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1. 发明申请

WO2007022667A1 MULTIPLE AUTOPIPETTE APPARATUS AND METHOD OF OPERATION 审中-公开
标题翻译：多种自动装置和操作方法
公开(公告)号：WO2007022667A1
公开(公告)日：2007-03-01
申请号：PCT/CN2006/000014
申请日：2006-01-06
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , WANG, Dong , ZHANG, Jingchun , GAO, Wei , LI, Yingna , ZOU, Kun , CHENG, Jing
发明人： WANG, Dong , ZHANG, Jingchun , GAO, Wei , LI, Yingna , ZOU, Kun , CHENG, Jing
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01L3/0279 , B01L3/0293 , B01L2400/0487 , G01N35/0099 , G01N35/1065 , G01N2035/103
摘要： An embodiment of the present invention comprises an automatic multichannel pipettor operating in coordination with a robotic positioner. A volumetrically apportioned pressure dividing manifold equally divides volumetric displacement from a syringe pump among a plurality of pipetting channels for simultaneous aspiration and dispensing. The automatic pipettor can use disposable pipette tips that can be automatically loaded and discarded.
摘要翻译：本发明的实施例包括与机器人定位器协调操作的自动多通道移液器。体积分配的分压歧管在多个用于同时抽吸和分配的移液通道之间等同地分配来自注射器泵的体积位移。自动移液器可以使用可以自动加载和丢弃的一次性吸头。

2. 发明申请

WO2021108794A1 COMPACT APPARATUS FOR HIGH-SPEED CHEMICAL SPECTRAL SIGNATURE MEASUREMENT AND METHOD OF USING SAME 审中-公开
公开(公告)号：WO2021108794A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/062624
申请日：2020-11-30
申请人： GAO, Wei , YONG, Chang , VELICU, Silviu , SIVANANTHAN, Sivalingam
发明人： GAO, Wei , YONG, Chang , VELICU, Silviu , SIVANANTHAN, Sivalingam
IPC分类号： G01J3/02 , G01J3/28 , G01J3/36 , G01J3/32
摘要： A multiband IR adjunct (MIRA) sensor to spectroscopically determine the content and the concentration of chemical composition of a targeted object, includes a sensor housing, a first front optics in a first optical channel,a second front optics in the first optical channel, an acousto-optic tunable filter (AOTF), a photo detector (PD), a set of back optics in the first optical channel that focuses polarized narrow-band light beams received from the AOTF device onto the PD, the PD converting the polarized narrow-band light beams into an electrical signal, and a data acquisition unit signal-connected to the PD, the data acquisition unit collecting the electrical signals. Multiple optical channels can be provided within the housing to analyze UV/VIS/near infrared (NIR), short-wavelength infrared (SWIR), mid-wavelength infrared (MWIR), and LWIR wavelength ranges respectively.

3. 发明申请

WO2012145469A1 HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR GLYPICAN-3 AND USE THEREOF 审中-公开
标题翻译：特异性的人类单克隆抗体及其用途的人类单克隆抗体
公开(公告)号：WO2012145469A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034186
申请日：2012-04-19
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES , HO, Mitchell , FENG, Mingqian , GAO, Wei , KIM, Heungnam , DIMITROV, Dimiter, S.
发明人： HO, Mitchell , FENG, Mingqian , GAO, Wei , KIM, Heungnam , DIMITROV, Dimiter, S.
IPC分类号： C07K16/30
CPC分类号： C07K16/3076 , A61K39/39558 , A61K47/6803 , A61K47/6813 , A61K47/6829 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K14/21 , C07K16/28 , C07K16/303 , C07K16/3092 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/33 , C07K2319/55 , G01N33/57438 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2400/40
摘要： Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies described herein are capable of inhibiting HCC cell growth and migration. Provided are human monoclonal antibodies specific for GPC3 or HS chains on GPC3, including immunoglobulin molecules, such as IgG antibodies, as well as antibody fragments, such as single -domain VH antibodies or single chain variable fragments (scFv). Further provided are compositions including the antibodies that bind GPC3 or HS chains on GPC3, nucleic acid molecules encoding these antibodies, expression vectors comprising the nucleic acids, and isolated host cells that express the nucleic acids. Methods of treating cancer and/or inhibiting tumor growth or metastasis are also provided. Further provided are methods of detecting cancer in a subject and confirming a diagnosis of cancer in a subject.
摘要翻译：本文描述了以高亲和力在GPC3上结合GPC3或硫酸乙酰肝素（HS）链的人单克隆抗体的鉴定。本文所述的抗体能够抑制HCC细胞生长和迁移。提供对GPC3上的GPC3或HS链特异性的人单克隆抗体，包括免疫球蛋白分子，例如IgG抗体，以及抗体片段，例如单畴VH抗体或单链可变片段（scFv）。进一步提供的是包含结合GPC3上的GPC3或HS链的抗体，编码这些抗体的核酸分子，包含核酸的表达载体和表达核酸的分离的宿主细胞的组合物。还提供了治疗癌症和/或抑制肿瘤生长或转移的方法。还提供了检测受试者中的癌症并确认受试者中癌症诊断的方法。

