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1. 发明申请

WO2006093932A3 USE OF EOTAXIN AS A DIAGNOSTIC INDICATOR FOR ATHEROSCLEROSIS AND VASCULAR INFLAMMATION 审中-公开
标题翻译：爱达可作为诊断指征和血管炎的诊断用途
公开(公告)号：WO2006093932A3
公开(公告)日：2007-02-08
申请号：PCT/US2006007018
申请日：2006-02-28
申请人： CEDARS SINAI MEDICAL CENTER , SHARIFI BEHROOZ , SHAH PREDIMAN K , WANG LAI
发明人： SHARIFI BEHROOZ , SHAH PREDIMAN K , WANG LAI
IPC分类号： G01N33/00 , G01N33/543
CPC分类号： C07K14/775 , A01K67/0276 , A01K2227/105 , A01K2267/02 , A01K2267/0375 , C07K14/78 , G01N33/6893 , G01N2333/52 , G01N2800/323
摘要： The invention disclosed herein relates to the detection or diagnosis of atherosclerosis by measuring the level of the protein eotaxin in an individual's serum. The presence of eotaxin above levels specified herein is indicative that atherosclerosis may be present. Detection of elevated eotaxin levels in serum may provide a means to diagnose atherosclerosis prior to the onset of symptoms.
摘要翻译：本文公开的本发明涉及通过测量个体血清中蛋白质嗜酸性粒细胞趋化因子的水平来检测或诊断动脉粥样硬化。高于本文规定水平的嗜酸细胞活化趋化因子的存在表明可能存在动脉粥样硬化。检测血清中升高的嗜酸性粒细胞趋化因子水平可能会在症状发作前诊断动脉粥样硬化。

2. 发明申请

WO2008100936A2 METHODS FOR ISOLATING AND USING HEMATOPOIETIC AND EMBRYONIC STEM CELLS OF THE PERITONEAL CAVITY 审中-公开
标题翻译：方法分离和使用造血和胚胎干细胞的腹腔
公开(公告)号：WO2008100936A2
公开(公告)日：2008-08-21
申请号：PCT/US2008053725
申请日：2008-02-12
申请人： CEDARS SINAI MEDICAL CENTER , SHARIFI BEHROOZ , WANG LAI , SHAH PREDIMAN K
发明人： SHARIFI BEHROOZ , WANG LAI , SHAH PREDIMAN K
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , A61L27/3804
摘要： The invention relates to the isolation and use of hematopoietic and embryonic stem cells. Additionally, the inventors identified the peritoneal cavity as a new source of hematopoietic stem cells. In one embodiment, the invention provides methods of isolating progenitor and/or stem cells from the peritoneal cavity. In another embodiment, the invention provides methods of transporting progenitor and/or stem cells from the peritoneal cavity to another organ. In another embodiment, the present invention provides methods of regenerating bioengineered tissues and/or reconstituting an hematopoietic system.
摘要翻译：本发明涉及造血和胚胎干细胞的分离和使用。另外，本发明人将腹腔确定为造血干细胞的新来源。在一个实施方案中，本发明提供了从腹膜腔分离祖细胞和/或干细胞的方法。在另一个实施方案中，本发明提供了将祖细胞和/或干细胞从腹腔输送到另一个器官的方法。在另一个实施方案中，本发明提供再生生物工程化组织和/或重建造血系统的方法。

