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1. 发明申请

WO2007078421A2 HEMODYNAMICALLY CONTROLLED ANTI-TACHYARRHYTHMIA PACING SYSTEM 审中-公开
标题翻译：血流动力学控制的抗痛觉兴奋剂起搏系统
公开(公告)号：WO2007078421A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/043459
申请日：2006-11-08
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , CARLSON, Gerrard M. , HAHN, Stephen J.
发明人： LI, Dan , CARLSON, Gerrard M. , HAHN, Stephen J.
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/36514
摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and at least one hemodynamic sensor that senses a hemodynamic signal. When a tachyarrhythmia episode is detected, the CRM system analyzes the hemodynamic signal to determine whether and/or when to deliver an ATP. In one embodiment, a hemodynamic parameter extracted from the hemodynamic signal is used to predict the potential effective of ATP in terminating the detected tachyarrhythmia episode. In another embodiment, a characteristic feature detected from the hemodynamic signal is used to determine an ATP window during which a delivery of ATP is initiated.
摘要翻译：心律管理（CRM）系统包括递送包括抗快速性心律失常起搏（ATP）的抗快速性心律失常疗法的可植入医疗装置和感测血液动力学信号的至少一个血液动力学传感器。当检测到快速性心律失常发作时，CRM系统分析血液动力学信号以确定是否和/或何时递送ATP。在一个实施例中，从血液动力学信号提取的血液动力学参数被用于预测ATP终止检测到的快速性心律失常发作的潜在有效性。在另一个实施方案中，从血液动力学信号中检测到的特征特征被用于确定开始递送ATP的ATP窗口。

2. 发明申请

WO2010090896A1 CROSS-CHANNEL NOISE DETECTOR IN IMPLANTABLE DEVICES 审中-公开
标题翻译：交叉通道噪声检测器在可移植设备中
公开(公告)号：WO2010090896A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/022028
申请日：2010-01-26
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , PERSCHBACHER, David, L.
发明人： LI, Dan , PERSCHBACHER, David, L.
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/3704 , A61N1/3718 , A61N1/3925
摘要： An apparatus comprises a primary cardiac signal sensing circuit to sense a first cardiac signal, a secondary cardiac signal sensing to sense a second cardiac signal, and an arrhythmia detection circuit. The primary sensing circuit includes at least first and second implantable electrodes, and the secondary sensing circuit includes a third implantable electrode to deliver high-energy shock therapy. The arrhythmia detection circuit detects tachyarrhythmia using the primary sensing circuit, determines correspondence between events sensed with the primary sensing circuit and events sensed with the secondary sensing circuit, and deems whether a detected rhythm is indicative of noise or is indicative of an arrhythmia according to the determined correspondence.
摘要翻译：一种装置包括用于感测第一心脏信号的主要心脏信号感测电路，感测第二心脏信号的次要心脏信号感测和心律失常检测电路。主感测电路至少包括第一和第二可植入电极，并且次级感测电路包括用于输送高能量休克疗法的第三可植入电极。心律失常检测电路使用主感测电路检测快速性心律失常，确定用主感测电路感测的事件与由次级感测电路感测的事件之间的对应关系，并且考虑检测到的节奏是指示噪声还是指示心律失常根据确定的信件。

3. 发明申请

WO2011088337A1 AUTOMATIC MECHANICAL ALTERNANS DETECTION 审中-公开
标题翻译：自动机械检测
公开(公告)号：WO2011088337A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021324
申请日：2011-01-14
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , SHUROS, Allan, C. , SHARMA, Arjun
发明人： LI, Dan , SHUROS, Allan, C. , SHARMA, Arjun
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/0215 , A61B5/0452 , A61B5/0538 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , G06F19/00
摘要： This document discusses, among other things, a cardiac mechanical alternans (MA) detector circuit. In an example, the mechanical alternans detector circuit is configured to determine a mechanical alternans (MA) condition. In an example, the MA detector circuit can include a physiologic impedance input configured to receive physiologic information indicative of mechanical alternans. In an example, the MA detector circuit can include an intravascular pressure input configured to receive physiologic information indicative of mechanical alternans.
摘要翻译：本文件还讨论了心脏机械交替（MA）检测器电路。在一个示例中，机械交替检测器电路被配置为确定机械交替（MA）条件。在一个示例中，MA检测器电路可以包括构造成接收指示机械交替的生理信息的生理阻抗输入。在一个示例中，MA检测器电路可以包括构造成接收指示机械交替的生理信息的血管内压力输入。

