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1. 发明申请

WO2007002225A2 IMPLANTABLE WIRELESS SENSOR FOR IN VIVO PRESSURE MEASUREMENT 审中-公开
标题翻译：用于体内压力测量的可植入式无线传感器
公开(公告)号：WO2007002225A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024185
申请日：2006-06-21
申请人： CARDIOMEMS, INC. , O'BRIEN, David , WHITE, Jason , FONSECA, Michael , CROS, Florent , KROH, Jason , STERN, David , ALLEN, Mark
发明人： O'BRIEN, David , WHITE, Jason , FONSECA, Michael , CROS, Florent , KROH, Jason , STERN, David , ALLEN, Mark
CPC分类号： A61B5/0031 , A61B5/0215 , A61B5/076 , A61B2560/0219 , A61B2562/028
摘要： A sensor suitable for in vivo implantation has a capacitive circuit and a three-dimensional inductor coil connected to the capacitive circuit to form an LC circuit. The LC circuit is hermetically encapsulated within an electrically insulating housing. An electrical characteristic of the LC circuit is responsive to a change in an environmental parameter.
摘要翻译：适用于体内植入的传感器具有电容电路和连接到电容电路的三维电感线圈，以形成LC电路。 LC电路气密地封装在电绝缘壳体内。 LC电路的电气特性响应于环境参数的变化。

2. 发明申请

WO2004014456A3 IMPLANTABLE WIRELESS SENSOR FOR BLOOD PRESSURE MEASUREMENT WITHIN AN ARTERY 审中-公开
公开(公告)号：WO2004014456A3
公开(公告)日：2004-02-19
申请号：PCT/US2003/024751
申请日：2003-08-07
申请人： CARDIOMEMS, INC. , ALLEN, Mark , FONSECA, Michael , WHITE, Jason , KROH, Jason , STERN, David
发明人： ALLEN, Mark , FONSECA, Michael , WHITE, Jason , KROH, Jason , STERN, David
IPC分类号： A61B5/02
摘要： Intra-arterial blood pressure is monitored by inserting a pressure transducer sensor (250) using a catheter (258) into an artery and then using a small, hand-held read out device to measure pressure easily, safely, inexpensively and accurately. In one aspect a sensor (250) is introduced into the body by the steps of folding or rolling the sensor into a cylinder, loading it into a catheter, and deploying into the artery by allowing it to unroll or unfold, either by itself or facilitated by the incorporation of a super-elastic allow component.

3. 发明申请

WO2003061504A1 IMPLANTABLE WIRELESS SENSOR 审中-公开
标题翻译：可植入无线传感器
公开(公告)号：WO2003061504A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/002001
申请日：2003-01-22
申请人： CARDIOMEMS, INC. , FONSECA, Michael , ALLEN, Mark , STERN, David , WHITE, Jason , KROH, Jason
发明人： FONSECA, Michael , ALLEN, Mark , STERN, David , WHITE, Jason , KROH, Jason
IPC分类号： A61B19/00
CPC分类号： A61B5/03 , A61B5/0002
摘要： The progress of a endovascular aneurysm repair can be monitored by inserting a pressure transducer sensor (110) using a catheter (92) into the sac during endovascular aneurysm repair and then using a small, hand-held read out device to measure pressure easily, safely, inexpensively and accurately. In one aspect a sensor (110) is introduced into the body by the steps of folding or rolling the sensor (110) into a cylinder, loading it into a catheter (94), and deploying into the aneurysm sac by allowing it to unroll or unfold, either by itself or facilitated by the incorporation of a super-elastic alloy component.
摘要翻译：血管内动脉瘤修复的进展可以通过在血管内动脉瘤修复期间使用导管（92）插入到囊中来插入压力换能器传感器（110）来监测，然后使用小的手持式读出装置来容易地，安全地测量压力，廉价和准确。在一个方面，传感器（110）通过将传感器（110）折叠或滚动成圆柱体，将其装载到导管（94）中并通过允许其展开或展开而部署到动脉瘤囊中的步骤被引入体内自身展开或通过加入超弹性合金组分来促进。