3. 发明申请

WO2009102731A3 DEVICES AND METHODS FOR ENHANCING BRIGHTNESS OF DISPLAYS USING ANGLE CONVERSION LAYERS 审中-公开
标题翻译：使用角度转换层增强显示亮度的设备和方法
公开(公告)号：WO2009102731A3
公开(公告)日：2009-11-26
申请号：PCT/US2009033698
申请日：2009-02-10
申请人： QUALCOMM MEMS TECHNOLOGIES INC , BITA ION , XU GANG , MIENKO MAREK , WANG LAI , GRUHLKE RUSSELL W
发明人： BITA ION , XU GANG , MIENKO MAREK , WANG LAI , GRUHLKE RUSSELL W
IPC分类号： G02F1/13357 , G02B6/00
CPC分类号： G02B6/0053 , G02B6/0018 , G02B6/0038 , G02B26/001
摘要： Various embodiments of the present invention relate to enhancing the brightness of displays that employ illumination systems. In some embodiments, the illumination systems include light guides (915), diffractive microstructure (910), and light-turning features (905). The diffractive microstructure may be configured to receive ambient light at a first angle and produce diffracted light at a second angle greater than the first angle and greater than the critical angle of the light guide. The light is thereby guided within the light guide. The light-turning features may be configured to turn the light guided within the light guide out of a light guide and onto, for example, the pixels (901) of a spatial light modulator at near normal incidence.
摘要翻译：本发明的各种实施例涉及增强采用照明系统的显示器的亮度。在一些实施例中，照明系统包括光导（915），衍射微结构（910）和光转向特征（905）。衍射微结构可以被配置为以第一角度接收环境光，并以大于第一角度并大于光导的临界角的第二角度产生衍射光。因此，光在光导内被引导。光转向特征可以被配置为将光导管内的光引导出光导并且在近似法线入射的状态下转动到例如空间光调制器的像素（901）上。

4. 发明申请

WO2009102672A3 INTEGRATED FRONT LIGHT SOLUTION 审中-公开
标题翻译：集成前灯解决方案
公开(公告)号：WO2009102672A3
公开(公告)日：2009-11-05
申请号：PCT/US2009033597
申请日：2009-02-09
申请人： QUALCOMM MEMS TECHNOLOGIES INC , MIENKO MAREK , XU GANG , BITA ION , WANG LAI , GRUHLKE RUSSELL W
发明人： MIENKO MAREK , XU GANG , BITA ION , WANG LAI , GRUHLKE RUSSELL W
IPC分类号： G02B6/00 , F21K99/00
CPC分类号： G02B6/0018 , G02B6/0011 , G02B6/0016 , G02B6/002 , G02B6/0028 , G09G3/3466
摘要： An illumination apparatus includes a light injection portion (101) having a first end (101a) for receiving light from a light source (92) and including material that supports propagation of said light along the length of the light injection portion. Turning microstructure (91) is disposed on a first side of the light injection and configured to turn at least a substantial portion of light incident on the first side and to direct the portion of the light out a second opposite side of the light injection portion. A slit (105) is disposed along the length of the light injection portion forming a total reflecting optical interface on the second opposite side of the light injection portion. The optical interface further transmits light turned by 'said turning microstructure. A light distribution (103) portion is disposed with respect to the slit to receive the light turned by said turning microstructure and transmitted out of the second side of the light injection portion and through said slit. At least one bridge (107) is disposed between light injection portion and the light distribution portion. The bridge mechanically connects the light injection portion to the light distribution portion.
摘要翻译：照明装置包括具有用于接收来自光源（92）的光的第一端（101a）的光注入部分（101），并且包括支撑沿着光注入部分的长度的所述光的传播的材料。转向微结构（91）设置在光注入的第一侧上并且被配置成使入射在第一侧上的至少大部分光转向并将光的一部分引导出光注入部分的第二相对侧。沿着光注入部分的长度设置狭缝（105），在光注入部分的第二相对侧上形成全反射光学界面。光学接口还透射由所述转动微结构转动的光。相对于狭缝设置配光部（103），以接收由所述转向微结构转动的光并从光注入部的第二侧透射出并通过所述狭缝。至少一个桥（107）设置在光注入部分和光分配部分之间。桥将光注入部分机械地连接到配光部分。

