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1. 发明申请

WO03102207A2 NOVEL MULTIMERIC MOLECULES, THE PREPARATION METHOD THEREOF AND USE OF SAME FOR THE PREPARATION OF MEDICAMENTS 审中-公开
标题翻译：新型多功能分子，其制备方法及其在制备药物中的应用
公开(公告)号：WO03102207A2
公开(公告)日：2003-12-11
申请号：PCT/FR0301613
申请日：2003-05-28
申请人： CENTRE NAT RECH SCIENT , GUICHARD GILLES FRANCOIS ROGER , FOURNEL SYLVIE VICTORINE LUCIE , BIANCO ALBERTO , HOEBEKE JOHAN FELICIEN , MULLER SYLVIANE
发明人： GUICHARD GILLES FRANCOIS ROGER , FOURNEL SYLVIE VICTORINE LUCIE , BIANCO ALBERTO , HOEBEKE JOHAN FELICIEN , MULLER SYLVIANE
IPC分类号： A61K47/48 , A61K38/00 , A61K39/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K1/08 , C07K5/09 , C07K5/11 , C07K7/02 , C07K14/525 , C07K14/705 , C07K14/725 , C12Q
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/1019 , C07K14/525 , C07K14/70575
摘要： The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D' group, in which B is a spacer and D and D' are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.
摘要翻译：本发明涉及可以模拟天然多聚体蛋白质配体的多聚体分子。本发明还涉及如上定义的多聚体分子，其特征在于其具有以下通式：A-Xn，其中：n等于3,4,5或6; A表示通过至少三个胺官能团或COOH官能团官能化的化学基团; 并且X表示D，BD或B（D）-D'基团，其中B是间隔基，D和D'是对应于衍生自配体并选自形成界面的残余物质的序列的肽或假肽与受体并可与受体相互作用。

2. 发明申请

WO2005121799A3 NON-COVALENT COMPLEXES COMPRISING CARBON NANOTUBES 审中-公开
标题翻译：包含碳纳米管的非共价复合物
公开(公告)号：WO2005121799A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005006036
申请日：2005-06-06
申请人： CENTRE NAT RECH SCIENT , UNIV LONDON THE SCHOOL OF PHAR , BIANCO ALBERTO , PANTAROTTO DAVIDE , KOSTARELOS KOSTAS , PRATO MAURIZIO
发明人： BIANCO ALBERTO , PANTAROTTO DAVIDE , KOSTARELOS KOSTAS , PRATO MAURIZIO
IPC分类号： C01B31/02 , C09C1/56 , C12Q1/68 , G01N33/543 , G01N33/551
CPC分类号： C09C1/565 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B2202/02 , C01B2202/06 , C01P2004/13 , C01P2004/133 , C09C1/48 , G01N33/54353 , G01N33/551 , Y10S977/746 , Y10S977/748 , Y10S977/75 , Y10S977/752
摘要： The present invention relates to the use of a carbon nanotube comprising positive and/or negative charges, said charges being carried by at least one charge-carrying group, said chargecarrying group being covalently bound to the surface of said carbon nanotube, for the manufacture of a complex between said carbon nanotube and at least one charged molecule, the bond between the carbon nanotube and the charged molecule being essentially electrostatic, and said charged molecule comprising at least one negative charge if said carbon nanotube comprises positive charges and/or at least one positive charge if said carbon nanotube comprises negative charges.
摘要翻译：本发明涉及包含正电荷和/或负电荷的碳纳米管的用途，所述电荷由至少一个电荷携带基团携带，所述电荷接受基团与所述碳纳米管的表面共价结合，用于制造所述碳纳米管与至少一个带电分子之间的复合物，所述碳纳米管与带电分子之间的键基本上是静电的，并且所述带电分子包含至少一个负电荷，如果所述碳纳米管包含正电荷和/或至少一个如果所述碳纳米管包含负电荷，则为正电荷。

3. 发明专利

FR2840307B1 未知
公开(公告)号：FR2840307B1
公开(公告)日：2006-07-07
申请号：FR0206631
申请日：2002-05-30
申请人： CENTRE NAT RECH SCIENT
发明人： GUICHARD GILLES FRANCOIS ROGER , FOURNEL SYLVIE VICTORINE LUCIE , BIANCO ALBERTO , HOEBEKE JOHAN , MULLER SYLVIANE
IPC分类号： A61K47/48 , C07K7/00 , A61K38/00 , A61K38/04 , A61K38/16 , A61K39/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K1/08 , C07K5/09 , C07K5/11 , C07K7/02 , C07K14/00 , C07K14/525 , C07K14/705 , C07K14/725 , C07K19/00
摘要： The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.

