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1. 发明申请

WO2008121185A1 ESTIMATING ACUTE RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
标题翻译：估计对心脏康复治疗的急性反应
公开(公告)号：WO2008121185A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/002097
申请日：2008-02-15
申请人： CARDIAC PACEMAKER, INC. , PATANGAY, Abhilash , SIEJKO, Krzysztof , KRISHNAN, Mohan , CARLSON, Gerrard, M.
发明人： PATANGAY, Abhilash , SIEJKO, Krzysztof , KRISHNAN, Mohan , CARLSON, Gerrard, M.
IPC分类号： A61N1/365 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量传送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩期定时间隔来确定患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

2. 发明申请

WO2008054580A3 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR HEALTH MANAGEMENT 审中-公开
公开(公告)号：WO2008054580A3
公开(公告)日：2008-05-08
申请号：PCT/US2007/020425
申请日：2007-09-20
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , HATLESTAD, John, D. , CARLSON, Gerrard, M. , DALAL, Yousufali , BROCKWAY, Marina, V. , LEE, Kent , KUENZLER, Richard, O. , HARO, Carlos , SIEJKO, Krzysztof, Z. , PATANGAY, Abhilash
发明人： ZHANG, Yi , HATLESTAD, John, D. , CARLSON, Gerrard, M. , DALAL, Yousufali , BROCKWAY, Marina, V. , LEE, Kent , KUENZLER, Richard, O. , HARO, Carlos , SIEJKO, Krzysztof, Z. , PATANGAY, Abhilash
IPC分类号： A61B5/02
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. Baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. Prediction processing may be performed by the at-least one implantable device or by an external device in communication therewith. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

3. 发明申请

WO2008130532A1 HEART SOUND TRACKING SYSTEM AND METHOD 审中-公开
标题翻译：心音追踪系统及方法
公开(公告)号：WO2008130532A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004832
申请日：2008-04-14
申请人： CARDIAC PACEMAKERS, INC. , PATANGAY, Abhilash , SIEJKO, Krzysztof Z. , CARLSON, Gerrard M.
发明人： PATANGAY, Abhilash , SIEJKO, Krzysztof Z. , CARLSON, Gerrard M.
IPC分类号： A61B7/00
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, or S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, or S4, respectively.
摘要翻译：一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。特定的心音可以包括S1，S2，S3或S4中的一个的至少一部分。此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3或S4中的一个的至少一部分。

4. 发明申请

WO2008091529A2 ISCHEMIA DETECTION USING PRESSURE SENSOR 审中-公开
标题翻译：使用压力传感器进行ISCHEMIA检测
公开(公告)号：WO2008091529A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/000628
申请日：2008-01-17
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , SIEJKO, Krzysztof Z. , FOGOROS, Richard , PATANGAY, Abhilash
发明人： ZHANG, Yi , SIEJKO, Krzysztof Z. , FOGOROS, Richard , PATANGAY, Abhilash
IPC分类号： A61B5/021
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/0205 , A61B5/145
摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure ("PAP") signal of a pulmonary artery ("PA") and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.
摘要翻译：本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算血液供应减少至少一部分的指示心脏使用来自PAP信号的信息。使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。

