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1. 发明申请

WO0218006A8 CORONARY VEINS LEAD FOR PACING OR SENSING 审中-公开
标题翻译：冠状动脉导管用于切开或感觉
公开(公告)号：WO0218006A8
公开(公告)日：2003-12-31
申请号：PCT/US0127022
申请日：2001-08-30
申请人： CARDIAC PACEMAKERS INC , WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HEIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
发明人： WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HEIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead (100) for monitoring or simulating cardiac activity is provided. The lead (100) is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator (140). The lead is constructed and arranged so that when it is implanted, the electrodes (122) are housed in the coronary vasculature and urged into intimate contact a vessel wall (128). The lead optionally includes a tapered, flexible lead body portion that is distal to a biased portion.
摘要翻译：提供了用于监测或模拟心脏活动的导联（100）。引线（100）适于植入在冠状脉管系统内或心脏周围，并用于连接到信号发生器（140）。引线被构造和布置成使得当其被植入时，电极（122）容纳在冠状脉管系统中并被促使与血管壁（128）紧密接触。导线可选地包括在偏压部分的远侧的锥形的柔性引线主体部分。

2. 发明申请

WO2007021413A3 BIOLOGIC DEVICE FOR REGULATION OF GENE EXPRESSION 审中-公开
标题翻译：用于调节基因表达的生物学设备
公开(公告)号：WO2007021413A3
公开(公告)日：2007-04-12
申请号：PCT/US2006027209
申请日：2006-07-13
申请人： CARDIAC PACEMAKERS INC , WAGNER DARRELL O , SIH HARIS J , QU JIHONG , ROSS JEFFREY , GIROUARD STEVEN , HEIL RONALD W JR
发明人： WAGNER DARRELL O , SIH HARIS J , QU JIHONG , ROSS JEFFREY , GIROUARD STEVEN , HEIL RONALD W JR
IPC分类号： A61K48/00 , A61N1/05
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

3. 发明专利

AU2007345606A1 Spiral configurations for intravascular lead stability 未知
公开(公告)号：AU2007345606A1
公开(公告)日：2008-08-07
申请号：AU2007345606
申请日：2007-11-30
申请人： CARDIAC PACEMAKERS INC
发明人： BLY MARK J , ZAREMBO PAUL E , KOOP BRENDAN E , HEIL RONALD W JR , WESTLUND RANDY W
IPC分类号： A61N1/05 , A61N1/36
摘要： A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes an expandable distal portion having one or more spirals for securing and stabilizing the lead within the vessel.

4. 发明专利

CA2249993C LEFT VENTRICULAR ACCESS LEAD FOR HEART FAILURE PACING 未知
公开(公告)号：CA2249993C
公开(公告)日：2004-06-22
申请号：CA2249993
申请日：1998-01-20
申请人： CARDIAC PACEMAKERS INC
发明人： CHASTAIN STUART R , WESTLUND RANDY , AURICCHIO ANGELO , ZYTKOVICZ JUNE MARILYN , HEIL RONALD W JR , TOCKMAN BRUCE A , SALO RODNEY W
IPC分类号： A61N1/368 , A61N1/05 , A61N1/365 , A61N1/37
摘要： An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip and transition ring that enhances the ability t o guide the lead through the coronary veins.

5. 发明专利

AU5914999A Controlled release drug delivery 未知
公开(公告)号：AU5914999A
公开(公告)日：2000-03-27
申请号：AU5914999
申请日：1999-09-09
申请人： CARDIAC PACEMAKERS INC
发明人： HEIL RONALD W JR , KENKNIGHT BRUCE H
IPC分类号： A61K9/22 , A61K9/00 , A61K9/48 , A61K47/34 , A61K31/57 , A61K31/165 , A61P9/06
摘要： Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or dispersed therein at least two compounds having a common biologically active nucleus, but with different solubility parameters. The combination of the two different variants of the same drug with different solubility parameters provides the material with control over the rate of release of the compounds (by varying the proportions of the variants) and most importantly, extending the useful life of the device by enabling release of effective levels of the compounds over a longer period of time. The cylindrical carrier medium, comprised of silicone, further includes a tail, a skirt, or a rate-limiting membrane.