5. 发明申请

WO0212854A3 SYSTEMS AND METHODS FOR PROVIDING INFORMATION CONCERNING CHROMOPHORES IN PHYSIOLOGICAL MEDIA 审中-公开
标题翻译：提供生理介质中色素信息的系统和方法
公开(公告)号：WO0212854A3
公开(公告)日：2002-12-19
申请号：PCT/US0124301
申请日：2001-08-03
申请人： PHOTONIFY TECHNOLOGIES INC , CHENG XUEFENG , XU XIAORONG , ZHOU SHUOMING , WANG LAI , WANG MING , LI FENG , HU GUOBAO
发明人： CHENG XUEFENG , XU XIAORONG , ZHOU SHUOMING , WANG LAI , WANG MING , LI FENG , HU GUOBAO
IPC分类号： G01N33/48 , A61B5/00 , A61B5/145 , A61B5/1455 , C12Q1/04 , G01N21/27 , G01N21/31 , G01N21/33 , G01N21/35 , G01N21/49 , G01N33/483 , G01N33/72 , G06F17/10
CPC分类号： A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/413 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , A61B2562/046 , G01N21/359 , G01N21/49 , G01N2021/3144
摘要： The present invention generally relates to systems and methods for providing information about chromophores in physiological media. More particularly, the invention relates to non-invasive systems and methods for determining absolute values of oxygenated and/or deoxygenated hemoglobins and their ratios in a physiological medium. The system generally includes a portable probe having a source module (122) for irradiating into the medium electromagnetic radiation, a detector module (124) detecting radiation from a target area in the medium, and a processing module (140) determining the absolute values of the chromophore concentrations and the ratios thereof based on input and output parameters of the source and detector modules. In one aspect, the invention provides a solution for unknown parameters of the chromophores in a medium using a novel processing algorithm. In another aspect, the invention concerns a portable unit for performing the requisite measurements, which unit includes a movable member having one or more radiation sources and one or more radiation detectors, and an actuator designed to cause the member to move along predetermined curvilinear paths. Properties of the chromophores are measured for individual voxels defined along each motion path, and/or cross-voxels defined at the intersection of voxels along different motion paths. These measured values are then used in a preferred embodiment to generate two- or three-dimensional images of the distribution of chromophores or their properties. In other aspects, the invention includes various patterns for the optimal distribution of sources and detectors for the optical probe, and self-calibrating operation of the probe substantially in real-time.
摘要翻译：本发明一般涉及在生理介质中提供关于发色团的信息的系统和方法。更具体地，本发明涉及用于确定氧合和/或脱氧血红蛋白的绝对值及其在生理介质中的比例的非侵入性系统和方法。该系统通常包括便携式探头，其具有用于照射介质电磁辐射的源模块（122），检测器模块（124），用于检测来自介质中的目标区域的辐射;以及处理模块（140），其确定绝对值基于源和检测器模块的输入和输出参数的发色团浓度及其比例。一方面，本发明使用新颖的处理算法提供了介质中发色团的未知参数的解决方案。在另一方面，本发明涉及用于执行必要的测量的便携式单元，该单元包括具有一个或多个辐射源和一个或多个辐射检测器的可动构件以及被设计成使构件沿着预定的曲线路径移动的致动器。对沿着每个运动路径定义的个体体素测量发色团的性质，和/或在沿不同运动路径的体素交点处定义的交叉体素。然后将这些测量值用于优选实施方案中以产生发色团分布或其性质的二维或三维图像。在其他方面，本发明包括用于光学探针的源和检测器的最佳分布的各种图案，以及基本上实时地自动校准探针的操作。

6. 发明申请

WO2012145255A3 DIAZONAMIDE ANALOGS 审中-公开
标题翻译：地氮酰胺类似物
公开(公告)号：WO2012145255A3
公开(公告)日：2012-12-27
申请号：PCT/US2012033715
申请日：2012-04-15
申请人： JOYANT PHARMACEUTICALS INC , WEI QI , ZHOU MING , XU XIAOMING , CALDWELL CHARLES , HARRAN SUSAN , WANG LAI
发明人： WEI QI , ZHOU MING , XU XIAOMING , CALDWELL CHARLES , HARRAN SUSAN , WANG LAI
IPC分类号： C07D498/22 , C07D413/14
CPC分类号： C07D498/06 , C07D491/04 , C07D498/08 , C07D498/20 , C07D498/22 , C07D519/00 , C07F9/6561
摘要： Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.
摘要翻译：提供了用于治疗癌症和其他增殖性疾病的具有抗有丝分裂活性的Diazonamide类似物，以及相关的药物组合物。

