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1. 发明申请

WO2019191258A1 PACING-BASED HYPERTENSION THERAPY SAFETY 审中-公开
公开(公告)号：WO2019191258A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024324
申请日：2019-03-27
申请人： CARDIAC PACEMAKERS, INC.
发明人： HAHN, Stephen J. , THAKUR, Pramodsingh Hirasingh , AN, Qi , AVERINA, Viktoria A. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh
IPC分类号： A61N1/365 , A61N1/368
摘要： This document discusses, among other things, systems to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, and alternate the first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay. Physiologic information can be received from the patient, and one of the first or second pacing period for delivery to the patient can be determined using the received physiologic information.

2. 发明申请

WO2018039322A1 CARDIAC RESYNCHRONIZATION USING FUSION PROMOTION FOR TIMING MANAGEMENT 审中-公开
标题翻译：基于时序管理的融合促进CARDIAC再同步
公开(公告)号：WO2018039322A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048179
申请日：2017-08-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： HAHN, Stephen J. , STEIN, Kenneth M. , YU, Yinghong , HEALY, Scott J. , MORGAN, John
IPC分类号： A61N1/375 , A61N1/39 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/37252 , A61B5/04525 , A61B5/0456 , A61N1/3627 , A61N1/36592 , A61N1/3682 , A61N1/36843 , A61N1/37288 , A61N1/37512 , A61N1/3756 , A61N1/378 , A61N1/3918 , A61N1/3962 , A61N1/39622
摘要： Methods, systems and devices for providing cardiac resynchronization therapy (CRT) to a patient using a Ieadless cardiac pacemaker and an extracardiac device. The extracardiac device is configured to analyze one or more QRS complexes of the patient's heart, determine whether fusion pacing is taking place, and, if not, to communicate with the Ieadless cardiac pacemaker to adjust intervals used in the CRT in order to generate desirable fusion of the pace and intrinsic signals. The extracardiac device may take the form of a subcutaneous implantable monitor, a subcutaneous implantable defibrillator, or other devices including wearable devices.
摘要翻译：使用无心脏心脏起搏器和心外装置向患者提供心脏再同步治疗（CRT）的方法，系统和设备。心外装置被配置为分析患者心脏的一个或多个QRS复合波，确定是否正在发生融合起搏，并且如果不是，则与无心脏心脏起搏器通信以调整在CRT中使用的间隔以产生期望的融合的步伐和内在信号。心外装置可以采取皮下植入式监测器，皮下植入式除颤器或包括可穿戴装置的其他装置的形式。

3. 发明申请

WO2017192870A1 ELECTRODE DESIGNS IN IMPLANTABLE DEFIBRILLATOR SYSTEMS 审中-公开
标题翻译：可植入式除颤器系统中的电极设计
公开(公告)号：WO2017192870A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031092
申请日：2017-05-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： DE KOCK, Andrew L. , REDDY, G. Shantanu , BROCK II, Robert D. , HAHN, Stephen J. , KOOP, Brendan E. , SWEENEY, Moira B. , STAHL, Wyatt K.
IPC分类号： A61N1/38 , A61N1/05
摘要： A subcutaneous implantable cardioverter-defibrillator (S-ICD) comprising shocking electrodes configured to reduce the defibrillation threshold. The S-ICD may include a canister housing a source of electrical energy, a capacitor, and operational circuitry that senses heart rhythms and an electrode and lead assembly. The electrode and lead assembly may comprise a lead, at least one sensing electrode, and at least one shocking electrode. The at least one shocking electrode may extend over a length in the range of 50 to 110 millimeters and a width in the range of 1 to 40 millimeters.
摘要翻译：皮下植入式心脏复律除颤器（S-ICD）包括构造成减小除颤阈值的冲击电极。 S-ICD可以包括容纳电能源的罐，电容器和感测心脏节律的操作电路以及电极和引线组件。电极和引线组件可以包括引线，至少一个感测电极和至少一个冲击电极。该至少一个冲击电极可以在50至110毫米范围内的长度和1至40毫米范围内的宽度上延伸。

