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1. 发明申请

WO2012166901A1 AN OFF-LINE SENSING METHOD AND ITS APPLICATIONS IN DETECTING UNDERSENSING, OVERSENSING, AND NOISE 审中-公开
标题翻译：离线感测方法及其在检测，过滤和噪声检测中的应用
公开(公告)号：WO2012166901A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040186
申请日：2012-05-31
申请人： CARDIAC PACEMAKERS, INC , DONG, Yanting , ZHANG, Shijie , MAHAJAN, Deepa , LIU, Chenguang , LI, Dan , LIN, Yayun , BOHN, Derek D.
发明人： DONG, Yanting , ZHANG, Shijie , MAHAJAN, Deepa , LIU, Chenguang , LI, Dan , LIN, Yayun , BOHN, Derek D.
IPC分类号： A61N1/37
CPC分类号： A61B5/0245 , A61B5/042 , A61B5/0452 , A61B5/7217 , A61N1/3704 , F04C2270/041
摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.
摘要翻译：一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。多遍处理确定心电图的至少第一个通道的位置。然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

2. 发明申请

WO2011112420A1 INTRACARDIAC ELECTROGRAM TIME FREQUENCY NOISE DETECTION 审中-公开
标题翻译：电磁干扰时频噪声检测
公开(公告)号：WO2011112420A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027036
申请日：2011-03-03
申请人： CARDIAC PACEMAKERS, INC. , MAHAJAN, Deepa , LIU, Chenguang , DONG, Yanting
发明人： MAHAJAN, Deepa , LIU, Chenguang , DONG, Yanting
IPC分类号： A61N1/37 , A61N1/39 , A61B5/0452
CPC分类号： A61N1/3704 , A61N1/3962
摘要： Systems, methods, and apparatus for identifying and classifying noise of an intracardiac electrogram of a cardiac rhythm management device to prevent inaccurate detection of a cardiac episode are disclosed. In an example, three channels are analyzed to identify and determine whether an episode or noise has been detected.
摘要翻译：公开了用于识别和分类心律管理装置的心内电描记图的噪声以防止不准确的心脏发作检测的系统，方法和装置。在一个示例中，分析三个通道以识别并确定是否已经检测到发作或噪声。

3. 发明申请

WO2010138332A1 ADAPTIVE EVENT STORAGE IN AN IMPLANTABLE DEVICE 审中-公开
标题翻译：自适应事件存储在可移植设备中
公开(公告)号：WO2010138332A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/035133
申请日：2010-05-17
申请人： CARDIAC PACEMAKERS, INC. , DONG, Yanting , PERSCHBACHER, David L. , STAHMANN, Jeffrey E. , LI, Dan , MAHAJAN, Deepa
发明人： DONG, Yanting , PERSCHBACHER, David L. , STAHMANN, Jeffrey E. , LI, Dan , MAHAJAN, Deepa
IPC分类号： A61N1/372 , A61B5/00
CPC分类号： A61N1/37252 , A61B5/02 , A61B5/04 , A61B5/0452 , A61B5/6846 , A61N1/025 , A61N1/3621 , A61N1/3702 , A61N1/372 , A61N1/3925
摘要： Monitoring physiological parameter using an implantable physiological monitor in order to detect a condition predictive of a possible future pathological episode and collecting additional physiological data associated with the condition predictive of a possible future pathological episode. Monitoring, using the physiological monitor, another physiological parameter in order to detect a condition indicative of the beginning of a present pathological episode and collecting additional pathological data in response to the condition. Determining that the condition predictive of a future episode and the condition indicative of a present episode are associated and, in response thereto, storing all the collected physiological data.
摘要翻译：使用植入式生理监测器监测生理参数，以便检测预测可能的未来病理发作的状况，并收集与预测可能的未来病理发作相关的条件相关的附加生理数据。使用生理监测器监测另一种生理参数，以便检测指示本病理发作开始的病症并响应于该病症收集额外的病理数据。确定预测未来事件的条件和指示当前情节的状况是相关联的，并且响应于此，存储所有收集的生理数据。