4. 发明申请

WO2010005919A1 METHOD AND KITS FOR REPAIRING NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：修复核酸序列的方法和工具
公开(公告)号：WO2010005919A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/049735
申请日：2009-07-07
申请人： GENERAL ELECTRIC COMPANY , NELSON, John R. , GAO, Wei
发明人： NELSON, John R. , GAO, Wei
IPC分类号： C12P19/34
CPC分类号： C12N9/1252 , C12N9/93
摘要： Methods and kits for DNA repair are provided. The methods and kits described herein repair multiple types of DNA damage. The kit may include a plurality of enzymes to repair a greater variety of lesions than any single enzyme is capable of repairing. Repair of damaged DNA may include releasing damaged bases from the DNA strand, nicking the DNA at the damaged sites, translating the nicks via 5´-3´ exonuclease activity, and sealing the nicks. The enzymes employed in the repair process may then be heat-inactivated, thereby obviating a purification process. The repaired DNA may then be analyzed using a variety of DNA analysis methods.
摘要翻译：提供DNA修复的方法和试剂盒。本文所述的方法和试剂盒修复多种类型的DNA损伤。试剂盒可以包括多种酶，以修复比任何单一酶能够修复的更多种病变。损伤的DNA的修复可能包括从DNA链释放受损的碱基，在受损位点切割DNA，通过5'-3外切核酸酶活性翻译切口，并密封缺口。然后可以将在修复过程中使用的酶热灭活，从而避免纯化过程。然后可以使用各种DNA分析方法分析修复的DNA。

5. 发明申请

WO2007147725A1 METHOD FOR DETECTING THE CUTTING OFF SIGNAL OF BJT IN AN ELECTRONIC BALLAST AND THE ELECTRONIC BALLAST 审中-公开
标题翻译：用于检测电子镇流器和电子镇流器中BJT的切断信号的方法
公开(公告)号：WO2007147725A1
公开(公告)日：2007-12-27
申请号：PCT/EP2007/055485
申请日：2007-06-04
申请人： PATENT-TREUHAND-GESELLSCHAFT FÜR ELEKTRISCHE GLÜHLAMPEN MBH , GAO, Wei , HECKMANN, Markus , LI, Ji , XUE, Yanshun
发明人： GAO, Wei , HECKMANN, Markus , LI, Ji , XUE, Yanshun
IPC分类号： H05B41/282 , H05B41/285 , H02M3/335
CPC分类号： H05B41/2856 , H02M1/38 , H05B41/2828 , Y02B20/186
摘要： This invention relates to a method for detecting the real cutting off signal of BJT (bipolar junction transistor) in an electronic ballast and the corresponding electronic ballast. Said electronic ballast comprises a half-bridge circuit composed of two BJTs, the voltage output signal of said half- bridge circuit is on the one hand provided to a lamp and on the other hand is grounded via a capacitor and a backward diode. In order to accurately and quickly detect the real cutting off signal of said BJT, the HB control unit measures the sharp slope of voltage at the connection point (N) between the capacitor and the diode. By measuring the time between the flank of the control pulse for cutting off BJT and the corresponding sharp slope of voltage appearing accordingly at the connection point, the storage times (Ts1, Ts2) of the two BJTs are obtained. Said storage times are compared with each other, wherein the shorter storage time is used to adjust the amplitude of IC output for base current regulation, and the longer storage time is used to adjust the deadtime of IC outputs to make sure that there is always enough and appropriate deadtime. Thereby an electronic ballast operating more safely is provided.
摘要翻译：本发明涉及一种用于检测电子镇流器中的BJT（双极结型晶体管）和相应的电子镇流器的实际截止信号的方法。所述电子镇流器包括由两个BJT组成的半桥电路，所述半桥电路的电压输出信号一方面提供给灯，另一方面通过电容器和反向二极管接地。为了准确，快速地检测到所述BJT的实际切断信号，HB控制单元测量电容器和二极管之间的连接点（N）处的电压的急剧斜率。通过测量用于切断BJT的控制脉冲的侧面与相应地在连接点出现的相应的急剧斜率之间的时间，获得两个BJT的存储时间（Ts1，Ts2）。所述存储时间相互比较，其中使用较短的存储时间来调节用于基极电流调节的IC输出的幅度，并且使用较长的存储时间来调整IC输出的死区时间，以确保总是足够和适当的死时间。从而提供更安全地操作的电子镇流器。