4. 发明专利

DE60307830D1 未知
公开(公告)号：DE60307830D1
公开(公告)日：2006-10-05
申请号：DE60307830
申请日：2003-05-28
申请人： CENTRE NAT RECH SCIENT
发明人： GUICHARD GILLES FRANCOIS ROGER , FOURNEL SYLVIE VICTORINE LUCIE , BIANCO ALBERTO , HOEBEKE JOHAN FELICIEN , MULLER SYLVIANE
IPC分类号： A61K47/48 , C07K5/08 , A61K38/00 , A61K38/04 , A61K38/16 , A61K39/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K1/08 , C07K5/09 , C07K5/10 , C07K5/11 , C07K7/02 , C07K14/525 , C07K14/705 , C07K14/725
摘要： The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.

5. 发明专利

AU2003255612A8 Novel multimeric molecules, the preparation method thereof and use of same for the preparation of medicaments 未知
公开(公告)号：AU2003255612A8
公开(公告)日：2003-12-19
申请号：AU2003255612
申请日：2003-05-28
申请人： CENTRE NAT RECH SCIENT
发明人： HOEBEKE JOHAN FELICIEN , GUICHARD GILLES FRANCOIS ROGER , BIANCO ALBERTO , MULLER SYLVIANE , FOURNEL SYLVIE VICTORINE LUCIE
IPC分类号： A61K47/48 , A61K38/00 , A61K39/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K1/08 , C07K5/09 , C07K5/11 , C07K7/02 , C07K14/525 , C07K14/705 , C07K14/725 , C07K5/08 , C07K5/10 , A61K38/16 , A61K38/04
摘要： The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.

6. 发明专利

AU2003224070A8 Functionalized carbon nanotubes, a process for preparing the same and their use in medicinal chemistry 未知
公开(公告)号：AU2003224070A8
公开(公告)日：2004-11-01
申请号：AU2003224070
申请日：2003-04-14
申请人： CENTRE NAT RECH SCIENT , UNIV DEGLI STUDI TRIESTE
发明人： BIANCO ALBERTO , PANTAROTTO DAVIDE , PRATO MAURIZIO
IPC分类号： A61K47/48 , A61P31/00 , A61P37/00 , A61P43/00 , C01B31/02 , G01N33/543 , G01N33/551
摘要： The present invention relates to functionalized carbon nanotubes, a process for preparing the same and their use, in particular in medicinal chemistry and more particularly in immunology.

7. 发明专利

DE60307830T2 未知
公开(公告)号：DE60307830T2
公开(公告)日：2007-06-06
申请号：DE60307830
申请日：2003-05-28
申请人： CENTRE NAT RECH SCIENT
发明人： GUICHARD GILLES FRANCOIS ROGER , FOURNEL SYLVIE VICTORINE LUCIE , BIANCO ALBERTO , HOEBEKE JOHAN FELICIEN , MULLER SYLVIANE
IPC分类号： A61K47/48 , C07K5/08 , A61K38/00 , A61K38/04 , A61K38/16 , A61K39/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K1/08 , C07K5/09 , C07K5/10 , C07K5/11 , C07K7/02 , C07K14/525 , C07K14/705 , C07K14/725
摘要： The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.

