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1. 发明申请

WO2007076688A1 METHODS AND DEVICES FOR CONTROLLING TEMPERATURE WITHOUT TEMPERATURE SENSOR 审中-公开
标题翻译：用于控制温度无温度传感器的方法和装置
公开(公告)号：WO2007076688A1
公开(公告)日：2007-07-12
申请号：PCT/CN2006/003542
申请日：2006-12-22
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUO, Min , SHEN, Keyue , ZHOU, Cheng , GUAN, Xiaosheng , CHENG, Jing
发明人： GUO, Min , SHEN, Keyue , ZHOU, Cheng , GUAN, Xiaosheng , CHENG, Jing
IPC分类号： G05D23/19 , H05B6/06 , G01K7/18
CPC分类号： G01K7/18 , G01K7/183 , G05D23/2401
摘要： Methods and devices for controlling temperature by precise heating without the need of using a temperature sensor are provided. The device comprises a resistive heating element (6), a controller (3), a heating circuit and a temperature sensing circuit. The temperature of the resistive heating element can be determined based on the resistance of the resistive heating element (6), which changes monotonically with its temperature. The resistive heating element (6) thus serves both as a heating element and as a temperature sensor, thereby obviating the need for a separate temperature sensor.
摘要翻译：提供了通过精确加热来控制温度而不需要使用温度传感器的方法和装置。该装置包括电阻加热元件（6），控制器（3），加热电路和温度检测电路。电阻加热元件的温度可以基于其温度单调变化的电阻加热元件（6）的电阻来确定。因此，电阻加热元件（6）既用作加热元件又用作温度传感器，从而避免需要单独的温度传感器。

2. 发明申请

WO2007082466A1 A CAPILLARY HEATING DEVICE 审中-公开
标题翻译：毛细管加热装置
公开(公告)号：WO2007082466A1
公开(公告)日：2007-07-26
申请号：PCT/CN2007/000161
申请日：2007-01-16
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUO, Min , SHEN, Keyue , ZHOU, Cheng , GUAN, Xiaosheng , CHENG, Jing
发明人： GUO, Min , SHEN, Keyue , ZHOU, Cheng , GUAN, Xiaosheng , CHENG, Jing
IPC分类号： B01L7/00
CPC分类号： B01L7/00 , B01L7/54 , B01L2200/147 , B01L2300/0838 , B01L2300/1827 , H05B3/42
摘要： A capillary heating device comprises a capillary tube for passing fluid, a resistive heating element (4) for heating the capillary tube, and a temperature regulation element for modifying the temperature of the capillary tube. The temperature regulation element can either be sandwiched between the resistive heating element (4) and the outer surface of the capillary tube, or wraps around the resistive heating element (4) and the capillary tube.
摘要翻译：毛细管加热装置包括用于通过流体的毛细管，用于加热毛细管的电阻加热元件（4）和用于改变毛细管温度的温度调节元件。温度调节元件可以夹在电阻加热元件（4）和毛细管的外表面之间，或者缠绕在电阻加热元件（4）和毛细管周围。

3. 发明申请

WO2007071174A1 BUBBLE-RESISTANT INJECTOR PORT FOR FLUIDIC DEVICES 审中-公开
标题翻译：用于流体设备的防爆喷嘴
公开(公告)号：WO2007071174A1
公开(公告)日：2007-06-28
申请号：PCT/CN2006/003471
申请日：2006-12-18
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUAN, Xiaosheng , HU, Yuming , GUO, Min , ZHOU, Cheng , CHENG, Jing
发明人： GUAN, Xiaosheng , HU, Yuming , GUO, Min , ZHOU, Cheng , CHENG, Jing
IPC分类号： G01N35/08
CPC分类号： G01N35/1095 , B01L3/502715 , B01L2200/027 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , G01N2035/1018 , Y10T156/10
摘要： An bubble-resistant injector port for fluidic and microfluidic devices includes an air-exhaustion feature to reduce the inclusion of bubbles or voids in injected samples, particularly in samples injected by a micropipette. The air-exhaustion feature comprises an air-exhaustion cavity in gas communication with the injector port through a narrowed channel that permits a flow of air into the cavity, while impeding a flow of injected liquid into the cavity.
摘要翻译：用于流体和微流体装置的防泡喷射器端口包括空气排出特征，以减少注入的样品中的气泡或空隙的包含，特别是在通过微量移液管注射的样品中。空气耗尽特征包括通过狭窄通道与注射器端口气体连通的排气腔，其允许空气流入空腔，同时阻止注入的液体流入空腔。