5. 发明申请

WO2008063288A2 RESPIRATION-SYNCHRONIZED HEART SOUND TRENDING 审中-公开
标题翻译：呼吸同步心脏声音趋势
公开(公告)号：WO2008063288A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/021503
申请日：2007-10-05
申请人： CARDIAC PACEMAKERS, INC. , HARO, Carlos , ZHANG, Yi , PATANGAY, Abhilash , CARLSON, Gerrard, M.
发明人： HARO, Carlos , ZHANG, Yi , PATANGAY, Abhilash , CARLSON, Gerrard, M.
IPC分类号： A61B5/00 , A61B7/00 , A61B5/113 , A61B5/08
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： Respiration-synchronized heart sound trends can be detected using an implantable medical device, including a respiration sensor, a respiration phase detector, a heart sound sensor, a heart sound detector, and a processor. The implantable medical device can also include a cardiac sensor. The respiration-synchronized heart sound trends can include heart sounds occurring during specific phases of a respiration signal, such as inspiration or expiration. The heart sound signal can be gated or the heart sound sensor can be enabled or disabled using the cardiac sensor or the respiration sensor. Further, the heart sound trends can be displayed using an external display, and can provide information about a cardiovascular status using an analysis module, or the analysis module and a blood volume sensor.
摘要翻译：可以使用可植入医疗装置来检测呼吸同步心音趋势，所述可植入医疗装置包括呼吸传感器，呼吸相位检测器，心脏声音传感器，心脏声音检测器和处理器。可植入医疗装置还可以包括心脏传感器。呼吸同步心音趋势可以包括在呼吸信号的特定阶段期间发生的心音，例如吸气或呼气。可以对心脏声音信号进行门控，或者可以使用心脏传感器或呼吸传感器启用或禁用心脏声音传感器。此外，可以使用外部显示器来显示心音趋势，并且可以使用分析模块或分析模块和血量传感器来提供关于心血管状态的信息。

6. 发明申请

WO2010033928A1 CONGESTIVE HEART FAILURE DECOMPENSATION DETECTION 审中-公开
标题翻译：焦虑心脏衰竭检测
公开(公告)号：WO2010033928A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057710
申请日：2009-09-21
申请人： CARDIAC PACEMAKERS, INC. , SIEJKO, Krzysztof Z. , AVERINA, Viktoria A. , PATANGAY, Abhilash
发明人： SIEJKO, Krzysztof Z. , AVERINA, Viktoria A. , PATANGAY, Abhilash
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0002 , A61B5/7264 , G06F19/00
摘要： In an example, physiologic information about a patient can be obtained and mapped to a first set of fuzzy logic membership functions, and a symptom status can be derived from the mapping of the physiologic information using a first fuzzy logic inference. In an example, the symptom status can be mapped to a second set of fuzzy logic membership functions, and a disease status can be derived from the mapping of the symptom status to the second set of fuzzy logic membership functions using a second fuzzy logic inference.
摘要翻译：在一个示例中，可以获得关于患者的生理信息并将其映射到第一组模糊逻辑隶属函数，并且可以使用第一模糊逻辑推断从生理信息的映射导出症状状态。在一个示例中，症状状态可被映射到第二组模糊逻辑隶属函数，并且可以使用第二模糊逻辑推理从症状状态与第二组模糊逻辑隶属函数的映射导出疾病状态。

7. 发明申请

WO2009110996A1 AUTOMATED HEART FUNCTION CLASSIFICATION TO STANDARDIZED CLASSES 审中-公开
标题翻译：自动心功能分类到标准化类
公开(公告)号：WO2009110996A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/001314
申请日：2009-03-02
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , ZHANG, Yi , PATANGAY, Abhilash
发明人： ZHANG, Yunlong , ZHANG, Yi , PATANGAY, Abhilash
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/7264 , A61B5/7275 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H50/30
摘要： A non-infrared sensitized low silver photographic element with a non-light sensitive layer, preferably an antihalation layer, containing a diphenylaminocyclopentene heptacyanine benzothiazolium infrared dye where the benzothiazolium groups have electron-withdrawing substituents on the phenyl ring and solubilzed alkyl groups on the nitrogen. The infrared dye can be present as a liquid-crystalline dispersion. This class of infrared dyes form J-aggregrated species in a liquid-crystalline or a solid particle dispersion with high IR density and low visible absorbance.
摘要翻译：一种具有非光敏层的非红外敏感低银照相元件，优选为防晕层，其含有二苯基氨基环戊烯七叶酸苯并噻唑鎓红外染料，其中苯并噻唑鎓基在苯环上具有吸电子取代基并在氮上溶解烷基。红外染料可以作为液晶分散体存在。这类红外染料在具有高IR密度和低可见光吸收度的液晶或固体颗粒分散体中形成J-聚集物。

