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1. 发明申请

WO2017152054A1 POLYMALIC ACID BASED NANOIMMUNOCONJUGATES AND USES THEREOF 审中-公开
标题翻译：基于多元酸的纳米无机复合物及其应用
公开(公告)号：WO2017152054A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020666
申请日：2017-03-03
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： LJUBIMOVA, Julia Y. , BLACK, Keith L. , HOLLER, Eggehard , LJUBIMOV, Alexander , DING, Hui
IPC分类号： A61K39/395 , A61K31/713 , A61K38/19 , A61K38/16 , A61K47/10 , A61P35/00 , A61P35/04
摘要： Nanoimmunoconjugates including a polymalic acid-based molecular scaffold, targeting ligands, anti-tumor immune response stimulators and anti-cancer agents are provided. Methods for treating cancer in a subject by administering the nanoimmunoconjugates that provide both systemic and local immune responses and synergistic anticancer effect are described.
摘要翻译：提供了包括基于聚苹果酸的分子支架，靶向配体，抗肿瘤免疫应答刺激剂和抗癌剂的纳米免疫缀合物。描述了通过施用提供全身和局部免疫应答以及协同抗癌作用的纳米免疫缀合物来治疗受试者的癌症的方法。

2. 发明申请

WO2019070645A1 METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY THROUGH MULTIPLE BIO BARRIERS 审中-公开
公开(公告)号：WO2019070645A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/053873
申请日：2018-10-02
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： HOLLER, Eggehard , LJUBIMOVA, Julia Y. , BLACK, Keith L.
IPC分类号： A61K38/00 , A61K47/48 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/435
摘要： Mini nanodrugs that include a polymalic-based molecular scaffold with one or more peptides capable of crossing the blood-brain barrier, one or more plaque-binding peptides and one or more therapeutic agents attached to the scaffold are provided. Methods of treating brain diseases or abnormal conditions, and imaging of the same in a subject by administering the mini nanodrugs are described. Methods for reducing formation of amyloid plaques in the brain of a subject are disclosed.

3. 发明申请

WO2012139030A1 POLYMALIC ACID BASED NANOCONJUGATES FOR IMAGING 审中-公开
标题翻译：基于聚合酸的纳米颗粒成像
公开(公告)号：WO2012139030A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032573
申请日：2012-04-06
申请人： CEDARS-SINAI MEDICAL CENTER , BLACK, Keith L. , LJUBIMOVA, Julia Y. , LJUBIMOV, Alexander V. , HOLLER, Eggehard
发明人： BLACK, Keith L. , LJUBIMOVA, Julia Y. , LJUBIMOV, Alexander V. , HOLLER, Eggehard
IPC分类号： A61K49/00 , C07C211/00
CPC分类号： A61K49/16 , A61K47/593 , A61K49/128
摘要： Nanoconjugates include a polymalic-based molecular scaffold with one or more imaging moiety and one or more targeting modules attached to the scaffold. At least one imaging moiety and at least one targeting module is conjugated to the polymalicacid based molecular scaffold. Methods of synthesizing the nanoconjugate involve providing a polymalic acid having a plurality of pendant carboxyi groups. The method reacts a compound containing sulfhydryl groups and amino acid groups through the pendant carboxyi groups to add sulfhydryl groups to the polymalic acid to form an activated polymalic acid. The method reacts at least one imaging moiety containing a sulfhydryl binding group to the activated polymalic acid to form a preconjugate. The method may involve administering to the subject a nanoconjugate that includes a polymalic acid-based molecular scaffold, at least one imaging moiety, and at least one targeting module.
摘要翻译：纳米缀合物包括具有一个或多个成像部分和连接到支架的一个或多个靶向模块的基于聚丙烯的分子支架。至少一个成像部分和至少一个靶向模块与基于聚缩水甘油的分子支架缀合。合成纳米缀合物的方法涉及提供具有多个侧链羧基的聚丙酸。该方法通过侧基羧基将含有巯基和氨基酸的化合物反应，以向聚丙酸中加入巯基以形成活化的聚丙酸。该方法将含有巯基结合基团的至少一个成像部分与活化的聚丙酸反应形成预共轭物。该方法可以包括向受试者施用包括基于聚丙酸的分子支架，至少一个成像部分和至少一个靶向模块的纳米缀合物。

