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1. 发明专利

AU2003255646A8 Use of benzo(c)quinolizinium derivatives for the treatment of diseases that are linked to smooth muscle cell constriction 未知
公开(公告)号：AU2003255646A8
公开(公告)日：2003-12-22
申请号：AU2003255646
申请日：2003-06-05
申请人： UNIV POITIERS , CENTRE NAT RECH SCIENT
发明人： BECQ FREDERIC , ROBERT RENAUD , PIGNOUX LAURENCE , ROGIER CHRISTIAN , METTEY YVETTE , VIERFOND JEAN MICHEL , JOFFRE MICHEL , MARIVINGT-MOUNIR CECILE
IPC分类号： A61K31/4375 , A61P9/12 , A61P11/06 , C07D455/06 , C07D471/14
摘要： Use of benzo(c)quinolizinium derivatives (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. Use of benzo(c)quinolizinium derivatives of formula (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. A = an aromatic or non-aromatic heterocycle, and if non-aromatic the nitrogen atom is attached to the 4a carbon atom by a double bond; R1-R5, R7-R10 = H, halo, 1-10 C alkyl, alkoxy, carbonyl, oxycarbonyl or ester (all optionally substituted by T), 5-10C aliphatic or aromatic ring (optionally substituted by T1), -OR1 or -NRbRc; or R1+R2, R2+R3, R3+R4, R4+R5, R7+R8, R8+R9, or R9+R10 = 5-10C aromatic or aliphatic ring optionally substituted by T1; or R3+R4 = indolyl substituted by Ra; T = halo, OH, primary, secondary or tertiary amino, or 5-10C aromatic or aliphatic rings that may themselves be optionally substituted; T1 = halo, OH, primary, secondary or tertiary amino; Ra-Rc = H, alkyl, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; Y = -ORd, -NReRf; Rd-Rf = H, alkyl, alkoxy, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; or Rd+R5, Rd+R7, Re+R5, Re+R7, Rf+R5, Rf+R7 = 5-10C aromatic or aliphatic ring optionally substituted by T1; X- = anion, e.g. halo or perchlorate. Independent claims are also included for new compounds (I; R5 = -COOR'). R' = 1-10C alkyl, especially ethyl.

2. 发明专利

FR2840610B1 未知
公开(公告)号：FR2840610B1
公开(公告)日：2008-04-04
申请号：FR0206916
申请日：2002-06-05
申请人： CENTRE NAT RECH SCIENT
发明人： BECQ FREDERIC , ROBERT RENAUD , PIGNOUX LAURENCE BULTEAU , ROGIER CHRISTIAN , METTEY YVETTE RENOULT , VIERFOND JEAN MICHEL , JOFFRE MICHEL , MARIVINGT MOUNIR CECILE
IPC分类号： C07D455/04 , A61K31/4375 , A61P9/12 , A61P11/06 , C07D209/08 , C07D213/20 , C07D455/03 , C07D455/06 , C07D471/14
摘要： Use of benzo(c)quinolizinium derivatives (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. Use of benzo(c)quinolizinium derivatives of formula (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. A = an aromatic or non-aromatic heterocycle, and if non-aromatic the nitrogen atom is attached to the 4a carbon atom by a double bond; R1-R5, R7-R10 = H, halo, 1-10 C alkyl, alkoxy, carbonyl, oxycarbonyl or ester (all optionally substituted by T), 5-10C aliphatic or aromatic ring (optionally substituted by T1), -OR1 or -NRbRc; or R1+R2, R2+R3, R3+R4, R4+R5, R7+R8, R8+R9, or R9+R10 = 5-10C aromatic or aliphatic ring optionally substituted by T1; or R3+R4 = indolyl substituted by Ra; T = halo, OH, primary, secondary or tertiary amino, or 5-10C aromatic or aliphatic rings that may themselves be optionally substituted; T1 = halo, OH, primary, secondary or tertiary amino; Ra-Rc = H, alkyl, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; Y = -ORd, -NReRf; Rd-Rf = H, alkyl, alkoxy, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; or Rd+R5, Rd+R7, Re+R5, Re+R7, Rf+R5, Rf+R7 = 5-10C aromatic or aliphatic ring optionally substituted by T1; X- = anion, e.g. halo or perchlorate. Independent claims are also included for new compounds (I; R5 = -COOR'). R' = 1-10C alkyl, especially ethyl.