6. 发明申请

WO2007073213A1 MICRO-ARC ASSISTED ELECTROLESS PLATING METHODS 审中-公开
标题翻译：微弧辅助电镀方法
公开(公告)号：WO2007073213A1
公开(公告)日：2007-06-28
申请号：PCT/NZ2006/000336
申请日：2006-12-20
申请人： AUCKLAND UNISERVICES LIMITED , GAO, Wei , LIU, Zhenmin
发明人： GAO, Wei , LIU, Zhenmin
IPC分类号： C25D11/00 , C23C18/32 , C23C18/16 , C25D15/00
CPC分类号： C23C18/1848 , C23C18/1834 , C23C18/32 , C23C18/36 , C25D11/026 , C25D11/04 , C25D11/18 , C25D11/26 , C25D11/30 , C25D11/34
摘要： A method for electorless plating of a substrate such as magnesium, aluminium, titanium or an alloy, comprises the steps of forming a very thin film of oxide on the substrate by plasma electrolytic oxidation before depositing a layer comprising nickel on the substrate by electroless nickel deposition.
摘要翻译：一种用于对诸如镁，铝，钛或合金的基底进行无电镀的方法包括以下步骤：通过等离子体电解氧化在衬底上形成非常薄的氧化物薄膜，然后通过无电镀镍沉积。

7. 发明申请

WO2022116203A1 SYSTEMS AND METHODS FOR UTILIZING MACHINE LEARNING TO MONITOR VEHICLE HEALTH 审中-公开
公开(公告)号：WO2022116203A1
公开(公告)日：2022-06-09
申请号：PCT/CN2020/134075
申请日：2020-12-04
申请人： CUMMINS INC. , GAO, Wei
发明人： CAO, Alex , GAO, Wei , LI, Bruce , LIU, Jiarui , PENG, Lixin , SHUAI, Sun , TANG, Steven , WANG, Xuewei , WU, Pingyu , ZHONG, Victor
IPC分类号： G06K9/62
摘要： A system includes a controller coupled to a vehicle system. The controller is structured to determine a predicted parameter regarding operation of the vehicle system based on execution of a machine learning predictive model utilizing a vehicle parameter associated with the predicted parameter, compare the predicted parameter to an actual vehicle parameter of the same operation of the vehicle system to determine a relationship between the predicted parameter and the actual vehicle parameter, run an iterations of the machine learning predictive model to determine the relationship between the predicted parameter and the actual vehicle parameter, use the machine learning predictive model to detect an error value if a difference between the predicted parameter and the actual vehicle parameter is at or above a predetermined threshold, use the relationship to predict the operation of the vehicle system, and generate an alert based on the detected error value.

8. 发明申请

WO2019128736A1 AQUEOUS THICKENER BLEND COMPOSITION 审中-公开
公开(公告)号：WO2019128736A1
公开(公告)日：2019-07-04
申请号：PCT/CN2018/121173
申请日：2018-12-14
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS COMPANY , CUI, Longlan , WANG, Rui , LI, Ling , GAO, Wei
发明人： CUI, Longlan , WANG, Rui , LI, Ling , GAO, Wei
IPC分类号： C08L33/08 , C08L33/10 , C08F216/16
摘要： An aqueous thickener blend composition comprising an aqueous hydrophobically-modified alkali soluble or alkali swellable thickener composition and an acid-suppressible associative thickener composition, affording high thickening efficiency and providing an aqueous coating composition comprising such aqueous thickener blend composition with good heat-age stability and color float stability.