8. 发明申请

WO2012082692A2 CARDIAC DECOMPENSATION DETECTION USING MULTIPLE SENSORS 审中-公开
标题翻译：用多传感器进行心脏分解检测
公开(公告)号：WO2012082692A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064553
申请日：2011-12-13
申请人： CARDIAC PACEMAKERS, INC. , THAKUR, Pramodsingh Hirasingh , PATANGAY, Abhilash
发明人： THAKUR, Pramodsingh Hirasingh , PATANGAY, Abhilash
IPC分类号： A61N1/368
CPC分类号： A61B5/0538 , A61B5/036 , A61B5/0809 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.
摘要翻译：可以在第一时间窗口上获得生理数据，例如胸阻抗数据，以建立基线，或者可以用于形成一个或多个数据聚类。可以获得额外的生理数据，例如在较晚的时间窗口上采集的胸部阻抗测试数据，并将其与基线或数据聚类进行比较以确定恶化的心力衰竭的指征。在一个例子中，可以监测一个或多个数据群的定量属性并用于提供恶化心力衰竭的指征。可以获得姿势辨别度量，例如使用在第一时间窗口上获得的生理数据。诸如可以在第二时间窗口上获得的附加生理数据可以与姿势辨别度量进行比较以提供患者姿势状态。

9. 发明申请

WO2012087696A3 PHYSIOLOGIC RESPONSE TO POSTURE 审中-公开
公开(公告)号：WO2012087696A3
公开(公告)日：2012-06-28
申请号：PCT/US2011/064811
申请日：2011-12-14
申请人： CARDIAC PACEMAKERS, INC. , AVERINA, Viktoria A. , HATLESTAD, John D. , PATANGAY, Abhilash , THAKUR, Pramodsingh Hirasingh , ZHANG, Yi , BECK, Kenneth C.
发明人： AVERINA, Viktoria A. , HATLESTAD, John D. , PATANGAY, Abhilash , THAKUR, Pramodsingh Hirasingh , ZHANG, Yi , BECK, Kenneth C.
IPC分类号： A61N1/365 , A61B5/11
摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

10. 发明申请

WO2012082698A2 POSTURE DETECTION USING THORACIC IMPEDANCE 审中-公开
标题翻译：使用THORACIC阻抗的检测
公开(公告)号：WO2012082698A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064560
申请日：2011-12-13
申请人： CARDIAC PACEMAKERS, INC. , THAKUR, Pramodsingh Hirasingh , PATANGAY, Abhilash
发明人： THAKUR, Pramodsingh Hirasingh , PATANGAY, Abhilash
IPC分类号： A61N1/368
CPC分类号： A61B5/0538 , A61B5/0205 , A61B5/103 , A61B5/1116 , A61B5/686 , A61B5/6869 , A61B2560/0462 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Physiological data, such as thoracic impedance data, can be obtained over a first time window to establish a baseline, or can be used to form one or more data clusters. Additional physiological data, such as thoracic impedance test data acquired over a later time window, can be obtained and compared to the baseline or data clusters to determine an indication of worsening heart failure. In an example, a quantitative attribute of one or more data clusters can be monitored and used to provide an indication of worsening heart failure. A posture discrimination metric can be obtained, such as using the physiological data obtained over the first time window. The additional physiological data, such as can be obtained over a second time window, can be compared to the posture discrimination metric to provide a patient posture status.
摘要翻译：可以在第一时间窗口中获得诸如胸部阻抗数据的生理数据以建立基线，或者可以用于形成一个或多个数据簇。可以获得额外的生理数据，例如在稍后时间窗口上获取的胸部阻抗测试数据，并与基线或数据簇进行比较，以确定心脏衰竭恶化的指示。在一个示例中，可以监视一个或多个数据集群的定量属性并用于提供恶化的心力衰竭的指示。可以获得姿势辨别度量，例如使用在第一时间窗口中获得的生理数据。可以将诸如在第二时间窗口上获得的附加生理数据与姿势辨别度量进行比较以提供患者姿势状态。

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