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1. 发明申请

WO1997044474A2 VIRAL PARTICLES WHICH ARE MASKED OR UNMASKED WITH RESPECT TO A CELL RECEPTOR 审中-公开
标题翻译：与细胞受体相关的病毒颗粒被隐藏或被忽略
公开(公告)号：WO1997044474A2
公开(公告)日：1997-11-27
申请号：PCT/FR1997000870
申请日：1997-05-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COSSET, François-Loîc , VALSESIA, Sandrine , RUSSELL, Stephen, J.
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/86
CPC分类号： C07K14/005 , A61K47/6901 , A61K48/00 , C07K1/1075 , C07K14/485 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N15/86 , C12N15/87 , C12N2740/13022 , C12N2740/13043 , C12N2740/13045 , C12N2740/13062 , C12N2810/60 , C12N2810/6018 , C12N2810/6054 , C12N2810/80 , C12N2810/851 , C12N2810/852 , C12N2810/854
摘要： The invention features the use of a peptide for transferring genes in a eukaryotic target cell, which peptide has about 10 to about 200, in particular about 15 to about 150 amino acids, and advantageously about 20 amino acids, in which 30 % at least of the amino acids are constituted by proline radicals, which proline radicals are regularly arranged so as to induce polypeptide chain turnings at about 180 DEG (" beta -turn" or "reverse-turn"), these turns being regularly spaced and gathering in a polyproline beta -turn helix, in a polypeptide construction containing, on the said peptide N-terminal side (upstream), an N-terminal (upstream) proteinic domain capable of recognising a targeted surface molecule or an antigen expressed on a cellular surface, in particular an appropriate receptor (targeted receptor) located on the said eukaryotic cell, and on the said peptide C-terminal side (downstream), a C-terminal (downstream) protein domain capable of recognising an appropriate receptor (auxiliary receptor) located on the said eukaryotic cell, which peptide is capable of facilitating or inhibiting interaction between the C-terminal (downstream) protein domain and the auxiliary receptor, the inhibition of this interaction taking place so long as the N-terminal (upstream) protein domain has not interacted with the targeted receptor, and the facilitating of the interaction between the C-terminal (downstream) protein domain and the auxiliary receptor taking place when the N-terminal (upstream) protein domain has interacted with the targeted receptor.
摘要翻译：本发明的特征在于使用肽在真核靶细胞中转移基因，该肽具有约10至约200，特别是约15至约150个氨基酸，并且有利地约20个氨基酸，其中至少30％氨基酸由脯氨酸基团构成，脯氨酸自由基被规则排列，以便在约180°（“β转”或“反转”）处诱导多肽链转角，这些转动规则地间隔开并聚集在聚脯氨酸特别是在所述肽N-末端侧（上游）上含有能够识别目标表面分子或表达于细胞表面的抗原的N末端（上游）蛋白质结构域的多肽构建体中，β转角螺旋位于所述真核细胞上的适当受体（靶向受体）和所述肽C-末端侧（下游），能够识别合适受体的C末端（下游）蛋白结构域（a 位于所述真核细胞上的所述肽，所述肽能够促进或抑制C-末端（下游）蛋白质结构域和辅助受体之间的相互作用，只要N末端（上游）蛋白质结构域没有与靶向受体相互作用，并且当N-末端（上游）蛋白质结构域与靶向受体相互作用时，C末端（下游）蛋白质结构域和辅助受体之间的相互作用的促进发生。

2. 发明申请

WO2004032967A1 ASSOCIATION ENTRE UN LIGAND DES PPAR ET UN AGENT ANTIOXYDANT ET UTILISATION DANS LE TRAITEMENT DE L'OBESITE 审中-公开
标题翻译： PPAR配体与抗氧化剂之间的关系及其用于治疗肥胖症的用途
公开(公告)号：WO2004032967A1
公开(公告)日：2004-04-22
申请号：PCT/FR2003/002986
申请日：2003-10-10
申请人： LABORATOIRES SERVIER , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CASTEILLA, Louis , PENICAUD, Luc , DACQUET, Catherine , RENARD, Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CASTEILLA, Louis , PENICAUD, Luc , DACQUET, Catherine , RENARD, Pierre
IPC分类号： A61K45/06
CPC分类号： A61K31/122 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： Association contenant un ou plusieurs ligands des récepteurs activés par les proliférateurs de peroxisomes et un agent antioxydant. Médicaments.
摘要翻译：本发明涉及含有一种或多种过氧化物酶体增殖物激活受体配体和抗氧化剂的结合物。本发明适用于药物。