9. 发明申请

WO2012144790A1 CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME 审中-公开
标题翻译：非生产菌株的循环肽，其生产方法和用于预防或治疗包含其的MYCOBACTERIA相关疾病的药物组合物
公开(公告)号：WO2012144790A1
公开(公告)日：2012-10-26
申请号：PCT/KR2012/002933
申请日：2012-04-18
申请人： B&C BIOPHARM CO., LTD. , MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION FOUNDATION , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , KIM, Jong Woo , LEE, Sang Wook , PARK, Sang Jin , SUH, Joo Won , LEE, In Ae , YOON, Tae Mi , CHOI, Jong Keun , LEE, Ji Ean , KIM, Jin Yong , JIN, Ying Yu , FRANZBLAU, Scott , CHO, Sanghyun , GAO, Wei , PAULI, Guido , McALPINE, James , NAPOLITANO, Jose , JAKI, Birgit , FRIESEN, Brent , RODRIGUEZ BRASCO, Maria Florencia , LANKIN, David
发明人： KIM, Jong Woo , LEE, Sang Wook , PARK, Sang Jin , SUH, Joo Won , LEE, In Ae , YOON, Tae Mi , CHOI, Jong Keun , LEE, Ji Ean , KIM, Jin Yong , JIN, Ying Yu , FRANZBLAU, Scott , CHO, Sanghyun , GAO, Wei , PAULI, Guido , McALPINE, James , NAPOLITANO, Jose , JAKI, Birgit , FRIESEN, Brent , RODRIGUEZ BRASCO, Maria Florencia , LANKIN, David
IPC分类号： C07K7/64
CPC分类号： C07K7/54 , A61K38/00 , C07K7/08
摘要： The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis , including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
摘要翻译：本发明涉及来自Nonomuraea sp。的新型抗TB环肽。 MJM5123是生产抗结核肽的方法和用于预防和治疗包含其的分枝杆菌感染的药物组合物。本发明的组合物对复制/非复制性结核分枝杆菌（包括MDR和XDR菌株）具有高度活性，因此可有效地用作结核病的治疗剂。

10. 发明申请

WO2010045754A1 METHOD FOR SINGULATING ELECTRONIC COMPONENTS FROM A SUBSTRATE 审中-公开
标题翻译：从基板上组合电子元件的方法
公开(公告)号：WO2010045754A1
公开(公告)日：2010-04-29
申请号：PCT/CN2008/001790
申请日：2008-10-23
申请人： FREESCALE SEMICONDUCTOR INC. , GAO, Wei , AMRINE, Craig, S. , GONG, Zhiwei , HAYES, Scott, M. , KESER, Lizabeth, Ann , LEAL, George, R. , LYTLE, William, H.
发明人： GAO, Wei , AMRINE, Craig, S. , GONG, Zhiwei , HAYES, Scott, M. , KESER, Lizabeth, Ann , LEAL, George, R. , LYTLE, William, H.
IPC分类号： H01L21/304 , H01L21/78 , H01L21/301 , H01L21/70 , H01L21/00
CPC分类号： H01L21/67092 , H01L21/568 , H01L21/67132 , H01L21/6835 , H01L21/78 , H01L23/3128 , H01L24/19 , H01L24/96 , H01L24/97 , H01L2221/68322 , H01L2221/68331 , H01L2224/0401 , H01L2224/04105 , H01L2224/12105 , H01L2224/20 , H01L2224/97 , H01L2924/01006 , H01L2924/01013 , H01L2924/01033 , H01L2924/014 , H01L2924/10329 , H01L2924/14 , H01L2924/15174 , H01L2924/15311 , H01L2924/181 , H01L2924/3511 , H01L2224/82 , H01L2924/00012 , H01L2924/00
摘要： Methods for forming electronic assemblies are provided. A device substrate (50) having a plurality of electronic components (42) embedded therein is provided. The device substrate (50) is attached to a carrier substrate (54) using an adhesive material (56). A plurality of cuts (68) are formed through the device substrate (50) to divide the device substrate into a plurality of portions (70). Each of the plurality of portions (70) includes at least one of the electronic components (42). A force is applied to each of the plurality of portions in a direction away from the carrier substrate (54) to remove the plurality of portions (70) from the carrier substrate (54).
摘要翻译：提供了形成电子组件的方法。提供具有嵌入其中的多个电子部件（42）的器件基板（50）。使用粘合剂材料（56）将器件衬底（50）附接到载体衬底（54）。通过装置基板（50）形成多个切口（68），以将装置基板分成多个部分（70）。多个部分（70）中的每一个包括电子部件（42）中的至少一个。在远离载体基板（54）的方向上对多个部分中的每一个施加力，以从载体基板（54）移除多个部分（70）。

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