4. 发明申请

WO2010132592A2 SYSTEMS AND METHODS FOR PROGRAMMING IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：用于编程可植入医疗器械的系统和方法
公开(公告)号：WO2010132592A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034587
申请日：2010-05-12
申请人： CARDIAC PACEMAKERS, INC. , MAHAJAN, Deepa , DONG, Yanting , AHMAD, Muhammad A.
发明人： MAHAJAN, Deepa , DONG, Yanting , AHMAD, Muhammad A.
IPC分类号： A61N1/372 , G06F19/00
CPC分类号： A61N1/37252 , A61N1/37247 , A61N1/37264 , G06F19/00 , G16H40/40 , G16H50/20
摘要： Embodiments of the invention are directed to systems and methods for programming implantable medical devices, amongst other things. In an embodiment, the invention includes a method of programming an implantable medical device. The method can include gathering parameter data representing a set of previously programmed parameter values from a plurality of implanted medical devices. The method can further include performing association analysis on the parameter data to form a set of association rules. The method can further include suggesting parameter choices to a system user regarding a specific patient based on the set of association rules. In an embodiment, the invention can include a medical system including a server configured to perform association analysis on a set of data representing previously programmed parameter values from a plurality of implanted medical devices to derive a set of association rules. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及用于编程可植入医疗装置的系统和方法。在一个实施例中，本发明包括编程可植入医疗装置的方法。该方法可以包括从多个植入的医疗装置收集表示一组先前编程的参数值的参数数据。该方法还可以包括对参数数据执行关联分析以形成一组关联规则。该方法还可以包括基于该组关联规则向系统用户建议关于特定患者的参数选择。在一个实施例中，本发明可以包括医疗系统，其包括服务器，该服务器被配置为对来自多个植入的医疗设备的代表先前编程的参数值的一组数据执行关联分析，以导出一组关联规则。本文还包括其它实施例。

5. 发明申请

WO2012162281A1 APPARATUS AND METHOD FOR COMBINED CARDIAC FUNCTION MANAGEMENT AND RENAL THERAPIES 审中-公开
标题翻译：用于组合心脏功能管理和肾脏治疗的装置和方法
公开(公告)号：WO2012162281A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/038920
申请日：2012-05-22
申请人： CARDIAC PACEMAKERS, INC. , MAHAJAN, Deepa , WARIAR, Ramesh , SHOME, Shibaji
发明人： MAHAJAN, Deepa , WARIAR, Ramesh , SHOME, Shibaji
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , A61M1/14 , A61M2205/05 , A61M2205/3507 , A61M2230/00 , A61N1/36117 , A61N1/3621 , G06F19/00 , G16H40/63
摘要： A system can coordinate operation of a cardiac function management (CFM) device and a renal device, such as during a vulnerable period in which a patient has an increased risk of tachyarrhythmia.
摘要翻译：系统可以协调心脏功能管理（CFM）装置和肾脏装置的操作，例如在患有快速性心律失常风险增加的脆弱时期。

6. 发明申请

WO2020028094A1 SYSTEMS AND METHODS FOR PRESENTING PHYSIOLOGIC DATA 审中-公开
公开(公告)号：WO2020028094A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/042986
申请日：2019-07-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： PERSCHBACHER, David L. , SAHA, Sunipa , MAHAJAN, Deepa , BOHN, Derek D.
IPC分类号： A61N1/372 , G16H50/70 , A61N1/08 , A61N1/37
摘要： Systems and methods for presenting physiologic data to a user are discussed. An exemplary system includes a presentation control circuit configured to generate signal metrics from data subsets of a physiologic signal corresponding to a device-detected presence of a physiologic event. The signal metrics represent characteristics of the physiologic event. The presentation control circuit may determine, from the plurality of data subsets, a target subset of clinical significance, which has the corresponding signal metric satisfying a specific condition. The presentation control circuit may present the recognized target subset over other subsets of the physiologic data. A user may adjudicate the device detection of the physiologic event or adjust device parameters.

7. 发明申请

WO2019173003A1 AUTO-THRESHOLD TEST FOR HIS-BUNDLE PACING 审中-公开
公开(公告)号：WO2019173003A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/014923
申请日：2019-01-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： BRISBEN, Amy Jean , TERNES, David J. , SHUROS, Allan Charles , MAHAJAN, Deepa , PERSCHBACHER, David L.
IPC分类号： A61N1/37 , A61N1/36
摘要： Systems and methods for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses. A sensing circuit senses a physiologic signal, and detect a local His-bundie activation discrete from a pacing artifact of the HBP pulse. A control circuit verifies capture status in response to the HBP pulses. Based on the capture status, the control circuit determines one or more pacing thresholds including a selective HBP threshold representing a threshold strength to capture only the His bundle but not the local myocardium, and a non-selective HBP threshold representing a threshold strength to capture both the His bundle and the local myocardium. The electrostimulation circuit may deliver HBP pulses based on the selective and non-selective HBP thresholds.