8. 发明专利

ES2274267T3 NUEVAS MOLECULAS MULTIMERICAS, SU PROCEDIMIENTO DE PREPARACION, Y SU UTILIZACION PARA LA PREPARACION DE MEDICAMENTOS. 未知
公开(公告)号：ES2274267T3
公开(公告)日：2007-05-16
申请号：ES03756015
申请日：2003-05-28
申请人： CENTRE NAT RECH SCIENT
发明人： GUICHARD GILLES FRANCOIS ROGER , FOURNEL SYLVIE VICTORINE LUCIE , BIANCO ALBERTO , HOEBEKE JOHAN FELICIEN , MULLER SYLVIANE
IPC分类号： A61K47/48 , C07K5/08 , A61K38/00 , A61K38/04 , A61K38/16 , A61K39/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K1/08 , C07K5/09 , C07K5/10 , C07K5/11 , C07K7/02 , C07K14/525 , C07K14/705 , C07K14/725
摘要： Molécula multimérica, caracterizada porque responde a la siguiente fórmula general: A-Xn en la que: - n es igual a 3, 4, 5 ó 6, - A es un grupo químico, funcionalizado por al menos tres funciones aminas o funciones COOH o funciones SH o funciones S-Npys (S-nitro-piridinasulfenilo) o funciones S-Pys (S-piridinasulfenilo), y es en particular diferente de una proteína, - X representa un grupo -D, -B-D o -B(D)-D'', en el que: * B es un brazo espaciador, * -D y -D'' representan péptidos o pseudopéptidos que corresponden a una secuencia derivada de un ligando, seleccionada de entre los residuos que forman la superficie de contacto con el receptor del ligando, secuencia que es susceptible de interactuar con el receptor, seleccionándose dicho ligando de entre los ligandos de receptores de la superfamilia del TNF, y en particular de entre los ligandos siguientes: EDA, CD40L, FasL, OX40L, AITRL, CD30L, VEGI, LIGHT, 4-1BBL, CD27L, LTalfa, TNF, LTbeta, TWEAK, APRIL, BLYS, RANKL y TRAIL, caracterizada porque: o bien A es un radical ramificado de simetría C3 de fórmula general siguiente: en la que: * m y m'''' son números enteros comprendidos de 1 a 5, * V representa un grupo -NH- o -CO- que forma un enlace amida con X, * Z representa un átomo de oxígeno o un grupo CH2, * Y representa o bien un átomo de nitrógeno, o bien un grupo R-C- o bien un grupo R-CONH-C-, en los que R puede ser un grupo alquilo con 1 a 10 átomos de carbono, un grupo alquenilo con 1 a 10 átomos de carbono, un grupo alquinilo con 1 a 10 átomos de carbono, un grupo arilo con 5 a 12 átomos de carbono, un grupo aralquilo con 5 a 14 átomos de carbono o un grupo heteroarilo con 1 a 10 átomos de carbono, pudiendo estar dichos grupos no sustituidos o sustituidos por 1 a 6 sustituyentes seleccionados de entre los grupos -COOH, -NH2, -CONH2 o alcoxi, o bien A es un radical C3 cíclico que responde a una de las fórmulas generales siguientes: ** ver fórmula** en las que: * Ra representa o bien un grupo -NH- o bien un grupo -CO- que forma un enlace amida con X, * Rb representa la cadena lateral de un aminoácido proteinogénico, * p es un número entero comprendido entre 1 y 4, * q es un número entero comprendido entre 0 y 4, o bien A es un radical ramificado no simétrico que responde a las fórmulas generales siguientes: ** ver fórmula**en las que: * k representa 3, 4, 5 ó 6, * R1 representa o bien un átomo de hidrógeno, o bien un residuo de aminoácido seleccionado de entre los aminoácidos proteinogénicos, o bien un grupo RCO-, ROCO- o RNHCO-, siendo R tal como se ha definido anteriormente, * R2 representa o bien un grupo -NH2, o bien un grupo -NHR, o bien un residuo de aminoácido seleccionado de entre los aminoácidos proteinogénicos, siendo R tal como se ha definido anteriormente.

9. 发明专利

AU2003224070A1 FUNCTIONALIZED CARBON NANOTUBES, A PROCESS FOR PREPARING THE SAME AND THEIR USE IN MEDICINAL CHEMISTRY 未知
公开(公告)号：AU2003224070A1
公开(公告)日：2004-11-01
申请号：AU2003224070
申请日：2003-04-14
申请人： CENTRE NAT RECH SCIENT
发明人： BIANCO ALBERTO , PANTAROTTO DAVIDE , PRATO MAURIZIO
IPC分类号： A61K47/48 , A61P31/00 , A61P37/00 , A61P43/00 , C01B31/02 , G01N33/543 , G01N33/551
摘要： The present invention relates to functionalized carbon nanotubes, a process for preparing the same and their use, in particular in medicinal chemistry and more particularly in immunology.

10. 发明专利

FR2840307A1 未知
公开(公告)号：FR2840307A1
公开(公告)日：2003-12-05
申请号：FR0206631
申请日：2002-05-30
申请人： CENTRE NAT RECH SCIENT
发明人： GUICHARD GILLES FRANCOIS ROGER , FOURNEL SYLVIE VICTORINE LUCIE , BIANCO ALBERTO , HOEBEKE JOHAN , MULLER SYLVIANE
IPC分类号： A61K47/48 , A61K38/00 , A61K39/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K1/08 , C07K5/09 , C07K5/11 , C07K7/02 , C07K14/525 , C07K14/705 , C07K14/725 , C07K7/00 , C07K14/00 , C07K19/00 , A61K38/04 , A61K38/16
摘要： The invention relates to a multimeric molecule which can imitate a natural multimeric proteinaceous ligand. The invention also relates to a multimeric molecule as defined above which is characterised in that it has the following general formula: A-Xn, wherein: n is equal to 3, 4, 5 or 6; A denotes a chemical group which is functionalised by at least three amine functions or COOH functions; and X denotes a D, B-D or B(D)-D′ group, in which B is a spacer and D and D′ are peptides or pseudopeptides corresponding to a sequence which is derived from the ligand and selected from residual matter forming the interface with the receptor and which can interact with the receptor.

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