专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CA3121162A1 RNASET2 COMPOSITIONS AND METHODS OF TREATMENT THEREWITH 未知
公开(公告)号：CA3121162A1
公开(公告)日：2020-06-04
申请号：CA3121162
申请日：2019-11-26
申请人： CEDARS SINAI MEDICAL CENTER
发明人： GONSKY REBECCA , TARGAN STEPHAN R
IPC分类号： C12Q1/6883 , A61K38/46 , A61P37/06 , C07K14/525 , C12N9/22 , C12Q1/68 , C12Q1/6876
摘要： Described herein are methods, systems, compositions, and kits useful for the diagnosis and/or treatment of a disease or condition in a subject. The present disclosure relates to methods and systems for identifying and stratifying patients suitable for treatment with a modulator of RNASET2, as described herein.

2. 发明专利

AU2014317991A1 Systems, devices and methods for anti-TL1A therapy 未知
公开(公告)号：AU2014317991A1
公开(公告)日：2016-03-10
申请号：AU2014317991
申请日：2014-09-05
申请人： CEDARS SINAI MEDICAL CENTER
发明人： TARGAN STEPHAN R , GONSKY REBECCA , DEEM RICHARD
IPC分类号： A61P37/06
摘要： The present invention relates to biomarker genes for diagnosing and treating diseases. Provided herein are systems and methods of diagnosing a disease in a patient based on the patient's expression levels of biomarker genes. Examples of the TL1A-associated disease include, but are not limited to, an inflammatory bowel disease (IBD), Crohn's disease (CD), ulcerative colitis (UC), and fibrosis. Also provided herein are systems and methods of identifying a patient likely to be responsive to an anti-TL1A therapy, prescribing and/or administrating an anti-TL1A therapy to the patient based on the patient's expression levels of biomarker genes.

3. 发明专利

CA2922381A1 SYSTEMS, DEVICES AND METHODS FOR ANTI-TL1A THERAPY 未知
公开(公告)号：CA2922381A1
公开(公告)日：2015-03-12
申请号：CA2922381
申请日：2014-09-05
申请人： CEDARS SINAI MEDICAL CENTER
发明人： TARGAN STEPHAN R , GONSKY REBECCA , DEEM RICHARD
IPC分类号： G01N33/48 , A61K31/7088 , A61K38/00 , A61K39/395 , A61P37/06 , C12Q1/68 , C40B30/04
摘要： The present invention relates to biomarker genes for diagnosing and treating diseases. Provided herein are systems and methods of diagnosing a disease in a patient based on the patient's expression levels of biomarker genes. Examples of the TL1A-associated disease include, but are not limited to, an inflammatory bowel disease (IBD), Crohn's disease (CD), ulcerative colitis (UC), and fibrosis. Also provided herein are systems and methods of identifying a patient likely to be responsive to an anti-TL1A therapy, prescribing and/or administrating an anti-TL1A therapy to the patient based on the patient's expression levels of biomarker genes.

4. 发明专利

CA3121167A1 METHODS OF STRATIFYING AND TREATING A SUB-POPULATION OF INFLAMMATORY BOWEL DISEASE PATIENTS 未知
公开(公告)号：CA3121167A1
公开(公告)日：2020-06-04
申请号：CA3121167
申请日：2019-11-27
申请人： CEDARS SINAI MEDICAL CENTER
发明人： GONSKY REBECCA , TARGAN STEPHAN R
IPC分类号： G01N33/50 , C12Q1/6883 , G16B20/00 , G16H50/20
摘要： Described herein are methods and systems for identifying subpopulations of patients having Crohn´s disease, including populations at risk of developing structuring or other severe disease, and populations susceptible to success or failure with surgical intervention. Further provided are therapies useful for treating subpopulations of patients having Crohn´s disease.

5. 发明专利

CA2830365A1 ROLE OF IFNG METHYLATION IN INFLAMMATORY BOWEL DISEASE 未知
公开(公告)号：CA2830365A1
公开(公告)日：2012-10-04
申请号：CA2830365
申请日：2012-03-26
申请人： CEDARS SINAI MEDICAL CENTER
发明人： GONSKY REBECCA , DEEM RICHARD , TARGAN STEPHAN R
IPC分类号： C12Q1/68 , C40B30/00 , G01N33/48
摘要： The invention relates to method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation. In one embodiment, the present invention provides a method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject, and diagnosing susceptibility to inflammatory bowel disease based on the presence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject. In another embodiment, the IBD is ulcerative colitis.

6. 发明申请

WO2012135146A2 ROLE OF IFNG METHYLATION IN INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译： IFNG甲基化在炎症性皮肤病中的作用
公开(公告)号：WO2012135146A2
公开(公告)日：2012-10-04
申请号：PCT/US2012030616
申请日：2012-03-26
申请人： CEDARS SINAI MEDICAL CENTER , GONSKY REBECCA , DEEM RICHARD , TARGAN STEPHAN R
发明人： GONSKY REBECCA , DEEM RICHARD , TARGAN STEPHAN R
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The invention relates to method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation. In one embodiment, the present invention provides a method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject, and diagnosing susceptibility to inflammatory bowel disease based on the presence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject. In another embodiment, the IBD is ulcerative colitis.
摘要翻译：本发明涉及通过从个体获得样品来诊断对个体的炎性肠病易感性（IBD）的方法，测定样品以确定一种或多种风险遗传变异体的存在或不存在和/或IFNG DNA的增加甲基化。在一个实施方案中，本发明提供了通过从个体获得样品来诊断个体中对炎症性肠病（IBD）的易感性的方法，测定样品以确定是否存在一种或多种风险遗传变体和/或相对于正常受试者，IFNG DNA甲基化的增加，以及基于一种或多种风险遗传变异体的存在和/或IFNG DNA甲基化相对于正常受试者的增加诊断对炎性肠病的易感性。在另一个实施方案中，IBD是溃疡性结肠炎。

7. 发明公开

EP2689034A4 ROLE OF IFNG METHYLATION IN INFLAMMATORY BOWEL DISEASE 有权
标题翻译： IFNG甲基化炎症性肠疾病中的作用
公开(公告)号：EP2689034A4
公开(公告)日：2014-12-17
申请号：EP12764214
申请日：2012-03-26
申请人： CEDARS SINAI MEDICAL CENTER
发明人： GONSKY REBECCA , DEEM RICHARD , TARGAN STEPHAN R
IPC分类号： C12Q1/68 , C07H21/04 , G01N33/50
CPC分类号： C12Q1/6883 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158

8. 发明公开

EP3041580A4 SYSTEMS, DEVICES AND METHODS FOR ANTI-TL1A THERAPY 审中-公开
标题翻译： SYSTEME，VORRICHTUNGEN UND VERFAHRENFÜRANTI-TL1A-THERAPIE
公开(公告)号：EP3041580A4
公开(公告)日：2017-05-03
申请号：EP14842590
申请日：2014-09-05
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： TARGAN STEPHAN R , GONSKY REBECCA , DEEM RICHARD
IPC分类号： G01N33/68 , A61P37/06 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16 , G01N33/6863 , G01N2333/7151 , G01N2800/52

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式