7. 发明申请

WO2009154957A2 FRONT LIGHT DEVICES AND METHODS OF FABRICATION THEREOF 审中-公开
标题翻译：前灯装置及其制造方法
公开(公告)号：WO2009154957A2
公开(公告)日：2009-12-23
申请号：PCT/US2009045186
申请日：2009-05-26
申请人： QUALCOMM MEMS TECHNOLOGIES INC , BITA ION , XU GANG , NARAYANAN KOLLENGODE S , GRUHLKE RUSSELL W , MIENKO MAREK , WANG LAI
发明人： BITA ION , XU GANG , NARAYANAN KOLLENGODE S , GRUHLKE RUSSELL W , MIENKO MAREK , WANG LAI
IPC分类号： G02B6/00
CPC分类号： G02B6/0016 , B82Y20/00 , G02B6/0036 , G02B6/0038 , G02B6/005 , G02B6/0065 , Y10T29/49002
摘要： A illumination device comprises a light guide having a first end for receiving light and configured to support propagation of light along the length of the light guide. A turning microstructure is disposed on a first side of the light guide configured to turn light incident on the first side and to direct the light out a second opposite side of the light guide, wherein the turning microstructure comprises a plurality of indentations. A cover is physically coupled to the light guide and disposed over the turning microstructure. An interlayer is between the cover and the light guide, wherein the interlayer physically couples the cover to the light guide. A plurality of open regions is between the interlayer and the plurality of indentations. Various embodiments include methods of coupling the cover to the light guide while preserving open regions between the cover and plurality of indentations.
摘要翻译：照明装置包括光导，其具有用于接收光的第一端并且被配置为支持沿着光导的长度的光的传播。转向微结构设置在导光体的第一侧上，其被配置为转动入射在第一侧上的光并将光引导出光导的第二相对侧，其中转动微结构包括多个凹陷。盖子物理耦合到光导并且设置在转向微结构上。中间层位于盖和光导之间，其中夹层将盖物理耦合到光导。多个开放区域在中间层和多个凹口之间。各种实施例包括将盖连接到光导的同时保持盖和多个凹口之间的开放区域的方法。

8. 发明申请

WO2009102731A2 DEVICES AND METHODS FOR ENHANCING BRIGHTNESS OF DISPLAYS USING ANGLE CONVERSION LAYERS 审中-公开
标题翻译：使用角度转换层增强显示亮度的设备和方法
公开(公告)号：WO2009102731A2
公开(公告)日：2009-08-20
申请号：PCT/US2009033698
申请日：2009-02-10
申请人： QUALCOMM MEMS TECHNOLOGIES INC , BITA ION , XU GANG , MIENKO MAREK , WANG LAI , GRUHLKE RUSSELL W
发明人： BITA ION , XU GANG , MIENKO MAREK , WANG LAI , GRUHLKE RUSSELL W
IPC分类号： G02F1/13357 , G02B6/00
CPC分类号： G02B6/0053 , G02B6/0018 , G02B6/0038 , G02B26/001
摘要： Various embodiments of the present invention relate to enhancing the brightness of displays that employ illumination systems. In some embodiments, the illumination systems include light guides, diffractive microstructure, and light-turning features. The diffractive microstructure may be configured to receive ambient light at a first angle and produce diffracted light at a second angle greater than the first angle and greater than the critical angle of the light guide. The light is thereby guided within the light guide. The light-turning features may be configured to turn the light guided within the light guide out of a light guide and onto, for example, a spatial light modulator at near normal incidence.
摘要翻译：本发明的各种实施例涉及增强采用照明系统的显示器的亮度。在一些实施例中，照明系统包括光导，衍射微结构和光转动特征。衍射微结构可以被配置为以第一角度接收环境光，并以大于第一角度并大于光导的临界角的第二角度产生衍射光。因此，光在光导内被引导。光转动特征可以被配置为将光导管内的光引导出光导并且以近似正常入射转动到例如空间光调制器。