3. 发明申请

WO2004002999A2 MODIFIED 2' AND 3' -NUCLEOSIDE PRODUGS FOR TREATING FLAVIRIDAE INFECTIONS 审中-公开
标题翻译：修饰的2'和3'核苷酸产物用于治疗FLAVIRIDAE感染
公开(公告)号：WO2004002999A2
公开(公告)日：2004-01-08
申请号：PCT/IB2003/003246
申请日：2003-06-27
申请人： IDENIX (CAYMAN) LIMITED , UNIVERSITA DEGLI STUDI DI CAGLIARI , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SOMMADOSSI, Jean-Pierre , LA COLLA, Poalo , STORER, Richard , GOSSELIN, Gilles
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SOMMADOSSI, Jean-Pierre , LA COLLA, Poalo , STORER, Richard , GOSSELIN, Gilles
IPC分类号： C07H19/00
CPC分类号： C07H19/10 , C07H19/00 , C07H19/20
摘要： 2' and/or 3' prodrugs of l', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
摘要翻译：描述了1'，2'，3'或4'-分支核苷的2'和/或3'前药及其药学上可接受的盐和衍生物。这些前体药物可用于预防和治疗黄病毒科感染，包括HCV感染和其他相关病症。描述了本发明前药的化合物和组合物。还提供了包括施用有效量的本发明的前药或其药学上可接受的盐或衍生物的方法和用途。这些药物可以任选地与另外的抗病毒剂组合或改变给药以预防或治疗黄病毒科感染和其他相关病症。