4. 发明申请

WO2007109956A1 FLUIDIC FLOW MERGING APPARATUS 审中-公开
标题翻译：流体流动装置
公开(公告)号：WO2007109956A1
公开(公告)日：2007-10-04
申请号：PCT/CN2007/000401
申请日：2007-02-06
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUAN, Xiaosheng , GUO, Min , ZHOU, Cheng , HU, Yuming , CHENG, Jing
发明人： GUAN, Xiaosheng , GUO, Min , ZHOU, Cheng , HU, Yuming , CHENG, Jing
IPC分类号： G05D7/00 , B01L3/00 , G01N27/447 , F17D1/08 , F17D1/20
CPC分类号： G01N27/44704 , B01F5/04 , B01F13/0059 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2200/143 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B33Y80/00 , Y10T137/0329 , Y10T137/2076 , Y10T137/8766
摘要： The present invention provides a device for handling fluids, and more particularly a merging apparatus for fluidic and microfluidic devices utilizing passive valving in conjunction with a single sensor to uniformly blend contributory working fluid streams. Symmetric and non symmetric embodiments with and without branch channels are described. The present invention also provides methods for merging liquids using the device of the invention.
摘要翻译：本发明提供了一种用于处理流体的装置，更具体地说，一种用于流体和微流体装置的合并装置，其利用与单个传感器结合的无源阀来均匀地混合贡献的工作流体流。描述了具有和不具有分支信道的对称和非对称实施例。本发明还提供了使用本发明的装置来合并液体的方法。

5. 发明申请

WO2007082480A1 CARTRIDGE-BASED MICROFLUIDIC ANALYZER 审中-公开
标题翻译：基于CARTRIDGE的微流感分析仪
公开(公告)号：WO2007082480A1
公开(公告)日：2007-07-26
申请号：PCT/CN2007/000198
申请日：2007-01-18
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUO, Min , GUAN, Xiaosheng , ZHOU, Cheng , WENG, Dongxu , HU, Yuming , ZHANG, Wanjie , GUO, Yonggang , ZHANG, Guanbin , CHENG, Jing
发明人： GUO, Min , GUAN, Xiaosheng , ZHOU, Cheng , WENG, Dongxu , HU, Yuming , ZHANG, Wanjie , GUO, Yonggang , ZHANG, Guanbin , CHENG, Jing
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L2200/0631 , B01L2200/10 , B01L2200/143 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0887 , B01L2300/1827 , B01L2300/1883 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , C12Q2565/628
摘要： An integrated polynucleotide amplification and nucleotide sequence identification system comprises an expendable microfluidic cartridge and a reusable external unit. Sample fluids and reagents are confined to the expendable microfluidic cartridge for processing. The reusable external unit comprises pumps, valves, sensors, and temperature controllers. Polynucleotide sample amplification through polymerase chain reaction (PCR), and nucleotide sequence identification using oligonucleotide arrays can be conducted in an automatic, integrated process.
摘要翻译：整合的多核苷酸扩增和核苷酸序列鉴定系统包括消耗性微流控盒和可重复使用的外部单元。样品流体和试剂限于消耗性微流控筒用于加工。可重复使用的外部单元包括泵，阀，传感器和温度控制器。通过聚合酶链反应（PCR）的多核苷酸样品扩增和使用寡核苷酸阵列的核苷酸序列鉴定可以在自动综合过程中进行。

