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1. 发明申请

WO2008143814A2 SYSTEMS AND METHODS FOR STIMULATING NEURAL TARGETS 审中-公开
标题翻译：用于刺激神经目标的系统和方法
公开(公告)号：WO2008143814A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/006023
申请日：2008-05-12
申请人： CARDIAC PACEMAKERS, INC. , AMURTHUR, Badri , LIBBUS, Imad
发明人： AMURTHUR, Badri , LIBBUS, Imad
IPC分类号： A61N1/05 , A61N1/36 , A61B5/00
CPC分类号： A61N1/36017 , A61B5/021 , A61B5/02405 , A61B5/02416 , A61B5/026 , A61B5/14532 , A61B5/1455 , A61B5/4041 , A61B5/6815 , A61B5/6826 , A61B5/6838 , A61B8/06 , A61N1/0452 , A61N1/0456 , A61N1/0492 , A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a method for stimulating neural targets in the vicinity of a human ear. According to an embodiment, a device is clipped on a patient ear lobe, the device including a neural stimulation electrode. A neural stimulation signal is applied to the electrode to transcutaneously stimulate neural targets in the vicinity of the ear lobe, according to an embodiment. A physiological parameter is sensed using a sensor connected to the device. According to an embodiment, the neural stimulation signal is adjusted in response to the sensed parameter. The method is used is a variety of treatment regimens, including anti-hypertensive and cardiac improvement therapy.
摘要翻译：本文公开了一种用于刺激人耳附近的神经靶的方法。根据实施例，将装置夹在患者耳垂上，该装置包括神经刺激电极。根据实施例，神经刺激信号被施加到电极以经皮刺激耳垂附近的神经靶。使用连接到该装置的传感器感测生理参数。根据实施例，响应于所感测的参数来调整神经刺激信号。使用的方法是多种治疗方案，包括抗高血压和心脏改善治疗。

2. 发明申请

WO2008042477A1 DISTRIBUTED NEUROMODULATION SYSTEM FOR TREATMENT OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于治疗心血管疾病的分布式神经调节系统
公开(公告)号：WO2008042477A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/070183
申请日：2007-06-01
申请人： CARDIAC PACEMAKERS, INC. , AMURTHUR, Badri , GIROUARD, Steven , LIBBUS, Imad
发明人： AMURTHUR, Badri , GIROUARD, Steven , LIBBUS, Imad
IPC分类号： A61N1/372 , A61N1/36 , A61N1/378
CPC分类号： A61N1/37288 , A61N1/36114 , A61N1/37247 , A61N1/3787
摘要： A distributed system is described that employs electrical neural stimulation to modulate autonomic activity and which allows titration of the neural stimulation therapy in accordance with physiological measurements reflective of autonomic activity and/or physiological variables affected by the neural stimulation. Such a system may include a plurality of implantable neuromodulation units that communicate with one another over a network.
摘要翻译：描述了一种使用电神经刺激来调节自主活动的分布式系统，并且其允许根据反映受神经刺激影响的自主活动和/或生理变量的生理测量来滴定神经刺激疗法。这样的系统可以包括通过网络彼此通信的多个可植入神经调节单元。

3. 发明申请

WO2008042476A1 IMPLANTABLE DEVICE FOR RESPONSIVE NEURAL STIMULATION THERAPY 审中-公开
标题翻译：用于反应性神经刺激治疗的可植入装置
公开(公告)号：WO2008042476A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/070180
申请日：2007-06-01
申请人： CARDIAC PACEMAKERS, INC. , AMURTHUR, Badri , LIBBUS, Imad
发明人： AMURTHUR, Badri , LIBBUS, Imad
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/36521
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. In one embodiment, the duty cycle for delivering neural stimulation is adjusted in accordance with one or more measured physiological variables.
摘要翻译：本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。在一个实施例中，根据一个或多个测量的生理变量来调整用于递送神经刺激的占空比。