4. 发明申请

WO2003061467A1 IMPLANTABLE WIRELESS SENSOR FOR PRESSURE MEASUREMENT WITHIN THE HEART 审中-公开
标题翻译：可植入的无线传感器用于心脏内的压力测量
公开(公告)号：WO2003061467A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/002002
申请日：2003-01-22
申请人： CARDIOMEMS, INC. , ALLEN, Mark , FONSECA, Michael , STERN, David , WHITE, Jason , KROH, Jason
发明人： FONSECA, Michael , STERN, David , WHITE, Jason , KROH, Jason
IPC分类号： A61B5/0215
CPC分类号： A61B5/0031 , A61B5/0215
摘要： The progress of a endovascular cardiac repair can be monitored by inserting a pressure transducer sensor with a first layer (242), a second layer (248), and a third layer (252), using a catheter into a chamber of the heart during endovascular repair and then using a small, hand-held read out device to measure pressure easily, safely, inexpensively and accurately. The sensor contains conductive spiral coils (244) and (254) to form an LC circuit. In one aspect a sensor is introduced into the body by the steps of folding or rolling the sensor into a cylinder, loading it into a catheter, and deploying into the heart chamber by allowing it to unroll or unfold, either by itself or facilitated by the incorporation of a super-elastic alloy component.
摘要翻译：通过使用导管插入具有第一层（242），第二层（248）和第三层（252）的压力传感器传感器，可以监测血管内心脏修复的进展在血管内修复过程中进入心脏腔内，然后使用小型手持式读出装置轻松，安全，便宜和准确地测量压力。传感器包含导电螺旋线圈（244）和（254）以形成LC电路。在一个方面，通过将传感器折叠或滚动到圆柱体中，将其装载到导管中，并且通过允许其自身展开或展开到心脏腔室中来将传感器引入到身体中，掺入超弹性合金成分。

5. 发明申请

WO2005027998A2 IMPLANTABLE WIRELESS SENSOR 审中-公开
标题翻译：可植入无线传感器
公开(公告)号：WO2005027998A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/030727
申请日：2004-09-16
申请人： CARDIOMEMS, INC. , O'BRIEN, David , WHITE, Jason , FONSECA, Michael , KROH, Jason , ALLEN, Mark , STERN, David
发明人： O'BRIEN, David , WHITE, Jason , FONSECA, Michael , KROH, Jason , ALLEN, Mark , STERN, David
IPC分类号： A61M
CPC分类号： A61B5/02014 , A61B5/0031 , A61B5/076 , Y10T29/49016 , Y10T29/49069 , Y10T29/49071 , Y10T29/49073
摘要： The progress of a endovascular aneurysm repair can be monitored by inserting a pressure transducer sensor using a catheter into the sac during endovascular aneurysm repair and then using a small, hand-held read out device to measure pressure easily, safely, inexpensively and accurately. In one aspect a sensor is introduced into the body by the steps of loading the sensor into a catheter, and deploying into the aneurysm sac. This invention also has other applications for measuring physical properties in patients or in other sites.
摘要翻译：血管内动脉瘤修复的进展可以通过在血管内动脉瘤修复期间使用导管插入囊中的压力传感器传感器来监测，然后使用小的手持式读出装置来容易，安全，低成本且准确地测量压力。在一个方面，通过将传感器加载到导管中并且部署到动脉瘤囊中的步骤将传感器引入体内。本发明还具有用于测量患者或其他部位物理性质的其它应用。

6. 发明申请

WO2007130628A2 IMPLANTABLE WIRELESS SENSOR FOR IN VIVO PRESSURE MEASUREMENT AND CONTINUOUS OUTPUT DETERMINATION 审中-公开
标题翻译：用于输血压力测量和连续输出测量的无侵入式无线传感器
公开(公告)号：WO2007130628A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010927
申请日：2007-05-04
申请人： CARDIOMEMS, INC. , STERN, David , RALPH, Stephen , WHITE, Jason , KROH, Jason , MOORE, Erik
发明人： STERN, David , RALPH, Stephen , WHITE, Jason , KROH, Jason , MOORE, Erik
IPC分类号： A61B5/00 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/0031
摘要： A method and apparatus for determining cardiac parameters within the body of a patient includes a wireless sensor positioned in the patient's pulmonary artery. An external RF telemetry device communicates wirelessly with the sensor and interrogates the sensor to determine changes in pressure in the pulmonary artery over time. The peak pressure difference is determined. Then, assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, a velocity-time function is determined. The velocity-time function is used to determine a velocity-time integral. The velocity-time integral is then used to determine cardiac stroke volume. The cardiac stroke volume is multiplied times the heartbeat rate to determine cardiac output. The cardiac output can be monitored over time to determine continuous cardiac output.
摘要翻译：用于确定患者体内的心脏参数的方法和装置包括位于患者肺动脉中的无线传感器。外部RF遥测装置与传感器无线通信，并询问传感器以确定肺动脉随时间变化的变化。确定峰值压力差。然后，假设在阀打开时和阀关闭时的血流速度为零，则确定速度 - 时间函数。速度 - 时间函数用于确定速度 - 时间积分。然后使用速度 - 时间积分来确定心脏搏动量。将心脏搏动量乘以心跳速率以确定心输出量。可以随时间监测心输出量以确定持续的心输出量。

