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1. 发明申请

WO2010120883A3 CARDIAC ABLATION CATHETERS FOR FORMING OVERLAPPING LESIONS 审中-公开
标题翻译：用于形成超重力的心脏吸收导管
公开(公告)号：WO2010120883A3
公开(公告)日：2011-03-24
申请号：PCT/US2010031034
申请日：2010-04-14
申请人： CARDIOFOCUS INC , MELSKY GERALD , SAGON STEPHEN W , STANCAMPIANO ALFRED , ARNOLD JEFFREY M , BAXTER LINCOLN S
发明人： MELSKY GERALD , SAGON STEPHEN W , STANCAMPIANO ALFRED , ARNOLD JEFFREY M , BAXTER LINCOLN S
IPC分类号： A61B18/24
CPC分类号： A61B18/245 , A61B2017/00057 , A61B2017/00061 , A61B2018/0097 , A61B2018/2261 , A61B2018/2266 , A61B2018/2272 , A61B2090/065 , A61N7/02
摘要： Methods and instruments are disclosed for creating lesions in tissue, especially cardiac tissue, for treatment of arrhythmias and the like, by employing an elastic balloon and an energy emitter, which is independently positionable within the lumen of the instrument and adapted to project a series of spots of ablative energy through a transmissive region of the balloon to a target tissue site. The energy emitter preferably is configured such the spots of energy result in a series of lesions formed in the target tissue region when the emitter is activated, the lesions having an average area ranging from about 5 mm2 to about 100 mm2. In one aspect of the invention, percutaneous ablation instruments are disclosed in the form of catheter bodies having one or more balloon structures at the distal end region of the instrument and an energy emitting element, which is independently positionable and rotatable within a lumen of the instrument and adapted to project ablative energy through a transmissive region of the balloon to a target tissue site in contact with, or proximal to, the balloon surface.
摘要翻译：公开了用于通过使用弹性球囊和能量发射器在组织，特别是心脏组织中产生病变以治疗心律失常等的方法和仪器，所述弹性球囊和能量发射器可独立地定位在所述仪器的内腔内并适于投射一系列通过球囊的透射区域到目标组织部位的烧蚀能量点。能量发射体优选配置成当发射器被激活时，这样的能量点会导致在靶组织区域中形成的一系列损伤，病变的平均面积范围为约5mm 2至约100mm 2。在本发明的一个方面，经皮消融器具以导管本体的形式被公开，所述导管主体在器械的远端区域具有一个或多个球囊结构，并且能量发射元件可独立地在仪器的内腔内定位和旋转并且适于将消融能量通过球囊的透射区域投射到与球囊表面接触或接近的目标组织部位。

2. 发明申请

WO2011041638A3 CARDIAC ABLATION SYSTEM WITH AUTOMATIC SAFETY SHUT-OFF FEATURE 审中-公开
标题翻译：具有自动安全关闭功能的心脏吸收系统
公开(公告)号：WO2011041638A3
公开(公告)日：2011-08-18
申请号：PCT/US2010051057
申请日：2010-10-01
申请人： CARDIOFOCUS INC , MELSKY GERALD , SAGON STEPHEN W
发明人： MELSKY GERALD , SAGON STEPHEN W
IPC分类号： A61B18/18 , A61B18/24 , A61F2/958 , A61M29/00 , A61N5/06
CPC分类号： A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00123 , A61B2017/0046 , A61B2018/00196 , A61B2018/00982 , A61B2018/1861 , A61B2018/2025 , A61B2018/2261 , A61B2018/2272 , A61B2090/306 , A61N7/022
摘要： A cardiac tissue ablation system according to one embodiment includes an elongate catheter configured to deliver a distal end thereof to a patient's heart and an expandable member formed at the distal portion of the catheter. The expandable member has an elastic portion configured to conform to the shape of a target tissue region upon expansion. The system further includes an energy emitter movably disposed within a lumen of the catheter. The energy emitter is configured to deliver radiant ablative energy to the target tissue region. The system further includes a controller that includes a safety shut-off feature for automatically shutting off power to the energy emitter when a prescribed event occurs resulting in power to the energy emitter being stopped.
摘要翻译：根据一个实施例的心脏组织消融系统包括被配置为将其远端传送到患者心脏的细长导管和形成在导管的远端部分处的可扩张构件。可膨胀构件具有弹性部分，其构造成在膨胀时符合目标组织区域的形状。该系统还包括可移动地设置在导管的内腔内的能量发射器。能量发射器被配置为向目标组织区域传递辐射消融能量。该系统还包括控制器，该控制器包括安全切断功能，用于在规定的事件发生时自动关闭对能量发射器的电力，导致能量发射器停止的电力。