4. 发明申请

WO2010077851A2 PATIENT MONITORING SYSTEMS AND METHODS 审中-公开
标题翻译：患者监测系统和方法
公开(公告)号：WO2010077851A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/068007
申请日：2009-12-15
申请人： CORVENTIS, INC. , LIBBUS, Imad , AMURTHUR, Badri , MANICKA, Yatheendhar D. , MAZAR, Scott T. , MERKERT, Matt , LANDRUM, Brett A.
发明人： LIBBUS, Imad , AMURTHUR, Badri , MANICKA, Yatheendhar D. , MAZAR, Scott T. , MERKERT, Matt , LANDRUM, Brett A.
IPC分类号： A61B5/00 , H04L12/00
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/002 , A61B5/01 , A61B5/02055 , A61B5/04085 , A61B5/0537 , A61B5/085 , A61B5/1115 , A61B5/1117 , A61B5/1455 , A61B5/4818 , A61B5/6833 , A61B2562/0219 , G06F19/00 , G06Q50/22 , Y10S128/903
摘要： An adherent patient device is configured to adhere to the skin of the patient and measure electrocardiogram data, impedance data, accelerometer data, blood oxygen data and temperature data. The adherent device can communicate wirelessly with gateways and a local processor system, such that the patient can wander about the hospital and update the monitoring station with the patient data when the patient is ambulatory. The local processor system can be configured to customize alerts for the patient, for example to notify automatically a specialist in response to a special condition of the patient. The adherent device may comprise a unique adherent device identifier such that the customized alert can be sent based on the unique device identifier. Each of the gateways can be carried and may comprise a unique gateway identifier, such that the unique device identifier and the unique gateway identifier can be used to locate the ambulatory patient.
摘要翻译：附着的患者装置被配置为粘附于患者的皮肤并且测量心电图数据，阻抗数据，加速度计数据，血氧数据和温度数据。附着设备可以与网关和本地处理器系统无线通信，使得患者可以在医院附近漫游，并在患者走动时用患者数据更新监测站。本地处理器系统可以被配置为为患者定制警报，例如响应于患者的特殊情况自动通知专家。附着设备可以包括唯一附着设备标识符，使得可以基于唯一设备标识符来发送定制告警。每个网关可以被携带并且可以包括唯一网关标识符，使得唯一设备标识符和唯一网关标识符可以被用于定位门诊患者。

5. 发明申请

WO2010105045A2 METHOD AND APPARATUS FOR FALL PREVENTION AND MONITORING 审中-公开
标题翻译：用于防止和监测的方法和装置
公开(公告)号：WO2010105045A2
公开(公告)日：2010-09-16
申请号：PCT/US2010/026967
申请日：2010-03-11
申请人： CORVENTIS, INC. , LIBBUS, Imad , MANICKA, Yatheendhar, D. , AMURTHUR, Badri
发明人： LIBBUS, Imad , MANICKA, Yatheendhar, D. , AMURTHUR, Badri
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/0402 , A61B5/11
CPC分类号： A61B5/1117 , A61B5/0205 , A61B5/0402 , A61B2562/0219 , G06F19/00 , G08B21/043 , G08B21/0446
摘要： Devices, systems, and methods for fall prevention and/or fall detection can include an adherent support configured to adhere to a skin of the patient, an accelerometer coupled with the support, and a processor coupled with the accelerometer and configured to detect a fall of the patient, an orientation of the patient, an orientation-restriction violation, and/or a movement-restriction violation. A restriction can be dynamically imposed or adjusted in response to detected patient conditions. The disclosed devices, systems, and related methods can provide notification of a patient fall and patient data useful in evaluating the severity and/or cause of the fall.
摘要翻译：用于防坠落和/或跌倒检测的装置，系统和方法可以包括配置成粘附到患者皮肤的贴附支撑件，与支撑件耦合的加速度计，以及与加速度计耦合的处理器，患者，患者的方向，定向限制违规和/或移动限制违规。可以响应于检测到的患者状况而动态地施加或调整限制。所公开的设备，系统和相关方法可以提供对评估坠落的严重性和/或原因有用的患者跌倒和患者数据的通知。