4. 发明申请

WO2017070279A1 MULTI-VECTOR SENSING IN CARDIAC DEVICES WITH SIGNAL COMBINATIONS 审中-公开
标题翻译：具有信号组合的心脏设备中的多矢量感测
公开(公告)号：WO2017070279A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/057802
申请日：2016-10-20
申请人： CARDIAC PACEMAKERS, INC.
发明人： BRISBEN, Amy Jean , ALLAVATAM, Venugopal , SIEJKO, Krzysztof Z. , MAHAJAN, Deepa , WIKA, Kevin G. , HERRMANN, Keith L. , HAHN, Stephen J.
IPC分类号： A61B5/0402 , A61B5/00 , A61B5/0456 , A61B5/0468 , A61N1/39 , A61B5/04 , A61B5/042 , A61N1/362 , A61B5/024 , A61B5/0245 , A61B5/0472 , A61B5/0452
CPC分类号： A61N1/36514 , A61B5/02416 , A61B5/0245 , A61B5/04011 , A61B5/04012 , A61B5/04017 , A61B5/0402 , A61B5/04028 , A61B5/042 , A61B5/0422 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/686 , A61B5/6869 , A61B5/72 , A61B5/7203 , A61B5/7221 , A61N1/046 , A61N1/05 , A61N1/0563 , A61N1/3622 , A61N1/3625 , A61N1/3704 , A61N1/3925 , A61N1/3956 , A61N1/3987
摘要： Methods and devices for combining multiple signals from multiple sensing vectors for use in wearable or implantable cardiac devices. Signals from multiple vectors may be combined using weighting factors and/or by conversion to different coordinate systems than the original inputs, which may or may not be normalized to patient anatomy. Signals from multiple sensing vectors may be combined prior to or after several analytical steps or processes including before or after filtering, and before or after cardiac cycle detection. Cardiac cycle detection information may be combined across multiple sensing vectors before or after analysis of individual vectors for noise or overdetection. Cardiac cycle detection information may also be combined across multiple sensing vectors to identify noise and/or overdetection.
摘要翻译：用于组合来自多个感测向量的多个信号以用于可穿戴或可植入的心脏装置的方法和设备。来自多个向量的信号可以使用加权因子和/或通过转换到与原始输入不同的坐标系统来组合，其可以或不可以针对患者解剖结构进行归一化。来自多个感测向量的信号可以在几个分析步骤或过程之前或之后进行组合，包括在过滤之前或之后以及在心动周期检测之前或之后。心脏周期检测信息可以在分析个体向量之前或之后跨过多个感测向量进行组合以用于噪声或过度检测。心脏周期检测信息也可以跨越多个感测向量组合以识别噪音和/或过度检测。

5. 发明申请

WO2019191283A1 PATTERNED PACING TO REDUCE HYPERTENSION 审中-公开
公开(公告)号：WO2019191283A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024358
申请日：2019-03-27
申请人： CARDIAC PACEMAKERS, INC.
发明人： HAHN, Stephen J. , THAKUR, Pramodsingh Hirasingh , AN, Qi , AVERINA, Viktoria A. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh
IPC分类号： A61N1/365 , A61N1/368
摘要： This document discusses, among other things, systems to receive physiologic information from a patient during different first and second pacing periods having respective, different first and second atrioventricular (AV) delays, determine first and second physiologic parameters using respective received physiologic information from the first and second pacing periods, and adjust the first AV delay using the determined first and second physiologic parameters, wherein the second AV delay is longer than the first AV delay.

6. 发明申请

WO2018089191A1 CARDIAC DEVICE ACCLIMATION PROFILE 审中-公开
标题翻译： CARDIAC设备接口配置文件
公开(公告)号：WO2018089191A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/058139
申请日：2017-10-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： HERRMANN, Keith L. , HAHN, Stephen J.
IPC分类号： A61N1/05 , A61N1/365 , A61N1/37
摘要： This document discusses, among other things, systems and methods to acclimate a patient to therapy from an implantable medical device. For instance, an implantable medical device can include pulse generation circuitry, sensing circuitry, and a controller. The pulse generation circuitry can generate electrical pulses. The sensing circuitry can be for sensing cardiac electrical activity of the patient. In an example, the controller can detect cardiac events that define pacing timing intervals and control the delivery of electrical pulses in accordance with a programmed mode. The controller can be programmed to provide instructions to the pulse generation circuitry to deliver electrical pulses to the heart of a patient. In an example, the electrical pulses can be based on a therapy parameter. The controller can be configured to adjust the therapy parameter according to an acclimation profile to acclimate the patient to a stimulation therapy.
摘要翻译：本文件讨论了适用于使患者适应来自可植入医疗设备的治疗的系统和方法。例如，可植入医疗装置可以包括脉冲生成电路，感测电路和控制器。脉冲发生电路可以产生电脉冲。感测电路可以用于感测患者的心脏电活动。在一个示例中，控制器可以检测定义起搏定时间隔的心脏事件，并根据编程模式控制电脉冲的输送。控制器可以被编程为向脉冲发生电路提供指令以将电脉冲输送到患者的心脏。在一个例子中，电脉冲可以基于治疗参数。控制器可以被配置为根据适应情况调整治疗参数以使患者适应刺激治疗。