3. 发明申请

WO2010120881A3 SYSTEM AND METHOD FOR VISUALIZING TISSUE DURING ABLATION PROCEDURES 审中-公开
标题翻译：系统和方法，用于在组织过程中可视化组织
公开(公告)号：WO2010120881A3
公开(公告)日：2011-02-10
申请号：PCT/US2010031032
申请日：2010-04-14
申请人： CARDIO FOCUS INC , MELSKY GERALD , SAGON STEPHEN W , SINOFSKY EDWARD L , FARR NORMAN E
发明人： MELSKY GERALD , SAGON STEPHEN W , SINOFSKY EDWARD L , FARR NORMAN E
IPC分类号： A61B1/05 , A61B1/06 , A61B17/125
CPC分类号： A61B18/24 , A61B1/00087 , A61B1/00165 , A61B1/0638 , A61B1/07 , A61B5/0044 , A61B5/0075 , A61B5/0084 , A61B5/4836 , A61B5/7264 , A61B5/743 , A61B2017/00057 , A61B2018/00011 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/0069 , A61B2018/00904 , A61B2018/00982 , A61B2576/023
摘要： Systems for visualizing cardiac tissue during an ablation procedure are provided. In general, the systems include an imaging module configured to measure absorbance data at first and second wavelengths wherein the ratio of these absorbance values identifies the nature of the tissue (e.g., lesion, de novo tissue, etc.). The imaging module can also include a video system having at least two chips with corresponding bandpass filters centered at the first and second target wavelengths. The system can also include a processor and/or video monitor for combining the images produced by the various chips, determining treated and non-treated tissue based on the ratio of absorbance values at the target wavelengths, and displaying images of the treatment area. Methods of visualizing cardiac treatment areas during ablation procedures are also provided herein.
摘要翻译：提供了在消融过程中可视化心脏组织的系统。通常，该系统包括成像模块，该成像模块被配置为测量第一和第二波长处的吸光度数据，其中这些吸光度值的比率识别组织的性质（例如病变，从头组织等）。成像模块还可以包括具有至少两个具有以第一和第二目标波长为中心的带通滤波器的芯片的视频系统。该系统还可以包括用于组合由各种芯片产生的图像的处理器和/或视频监视器，基于目标波长处的吸光度值的比率和显示处理区域的图像来确定处理和未处理的组织。本文还提供了在消融过程中可视化心脏治疗区域的方法。

4. 发明申请

WO2011041635A2 CARDIAC ABLATION SYSTEM WITH INFLATABLE MEMBER HAVING MULTIPLE INFLATION SETTINGS 审中-公开
标题翻译：具有多个充气设置的可充气会员的心脏吸收系统
公开(公告)号：WO2011041635A2
公开(公告)日：2011-04-07
申请号：PCT/US2010051054
申请日：2010-10-01
申请人： CARDIOFOCUS INC , MELSKY GERALD , ESTABROOK BRIAN , STANCAMPIANO ALFRED
发明人： MELSKY GERALD , ESTABROOK BRIAN , STANCAMPIANO ALFRED
IPC分类号： A61B18/18 , A61B18/24 , A61F2/958 , A61M29/00 , A61N5/06
CPC分类号： A61B18/24 , A61B34/25 , A61B2017/00243 , A61B2017/22059 , A61B2018/00982 , A61B2018/2025 , A61B2018/2266 , A61B2018/2272 , A61B2090/306 , A61B2090/3614
摘要： A cardiac tissue ablation system includes an elongate catheter configured to deliver a distal end thereof to a patient's heart and an expandable member formed at the distal portion of the catheter. The expandable member has an elastic portion configured to conform to the shape of a target tissue region upon expansion. The expandable member has a plurality of inflation settings that correspond to different levels of inflation of the expandable member. The system also includes a controller for selecting an inflation setting for the expandable member and an energy emitter movably disposed within a lumen of the catheter. The energy emitter is configured to deliver radiant ablative energy to the target tissue region.
摘要翻译：心脏组织消融系统包括细长导管，其构造成将其远端输送到患者的心脏，以及形成在导管的远端部分处的可扩张构件。可扩张构件具有弹性部分，其构造成在扩张时符合目标组织区域的形状。可膨胀构件具有对应于可膨胀构件的不同膨胀水平的多个充气设定。该系统还包括用于选择用于可膨胀构件的膨胀设定的控制器和可移动地设置在导管内腔内的能量发射器。能量发射器被配置为向目标组织区域传递辐射消融能量。