4. 发明申请

WO1998029877A1 PROTON CONDUCTOR IN LIQUID FORM 审中-公开
标题翻译：液体导体
公开(公告)号：WO1998029877A1
公开(公告)日：1998-07-09
申请号：PCT/CA1997001012
申请日：1997-12-30
申请人： HYDRO-QUEBEC , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ARMAND, Michel , MICHOT, Christophe , KAPFER, Bruno
发明人： HYDRO-QUEBEC , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： H01B01/12
CPC分类号： B01J31/0224 , B01J31/0215 , B01J31/0222 , B01J31/0225 , B01J31/0227 , B01J31/0235 , B01J31/0239 , B01J31/0247 , B01J31/0251 , B01J31/0252 , B01J31/0267 , B01J31/0271 , B01J31/0281 , B01J31/0288 , B01J31/0289 , B01J31/04 , B01J31/06 , B01J31/068 , B01J31/124 , B01J31/1815 , B01J31/2208 , B01J2231/122 , B01J2231/14 , B01J2231/326 , B01J2231/341 , B01J2231/348 , B01J2231/4205 , B01J2231/543 , B01J2531/35 , B01J2531/824 , C07B37/02 , C07B37/12 , C07C45/46 , C07C45/69 , C07C67/00 , C07C255/10 , C07C255/17 , C07C255/27 , C07C255/46 , C07C255/65 , C07C257/14 , C07C311/03 , C07C311/04 , C07C311/09 , C07C311/48 , C07C317/04 , C07C317/08 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/34 , C07C317/44 , C07C2601/10 , C07C2602/42 , C07D207/452 , C07D213/76 , C07D219/10 , C07D231/18 , C07D233/90 , C07D239/60 , C07D241/42 , C07D249/04 , C07D249/10 , C07D249/12 , C07D251/70 , C07D277/64 , C07D277/82 , C07D285/125 , C07D285/135 , C07D285/15 , C07D285/16 , C07D303/34 , C07D307/54 , C07D307/64 , C07D311/52 , C07D311/58 , C07D311/82 , C07D319/06 , C07D333/16 , C07D333/24 , C07D405/06 , C07D409/12 , C07D417/10 , C07D417/14 , C07F17/02 , C08F4/04 , C08G65/3344 , C09B69/00 , C09B69/02 , C09B69/10 , G02F1/1525 , G02F2001/151 , H01B1/122 , H01B1/128 , H01G9/022 , H01G9/038 , H01G11/02 , H01G11/62 , H01M4/00 , H01M4/02 , H01M4/131 , H01M4/133 , H01M4/134 , H01M4/382 , H01M4/405 , H01M4/48 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/5815 , H01M4/5825 , H01M4/60 , H01M4/625 , H01M4/661 , H01M6/00 , H01M6/04 , H01M6/164 , H01M6/166 , H01M6/168 , H01M6/181 , H01M6/183 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M10/0567 , H01M10/0568 , Y02E60/13 , Y10S430/127 , Y10T29/49108 , Y10T428/2918 , C07C49/84 , C07C49/553
摘要： Disclosed is a proton conductor in liquid form, comprised of a mixture of the following components: (a) a salt combined with a nitrogenated base along with an acid, according to formula (I), wherein Z1, Z2, Z3, and Z4, whether identical or different, represent a group -N= or -C(Zi)=, wherein Zi represents a hydrogen atom, a linear or branched alkyl radical with from 1 to 20 carbon atoms, a fluoroalkyl radical with from 1 to 20 carbon atoms, or an oxoalkyl or azaalkyl radical with from 1 to 20 carbon atoms, as long as at least one and at most two of the groups Z1, Z2, Z3, and Z4 represent -N=; two adjacent carbon atoms are possibly hydrogenated; the nitrogenated base possibly forms part of a polymeric matrix; and X represents an anion derivative of an acid selected from the group formed by the sulphonic acids of the formula R 3 F 2 F 2 F 2 F 2 2 F 2 F 2 F 2 F F F 2 n 1 2 3 4
摘要翻译：公开了液体形式的质子导体，其由以下组分的混合物组成：（a）根据式（I）的与氮化合的碱与盐结合的盐，其中Z1，Z2，Z3和Z4，无论相同或不同，表示基团-N =或-C（Zi）=，其中Zi表示氢原子，具有1至20个碳原子的直链或支链烷基，具有1至20个碳原子的氟代烷基，或具有1至20个碳原子的氧代烷基或氮杂烷基，只要基团Z1，Z2，Z3和Z4中的至少一个和至多两个表示-N =; 两个相邻的碳原子可能被氢化; 氮化碱可能形成聚合物基体的一部分; 并且X 1表示酸式的阴离子衍生物，其选自由式R fSO 3，H的磺酸形成的基团，式（R 1 F F 2 <）（R'> F 2 <）CH> 2或者R“F 2 < （R“> F 2 <）（R”> F 2 <）CH，其中R“F”，R“> F”或“独立地表示基团F（CF> 2 n < - ，n包含在0和6之间，而酸可能形成聚合物基体的一部分; 和（b）根据式（II）的氮化碱，其中Z> 1，Z 2，Z 3和Z 4具有上述含义，并且氮化碱可能是聚合物基质。组分（a）和（b）以允许形成熔点小于25℃的组合物的比例存在。本发明公开的质子导体可用作液体，凝胶或聚合物电解质在各种电化学系统中。

5. 发明申请

WO1998021959A1 USE OF ASCIDIDEMIN AND DERIVATIVES IN BIOLOGICAL ANTISOILING COMPOSITIONS 审中-公开
标题翻译：在生物防腐组合物中使用抗坏血酸和衍生物
公开(公告)号：WO1998021959A1
公开(公告)日：1998-05-28
申请号：PCT/FR1997002102
申请日：1997-11-20
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DEBARD, Witold +hm , DEBARD, Catherine +hf , DEBARD, Sophie +hf , DEBARD, Nathalie +hf , COMBAUT, Georges , BANAIGS, Bernard , FRANCISCO, Christian , COMMEYRAS, Auguste
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DEBARD, Witold +hm , DEBARD, Catherine +hf , DEBARD, Sophie +hf , DEBARD, Nathalie +hf , DEBARD, Hélène +di
IPC分类号： A01N43/90
CPC分类号： A01N43/90 , C09D5/1625
摘要： The invention concerns the use of compounds of general formula (I) in which R1 and R2, independently of each other, represent a hydrogen atom, or saturated or unsaturate radicals with one or several double bonds, in particular a C1-C10 alkyl group, or substituted amines, or R1 and R2 constitute a C4-C8 cycle, or containing one or several heteroatoms instead of said carbon atoms in the cycle, particularly a benzene ring or a pyridin ring, as biological antisoiling agents (also called antifouling agents).
摘要翻译：本发明涉及使用通式（I）的化合物，其中R 1和R 2彼此独立地表示氢原子或具有一个或多个双键的饱和或不饱和基团，特别是C 1 -C 10烷基，或取代的胺，或者R1和R2构成C4-C8循环，或者在循环中含有一个或多个杂原子代替所述碳原子，特别是苯环或吡啶环，作为生物防垢剂（也称为防污剂）。