4. 发明申请

WO2010011301A2 MORPHOLOGY FEATURE EVALUATION IN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械中的形态学特征评估
公开(公告)号：WO2010011301A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/004242
申请日：2009-07-22
申请人： CARDIAC PACEMAKERS, INC. , DONG, Yanting , BROOKE, M., Jason , LI, Dan , STALSBERG, Kevin, J.
发明人： DONG, Yanting , BROOKE, M., Jason , LI, Dan , STALSBERG, Kevin, J.
IPC分类号： A61B5/00 , A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0002 , A61B5/04525 , A61N1/365 , A61N1/3702
摘要： An apparatus comprises an implantable sensor, which provides a plurality of physiologic sensor signals of a subject, and a processor. The processor includes a feature module and a detection module. The feature module is configured to identify a feature in the sensor signals and to determine a measure of quality of the feature in the sensor signals. The detection module is configured to perform a morphology analysis of a subsequent portion of at least one of the sensor signals using the feature when the measure of quality of the feature satisfies a quality measure threshold.
摘要翻译：一种装置包括可植入传感器，其提供对象的多个生理传感器信号和处理器。处理器包括特征模块和检测模块。特征模块被配置为识别传感器信号中的特征并且确定传感器信号中的特征的质量的度量。所述检测模块被配置为当所述特征的质量度量满足质量测量阈值时，使用所述特征来对所述传感器信号中的至少一个的后续部分进行形态分析。

5. 发明申请

WO2008137166A1 SYSTEM AND METHOD TO DETERMINE HEMODYNAMIC TOLERABILITY 审中-公开
标题翻译：确定血液动力学耐受性的系统和方法
公开(公告)号：WO2008137166A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/005832
申请日：2008-05-07
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , SHUROS, Allan, C. , LI, Dan
发明人： ZHANG, Yi , SHUROS, Allan, C. , LI, Dan
IPC分类号： A61N1/365 , A61B5/0464 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/0464 , A61B5/0535 , A61B5/0538 , A61B5/7264
摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.
摘要翻译：可植入医疗装置检测心脏的快速性心律失常。在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。然后，当针对心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。灌注信息也可用于改变快速性心律失常检测或分类。

6. 发明申请

WO2011100182A1 DETECTING HEMODYNAMIC STABILITY DURING ARRHYTHMIA USING THE CHANGES IN ATRIAL ACTIVATION 审中-公开
标题翻译：使用ATRAC激活的变化检测ARRHYTHMIA期间的HEMODYMM稳定性
公开(公告)号：WO2011100182A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/023864
申请日：2011-02-07
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , SHARMA, Arjun
发明人： LI, Dan , SHARMA, Arjun
IPC分类号： A61N1/362 , A61B5/0464 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3962
摘要： Detected changes in atrial activation can be used to discriminate between hemodynamically stable and hemodynamically unstable tachyarrhythmias.
摘要翻译：检测到心房激活的变化可用于区分血液动力学稳定和血液动力学不稳定的快速性心律失常。

7. 发明申请

WO2010093489A2 DEPLOYABLE SENSOR PLATFORM ON THE LEAD SYSTEM OF AN IMPLANTABLE DEVICE 审中-公开
标题翻译：可移植设备引导系统上的可配置传感器平台
公开(公告)号：WO2010093489A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/020756
申请日：2010-01-12
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , SHUROS, Allan C. , ACUNA, Andrea , TOCKMAN, Bruce A.
发明人： LI, Dan , SHUROS, Allan C. , ACUNA, Andrea , TOCKMAN, Bruce A.
IPC分类号： A61M25/06 , A61N1/365
CPC分类号： A61N1/056 , A61B5/042 , A61B5/6846 , A61B5/6852 , A61M25/0082 , A61M25/01 , A61M25/0102 , A61M25/0662 , A61M2025/0681 , A61N1/37211 , A61N2001/0585
摘要： Systems and methods for deploying a sensor assembly onto a cardiac lead are disclosed. The sensor assembly can include a resilient cuff having one or more sensor modules for sensing physiological parameters within the body. The resilient cuff may have a substantially cylindrical shape having an inner diameter that is smaller than an outer diameter of the lead body onto which the cuff is deployed such that the cuff is retained on the lead body by frictional forces. The sensor assembly may be deployed in conjunction with a new lead to be implanted within a chamber of the patient's heart or a body vessel, or may be deployed onto an existing, implanted lead implanted within the patient's body.
摘要翻译：公开了将传感器组件部署到心脏引线上的系统和方法。传感器组件可以包括具有用于感测身体内的生理参数的一个或多个传感器模块的弹性袖带。弹性箍可以具有基本上圆柱形的形状，其内径小于引导体的外径，袖带在其上展开，使得袖带通过摩擦力保持在引线体上。传感器组件可以与将要植入患者心脏或身体容器的腔室内的新导线一起部署，或者可以部署到植入患者体内的现有植入的导线上。