5. 发明申请

WO2011041629A3 CARDIAC ABLATION SYSTEM WITH PULSED AIMING LIGHT 审中-公开
标题翻译：带有脉冲瞄准灯的CARDIAC消融系统
公开(公告)号：WO2011041629A3
公开(公告)日：2011-08-18
申请号：PCT/US2010051047
申请日：2010-10-01
申请人： CARDIOFOCUS INC , MELSKY GERALD , OSTROWSKI SUSAN
发明人： MELSKY GERALD , OSTROWSKI SUSAN
IPC分类号： A61B18/18 , A61B18/24 , A61F2/958 , A61M29/00 , A61N5/06
CPC分类号： A61B18/24 , A61B90/361 , A61B2017/22051 , A61B2017/22059 , A61B2018/2025 , A61B2090/3618
摘要： A method for treating a cardiac condition with visual inspection of a tissue treatment site includes the step of delivering an expanding member formed on a distal end of a catheter to a position adjacent a tissue treatment area within a patient's heart. The expandable member has an elastic portion configured to conform to the tissue treatment area. The method further includes the steps of expanding the expandable member thereby allowing the elastic portion of the expandable member to conform to the tissue treatment area and positioning an energy emitter at a first location within an inner lumen of the catheter. A visible aiming beam is projected during positioning of the energy emitter and ablative energy is delivered from the energy emitter to the tissue treatment area thereby resulting in a first spot lesion. The ablative energy is coincident with the aiming beam and the aiming beam is in the form of pulsed visible light to allow intermittent visual inspection of the first spot lesion at times when the arming beam is not projected onto the tissue treatment area, thereby allowing visual inspection of the ablative characteristics and sufficiency of the first spot lesion.
摘要翻译：通过对组织治疗部位的视觉检查来治疗心脏状况的方法包括将形成在导管的远端上的扩张构件递送到邻近患者心脏内的组织治疗区域的位置的步骤。可扩张构件具有构造成符合组织治疗区域的弹性部分。该方法还包括以下步骤：扩张可扩张构件，从而允许可扩张构件的弹性部分与组织治疗区域一致，并且将能量发射器定位在导管的内腔内的第一位置处。在定位能量发射器期间投射可见的瞄准光束，并且从能量发射器向组织治疗区域传递消融能量，从而导致第一斑点损伤。消融能量与瞄准光束重合，并且瞄准光束为脉冲可见光的形式，以允许在武装光束未投射到组织治疗区域上时对第一斑点病变进行间歇视觉检查，从而允许目视检查第一次斑点损伤的消融特征和充分性。

6. 发明申请

WO2011044248A3 CARDIAC ABLATION IMAGE ANALYSIS SYSTEM AND PROCESS 审中-公开
标题翻译：心脏吸收图像分析系统和过程
公开(公告)号：WO2011044248A3
公开(公告)日：2011-08-18
申请号：PCT/US2010051648
申请日：2010-10-06
申请人： CARDIOFOCUS INC , MELSKY GERALD
发明人： MELSKY GERALD
IPC分类号： A61B18/18 , A61B1/04 , A61B17/94 , A61B18/24 , A61B19/00
CPC分类号： A61B18/24 , A61B34/25 , A61B2017/0046 , A61B2018/00982 , A61B2018/2025 , A61B2090/306 , A61B2090/365
摘要： A system is provided for identifying the sufficiency of lesions formed during a tissue ablation procedure. The system captures live and still images from the surgical site and provides composite imaging to the operator. Through the use of the system, the aiming light used to direct ablative energy is captured on the still images and used to indicate locations in a surgical site where energy has been directed. Through the use of processing modules, the system can analyze the lesions and determine the sufficiency thereof.
摘要翻译：提供了一种用于识别在组织消融过程中形成的损伤的充分性的系统。该系统捕获来自外科手术部位的实时和静态图像，并向操作者提供复合成像。通过使用该系统，用于引导烧蚀能量的瞄准光被捕获在静止图像上，并用于指示能量被引导的手术部位中的位置。通过使用处理模块，系统可以分析病变并确定病变的充分性。