7. 发明申请

WO2018039335A1 INTEGRATED MULTI-DEVICE CARDIAC RESYNCHRONIZATION THERAPY USING P-WAVE TO PACE TIMING 审中-公开
标题翻译：利用P波进行时间同步的集成多器件心脏同步治疗
公开(公告)号：WO2018039335A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048199
申请日：2017-08-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： HAHN, Stephen J. , SIEJKO, Krzysztof Z. , BRISBEN, Amy Jean , MAILE, Keith R.
IPC分类号： A61B5/0452 , A61N1/372 , A61N1/375 , A61N1/39 , A61N1/365 , A61N1/37
摘要： Methods, systems and devices for providing cardiac resynchronization therapy (CRT) to a patient using a leadless cardiac pacemaker (LCP) and an extracardiac device (ED). The LCP is configured to deliver pacing therapy at a pacing interval. Illustratively, the ED may be configured to analyze the cardiac cycle including a portion preceding the pacing therapy delivery for one or several cardiac cycles, and determine whether an interval from the P-wave to the pace therapy in the cardiac cycle(s) is in a desired range. In an example, if the P-wave to pace interval is outside the desired range, the ED communicates to the LCP to adjust the pacing interval.
摘要翻译：使用无引线心脏起搏器（LCP）和心外装置（ED）向患者提供心脏再同步治疗（CRT）的方法，系统和设备。 LCP配置为以起搏间隔递送起搏治疗。说明性地，ED可以被配置为分析包括一个或多个心动周期的起搏治疗递送之前的部分的心动周期，并且确定从心动周期中的P波到步速治疗的时间间隔是否在一个理想的范围。在一个例子中，如果P波到步调间隔超出了预期的范围，ED就会与LCP通信以调整起搏间隔。

8. 发明申请

WO2012078413A1 SYSTEMS AND METHODS FOR INCREASING STIMULATION DOSE 审中-公开
标题翻译：用于增加刺激剂量的系统和方法
公开(公告)号：WO2012078413A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/062451
申请日：2011-11-29
申请人： CARDIAC PACEMAKERS, INC. , HAHN, Stephen J. , HAMANN, Jason J. , TERNES, David J.
发明人： HAHN, Stephen J. , HAMANN, Jason J. , TERNES, David J.
IPC分类号： A61N1/372 , A61N1/05
CPC分类号： A61N1/37282 , A61N1/0556 , A61N1/36132 , A61N1/3615 , A61N1/36178 , A61N1/36185 , A61N1/37252
摘要： A system embodiment comprises a neural stimulator and a controller. The neural stimulator is configured to deliver neural stimulation therapy to the patient. The controller is configured to perform a programmed routine to intermittently and incrementally increase a dose of the neural stimulation therapy to increase the dose by a plurality of dose increments over time, deliver the neural stimulation using the increased dose after each of the plurality of dose increments, monitor for a patient-controlled request to reduce the dose, and respond to the patient-controlled request by reducing the dose by at least one of the plurality of dose increments.
摘要翻译：系统实施例包括神经刺激器和控制器。神经刺激器配置为向患者传递神经刺激疗法。控制器被配置为执行编程程序以间歇地和递增地增加神经刺激治疗的剂量，以随着时间推移多个剂量增量来增加剂量，在多个剂量增量中的每一个之后使用增加的剂量递送神经刺激监测患者控制的请求以减少剂量，并且通过以多个剂量增量中的至少一个减小剂量来响应患者控制的请求。

9. 发明申请

WO2019191268A1 PACING-BASED HYPERTENSION THERAPY METABOLIC DEMAND ADJUSTMENT 审中-公开
公开(公告)号：WO2019191268A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024338
申请日：2019-03-27
申请人： CARDIAC PACEMAKERS, INC.
发明人： HAHN, Stephen J. , THAKUR, Pramodsingh Hirasingh , AN, Qi , AVERINA, Viktoria A. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh
IPC分类号： A61N1/365 , A61N1/368
摘要： This document discusses, among other things, systems to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, to alternate first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, to receive information indicative of patient metabolic demand, and to determine an adjusted pacing-based hypertension therapy parameter using the received information indicative of patient metabolic demand, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay.

10. 发明申请

WO2019136073A1 HIS-BUNDLE PACING SYSTEM WITH LEFT-VENTRICULAR PACING 审中-公开
公开(公告)号：WO2019136073A1
公开(公告)日：2019-07-11
申请号：PCT/US2019/012059
申请日：2019-01-02
申请人： CARDIAC PACEMAKERS, INC.
发明人： HERRMANN, Keith L. , MAHAJAN, Deepa , HAHN, Stephen J. , SHUROS, Allan Charles
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3706 , A61N1/365 , A61N1/368 , A61N1/3702 , A61N1/3704 , A61N1/371 , A61N1/3712
摘要： Systems and methods for cardiac pacing are described in this document. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses to capture a His bundle, and LV pacing (LVP) pulses to capture a left ventricle. A sensing circuit may sense a cardiac activity, such as an atrial or an LV cardiac electrical activity. The system includes a control circuit controlling the delivery of HBP and LVP pulses. The HBP and LVP may be delivered concurrently or sequentially. In an example, the LVP pulses may be delivered based on a His-bundle capture status in response to the HBP pulse. The system may adjust one or more His-bundle stimulation parameters based on the His-bundle capture status.

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