4. 发明公开

EP3691670A1 METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY THROUGH MULTIPLE BIO BARRIERS 审中-公开
公开(公告)号：EP3691670A1
公开(公告)日：2020-08-12
申请号：EP18864985.9
申请日：2018-10-02
申请人： Cedars-Sinai Medical Center
发明人： HOLLER, Eggehard , LJUBIMOVA, Julia Y. , BLACK, Keith L.
IPC分类号： A61K38/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/435

5. 发明公开

EP3423096A1 POLYMALIC ACID BASED NANOIMMUNOCONJUGATES AND USES THEREOF 审中-公开
公开(公告)号：EP3423096A1
公开(公告)日：2019-01-09
申请号：EP17760901.3
申请日：2017-03-03
申请人： Cedars-Sinai Medical Center
发明人： LJUBIMOVA, Julia Y. , BLACK, Keith L. , HOLLER, Eggehard , LJUBIMOV, Alexander , DING, Hui
IPC分类号： A61K39/395 , A61K31/713 , A61K38/19 , A61K38/16 , A61K47/10 , A61P35/00 , A61P35/04

6. 发明公开

EP2694117A1 POLYMALIC ACID BASED NANOCONJUGATES FOR IMAGING 审中-公开
标题翻译：基于聚马来成像纳米缀
公开(公告)号：EP2694117A1
公开(公告)日：2014-02-12
申请号：EP12768248.2
申请日：2012-04-06
申请人： Cedars-Sinai Medical Center
发明人： BLACK, Keith L. , LJUBIMOVA, Julia Y. , LJUBIMOV, Alexander V. , HOLLER, Eggehard
IPC分类号： A61K49/00 , C07C211/00
CPC分类号： A61K49/16 , A61K47/593 , A61K49/128
摘要： Nanoconjugates include a polymalic-based molecular scaffold with one or more imaging moiety and one or more targeting modules attached to the scaffold. At least one imaging moiety and at least one targeting module is conjugated to the polymalicacid based molecular scaffold. Methods of synthesizing the nanoconjugate involve providing a polymalic acid having a plurality of pendant carboxyi groups. The method reacts a compound containing sulfhydryl groups and amino acid groups through the pendant carboxyi groups to add sulfhydryl groups to the polymalic acid to form an activated polymalic acid. The method reacts at least one imaging moiety containing a sulfhydryl binding group to the activated polymalic acid to form a preconjugate. The method may involve administering to the subject a nanoconjugate that includes a polymalic acid-based molecular scaffold, at least one imaging moiety, and at least one targeting module.

7. 发明公开

EP1037986A1 GENE ASSOCIATED WITH NEOPLASTIC DISEASE OR MALIGNANCY ASSOCIATED GENE 审中-公开
标题翻译： GEN相关的肝脏疾病或肿瘤恶性相关基因
公开(公告)号：EP1037986A1
公开(公告)日：2000-09-27
申请号：EP98963127.0
申请日：1998-12-11
申请人： Cedars-Sinai Medical Center
发明人： BLACK, Keith , LJUBIMOVA, Julia Y. , DEMETRIOU, Achilles, A.
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , G01N33/574 , C12Q1/68 , C12N15/66 , C07K16/18
CPC分类号： C07K14/47 , A61K38/00
摘要： A nucleic acid encodes a polypeptide associated with liver neoplastic diseases, such as liver cirrhosis and hepatocellular carcinoma, among others. Significantly, the polypeptide is not expressed in normal, non-neoplastic liver. An antibody(ies) binds to the polypeptide of the invention. The polynucleotide, polypeptide and antibody are also provided in kits, and applied to the diagnosis of, and screening of populations for, neoplastic diseases such as liver disease.

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