6. 发明申请

WO2009036313A1 ADHERENT DEVICE WITH MULTIPLE PHYSIOLOGICAL SENSORS 审中-公开
标题翻译：具有多种生理传感器的附属装置
公开(公告)号：WO2009036313A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076226
申请日：2008-09-12
申请人： CORVENTIS, INC. , MANICKA, Yatheendhar, D. , AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , LIBBUS, Imad , MAZAR, Scott, T. , WANG, Jerry, S.
发明人： MANICKA, Yatheendhar, D. , AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , LIBBUS, Imad , MAZAR, Scott, T. , WANG, Jerry, S.
IPC分类号： A61B5/00
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a hydration signal of the patient. Electrocardiogram circuitry is coupled to at least two of the at least four electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate a signal in response to at least one of an activity or a position of the patient.
摘要翻译：用于监测患者的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的水合信号。心电图电路耦合到至少四个电极中的至少两个，以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生信号。

7. 发明申请

WO2010105053A2 ACUTE PATIENT MANAGEMENT FOR MILITARY AND EMERGENCY APPLICATIONS 审中-公开
标题翻译：急诊患者应急管理
公开(公告)号：WO2010105053A2
公开(公告)日：2010-09-16
申请号：PCT/US2010/026977
申请日：2010-03-11
申请人： CORVENTIS, INC. , AMURTHUR, Badri , LIBBUS, Imad , MANICKA, Yatheendhar D.
发明人： AMURTHUR, Badri , LIBBUS, Imad , MANICKA, Yatheendhar D.
IPC分类号： A61B5/0402 , A61B5/0408 , H04B7/24
CPC分类号： A61B5/1112 , A61B5/0002 , A61B5/1117 , A61B5/6832 , A61B2560/0412 , A61B2562/063 , A61B2562/14 , A61B2562/166
摘要： Devices, system, and methods for monitoring the physiological status of one or more persons and/or for coordination of medical treatment of one or more persons are provided. A monitoring system can comprise an adherent support configured to adhere to the skin of a person, one or more physiological sensors coupled with the support and supported with the support, a processor coupled with the one or more physiological sensors, and an input/output device configured to display at least one of a condition for the monitored person and/or data for the monitored person. A monitoring system can further comprise a monitoring subsystem for use by a first responder in locating and/or treating a monitored person.
摘要翻译：提供了用于监测一个或多个人的生理状况和/或协调一个或多个人的医疗的装置，系统和方法。监测系统可以包括被配置为粘附到人的皮肤上的粘附支撑件，与支撑件耦合并由支撑件支撑的一个或多个生理传感器，与一个或多个生理传感器耦合的处理器，以及输入/输出装置被配置为显示所监视的人的条件和/或所监视的人的数据中的至少一个。监视系统还可以包括监视子系统，供第一响应者用于定位和/或处理受监视的人。

8. 发明申请

WO2009036326A1 ADHERENT ATHLETIC MONITOR 审中-公开
标题翻译：附属运动员监视器
公开(公告)号：WO2009036326A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076240
申请日：2008-09-12
申请人： CORVENTIS, INC. , JAMES, Kristofer J. , AMURTHUR, Badri , BLY, Mark J. , LIBBUS, Imad
发明人： JAMES, Kristofer J. , AMURTHUR, Badri , BLY, Mark J. , LIBBUS, Imad
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/02055 , A61B5/04085 , A61B5/6833 , A61B2560/0412 , A61B2562/164
摘要： ABSTRACT OF THE DISCLOSURE A system is provided for tracking an individual, engaged in extreme physical activity, physiological status and detecting and predicting negative physiological events. A monitoring system is provided that includes a plurality of sensors. Each sensor has a sensor output, and a combination of the sensor outputs is used to determine distress of the monitored individual engaged in extreme physical activity. A wireless communication device is coupled to the plurality of sensors and transfers data directly or indirectly from the plurality of sensors to a remote monitoring system. A remote monitoring system is coupled to the wireless communication device and configured to receive the processed data.
摘要翻译：发明内容提供一种系统，用于跟踪个体，从事极端身体活动，生理状态，检测和预测负面生理事件。提供了包括多个传感器的监视系统。每个传感器都有一个传感器输出，并且传感器输出的组合用于确定从事极端身体活动的受监视人员的困扰。无线通信设备耦合到多个传感器并将数据直接或间接地从多个传感器传送到远程监视系统。远程监控系统耦合到无线通信设备并被配置为接收处理后的数据。