8. 发明申请

WO2019152383A1 SYSTEMS FOR PRESENTING ARRHYTHMIA EPISODES 审中-公开
公开(公告)号：WO2019152383A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/015603
申请日：2019-01-29
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAHAJAN, Deepa , PERSCHBACHER, David, L. , SAHA, Sunipa
IPC分类号： A61N1/362 , A61N1/37 , A61N1/372
CPC分类号： A61N1/37247 , A61B5/046 , A61B5/0468 , A61B5/7475 , A61N1/3621 , A61N1/3627 , A61N1/3702 , A61N1/3704
摘要： Systems and methods for managing machine-generated alert notifications of medical events detected from one or more patients are described herein. An embodiment of a data management system may receive an adjudication of a medical event episode including an episode characterization. A storage unit stores an association between one or more episode characterizations and corresponding detection algorithms for detecting a medical event having respective episode characterizations. An episode management circuit may detect from a subsequent episode, using the stored association, a medical event having an episode characterization of at least one medical event episode presented for adjudication, and schedule presenting at least a portion of the subsequent episode based on the detection.

9. 发明申请

WO2016160674A1 ATRIAL FIBRILLATION DETECTION 审中-公开
标题翻译： ATRIAL FIBRILLATION检测
公开(公告)号：WO2016160674A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/024463
申请日：2016-03-28
申请人： CARDIAC PACEMAKERS, INC.
发明人： PERSCHBACHER, David L. , MAHAJAN, Deepa , SIMMS JR., Howard D.
IPC分类号： A61N1/39 , A61B5/00 , A61B5/0464 , A61N1/362
CPC分类号： A61B5/046 , A61B5/0031 , A61B5/0245 , A61B5/042 , A61B5/0432 , A61B5/0464 , A61B5/686 , A61N1/3621 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： An apparatus includes a sensing circuit configured to generate a sensed physiological signal representative of cardiac activity of a subject, and an arrhythmia detection circuit. The arrhythmia detection circuit is configured to monitor information corresponding to ventricular depolarization (V-V) intervals using the sensed physiological signal; determine a V-V interval distribution; determine a heart rate density index (HRDI) as a portion of samples of the V-V interval distribution corresponding to a V-V interval occurring most often in the distribution; and generate an indication of atrial fibrillation (AF) using the HRDI.
摘要翻译：一种装置包括：感测电路，被配置为产生表示受试者的心脏活动的感测生理信号，以及心律失常检测电路。心律失常检测电路被配置为使用感测到的生理信号监视与心室去极化（V-V）间隔相对应的信息; 确定V-V间隔分布; 确定心率密度指数（HRDI）作为对应于在分布中最常出现的V-V间隔的V-V间隔分布的样本的一部分; 并使用HRDI产生心房颤动（AF）的指征。

10. 发明申请

WO2020010001A1 ADJUSTABLE SENSING IN A HIS-BUNDLE PACEMAKER 审中-公开
公开(公告)号：WO2020010001A1
公开(公告)日：2020-01-09
申请号：PCT/US2019/040144
申请日：2019-07-01
申请人： CARDIAC PACEMAKERS, INC.
发明人： CASAVANT, David Arthur , PERSCHBACHER, David L. , MAHAJAN, Deepa
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368 , A61N1/37
摘要： Systems and methods for pacing cardiac conductive tissue are described. An embodiment of a medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses to stimulate a His bundle, and a cardiac event detector to detect a His-bundle activity within a time window following an atrial activity. The cardiac event detector may use a cross-chamber blanking, or an adjustable His-bundle sensing threshold, to avoid or reduce over-sensing of far-field atrial activity and inappropriate inhibition of HBP therapy. The electrostimulation circuit may deliver HBP in the presence of the His-bundle activity. The system may further recognize the detected His-bundle activity as either a FFPW or a valid inhibitory event, and deliver or withhold HBP therapy based on the recognition of the His-bundle activity.

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