7. 发明申请

WO2004110258A3 GUIDED CARDIAC ABLATION CATHETERS 审中-公开
标题翻译：指导性戒毒导管
公开(公告)号：WO2004110258A3
公开(公告)日：2005-08-25
申请号：PCT/US2004018471
申请日：2004-06-10
申请人： CARDIOFOCUS INC , MELSKY GERALD , ARNOLD JEFFREY M , SINOFSKY EDWARD L , FARR NORMAN E
发明人： MELSKY GERALD , ARNOLD JEFFREY M , SINOFSKY EDWARD L , FARR NORMAN E
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/24 , A61B19/00 , A61N7/02
CPC分类号： A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/0022 , A61B2018/00982 , A61B2018/0212 , A61B2090/3937 , A61N7/02
摘要： Guided ablation instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias, including atrial fibrillation. In one aspect of the invention, a percutaneous catheter is disclosed with an endoscope positionable in the instrument's distal end region to obtain an image. The image allows the clinician to determine whether contact has been achieved (or blood has been cleared from an ablative energy transmission path) before ablation begins or while ablation is occurring. In one embodiment, percutaneous ablation catheters are disclosed having at least one central lumen and one or more balloon structures at the distal end region of the instrument. Also disposed in the distal end region are an illuminating light source and an endoscope capable of collecting sufficient light to relay an image to the user. The instruments can further include an ablation element. The ablation element can be a contact ablation element, or a radiant energy emitter, which is preferably independently positionable within the lumen of the instrument and adapted to project ablative energy through a transmissive region of the instrument body (and/or balloon) to a target tissue site proximate to the pulmonary veins. The energy can delivered without the need for contact between the energy emitter and the target tissue so long as a clear transmission pathway is established. The endoscope element of the instrument allows the clinician to determine the position of the instrument and, if radiant energy is to be employed, see if such a pathway is clear. Moreover, because the position of the radiant energy emitter can be varied, endoscopic guidance permits the clinician to select a desired location and dose for the lesion.
摘要翻译：公开了引导消融器械用于在组织中产生损伤，特别是用于治疗心律失常的心脏组织，包括房颤。在本发明的一个方面，公开了一种经皮导管，其具有可置于仪器的远端区域中的内窥镜，以获得图像。图像允许临床医生确定在消融开始之前还是在消融期间已经实现了接触（或者从消融能量传递路径中清除血液）。在一个实施例中，公开了经皮消融导管，其在器械的远端区域具有至少一个中心腔和一个或多个气囊结构。还设置在远端区域中的是能够收集足够的光以将图像中继给用户的照明光源和内窥镜。仪器还可以包括消融元件。消融元件可以是接触消融元件或辐射能发射器，其优选地可独立地定位在器械的内腔内并且适于将烧蚀能量穿过器械主体（和/或气囊）的透射区域投射到靶靠近肺静脉的组织部位。只要建立清晰的传输路径，能量可以传送而不需要能量发射器和目标组织之间的接触。仪器的内窥镜元件允许临床医生确定仪器的位置，并且如果要使用辐射能量，看看这样的通路是否清晰。此外，由于辐射能发射器的位置可以改变，所以内窥镜引导允许临床医生选择病变的期望位置和剂量。