9. 发明申请

WO2009036319A1 ADHERENT EMERGENCY PATIENT MONITOR 审中-公开
标题翻译：临床紧急病人监护人
公开(公告)号：WO2009036319A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076233
申请日：2008-09-12
申请人： CORVENTIS, INC. , LIBBUS, Imad , AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , MANICKA, Yatheendhar, D. , MAZAR, Scott, T. , WANG, Jerry, S.
发明人： LIBBUS, Imad , AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , MANICKA, Yatheendhar, D. , MAZAR, Scott, T. , WANG, Jerry, S.
IPC分类号： A61B5/08
CPC分类号： A61B5/04087 , A61B5/6833
摘要： An adherent device comprises an adhesive patch to adhere to a skin of the patient. At least two electrodes are connected to the patch and capable of electrically coupling to the patient. Electrocardiogram circuitry can be coupled to at the least two electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate an accelerometer signal in response to at least one of an activity or a position of the patient. A processor comprising a tangible medium can be configured to communicate with the electrocardiogram circuitry and the accelerometer to generate an alarm signal in response to the electrocardiogram signal and the accelerometer signal.
摘要翻译：粘附装置包括粘附到患者皮肤上的粘贴剂。至少两个电极连接到贴片并且能够电耦合到患者。心电图电路可耦合到至少两个电极以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生加速度计信号。包括有形介质的处理器可以被配置为与心电图电路和加速度计通信以响应于心电图信号和加速度计信号产生报警信号。

10. 发明申请

WO2009036321A1 ADHERENT DEVICE FOR CARDIAC RHYTHM MANAGEMENT 审中-公开
标题翻译： CARDIAC RHYTHM管理的附加设备
公开(公告)号：WO2009036321A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076235
申请日：2008-09-12
申请人： CORVENTIS, INC. , LIBBUS, Imad , AMURTHUR, Badri
发明人： LIBBUS, Imad , AMURTHUR, Badri
IPC分类号： A61N1/00
CPC分类号： A61N1/046 , A61B5/0205 , A61B5/085 , A61B5/1118 , A61N1/0492 , A61N1/36585 , A61N1/37 , A61N1/3925 , A61N1/3987
摘要： An adherent device to monitor and treat a patient comprises an adhesive patch to adhere to a skin of the patient. At least two electrodes are connected to the patch and capable of electrically coupling to the patient. Sensor circuitry is coupled to the at least two electrodes and configured to measure at least two of an electrocardiogram signal of the patient, a respiration signal of the patient or an activity signal of the patient. Therapy circuitry is coupled to the at least two electrodes and configured to deliver a high-energy shock therapy for cardioversion and/or defibrillation. A processor system comprising a tangible medium and coupled to the sensor circuitry and therapy circuitry, the processor is configured to generate a treatment signal to deliver the high-energy shock therapy in response to the at least two of the electrocardiogram signal, the respiration signal or the activity signal.
摘要翻译：用于监测和治疗患者的粘附装置包括粘附到患者皮肤上的粘合贴片。至少两个电极连接到贴片并且能够电耦合到患者。传感器电路耦合到所述至少两个电极并且被配置为测量患者的心电图信号中的至少两个，患者的呼吸信号或患者的活动信号。治疗电路耦合到至少两个电极并且被配置为递送用于心脏复律和/或除颤的高能量休克疗法。一种处理器系统，包括有形介质并且耦合到所述传感器电路和治疗电路，所述处理器被配置为产生治疗信号以响应于所述心电图信号，所述呼吸信号或所述呼吸信号中的所述至少两个来递送所述高能量休克疗法活动信号。

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