8. 发明申请

WO2009154758A2 CARDIAC RHYTHM MANAGEMENT SYSTEM WITH HEMODYNAMIC TOLERABILITY ANALYZER 审中-公开
标题翻译：具有抗肿瘤耐受性分析仪的CARDIAC RHYTHM管理系统
公开(公告)号：WO2009154758A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/003638
申请日：2009-06-18
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , LI, Dan
发明人： SHUROS, Allan, C. , LI, Dan
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/0215 , A61B5/053 , A61B5/4884 , A61B5/7264 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/37247 , A61N1/385
摘要： A cardiac rhythm management system identifies a relationship between one or more hemodynamic parameters sensed from a patient and levels of hemodynamic tolerability of the patient. The identified relationship allows an implantable medical device to control delivery of anti-tachyarrhythmia therapy using the patient's hemodynamic tolerability during a detected tachyarrhythmia episode, in addition to classifying the detected tachyarrhythmia episode by its type and origin.
摘要翻译：心律管理系统识别从患者感测的一个或多个血液动力学参数与患者的血液动力学耐受性水平之间的关系。所识别的关系允许可植入医疗装置在检测到的快速性心律失常发作期间使用患者的血液动力学耐受性来控制抗快速性心律失常治疗的递送，以及根据其类型和来源对检测到的快速性心律失常发作进行分类。

9. 发明申请

WO2009126642A2 HIGH-ENERGY ANTI-TACHYCARDIA THERAPY 审中-公开
标题翻译：高能量抗惊厥药治疗
公开(公告)号：WO2009126642A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/039798
申请日：2009-04-07
申请人： CARDIAC PACEMAKERS, INC , SHUROS, Allan, Charles , ARCOT-KRISHNAMURTHY, Shantha , LI, Dan
发明人： SHUROS, Allan, Charles , ARCOT-KRISHNAMURTHY, Shantha , LI, Dan
IPC分类号： A61N1/39 , A61N1/365
CPC分类号： A61N1/3621 , A61N1/3906
摘要： A solution for performing a data correction on a hierarchical integrated circuit layout is provided. A method includes: receiving a CD compensation map for the long range critical dimension variation prior to the data correction; grouping compensation amounts of the CD compensation into multiple compensation ranges; generating multiple target layers corresponding to the multiple compensation ranges; super-imposing a region of the CD compensation map having a compensation amount falling into a compensation range over a respective target layer to generate a target shape; performing the data correction on the layout to generate a data corrected layout; performing the data correction on the target shape separately to generate a data corrected target shape; and combining the data corrected layout and the data corrected target shape based on the CD compensation map.
摘要翻译：提供了一种用于在分层集成电路布局上执行数据校正的解决方案。一种方法包括：在数据校正之前接收用于长距离临界尺寸变化的CD补偿图; 将CD补偿的补偿量分组为多个补偿范围; 产生对应于多个补偿范围的多个目标层; 超级CD补偿图的区域具有落在相应目标层上的补偿范围内的补偿量以产生目标形状; 在布局上执行数据校正以生成数据校正布局; 分别对目标形状进行数据校正，生成数据校正对象形状; 并且基于CD补偿图组合数据校正布局和数据校正目标形状。

10. 发明申请

WO2009123951A1 TEMPERATURE BASED SYSTEMS AND METHODS FOR TACHYCARDIA DISCRIMINATION AND THERAPY 审中-公开
标题翻译：基于温度的系统和方法用于卡卡里亚歧视和治疗
公开(公告)号：WO2009123951A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/038743
申请日：2009-03-30
申请人： CARDIAC PACEMAKERS, INC. , SALO, Rodney, W. , SHUROS, Allan, Charles , LI, Dan
发明人： SALO, Rodney, W. , SHUROS, Allan, Charles , LI, Dan
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3962
摘要： Embodiments of the invention are related to an implantable medical system, amongst other things. In an embodiment, the invention includes a processor, an electrical sensor, and a temperature sensor. The processor is configured to monitor myocardial electrical activity with input from the electrical sensor; identify myocardial electrical activity indicative of an arrhythmia, measure temperature of blood in the coronary venous system with input from the temperature sensor; determine if the arrhythmia is hemodynamically stable or hemodynamically unstable based on the temperature of blood in the coronary venous system, and initiate high-voltage shock therapy if the arrhythmia is hemodynamically unstable. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及可植入医疗系统等等。在一个实施例中，本发明包括处理器，电传感器和温度传感器。处理器被配置为通过来自电传感器的输入来监测心肌电活动; 识别指示心律失常的心肌电活动，用来自温度传感器的输入测量冠状静脉系统中血液的温度; 根据冠状静脉系统中的血液温度，确定心律失常是否为血液动力学稳定或血液动力学不稳定，如果心律失常是血液动力学不稳定的话，开始进行高压休克治疗。本文还包括其它实施例。

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