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1. 发明申请

WO2018009535A1 METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS 审中-公开
标题翻译：方法和组合物用于检测食管中食管嗜酸性细胞增生症和/或胃食管反流病
公开(公告)号：WO2018009535A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040708
申请日：2017-07-05
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： MARKOWITZ, Sanford, D. , MOINOVA, Helen , CHAK, Amitabh , WILLIS, Joseph , LAFRAMBOISE, Thomas
IPC分类号： C12Q1/68 , G01N33/574
摘要： The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
摘要翻译：本披露提供了用于鉴定在化生（例如巴雷特食管）和/或肿瘤性癌症（例如食道癌）中差异甲基化的基因组基因座（例如波形蛋白和/或SqBE18）的方法。甲基化基因组基因座的鉴定具有多种用途，包括例如表征疾病风险，预测对治疗的响应性，非侵入性诊断受试者和治疗被确定患有胃肠变形和/或瘤形成的受试者。

2. 发明申请

WO2016109782A2 METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL NEOPLASIAS 审中-公开
标题翻译：用于检测色素神经元的方法和组合物
公开(公告)号：WO2016109782A2
公开(公告)日：2016-07-07
申请号：PCT/US2015/068252
申请日：2015-12-31
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： MARKOWITZ, Sanford, D. , WILLIS, Joseph, E. , MOINOVA, Helen , LAFRAMBOISE, Thomas , DE LA CRUZ CABRERA, Omar , FECTEAU, Ryan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156
摘要： The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have colorectal neoplasias.
摘要翻译：本公开提供了用于鉴定在结肠直肠肿瘤中差异甲基化的基因组基因座的方法。甲基化基因组基因座的鉴定具有许多用途，包括例如表征疾病风险，预测对治疗的反应性，非侵入性诊断受试者和治疗被确定为具有结肠直肠肿瘤的受试者。

3. 发明公开

EP3481965A1 METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS 审中-实审
公开(公告)号：EP3481965A1
公开(公告)日：2019-05-15
申请号：EP17824802.7
申请日：2017-07-05
申请人： Case Western Reserve University
发明人： MARKOWITZ, Sanford, D. , MOINOVA, Helen , CHAK, Amitabh , WILLIS, Joseph , LAFRAMBOISE, Thomas
IPC分类号： C12Q1/68 , G01N33/574

4. 发明申请

WO2020243240A1 COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION 审中-公开
公开(公告)号：WO2020243240A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/034830
申请日：2020-05-28
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： MARKOWITZ, Sanford, D. , MOINOVA, Helen , WURTMAN, David
IPC分类号： C12Q1/6806 , C12N15/10 , A01N1/00
摘要： The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time.The disclosure also provides for methods of using methylated DNA stored in such storage solutions.

5. 发明申请

WO2014015028A1 METHODS FOR CHARACTERIZING PATIENTS WITH COLON CANCER 审中-公开
标题翻译：用于确定患有结肠癌的患者的方法
公开(公告)号：WO2014015028A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050873
申请日：2013-07-17
申请人： CASE WESTERN RESERVE UNIVERSITY , MARKOWITZ, Sanford, D. , FINK, Stephen , MYEROFF, Lois
发明人： MARKOWITZ, Sanford, D. , FINK, Stephen , MYEROFF, Lois
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present application provides methods for characterizing colon cancer patients by measuring their ColoUp-1 expression levels. In particular, the present application provides among other things methods for determining the survival prognosis of colon cancer patients and methods for determining the efficacy of treatment regimens of colon cancer patients.
摘要翻译：本申请提供了通过测量其ColoUp-1表达水平来表征结肠癌患者的方法。特别地，本申请尤其提供了用于确定结肠癌患者的生存预后的方法以及用于确定结肠癌患者的治疗方案的功效的方法。