3. 发明专利

DE60309864D1 未知
公开(公告)号：DE60309864D1
公开(公告)日：2007-01-04
申请号：DE60309864
申请日：2003-06-05
申请人： CENTRE NAT RECH SCIENT , UNIV POITIERS
发明人： BECQ FREDERIC , ROBERT RENAUD , PIGNOUX LAURENCE , ROGIER CHRISTIAN , METTEY YVETTE , VIERFOND MICHEL , JOFFRE MICHEL , MARIVINGT-MOUNIR CECILE
IPC分类号： C07D455/06 , A61K31/4375 , A61P9/12 , A61P11/06 , C07D471/14
摘要： Use of benzo(c)quinolizinium derivatives (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. Use of benzo(c)quinolizinium derivatives of formula (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. A = an aromatic or non-aromatic heterocycle, and if non-aromatic the nitrogen atom is attached to the 4a carbon atom by a double bond; R1-R5, R7-R10 = H, halo, 1-10 C alkyl, alkoxy, carbonyl, oxycarbonyl or ester (all optionally substituted by T), 5-10C aliphatic or aromatic ring (optionally substituted by T1), -OR1 or -NRbRc; or R1+R2, R2+R3, R3+R4, R4+R5, R7+R8, R8+R9, or R9+R10 = 5-10C aromatic or aliphatic ring optionally substituted by T1; or R3+R4 = indolyl substituted by Ra; T = halo, OH, primary, secondary or tertiary amino, or 5-10C aromatic or aliphatic rings that may themselves be optionally substituted; T1 = halo, OH, primary, secondary or tertiary amino; Ra-Rc = H, alkyl, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; Y = -ORd, -NReRf; Rd-Rf = H, alkyl, alkoxy, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; or Rd+R5, Rd+R7, Re+R5, Re+R7, Rf+R5, Rf+R7 = 5-10C aromatic or aliphatic ring optionally substituted by T1; X- = anion, e.g. halo or perchlorate. Independent claims are also included for new compounds (I; R5 = -COOR'). R' = 1-10C alkyl, especially ethyl.

4. 发明专利

FR2840610A1 Use of benzo(c)quinolizinium derivatives for the treatment of disorders due to smooth muscle constriction, especially arterial hypertension and asthma 未知
公开(公告)号：FR2840610A1
公开(公告)日：2003-12-12
申请号：FR0206916
申请日：2002-06-05
申请人： CENTRE NAT RECH SCIENT
发明人： BECQ FREDERIC , ROBERT RENAUD , PIGNOUX LAURENCE BULTEAU , ROGIER CHRISTIAN , METTEY YVETTE RENOULT , VIERFOND JEAN MICHEL , JOFFRE MICHEL , MARIVINGT MOUNIR CECILE
IPC分类号： A61K31/4375 , A61P9/12 , A61P11/06 , C07D455/06 , C07D471/14 , C07D455/04 , C07D455/03
摘要： Use of benzo(c)quinolizinium derivatives (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. Use of benzo(c)quinolizinium derivatives of formula (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. A = an aromatic or non-aromatic heterocycle, and if non-aromatic the nitrogen atom is attached to the 4a carbon atom by a double bond; R1-R5, R7-R10 = H, halo, 1-10 C alkyl, alkoxy, carbonyl, oxycarbonyl or ester (all optionally substituted by T), 5-10C aliphatic or aromatic ring (optionally substituted by T1), -OR1 or -NRbRc; or R1+R2, R2+R3, R3+R4, R4+R5, R7+R8, R8+R9, or R9+R10 = 5-10C aromatic or aliphatic ring optionally substituted by T1; or R3+R4 = indolyl substituted by Ra; T = halo, OH, primary, secondary or tertiary amino, or 5-10C aromatic or aliphatic rings that may themselves be optionally substituted; T1 = halo, OH, primary, secondary or tertiary amino; Ra-Rc = H, alkyl, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; Y = -ORd, -NReRf; Rd-Rf = H, alkyl, alkoxy, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; or Rd+R5, Rd+R7, Re+R5, Re+R7, Rf+R5, Rf+R7 = 5-10C aromatic or aliphatic ring optionally substituted by T1; X- = anion, e.g. halo or perchlorate. Independent claims are also included for new compounds (I; R5 = -COOR'). R' = 1-10C alkyl, especially ethyl.

5. 发明专利

DE60309864T2 未知
公开(公告)号：DE60309864T2
公开(公告)日：2007-09-06
申请号：DE60309864
申请日：2003-06-05
申请人： CENTRE NAT RECH SCIENT , UNIV POITIERS
发明人： BECQ FREDERIC , ROBERT RENAUD , PIGNOUX LAURENCE , ROGIER CHRISTIAN , METTEY YVETTE , VIERFOND MICHEL , JOFFRE MICHEL , MARIVINGT-MOUNIR CECILE
IPC分类号： C07D455/06 , A61K31/4375 , A61P9/12 , A61P11/06 , C07D471/14
摘要： Use of benzo(c)quinolizinium derivatives (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. Use of benzo(c)quinolizinium derivatives of formula (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. A = an aromatic or non-aromatic heterocycle, and if non-aromatic the nitrogen atom is attached to the 4a carbon atom by a double bond; R1-R5, R7-R10 = H, halo, 1-10 C alkyl, alkoxy, carbonyl, oxycarbonyl or ester (all optionally substituted by T), 5-10C aliphatic or aromatic ring (optionally substituted by T1), -OR1 or -NRbRc; or R1+R2, R2+R3, R3+R4, R4+R5, R7+R8, R8+R9, or R9+R10 = 5-10C aromatic or aliphatic ring optionally substituted by T1; or R3+R4 = indolyl substituted by Ra; T = halo, OH, primary, secondary or tertiary amino, or 5-10C aromatic or aliphatic rings that may themselves be optionally substituted; T1 = halo, OH, primary, secondary or tertiary amino; Ra-Rc = H, alkyl, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; Y = -ORd, -NReRf; Rd-Rf = H, alkyl, alkoxy, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; or Rd+R5, Rd+R7, Re+R5, Re+R7, Rf+R5, Rf+R7 = 5-10C aromatic or aliphatic ring optionally substituted by T1; X- = anion, e.g. halo or perchlorate. Independent claims are also included for new compounds (I; R5 = -COOR'). R' = 1-10C alkyl, especially ethyl.