6. 发明专利

AU708415B2 Left ventricular access lead for heart failure pacing 未知
公开(公告)号：AU708415B2
公开(公告)日：1999-08-05
申请号：AU8949198
申请日：1998-01-20
申请人： CARDIAC PACEMAKERS INC
发明人： AURICCHIO ANGELO , SALO RODNEY W , TOCKMAN BRUCE A , HEIL RONALD W JR , WESTLUND RANDY , CHASTAIN STUART R
IPC分类号： A61N1/368 , A61N1/05

7. 发明专利

AU658739B2 Positive fixation device 未知
公开(公告)号：AU658739B2
公开(公告)日：1995-04-27
申请号：AU3984793
申请日：1993-05-26
申请人： CARDIAC PACEMAKERS INC
发明人： HEIL RONALD W JR , WICKHAM ROBERT W JR , KENKNIGHT BRUCE H
IPC分类号： A61N1/05 , A61N1/39
摘要： An implantable defibrillation electrode including a conductive distal end portion and a non-conductive proximal end portion is provided with at least a major portion of the length of the distal end portion having a pre-configured shape and being resiliently deformable into a generally straight condition. The distal end portion includes distal and proximal ends and at least one of those ends is hollow and has hook structure shiftably supported therein for movement longitudinally thereof from a retracted position at least substantially contained within the hollow end and an extended position at least substantially fully outwardly projected from the hollow end. Spring structure is provided for yieldingly biasing the hook structure from the extended position toward the retracted position and axial thrust developing structure is slidingly telescoped through the proximal end portion and operatively associated with the hook structure for exerting an axial thrust thereon from the terminal end of the proximal end portion in order to effect shifting of the hook structure from the retracted position to the extended position.

8. 发明专利

DE602004018673D1 未知
公开(公告)号：DE602004018673D1
公开(公告)日：2009-02-05
申请号：DE602004018673
申请日：2004-10-22
申请人： CARDIAC PACEMAKERS INC
发明人： COE M SEAN , HEIL RONALD W JR , KELLEY PETER T , PALME DONALD F , SHIROFF JASON ALAN , WESTLUND RANDY W , YINGLING DAVID B , GRESL CHARLES
IPC分类号： A61N1/05 , A61B5/296 , A61B17/04 , A61B17/06
摘要： A myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes a lead body, an anchor mechanism formed of a bioabsorbable or biodegradable polymer for engaging a surface of the patient's heart and a surface feature formed on a portion of the lead body for promoting formation of scar tissue around said portion of the lead body.

9. 发明专利

AU1967601A Drug delivery system for implantable cardiac device 未知
公开(公告)号：AU1967601A
公开(公告)日：2001-04-30
申请号：AU1967601
申请日：2000-10-18
申请人： CARDIAC PACEMAKERS INC
发明人： SCHEINER AVRAM , HERNER MARK , HEIL RONALD W JR , GIROUARD STEVEN D
IPC分类号： A61N1/30 , A61N1/362 , A61M5/00
摘要： A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

10. 发明专利

CA2249993A1 LEFT VENTRICULAR ACCESS LEAD FOR HEART FAILURE PACING 未知
公开(公告)号：CA2249993A1
公开(公告)日：1998-10-08
申请号：CA2249993
申请日：1998-01-20
申请人： CARDIAC PACEMAKERS INC
发明人： HEIL RONALD W JR , AURICCHIO ANGELO , SALO RODNEY W , CHASTAIN STUART R , WESTLUND RANDY , ZYTKOVICZ JUNE MARILYN , TOCKMAN BRUCE A
IPC分类号： A61N1/368 , A61N1/05 , A61N1/365 , A61N1/37
摘要： An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip and transition ring that enhances the ability to guide the lead through the coronary veins.

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