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1. 发明申请

WO2008044846A1 PEPTIDES HAVING ACTIVITIES OF EPIDERMAL GROWTH FACTOR AND ITS USES 审中-公开
标题翻译：具有活性生长因子活性及其用途的肽
公开(公告)号：WO2008044846A1
公开(公告)日：2008-04-17
申请号：PCT/KR2007/004895
申请日：2007-10-08
申请人： CAREGEN CO., LTD , CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
发明人： CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
IPC分类号： C07K14/485 , A61K38/00
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55
摘要： The present invention relates to peptides comprising the amino acid sequence represented by the following formula 1 and having the activities of epidermal growth factor and their uses: Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp (1) The EGF-mimicking peptides of the present invention possess identical functions or activities to natural-occurring human EGF and are able to promote the generation of autocrine EGF in cells. In addition the peptides of the present invention are much higher stability and skin penetration potency than natural- occurring EGF. Therefore, the composition containing the peptide exhibits excellent treatment and prevention efficacies on diseases or conditions demanding EGF activities, and can be advantageously applied to pharmaceutical compositions, quasi- drugs and cosmetics.
摘要翻译：本发明涉及包含由下式1表示的氨基酸序列并具有表皮生长因子活性及其用途的肽：Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp（1）本发明的EGF模拟肽对天然存在的人类EGF具有相同的功能或活性，并且能促进细胞中自分泌EGF的产生。此外，本发明的肽比天然发生的EGF具有更高的稳定性和皮肤穿透效力。因此，含有肽的组合物对于要求EGF活性的疾病或病症表现出优异的治疗和预防功效，并且可以有利地应用于药物组合物，准药物和化妆品。

2. 发明申请

WO2008130082A1 TGFP-CAP PEPTIDE AND ITS USES 审中-公开
标题翻译： TGFP-CAP肽及其用途
公开(公告)号：WO2008130082A1
公开(公告)日：2008-10-30
申请号：PCT/KR2007/004405
申请日：2007-09-12
申请人： CAREGEN CO., LTD , CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
IPC分类号： C07K19/00
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有衍生自TGF-β1（转化生长因子-β1）的氨基酸序列和细胞粘附序列的GFP-CAP肽，其中衍生自TGF-β1的氨基酸序列由 SEQ ID NO：1，TGFP-CAP肽由下式I表示：Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-细胞粘附序列（I）。本发明的TGFP-CAP肽表现出优异的抗血管生成活性。此外，本发明的TGFP-CAP肽有效地防止皮肤中的黑色素生成，从而具有皮肤美白效果。本发明的肽显示比天然存在的TGF-β1更高的稳定性和对皮肤的渗透性。本发明肽的这种合理的活性和安全性有利地适用于药物，准药物和化妆品。

3. 发明授权

EP2474555B1 WNT10-DERIVED PEPTIDE AND USE THEREOF 有权
标题翻译： WNT10肽和使用
公开(公告)号：EP2474555B1
公开(公告)日：2015-08-05
申请号：EP09849032.9
申请日：2009-11-24
申请人： Caregen Co., Ltd.
发明人： CHUNG, Young Ji , KIM, Eun Mi , SONG, Sang Su , CHO, Kyoung Mi
IPC分类号： C07K14/475 , A61K38/18 , A61K8/64 , A61Q7/00 , A61Q19/00
CPC分类号： A61K8/64 , A61K38/18 , A61Q7/00 , A61Q19/00 , C07K14/475

4. 发明授权

EP2078035B1 PEPTIDES HAVING ACTIVITIES OF EPIDERMAL GROWTH FACTOR AND ITS USES 有权
标题翻译：肽效益比表皮生长因子体和应用
公开(公告)号：EP2078035B1
公开(公告)日：2013-07-03
申请号：EP07833206.1
申请日：2007-10-08
申请人： Caregen Co., Ltd.
发明人： CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
IPC分类号： C07K14/485 , A61K38/00 , A61K38/18 , A61K8/64 , A61Q7/00 , A61Q19/08
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55

5. 发明授权

EP2383283B1 NOGGIN-DERIVED PEPTIDE AND USE THEREOF 有权
标题翻译： NOGGIN肽和使用
公开(公告)号：EP2383283B1
公开(公告)日：2015-07-08
申请号：EP09838926.5
申请日：2009-11-24
申请人： Caregen Co., Ltd.
发明人： CHUNG, Young Ji , KIM, Young Deug , KIM, Eun Mi , SONG, Sang Su , HONG, Il , CHO, Kyoung Mi , KIM, Su Mi , HAN, Sang Min
IPC分类号： C07K7/08 , C07K7/06 , C07K14/47
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00