6. 发明专利

AT346066T 未知
公开(公告)号：AT346066T
公开(公告)日：2006-12-15
申请号：AT03757110
申请日：2003-06-05
申请人： CENTRE NAT RECH SCIENT , UNIV POITIERS
发明人： BECQ FREDERIC , ROBERT RENAUD , PIGNOUX LAURENCE , ROGIER CHRISTIAN , METTEY YVETTE , VIERFOND JEAN MICHEL , JOFFRE MICHEL , MARIVINGT-MOUNIR CECILE
IPC分类号： A61K31/4375 , A61P9/12 , A61P11/06 , C07D455/06 , C07D471/14
摘要： Use of benzo(c)quinolizinium derivatives (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. Use of benzo(c)quinolizinium derivatives of formula (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. A = an aromatic or non-aromatic heterocycle, and if non-aromatic the nitrogen atom is attached to the 4a carbon atom by a double bond; R1-R5, R7-R10 = H, halo, 1-10 C alkyl, alkoxy, carbonyl, oxycarbonyl or ester (all optionally substituted by T), 5-10C aliphatic or aromatic ring (optionally substituted by T1), -OR1 or -NRbRc; or R1+R2, R2+R3, R3+R4, R4+R5, R7+R8, R8+R9, or R9+R10 = 5-10C aromatic or aliphatic ring optionally substituted by T1; or R3+R4 = indolyl substituted by Ra; T = halo, OH, primary, secondary or tertiary amino, or 5-10C aromatic or aliphatic rings that may themselves be optionally substituted; T1 = halo, OH, primary, secondary or tertiary amino; Ra-Rc = H, alkyl, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; Y = -ORd, -NReRf; Rd-Rf = H, alkyl, alkoxy, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; or Rd+R5, Rd+R7, Re+R5, Re+R7, Rf+R5, Rf+R7 = 5-10C aromatic or aliphatic ring optionally substituted by T1; X- = anion, e.g. halo or perchlorate. Independent claims are also included for new compounds (I; R5 = -COOR'). R' = 1-10C alkyl, especially ethyl.

7. 发明专利

AU2003255646A1 USE OF BENZO(C)QUINOLIZINIUM DERIVATIVES FOR THE TREATMENT OF DISEASES THAT ARE LINKED TO SMOOTH MUSCLE CELL CONSTRICTION 未知
公开(公告)号：AU2003255646A1
公开(公告)日：2003-12-22
申请号：AU2003255646
申请日：2003-06-05
申请人： CENTRE NAT RECH SCIENT
发明人： BECQ FREDERIC , ROBERT RENAUD , PIGNOUX LAURENCE , ROGIER CHRISTIAN , METTEY YVETTE , VIERFOND JEAN MICHEL , JOFFRE MICHEL , MARIVINGT-MOUNIR CECILE
IPC分类号： A61K31/4375 , A61P9/12 , A61P11/06 , C07D455/06 , C07D471/14
摘要： Use of benzo(c)quinolizinium derivatives (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. Use of benzo(c)quinolizinium derivatives of formula (I) in medicines for the treatment of pathological states due to constriction of smooth muscle cells, is new. A = an aromatic or non-aromatic heterocycle, and if non-aromatic the nitrogen atom is attached to the 4a carbon atom by a double bond; R1-R5, R7-R10 = H, halo, 1-10 C alkyl, alkoxy, carbonyl, oxycarbonyl or ester (all optionally substituted by T), 5-10C aliphatic or aromatic ring (optionally substituted by T1), -OR1 or -NRbRc; or R1+R2, R2+R3, R3+R4, R4+R5, R7+R8, R8+R9, or R9+R10 = 5-10C aromatic or aliphatic ring optionally substituted by T1; or R3+R4 = indolyl substituted by Ra; T = halo, OH, primary, secondary or tertiary amino, or 5-10C aromatic or aliphatic rings that may themselves be optionally substituted; T1 = halo, OH, primary, secondary or tertiary amino; Ra-Rc = H, alkyl, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; Y = -ORd, -NReRf; Rd-Rf = H, alkyl, alkoxy, carbonyl, oxycarbonyl, ester, or an aromatic or aliphatic ring; or Rd+R5, Rd+R7, Re+R5, Re+R7, Rf+R5, Rf+R7 = 5-10C aromatic or aliphatic ring optionally substituted by T1; X- = anion, e.g. halo or perchlorate. Independent claims are also included for new compounds (I; R5 = -COOR'). R' = 1-10C alkyl, especially ethyl.

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