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1. 发明申请

US20190151435A1 AUTOLOGOUS AND ALLOGENIC HIV-1 PROTEINS FOR THE TREATMENT OF LATENT HIV-1 INFECTION 审中-公开
公开(公告)号：US20190151435A1
公开(公告)日：2019-05-23
申请号：US16252108
申请日：2019-01-18
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts
IPC分类号： A61K39/12 , A61P31/18 , A61K39/39
摘要： A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes administering to the subject at least one HIV-1 protein and a pharmaceutically acceptable carrier, wherein the at least one HIV-1 protein is derived from an allogenic infecting HIV-1 virus, and wherein the HIV-1 protein stimulates latent HIV-specific memory CD4+ T cells to induce latent HIV-1 replication resulting in HIV-specific memory-CD4+ T cell death in the subject.

2. 发明申请

US20160220663A1 HIV-1 VACCINE 有权
标题翻译： HIV-1疫苗
公开(公告)号：US20160220663A1
公开(公告)日：2016-08-04
申请号：US14524923
申请日：2014-10-27
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts
IPC分类号： A61K39/21 , C07K16/28 , C12N7/00
CPC分类号： C07K16/2812 , A61K39/12 , A61K2039/5254 , A61K2039/575 , C07K16/1063 , C12N2740/16122 , C12N2740/16134
摘要： A method for inducing an immune response against HIV in a subject includes the step of preparing an HIV-1 gp120 envelope protein coding sequence particle having an N425K mutation, introducing the HIV-1 gp120 protein coding sequence particle having an N425K mutation into an expression construct using yeast homologous recombination, transfecting a cell with the expression construct, wherein the HIV-1 particle is secreted by the cell, and administering the secreted HIV-1 particle and a pharmaceutically acceptable carrier to the subject, wherein the secreted HIV-1 particle stimulates an immune response in the subject.
摘要翻译：在受试者中诱导针对HIV的免疫应答的方法包括制备具有N425K突变的HIV-1 gp120包膜蛋白编码序列粒子的步骤，将具有N425K突变的HIV-1 gp120蛋白质编码序列粒子引入表达构建体使用酵母同源重组，用表达构建体转染细胞，其中所述HIV-1颗粒由细胞分泌，以及向受试者施用分泌的HIV-1颗粒和药学上可接受的载体，其中分泌的HIV-1颗粒刺激受试者的免疫反应。

3. 发明申请

US20160206689A1 AUTOLOGOUS HIV-1 PROTEINS FOR THE TREATMENT OF LATENT HIV-1 INFECTION 有权
标题翻译：用于治疗HIV-1感染的自动HIV-1蛋白
公开(公告)号：US20160206689A1
公开(公告)日：2016-07-21
申请号：US14735662
申请日：2015-06-10
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts
IPC分类号： A61K38/16 , A61K45/06
CPC分类号： A61K38/162 , A61K45/06 , C12N2740/16033
摘要： A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes the steps of: preparing at least one HIV-1 protein coding sequence from a sample obtained from the subject, wherein the sample includes HIV-1 RNA; introducing the at least one HIV-1 protein coding sequence into at least one expression construct using yeast homologous recombination; transfecting a cell with the at least one expression construct, wherein the HIV-1 protein is secreted by the cell and administering a therapeutically effective amount of the secreted HIV-1 protein and a pharmaceutically acceptable carrier to the subject, wherein the secreted HIV-1 protein stimulates latent HIV-specific memory-CD4+ T cells to induce latent HIV-1 replication resulting in HIV-specific memory-CD4+ T cell death in the subject.
摘要翻译：降低受试者潜伏HIV特异性记忆 - CD4 + T细胞池的方法包括以下步骤：从获自受试者的样品制备至少一种HIV-1蛋白编码序列，其中样品包括HIV-1 RNA; 使用酵母同源重组将至少一种HIV-1蛋白质编码序列引入至少一种表达构建体; 用所述至少一种表达构建体转染细胞，其中所述HIV-1蛋白由细胞分泌并向受试者施用治疗有效量的分泌的HIV-1蛋白和药学上可接受的载体，其中分泌的HIV-1 蛋白质刺激潜伏的HIV特异性记忆 - CD4 + T细胞诱导潜伏的HIV-1复制，导致受试者的HIV特异性记忆 - CD4 + T细胞死亡。

4. 发明申请

US20150337399A1 HIV-1 GENOTYPING AND CORECEPTOR TROPISM ASSAY 审中-公开
标题翻译：艾滋病毒1基因组和正常人TROPISM测定
公开(公告)号：US20150337399A1
公开(公告)日：2015-11-26
申请号：US14540774
申请日：2014-11-13
申请人： Case Western Reserve University
发明人： Miguel E. Quinones-Mateu , Eric J. Arts
IPC分类号： C12Q1/70
CPC分类号： C12Q1/703 , C12Q1/70 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： A method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance and HIV tropism includes generating a plurality of cDNA species from a plurality of RNA molecules in an HIV sample population, amplifying a plurality of first amplicons and second amplicons from the cDNA species, wherein the first amplicons are amplified using first pairs of primers that amplify a HIV genomic region of the cDNA species encoding the Gag proteins p2, p7, p1 and p6, and the protease, reverse transcriptase, and integrase enzymes and the second amplicons are amplified using second pairs of primers that amplify a HIV genomic encoding region of the cDNA species encoding the env-C2V3 region; determining the nucleic acid sequence compositions of the amplified first amplicons second amplicons; identifying variants in the determined sequence by comparing the determined nucleic sequence to a guide sequence; and correlating the determined variants with variants of HIV drug resistance and HIV tropism.
摘要翻译：用于检测与耐药性和HIV向性相关的一个或多个HIV序列变体的低频发生的方法包括从HIV样品群中的多个RNA分子生成多个cDNA种类，从多个RNA分子中扩增多个第一扩增子和第二扩增子 cDNA种类，其中使用扩增编码Gag蛋白质p2，p7，p1和p6的cDNA种类的HIV基因组区域的第一对引物以及蛋白酶，逆转录酶和整合酶扩增第一扩增子，第二扩增子扩增使用扩增编码env-C2V3区域的cDNA种的HIV基因组编码区的第二对引物扩增扩增子; 确定扩增的第一扩增子第二扩增子的核酸序列组成; 通过将确定的核酸序列与引导序列进行比较来鉴定所确定的序列中的变体; 并将确定的变体与HIV耐药性和HIV趋向性的变体相关联。