6. 发明申请

WO1998019142A1 OPTICAL COMPONENT OF POLARIZING MODULATION, AND ITS USE IN A POLARIMETER OR IN AN ELLIPSOMETER 审中-公开
标题翻译：极化调制的光学元件及其在极化仪中或在偏振仪中的应用
公开(公告)号：WO1998019142A1
公开(公告)日：1998-05-07
申请号：PCT/FR1997001849
申请日：1997-10-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DREVILLON, Bernard , COMPAIN, Eric
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01J04/00
CPC分类号： G01N21/211 , G01J4/00 , G02F1/0327
摘要： The invention concerns an optical component of polarizing modulation, a polarimeter and a Mueller ellipsometer comprising this optical component. The optical component modulates an incident light beam (10) linearly polarized and sends back a modulated beam (11). It comprises a coupled phase modulator (6B) modulating twice successively the incident beam, the two modulations being at the same frequency omega /2 pi and being coupled by a system (61) modifying the state of polarization of the light between the two modulations. The ellipsometer comprises means for sensing a measuring beam sent back by a sample, which receives the modulated beam, and a processing unit. The sensing means include a polarimeter generating n measured quantities representing the states of polarization of the beam and the processing unit generates by Fourier transform m values for each of these quantities, with n x m >/= 16 and m >/= 4, for simultaneously acceding to the sixteen coefficients of the Mueller matrix of the sample.
摘要翻译：本发明涉及偏振调制的光学部件，偏振计和包含该光学部件的米勒椭偏仪。光学部件调制线偏振的入射光束（10）并发送回调制光束（11）。它包括耦合相位调制器（6B），连续调制入射光束两次，两个调制处于相同的频率ω/2π，并通过修改两个调制之间的光的偏振状态的系统（61）耦合。椭偏仪包括用于感测由接收调制束的样本发回的测量光束的装置和处理单元。感测装置包括产生表示光束的极化状态的n个测量量的旋转计，并且处理单元通过用这些量的每一个的傅立叶变换m值产生，其中nxm> = 16和m> / = 4，用于同时加入到样本的Mueller矩阵的十六个系数。

7. 发明申请

WO1997045549A1 DNA SEQUENCES CODING FOR LACCASES, AND THEIR APPLICATIONS IN THE FIELD OF PLANT LIGNIN CONTENT CONTROL. 审中-公开
标题翻译： DNA序列编码为LACCASES，以及它们在植物木质素含量控制领域的应用。
公开(公告)号：WO1997045549A1
公开(公告)日：1997-12-04
申请号：PCT/FR1997000948
申请日：1997-05-30
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , FAYE, Loïc , GOMORD, Véronique-Martine , KIEFER-MEYER, Marie-Christine , O'CONNEL, Ann
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/82
CPC分类号： C12N9/0061 , C12N15/8255
摘要： The invention discloses any DNA sequence containing, as coding region, all or part of the nucleotide sequence coding for an mRNA coding for a laccase, or all or part of the complementary nucleotide sequence of the latter and coding for an antisense mRNA capable of being hybridized with the above mentioned mRNA. The invention also discloses the use of the above mentioned sequences for implementing methods of controlling lignin biosynthesis in plants.
摘要翻译：本发明公开了含有编码区域的编码全部或部分编码漆酶的mRNA的核苷酸序列的任何DNA序列，或后者的全部或部分互补核苷酸序列，并编码能够杂交的反义mRNA 与上述mRNA。本发明还公开了上述序列用于实施植物中木质素生物合成控制方法。