6. 发明申请

WO2007071165A1 WICKING INHIBITOR FOR FLUIDIC DEVICES 审中-公开
标题翻译：用于流体设备的防静电剂
公开(公告)号：WO2007071165A1
公开(公告)日：2007-06-28
申请号：PCT/CN2006/003426
申请日：2006-12-15
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUAN, Xiaosheng , GUO, Min , ZHOU, Cheng , HU, Yuming , CHENG, Jing
发明人： GUAN, Xiaosheng , GUO, Min , ZHOU, Cheng , HU, Yuming , CHENG, Jing
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L2200/12 , B01L2300/0816 , B01L2400/0688 , B01L2400/084 , B33Y80/00
摘要： An wicking inhibitor for fluidic and microfluidic devices reduces wicking by providing a structure that interrupts the flow of a working fluid through a fluidic channel interface having corner angles greater than ninety degrees.
摘要翻译：用于流体和微流体装置的芯吸抑制剂通过提供通过具有大于九十度的角角的流体通道界面来中断工作流体的流动的结构来减少芯吸。

7. 发明申请

WO2008083526A1 MICROFLUIDIC DEVICES AND METHODS FOR MULTIPLE ANALYTE DETECTION 审中-公开
标题翻译：微流体装置和多种分析物检测方法
公开(公告)号：WO2008083526A1
公开(公告)日：2008-07-17
申请号：PCT/CN2007/000757
申请日：2007-03-09
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUAN, Xiaosheng , GUO, Min , ZHANG, Rong , DONG, Dong , HU, Yuming , CUI, Ting , CHENG, Jing
发明人： GUAN, Xiaosheng , GUO, Min , ZHANG, Rong , DONG, Dong , HU, Yuming , CUI, Ting , CHENG, Jing
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L3/50273 , B01L7/52 , B01L2200/0605 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2400/0487 , G01N35/08 , G01N35/10 , G01N2035/00356 , G01N2035/1032 , G01N2035/1034 , Y10T137/0396 , Y10T436/2575
摘要： The invention is directed to microfluidic devices comprising at least two processing channels, wherein each of the processing channels comprises an inlet, an outlet, and a high-flow-resistant and hydrophilic conduit; a distributing channel, wherein the distributing channel comprises an upstream end and a downstream end, and is in fluid communication with each inlet of the processing channels via the high-flow-resistant and hydrophilic conduit; and a flushing channel, wherein the flushing channel comprises an upstream end and a downstream end, and is in fluid communication with each outlet of the processing channels. The invention also provides methods of using the microfluidic devices.
摘要翻译：本发明涉及包括至少两个处理通道的微流体装置，其中每个处理通道包括入口，出口和高流阻和亲水导管; 分配通道，其中所述分配通道包括上游端和下游端，并且经由所述高阻流和亲水导管与所述处理通道的每个入口流体连通; 和冲洗通道，其中所述冲洗通道包括上游端和下游端，并且与所述处理通道的每个出口流体连通。本发明还提供使用微流体装置的方法。

8. 发明申请

WO2007079663A1 METHODS FOR IMPROVING EFFICIENCY OF CELL ELECTROPORATION USING DIELECTROPHORESES 审中-公开
标题翻译：使用电介质提高电解质电解效率的方法
公开(公告)号：WO2007079663A1
公开(公告)日：2007-07-19
申请号：PCT/CN2007/000012
申请日：2007-01-04
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , WANG, Lei , WANG, Lei , GUO, Min , CHENG, Jing
发明人： WANG, Lei , WANG, Lei , GUO, Min , CHENG, Jing
IPC分类号： C12N15/87 , C12N13/00 , C12M1/42 , C12N5/10
CPC分类号： C12N13/00 , C12M23/16 , C12M33/00 , C12M35/02
摘要： The present invention provides methods for enhancing the efficiency of cell electroporation using dielectrophoresis-assisted cell localization and uses thereof in a microfluidic biochip system. Cells are first subject to dielectrophoresis and localized to regions where the electric field intensity is high enough to render cells electroporated. The invention enhances the efficiency of in situ cell electroporation on a traditional microfluidic biochip.
摘要翻译：本发明提供使用介电电泳辅助细胞定位提高细胞电穿孔效率的方法及其在微流体生物芯片系统中的用途。细胞首先进行介导电泳，并定位于电场强度足以使细胞电穿孔的区域。本发明增强了传统微流体生物芯片上原位细胞电穿孔的效率。