5. 发明公开

US20240368624A1 GENOMIC RNA PACKAGING ENHANCER ELEMENT 审中-公开
公开(公告)号：US20240368624A1
公开(公告)日：2024-11-07
申请号：US18594781
申请日：2024-03-04
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts
IPC分类号： C12N15/86 , C07K14/005
CPC分类号： C12N15/86 , C07K14/005 , C12N2740/15042 , C12N2740/15052 , C12N2740/16043 , C12N2740/16222
摘要： A synthetic lentiviral vector construct comprises a genomic RNA packaging enhancer (GRPE) element and lentiviral nucleic acid sequences sufficient for reverse transcription and packaging in a host cell.

6. 发明授权

US11192949B2 HIV-1 vaccine 有权
公开(公告)号：US11192949B2
公开(公告)日：2021-12-07
申请号：US16000695
申请日：2018-06-05
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts , Annette Burkhouse
IPC分类号： C07K16/28 , A61K39/12 , C07K16/10 , A61K39/00
摘要： A method for inducing an immune response against HIV in a subject includes the step of preparing an HIV-1 gp120 envelope protein coding sequence particle having an N425K mutation, introducing the HIV-1 gp120 protein coding sequence particle having an N425K mutation into an expression construct using yeast homologous recombination, transfecting a cell with the expression construct, wherein the HIV-1 particle is secreted by the cell, and administering the secreted HIV-1 particle and a pharmaceutically acceptable carrier to the subject, wherein the secreted HIV-1 particle stimulates an immune response in the subject.

7. 发明申请

US20210170015A1 AUTOLOGOUS AND ALLOGENIC HIV-1 PROTEINS FOR THE TREATMENT OF LATENT HIV-1 INFECTION 有权
公开(公告)号：US20210170015A1
公开(公告)日：2021-06-10
申请号：US17115355
申请日：2020-12-08
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts , Jamie Mann
IPC分类号： A61K39/12 , A61P31/18 , A61K39/39 , A61K39/00 , A61K45/06
摘要： A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes administering to the subject at least one HIV-1 protein and a pharmaceutically acceptable carrier, wherein the at least one HIV-1 protein is derived from an allogenic infecting HIV-1 virus, and wherein the HIV-1 protein stimulates latent HIV-specific memory CD4+ T cells to induce latent HIV-1 replication resulting in HIV-specific memory-CD4+ T cell death in the subject.

8. 发明授权

US10106816B2 Genomic RNA packaging enhancer element 有权
公开(公告)号：US10106816B2
公开(公告)日：2018-10-23
申请号：US14652335
申请日：2013-12-16
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts
IPC分类号： C12N15/00 , C12N15/63 , C07H21/04 , C12N15/86 , C07K14/005 , A01K67/00
摘要： A synthetic lentiviral vector construct comprises a genomic RNA packaging enhancer (GRPE) element and lentiviral nucleic acid sequences sufficient for reverse transcription and packaging in a host cell.

9. 发明授权

US09988451B2 HIV-1 vaccine 有权
公开(公告)号：US09988451B2
公开(公告)日：2018-06-05
申请号：US14524923
申请日：2014-10-27
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts , Annette Burkhouse
IPC分类号： A61P31/18 , A61P37/04 , A61K39/12 , A61K39/21 , C12N7/00 , C07K14/16 , C07K16/28 , C07K16/10 , A61K39/00
CPC分类号： C07K16/2812 , A61K39/12 , A61K2039/5254 , A61K2039/575 , C07K16/1063 , C12N2740/16122 , C12N2740/16134
摘要： A method for inducing an immune response against HIV in a subject includes the step of preparing an HIV-1 gp120 envelope protein coding sequence particle having an N425K mutation, introducing the HIV-1 gp120 protein coding sequence particle having an N425K mutation into an expression construct using yeast homologous recombination, transfecting a cell with the expression construct, wherein the HIV-1 particle is secreted by the cell, and administering the secreted HIV-1 particle and a pharmaceutically acceptable carrier to the subject, wherein the secreted HIV-1 particle stimulates an immune response in the subject.

10. 发明授权

US11920147B2 Genomic RNA packaging enhancer element 有权
公开(公告)号：US11920147B2
公开(公告)日：2024-03-05
申请号：US16168549
申请日：2018-10-23
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Eric J. Arts
IPC分类号： C12N15/86 , C07K14/005 , C12N15/63 , A61K48/00
CPC分类号： C12N15/86 , C07K14/005 , C12N2740/15042 , C12N2740/15052 , C12N2740/16043 , C12N2740/16222
摘要： A synthetic lentiviral vector construct comprises a genomic RNA packaging enhancer (GRPE) element and lentiviral nucleic acid sequences sufficient for reverse transcription and packaging in a host cell.

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