8. 发明申请

WO1997039006A1 USE OF ORGANOMETALLIC COMPOUNDS FOR PREPARING RADIOPHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：用于制备放射性产物的有机化合物的使用
公开(公告)号：WO1997039006A1
公开(公告)日：1997-10-23
申请号：PCT/FR1997000610
申请日：1997-04-04
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , JAOUEN, Gérard , TOP, Siden , PANKOWSKI, Marek
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07F13/00
CPC分类号： C07F13/005 , C07F17/00
摘要： The invention features the use of a compound of formula M2(CO)10 in which M represents Re or Tc, M being in radioactive or non-radioactive form, for preparing radiopharmaceutical products useful as diagnostic and therapeutic products. The compound M2(CO)10 is obtained through the reduction of MO4- by a reducing agent not capable of decomposing M2(CO)10 and reactive to MO4-, in the presence of a solvent with a solubility of at least 5 mmol/1 in CO and a temperature of ebullition in the range of about 30 DEG C to about 150 DEG C and more particularly of about 60 DEG C to about 120 DEG C, at a CO pressure of about 1 to about 10 atmospheres, more particularly of about 1 to about 5 atmospheres and optimally of about 1 atmosphere, at a temperature of about 20 DEG C to about 100 DEG C, optimally about 70 DEG C to about 80 DEG C.
摘要翻译：本发明的特征在于使用式M2（CO）10化合物，其中M表示Re或Tc，M为放射性或非放射性形式，用于制备可用作诊断和治疗产品的放射性药物产品。化合物M2（CO）10是通过在溶剂存在下溶解度至少为5mmol / l的还原剂通过不能分解M2（CO）10并与MO4-反应的还原剂还原得到的在约30℃至约150℃，更特别是约60℃至约120℃的范围内，在约1至约10个大气压的CO压力下，更特别是约约1至约5个大气压，最佳约1个大气压，约20℃至约100℃，最佳约70℃至约80℃。

9. 发明申请

WO1997033919A1 THIOUREIDO-CYCLODEXTRINS PARTICULARLY USEFUL FOR SOLUBILISING ANTITUMORAL AND ANTIPARASITIC AGENTS, AND METHODS FOR PREPARING SAME 审中-公开
标题翻译：特别是用于溶解抗肿瘤剂和抗微生物剂的抗氧化环孢菌素及其制备方法
公开(公告)号：WO1997033919A1
公开(公告)日：1997-09-18
申请号：PCT/FR1997000449
申请日：1997-03-13
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DEFAYE, Jacques , ORTIZ-MELLET, Carmen , GARCIA-FERNANDEZ, José-Manuel
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C08B37/16
CPC分类号： B82Y5/00 , A61K47/6951 , C08B37/0012
摘要： Thioureido-cyclodextrins particularly useful for solubilising antitumoral and antiparasitic agents, and methods for preparing same, are disclosed. The thioureido-cyclodextrins are of formula (I), wherein m is 6, 7 or 8, R is OH or NH-CS-NHR2, with at least one R being NH-CS-NHR2, and R is an alkyl, monosaccharide, oligosaccharide, glycosyl-amino acid or glycopeptide group. Said cyclodextrins are useful for solubilising antitumoral and antiparasitic agents from the taxol family.
摘要翻译：公开了特别可用于增溶抗肿瘤和抗寄生虫药物的硫脲 - 环糊精及其制备方法。硫脲基 - 环糊精具有式（I），其中m为6,7或8，R 1为OH或NH-CS-NHR 2，其中至少一个R 1为NH-CS-NHR 2，R 2是烷基，单糖，寡糖，糖基 - 氨基酸或糖肽组。所述环糊精可用于从紫杉醇家族中增溶抗肿瘤和抗寄生虫药物。

10. 发明申请

WO1997019182A1 PRODUCTION OF RETROVIRAL VECTORS USING HERPES VECTORS 审中-公开
标题翻译：使用草本矢量生产退变矢量
公开(公告)号：WO1997019182A1
公开(公告)日：1997-05-29
申请号：PCT/FR1996001817
申请日：1996-11-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , EPSTEIN, Alberto, Luis , COSSET, François-Loïc , SAVARD, Nathalie
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2710/16143 , C12N2710/16162 , C12N2710/16644 , C12N2740/13022 , C12N2740/13043
摘要： A method for producing retroviral vectors useful for transferring nucleic acid sequences into eukaryotic cells, wherein a eukaryotic cell is infected with at least one herpetic viral vector, is disclosed. The retroviral elements needed to complete the retroviral cycle are provided by the herpetic vector(s) alone or in combination with retroviral elements within the genome of the eukaryotic cell.
摘要翻译：公开了用于产生用于将核酸序列转移到真核细胞中的逆转录病毒载体的方法，其中真核细胞被至少一种疱疹病毒载体感染。完成逆转录病毒循环所需的逆转录病毒元件由单独的疱疹载体或与真核细胞基因组内的逆转录病毒元件组合提供。

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