6. 发明公开

EP2078035A1 PEPTIDES HAVING ACTIVITIES OF EPIDERMAL GROWTH FACTOR AND ITS USES 有权
标题翻译：肽效益比表皮生长因子体和应用
公开(公告)号：EP2078035A1
公开(公告)日：2009-07-15
申请号：EP07833206.1
申请日：2007-10-08
申请人： Caregen Co., Ltd.
发明人： CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
IPC分类号： C07K14/485 , A61K38/00
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55
摘要： The present invention relates to peptides comprising the amino acid sequence represented by the following formula 1 and having the activities of epidermal growth factor and their uses: Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp (1) The EGF-mimicking peptides of the present invention possess identical functions or activities to natural-occurring human EGF and are able to promote the generation of autocrine EGF in cells. In addition the peptides of the present invention are much higher stability and skin penetration potency than natural- occurring EGF. Therefore, the composition containing the peptide exhibits excellent treatment and prevention efficacies on diseases or conditions demanding EGF activities, and can be advantageously applied to pharmaceutical compositions, quasi- drugs and cosmetics.

7. 发明授权

EP2142572B1 TGFP-CAP PEPTIDE AND ITS USES 有权
标题翻译： TGFP CAP肽及其用途
公开(公告)号：EP2142572B1
公开(公告)日：2015-07-29
申请号：EP07808197.3
申请日：2007-09-12
申请人： Caregen Co., Ltd.
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
IPC分类号： C07K19/00 , A61K8/18 , A61K38/10 , A61K38/17 , C07K9/00
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08

8. 发明公开

EP2142572A1 TGFP-CAP PEPTIDE AND ITS USES 有权
标题翻译： TGFP CAP肽及其用途
公开(公告)号：EP2142572A1
公开(公告)日：2010-01-13
申请号：EP07808197.3
申请日：2007-09-12
申请人： Caregen Co., Ltd.
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
IPC分类号： C07K19/00
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.

9. 发明公开

EP2474555A1 WNT10-DERIVED PEPTIDE AND USE THEREOF 有权
标题翻译： WNT10-PEPTID UND SEINE VERWENDUNG
公开(公告)号：EP2474555A1
公开(公告)日：2012-07-11
申请号：EP09849032.9
申请日：2009-11-24
申请人： Caregen Co., Ltd.
发明人： CHUNG, Young Ji , KIM, Eun Mi , SONG, Sang Su , CHO, Kyoung Mi
IPC分类号： C07K14/47 , A61K38/17 , A61Q9/04
CPC分类号： A61K8/64 , A61K38/18 , A61Q7/00 , A61Q19/00 , C07K14/475
摘要： The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder using the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及WNT10衍生肽，用于改善脱发的组合物和使用该组合物的皮肤状态，以及使用该组合物治疗WNT10信号转导通路相关病症和DKK-1蛋白质诱导障碍的组合物。本发明的WNT10衍生肽与天然存在的WNT10具有相同或相似的活性，并且比天然存在的WNT10具有高得多的稳定性和皮肤穿透效力。因此，含有本发明肽的组合物不仅对改善脱发（例如促进头发生长或毛发生产）显示出优异的效果，而且对治疗WNT10信号转导通路相关病症和 DKK-1蛋白诱导的病症。此外，上述本发明肽的突出活性和稳定性在应用于药物组合物，准药物和化妆品中可能是非常有利的。

10. 发明公开

EP2383283A2 NOGGIN-DERIVED PEPTIDE AND USE THEREOF 有权
标题翻译： NOGGIN-PEPTID UND SEINE VERWENDUNG
公开(公告)号：EP2383283A2
公开(公告)日：2011-11-02
申请号：EP09838926.5
申请日：2009-11-24
申请人： Caregen Co., Ltd.
发明人： CHUNG, Young Ji , KIM, Young Deug , KIM, Eun Mi , SONG, Sang Su , HONG, Il , CHO, Kyoung Mi , KIM, Su Mi , HAN, Sang Min
IPC分类号： C07K7/08 , C07K7/06 , C07K14/47
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.
摘要翻译：公开了一种头蛋白衍生肽和含有它们的组合物，用于促进毛发生长，改善皮肤状况，提供抗炎功能，或预防或治疗骨骼疾病。所公开的头蛋白衍生肽具有与天然人头蛋白相同或相似的功能，与其相比，其稳定性和皮肤渗透性优异。含有本公开的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着的优异效果，例如，脱发，皮肤状况或切割，或治疗，预防或改善生长因子过表达相关症状。因此，本公开的肽的优异的活性和稳定性在应用于药物，准药物和化妆品方面是非常有利的。

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