8. 发明申请

WO0015147A8 TRANSMYCARDIAL SHUNT AND ITS ATTACHMENT MECHANISM, FOR LEFT VENTRICULAR REVASCULARIZATION 审中-公开
标题翻译：转移性分支及其附着机制，用于左心室舒张
公开(公告)号：WO0015147A8
公开(公告)日：2000-06-15
申请号：PCT/US9920714
申请日：1999-09-10
申请人： PERCARDIA INC , PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M , RENATI RICHARD J , MELSKY GERALD , GUILES MARVIN
发明人： PHELPS DAVID Y , FURNISH GREG R , HALL TODD A , GRIFFIN MARK , WOLF SCOTT J , WILK PETER J , SCHMELTER JAY W , FURNISH SIMON M , RENATI RICHARD J , MELSKY GERALD , GUILES MARVIN
IPC分类号： A61B17/00 , A61F2/02 , A61F2/24 , A61F2/82 , A61F2/94 , A61F2/06
CPC分类号： A61F2/915 , A61F2/24 , A61F2/2493 , A61F2/848 , A61F2/91 , A61F2/94 , A61F2/958 , A61F2002/821 , A61F2002/826 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2220/0008 , A61F2220/0016 , A61F2230/0013 , A61F2230/005 , A61F2230/006
摘要： A conduit is provided to provide a bypass around a blockage in the coronary artery. The conduit is adapted to be positioned in the myocardium or heart wall to provide a passage for blood to flow between a chamber of the heart such as the left ventricle and the coronary artery, distal to the blockage. The stent is self-expanding or uses a balloon to expand the stent in the heart wall. Various attachment means are provided to anchor the stent and prevent its migration. In one embodiment, a conduit is provided having a distal top which is more preferably a ball top, wire top, flare top or flip-down top. These top configurations anchor the shunt at one end in the coronary artery.
摘要翻译：提供导管以提供围绕冠状动脉阻塞的旁路。导管适于定位在心肌或心脏壁中，以提供血液在心脏室之间流动的通路，例如左心室和冠状动脉之间，远离阻塞。支架自扩张或使用球囊来扩张心脏壁内的支架。提供各种附接装置以锚定支架并防止其移动。在一个实施例中，提供了具有远侧顶部的导管，更优选地是球顶，线顶，喇叭口顶部或翻倒顶部。这些顶部配置将冠状动脉一端分流。

9. 发明申请

WO2006110405A3 METHODS AND APPARATUS FOR THERMAL REGULATION OF A BODY 审中-公开
标题翻译：一种身体温度调节的方法和装置
公开(公告)号：WO2006110405A3
公开(公告)日：2007-07-05
申请号：PCT/US2006012561
申请日：2006-04-03
申请人： MEDCOOL INC , LENNOX CHARLES D , ALLAIRE KEVIN , RADZIUNAS JEFFREY , THOMPSON JOHN , DICESARE PAUL , HIRES GREG , MELSKY GERALD
发明人： LENNOX CHARLES D , ALLAIRE KEVIN , RADZIUNAS JEFFREY , THOMPSON JOHN , DICESARE PAUL , HIRES GREG , MELSKY GERALD
IPC分类号： A61F7/00
CPC分类号： A61F7/02 , A61F2007/0002 , A61F2007/0011 , A61F2007/0056
摘要： A thermal regulation system includes a thermal exchange collar for application to a neck of a patient, a thermal regulation pad for application to a body region, such as an axilla region of the patient, and a thermal regulation cap for application to a head of the patient.
摘要翻译：热调节系统包括用于应用于患者颈部的热交换套环，用于应用于身体区域（例如患者的腋窝区域）的热调节垫，以及用于应用于患者的头部的热调节帽患者。

10. 发明申请

WO0238012A3 LIMITED FLOW CUP 审中-公开
标题翻译：有限公司
公开(公告)号：WO0238012A3
公开(公告)日：2002-08-29
申请号：PCT/US0151171
申请日：2001-11-02
申请人： RELIANT MEDICAL PRODUCTS INC , MELSKY GERALD , PORTER JERRY , BURKE ANDREA , PORAT DAVID
发明人： MELSKY GERALD , PORTER JERRY , BURKE ANDREA , PORAT DAVID
IPC分类号： A47G19/22 , G01F11/26
CPC分类号： A47G19/2272 , A47G2200/048
摘要： A limited flow cup (10) is provided that includes an outer cup (12), and, in nested relationship with the outer cup (12), an inner cup (26) defining a fluid reservoir (38), the nested relationship of the outer cup and inner cup defining a metering chamber (42, 56) constructed to contain an amount of fluid that is delivered to the user during a single drinking motion.
摘要翻译：提供了一种有限的流动杯（10），其包括外杯（12），并且与外杯（12）嵌套关系，限定流体储存器（38）的内杯（26），嵌套关系外杯和内杯，其限定计量腔（42,56），其被构造成容纳在单次饮酒运动期间输送给使用者的一定量的流体。

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