6. 发明申请

WO2003104427A2 METHODS AND COMPOSITIONS FOR DETECTING CANCERS 审中-公开
标题翻译：检测癌症的方法和组合物
公开(公告)号：WO2003104427A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/018239
申请日：2003-06-05
申请人： CASE WESTERN RESERVE UNIVERSITY , MARKOWITZ, Sanford, D.
发明人： MARKOWITZ, Sanford, D.
IPC分类号： C12N
CPC分类号： C12N15/8509 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C07K14/4702 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154
摘要： In certain aspects, the invention provides isolated SLC5A8 (also referred to as Huil) nucleic acid molecules, which encode novel sodium solute symporter members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLC5A8 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLC5A8 gene has been introduced or disrupted. The invention still further provides isolated SLC5A8 proteins, fusion proteins, antigenic peptides, and anti-SLC5A8 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. In other aspects, the invention provides methods and compositions for detecting and treating SLC5A8-associated cancer. Differential methylation of the SLC5A8 nucleotide sequences has been observed in SLC5A8-associated cancer, such as colon cancer, breast cancer, thyroid cancer, or stomach cancer.
摘要翻译：在某些方面，本发明提供了分离的SLC5A8（也称为Huil）核酸分子，其编码新的钠溶质对转体成员。本发明还提供了反义核酸分子，含有SLC5A8核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏SLC5A8基因的非人转基因动物。本发明还进一步提供了分离的SLC5A8蛋白，融合蛋白，抗原肽和抗SLC5A8抗体。还提供了利用本发明组合物的诊断方法。在其它方面，本发明提供了用于检测和治疗SLC5A8相关癌症的方法和组合物。已经在SLC5A8相关癌症如结肠癌，乳腺癌，甲状腺癌或胃癌中观察到SLC5A8核苷酸序列的差异甲基化。

7. 发明申请

WO2012178074A1 METHODS AND COMPOSITIONS FOR DETECTING GASTROINTESTINAL AND OTHER CANCERS 审中-公开
标题翻译：检测胃肠癌和其他癌症的方法和组成
公开(公告)号：WO2012178074A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043834
申请日：2012-06-22
申请人： CASE WESTERN RESERVE UNIVERSITY , MARKOWITZ, Sanford, D. , WILLIS, Joseph , CHAK, Amitabh , LEIDNER, Rom
发明人： MARKOWITZ, Sanford, D. , WILLIS, Joseph , CHAK, Amitabh , LEIDNER, Rom
IPC分类号： G01N33/38
CPC分类号： C12Q1/6886 , C07H21/04 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.
摘要翻译：本申请描述了用于检测和治疗波形蛋白相关瘤形成的方法和组合物。已经观察到波形蛋白核苷酸序列的差异甲基化在波形蛋白相关瘤形成中，例如上，下胃肠道，胰腺和/或膀胱的瘤形成。

8. 发明申请

WO2005017207A3 METHODS AND COMPOSITIONS FOR DETECTING COLON CANCERS 审中-公开
公开(公告)号：WO2005017207A3
公开(公告)日：2005-02-24
申请号：PCT/US2004/026478
申请日：2004-08-16
申请人： CASE WESTERN RESERVE UNIVERSITY , MARKOWITZ, Sanford, D.
发明人： MARKOWITZ, Sanford, D.
IPC分类号： C12Q1/68
摘要： This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.

9. 发明申请

WO2004018648A2 METHODS FOR TREATING PATIENTS AND IDENTIFYING THERAPEUTICS 审中-公开
标题翻译：治疗患者和鉴别治疗方法
公开(公告)号：WO2004018648A2
公开(公告)日：2004-03-04
申请号：PCT/US2003/027086
申请日：2003-08-26
申请人： CASE WESTERN RESERVE UNIVERSITY , MARKOWITZ, Sanford, D.
发明人： MARKOWITZ, Sanford, D.
IPC分类号： C12N
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/136 , G01N33/57419 , G01N2500/00
摘要： The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in designing, screening for and targeting .
摘要翻译：本公开尤其提供了用于分类患者的肿瘤状态的分子标记，在设计，筛选和靶向中使用分子标记的方法。

10. 发明申请

WO2003104427A3 METHODS AND COMPOSITIONS FOR DETECTING CANCERS 审中-公开
公开(公告)号：WO2003104427A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/018239
申请日：2003-06-05
申请人： CASE WESTERN RESERVE UNIVERSITY , MARKOWITZ, Sanford, D.
发明人： MARKOWITZ, Sanford, D.
IPC分类号： A61K38/00
摘要： In certain aspects, the invention provides isolated SLC5A8 (also referred to as Huil) nucleic acid molecules, which encode novel sodium solute symporter members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLC5A8 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLC5A8 gene has been introduced or disrupted. The invention still further provides isolated SLC5A8 proteins, fusion proteins, antigenic peptides, and anti-SLC5A8 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. In other aspects, the invention provides methods and compositions for detecting and treating SLC5A8-associated cancer. Differential methylation of the SLC5A8 nucleotide sequences has been observed in SLC5A8-associated cancer, such as colon cancer, breast cancer, thyroid cancer, or stomach cancer.

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