9. 发明申请

WO2012094158A2 LIGHT GUIDE WITH UNIFORM LIGHT DISTRIBUTION 审中-公开
标题翻译：具有均匀光分配的光指导
公开(公告)号：WO2012094158A2
公开(公告)日：2012-07-12
申请号：PCT/US2011066579
申请日：2011-12-21
申请人： QUALCOMM MEMS TECHNOLOGIES INC , BITA ION , WANG LAI , LI KEBIN , BURSTEDT DOUGLAS CARL , SU YI-FAN
发明人： BITA ION , WANG LAI , LI KEBIN , BURSTEDT DOUGLAS CARL , SU YI-FAN
IPC分类号： G02B6/00 , G02B26/08
CPC分类号： G02B6/0065 , G02B6/0016 , G02B6/0055 , G02B6/0068 , G02B6/0073 , Y10T29/49
摘要： This disclosure provides systems, methods and apparatus for providing illumination by using a light guide to distribute light. In one aspect, the light guide has a light input edge into which light is injected and transverse edges transverse to the light input edge. The transverse edges are smooth and act as specular reflectors. The light input edge is rough and provides a diffusive interface. The light emitters are adjacent and centered along the light input edge, with the pitch of the light emitters being about ?L, where ?L is the distance between the transverse edges divided by the number of light emitters. The diffusive light input edge can diffuse light entering into the light guide, and the transverse edges can reflect light with a low level of artifacts and the reflections also act as virtual light sources to facilitate a highly uniform distribution of light within the light guide. The light guide can be provided with light turning features that redirect light out of the light guide. In some implementations, the redirected light can be applied to illuminate a display.
摘要翻译：本公开提供了通过使用光导来分配光来提供照明的系统，方法和装置。在一个方面，光导具有光输入边缘，光注入到该光输入边缘中，横向边缘横向于光输入边缘。横向边缘是光滑的并且用作镜面反射器。光输入边缘粗糙并提供扩散界面。光发射器相邻并沿着光输入边缘居中，发光体的间距约为λL，其中λL是横向边缘之间的距离除以发光体的数量。扩散光输入边缘可以漫射进入光导的光，并且横向边缘可以以低水平的伪像反射光，并且反射也用作虚拟光源，以促进光在光导内的高度均匀分布。光导可以设置有将光从光导引导出的光转向特征。在一些实施方案中，可以应用重定向的光来照亮显示器。

10. 发明申请

WO2009149118A2 EDGE SHADOW REDUCING METHODS FOR PRISMATIC FRONT LIGHT 审中-公开
标题翻译：边缘减光方法用于前置灯
公开(公告)号：WO2009149118A2
公开(公告)日：2009-12-10
申请号：PCT/US2009046020
申请日：2009-06-02
申请人： QUALCOMM MEMS TECHNOLOGIES INC , WANG LAI , XU GANG , BITA ION , MIENKO MAREK , GRUHLKE RUSSELL
发明人： WANG LAI , XU GANG , BITA ION , MIENKO MAREK , GRUHLKE RUSSELL
CPC分类号： G02B6/0036 , G02B6/0028 , G02B6/0038 , G02B6/0073
摘要： Embodiments herein relate to light systems designed to reduce Moire interference while simultaneously reducing dark regions due to the edge shadow effect. For example, configurations of light sources, light guides and turning features may direct light across a display while reducing Moire interference.
摘要翻译：本文的实施例涉及设计用于减少莫尔干涉同时由于边缘阴影效应而减少暗区的光系统。例如，光源，光导和车削特征的配置可以在显示器上引导光，同时减少莫尔干涉。

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