7. 发明申请

WO2007106533A1 SENSOR, DELIVERY SYSTEM, AND METHOD OF FIXATION 审中-公开
标题翻译：传感器，传送系统和固定方法
公开(公告)号：WO2007106533A1
公开(公告)日：2007-09-20
申请号：PCT/US2007/006441
申请日：2007-03-14
申请人： CardioMEMS, Inc. , STERN, David , WHITE, Jason
发明人： STERN, David , WHITE, Jason
IPC分类号： A61B5/02
CPC分类号： A61B5/0002 , A61B5/02007 , A61B5/021 , A61B5/02152 , A61B5/061 , A61B5/07 , A61B5/6882
摘要： An implant assembly for releasing into a vessel at an implant location includes an intracorporeal device and an anchor. The anchor comprises a pair of resiliently deformable loops operatively associated with the intracorporeal device, both of the loops extending toward the same side of a plane defined by the intracorporeal device. The deformable loops have a relaxed state and a deformed state. When the deformable loops are in a relaxed state, the implant assembly has a major dimension in a direction out of the plane that is greater than the diameter of a vessel at the implant location. The loops are deformable to permit insertion of the implant assembly into the vessel. The tendency of the loops to return to their relaxed state exerts a force on a wall of the vessel that imposes the intracorporeal device against an opposite wall of the vessel.
摘要翻译：用于在植入位置释放到血管中的植入物组件包括体内装置和锚。锚固件包括一对与体内装置可操作地相关联的可弹性变形的环，两个环向着由体内装置限定的平面的相同侧延伸。可变形环具有松弛状态和变形状态。当可变形环处于松弛状态时，植入物组件在离开平面的方向上具有大于植入位置处的血管直径的主要尺寸。环可变形以允许将植入物组件插入容器中。循环回到其松弛状态的趋势在容器的壁上施加力，该力将体内装置施加在容器的相对壁上。

8. 发明公开

EP4073573A1 METHODS AND SYSTEMS FOR THREE-DIMENSIONAL LIGHTSHEET IMAGING 审中-实审
公开(公告)号：EP4073573A1
公开(公告)日：2022-10-19
申请号：EP20899785.8
申请日：2020-12-09
申请人： Enumerix, Inc. , Lai, Janice , Stern, David
发明人： LAI, Janice , STERN, David
IPC分类号： G02B27/09

9. 发明申请

WO2005042782A1 METHODS FOR REDUCING SEIZURE-INDUCED NEURONAL DAMAGE 审中-公开
标题翻译：减少癫痫诱发神经损伤的方法
公开(公告)号：WO2005042782A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/036173
申请日：2004-10-28
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , YAN, Shi Du , MCKHANN, Guy , STERN, David
发明人： YAN, Shi Du , MCKHANN, Guy , STERN, David
IPC分类号： C12Q1/68
CPC分类号： C07K14/70503 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K48/00 , C12N15/8509
摘要： This invention provides a method for treating a subject either during or soon after a seizure, in order to reduce the extent of neuronal damage in the subject resulting from the seizure comprising administering to the subject, either during or soon after the seizure, a therapeutically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to thereby reduce the extent of neuronal damage in the subject. This invention further provides a method for inhibiting neuronal damage which would otherwise result from a seizure in a subject predisposed to having a seizure, comprising administering to the subject a prophylactically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to inhibit neuronal damage which would otherwise result from a seizure in the event the subject were to suffer a seizure. This invention further provides related articles of manufacture.
摘要翻译：本发明提供了一种在癫痫发作期间或之后治疗受试者的方法，以便减少由于癫痫发作引起的受试者神经元损伤的程度，包括在癫痫发作期间或之后对受试者施用治疗有效的用于晚期糖基化终产物（RAGE）的受体抑制剂的量，从而减少受试者的神经元损伤的程度。本发明进一步提供了一种抑制神经元损伤的方法，否则这些损伤将由预先发生癫痫发作的受试者的癫痫发作引起，其包括向受试者施用预防有效量的晚期糖基化终末产物受体抑制剂（RAGE），以便以抑制在受试者遭受癫痫发作的情况下由于癫痫发作而导致的神经元损伤。本发明还提供了相关的制造品。

10. 发明公开

EP1993438A1 SENSOR, DELIVERY SYSTEM, AND METHOD OF FIXATION 审中-公开
标题翻译：传感器，输出系统及固定方法
公开(公告)号：EP1993438A1
公开(公告)日：2008-11-26
申请号：EP07753092.1
申请日：2007-03-14
申请人： CardioMems, Inc.
发明人： STERN, David , WHITE, Jason
IPC分类号： A61B5/02
CPC分类号： A61B5/0002 , A61B5/02007 , A61B5/021 , A61B5/02152 , A61B5/061 , A61B5/07 , A61B5/6882
摘要： An implant assembly for releasing into a vessel at an implant location includes an intracorporeal device and an anchor. The anchor comprises a pair of resiliently deformable loops operatively associated with the intracorporeal device, both of the loops extending toward the same side of a plane defined by the intracorporeal device. The deformable loops have a relaxed state and a deformed state. When the deformable loops are in a relaxed state, the implant assembly has a major dimension in a direction out of the plane that is greater than the diameter of a vessel at the implant location. The loops are deformable to permit insertion of the implant assembly into the vessel. The tendency of the loops to return to their relaxed state exerts a force on a wall of the vessel that imposes the intracorporeal device against an opposite wall of the vessel.

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