9. 发明申请

WO2007076687A1 MULTI-CHANNEL CAPILLARY ELECTROPHORESIS MICROCHIPS AND USES THEREOF 审中-公开
标题翻译：多通道毛细管电泳细胞及其用途
公开(公告)号：WO2007076687A1
公开(公告)日：2007-07-12
申请号：PCT/CN2006/003541
申请日：2006-12-22
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , GUO, Min , DU, Guibin , GU, Guangsheng , XING, Wanli , CHENG, Jing
发明人： GUO, Min , DU, Guibin , GU, Guangsheng , XING, Wanli , CHENG, Jing
IPC分类号： G01N27/447
CPC分类号： G01N27/44791
摘要： A multi-channel capillary electrophoresis microchip for analysis of multiple samples comprising: at least two sample reservoirs, at least two sample channels corresponding to said sample reservoirs, a sample buffer reservoir, a sample waste reservoir, a separation buffer reservoir, a separation waste reservoir, a sample loading channel, and a separation channel, wherein each of said sample channels is connected at one end to said sample loading channel at a place between said sample buffer reservoir and said intersection of said sample loading channel and said separation channel, and the other end of each of said sample channels is connected to each of said sample reservoirs. A method of capillary electrophoresis separation for sequentially analysis of multiple samples.
摘要翻译：一种用于分析多个样品的多通道毛细管电泳微芯片，包括：至少两个样品储存器，对应于所述样品储存器的至少两个样品通道，样品缓冲液储存器，样品废物储存器，分离缓冲液储存器，分离废液储存器，样品加载通道和分离通道，其中每个所述样品通道在一端连接到所述样品缓冲液储存器和所述样品加载通道与所述分离通道的交叉点之间的位置处的所述样品加载通道，并且每个所述样品通道的另一端连接到每个所述样品储存器。毛细管电泳分离方法，用于顺序分析多个样品。

10. 发明申请

WO2004067964A1 A METHOD FOR FLUID TRANSFER AND THE MICRO PERISTALTIC PUMP 审中-公开
标题翻译：一种流体传递方法和微乳液泵
公开(公告)号：WO2004067964A1
公开(公告)日：2004-08-12
申请号：PCT/CN2003/000563
申请日：2003-07-14
申请人： TSINGHUA UNIVERSITY , CAPITAL BIOCHIP COMPANY, LTD. , LIU, Chengxun , GUO, Min , CHENG, Jing
发明人： LIU, Chengxun , GUO, Min , CHENG, Jing
IPC分类号： F04B43/14
CPC分类号： F04B43/02 , F04B43/028 , F04B43/14
摘要： This invention relates generally to a method for fluid transfer and a micro peristaltic pump based upon the method. The micro peristaltic pump, which comprises: a) an actuating part compring a motor and a first force effector driven by the motor; b) a cartridge part comprising an elastic membrane attached to a cartridge body, wherein said elastic membrane attached to said cartridge body forms an enclosed space within the cartridge body comprising at least three chambers, and the cartridge also comprising a second force effector which interacts with the first force effector; c) at least three said chambers have inlets and outlets, which are sealingly connected in tandem. Compared with prior art in the micro pump field, the micro peristaltic pump in this invention can generate much greater actuating forces with equivalent overall size. In addition, since the micro peristaltic pump is composed by two separate parts, with one entirely close and disposable and the other reusable, the performance of this micro pump is very high with low cost for production.
摘要翻译：本发明一般涉及一种基于该方法的流体转移方法和微型蠕动泵。微型蠕动泵，包括：a）一个驱动部件，包括一个马达和一个由马达驱动的第一个力效应器; b）包括附接到盒体的弹性膜的盒部件，其中附接到所述盒体的所述弹性膜在所述盒体内形成包括至少三个室的封闭空间，并且所述盒还包括与第二力效应器相互作用的第二力效应器第一个力效应器; c）至少三个所述腔室具有串联密封连接的入口和出口。与微泵领域的现有技术相比，本发明的微蠕动泵可以产生相当大的致动力。另外，由于微型蠕动泵由两个独立的部件组成，其中一个完全紧密且一次性可重复使用，另一个可重复使用，该微型泵的性能非常高，生产成本低。

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