNMTi）起反应的方法，包括：i。测定从所述患者ii获得的生物样品中选自表A的几个基因G I-G n的表达水平（ELi）。将步骤i）确定的表达水平（ELi）与预定参考水平（ELRi）iii进行比较。通过以下公式（I）计算DMS得分，其中如果基因G i（ELi）的表达高于预定参考水平（ELRi），则其表示基因G i和Ci = 1的回归β系数参考值，或如果基因（ELi）的表达低于或等于预定参考水平（ELRi），则Ci = -1，将步骤iii）确定的评分DMS与预定参考值DMSR进行比较，并推断患者将响应当DMS分数高于预定参考值DMS R时，向DNMTi发送该分数，或者当DMS分数低于预定参考值DMS R时，推断患者不会响应DNMTi。

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