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1. 发明申请

WO2011028860A2 COMPOUNDS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：WO2011028860A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047615
申请日：2010-09-02
申请人： CANTHERA THERAPEUTICS, INC. , FOLEY, Michael, Andrew , GOULD, Robert , ELLIOT, Peter , MANDINOVA, Anna , LEE, Sam
发明人： FOLEY, Michael, Andrew , GOULD, Robert , ELLIOT, Peter , MANDINOVA, Anna , LEE, Sam
IPC分类号： C07D413/12 , C07D211/76 , A61K31/5377 , A61P35/00
CPC分类号： C07D211/86 , A61K31/4412 , A61K31/5377
摘要： The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.
摘要翻译：本发明涉及用于治疗和预防癌症的化合物和组合物。本发明还包括可以通过选择性调节患病细胞与正常细胞中活性氧水平的水平来治疗的所有疾病。还公开了用于制备和施用这种组合物的方法。

2. 发明公开

EP2473506A2 COMPOUNDS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：EP2473506A2
公开(公告)日：2012-07-11
申请号：EP10814469.2
申请日：2010-09-02
申请人： Canthera Therapeutics, Inc.
发明人： FOLEY, Michael, Andrew , GOULD, Robert , ELLIOT, Peter , MANDINOVA, Anna , LEE, Sam
IPC分类号： C07D413/12 , C07D211/76 , A61K31/5377 , A61P35/00
CPC分类号： C07D211/86 , A61K31/4412 , A61K31/5377
摘要： The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.
摘要翻译：本发明涉及用于治疗和预防癌症的化合物和组合物。本发明还包括可以通过选择性调节患病细胞与正常细胞中活性氧水平的水平来治疗的所有疾病。还公开了用于制备和施用这种组合物的方法。

3. 发明申请

WO2005119186A1 RECONFIGURABLE METERED MATERIAL DISPENSER 审中-公开
标题翻译：可重新配置的计量材料分配器
公开(公告)号：WO2005119186A1
公开(公告)日：2005-12-15
申请号：PCT/US2004/041755
申请日：2004-12-14
申请人： SONOCO DEVELOPEMENT, INC. , PETERSON, Scott , TUCKER, Michael , ELLIOT, Peter , JOHANSON, James, E. , BARANOV, Fedor , BARANOV, Innesa , ANTAL, Keith, E., Sr.
发明人： PETERSON, Scott , TUCKER, Michael , ELLIOT, Peter , JOHANSON, James, E. , BARANOV, Fedor , BARANOV, Innesa , ANTAL, Keith, E., Sr.
IPC分类号： G01F11/26
CPC分类号： G01F11/261
摘要： A dispenser is provided for delivering a controlled quantity of a granular material. The dispenser includes a container assembly, a diffuser and a metering cup. The container includes a reservoir which supports a disposable cartridge of granular material. The cartridge is supported in the reservoir so as to define a passageway therebetween. A nozzle is defined for the outflow of material from the cartridge. The diffuser is disposed on one end of the container and includes a plurality of apertures. The metering cup is disposed on the opposite end of the container and has an open end adapted to receive granular material. Adjustment of the axial spacing between the nozzle and metering cup varies the quantity of granular material collected in the cup. The granular material is dispensed by inverting the container to a second orientation, such that material flows out of the metering cup, through the passageway and out of the diffuser. The nozzle may serve as a piercing mechanism for opening the disposable cartridge upon its insertion into the reservoir.
摘要翻译：提供分配器用于输送受控量的颗粒材料。分配器包括容器组件，扩散器和计量杯。容器包括一个支撑粒状材料的一次性盒的储存器。墨盒被支撑在储存器中，以便在其间限定通道。一个喷嘴被定义为用于材料从墨盒中流出。扩散器设置在容器的一端并且包括多个孔。计量杯设置在容器的相对端，并且具有适于容纳颗粒材料的开口端。喷嘴和计量杯之间的轴向间距的调节会改变杯中收集的颗粒物质的数量。通过将容器翻转到第二取向来分配颗粒材料，使得材料从计量杯中流出通过通道并离开扩散器。喷嘴可以用作穿刺机构，用于在一次性盒被插入储存器中时打开一次性盒。

4. 发明申请

WO2009140562A1 SIRT1 POLYMORPHIC VARIANTS AND METHODS OF USE THEREOF 审中-公开
标题翻译： SIRT1多态性变体及其使用方法
公开(公告)号：WO2009140562A1
公开(公告)日：2009-11-19
申请号：PCT/US2009/044054
申请日：2009-05-15
申请人： SIRTRIS PHARMACEUTICALS, INC. , WESTPHAL, Christoph, H. , UNIVERSITY OF ZURICH , DONATH, Marc , ELLIOT, Peter , JIROUSEK, Michael , MILNE, Jill
发明人： WESTPHAL, Christoph, H. , DONATH, Marc , ELLIOT, Peter , JIROUSEK, Michael , MILNE, Jill
IPC分类号： C12Q1/68
CPC分类号： C07K14/4702 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein are Sirtl polymorphic variants having a substitution at amino acid residue 107 or nucleotide 373. In certain embodiments, the Sirt1 polypeptide variants have a L107P substitution and the nucleic acid variants have a T373C substitution. Genetic and/or biochemical testing may be performed to identify whether a patient carries one of the disclosed polymorphic variants. Based on the polymorphic variant the patient carries, a medical practitioner may administer an appropriate therapy, such as a sirtuin activator.
摘要翻译：本文提供了在氨基酸残基107或核苷酸373处具有取代的Sirt1多态性变体。在某些实施方案中，Sirt1多肽变体具有L107P取代，并且核酸变体具有T373C取代。可以进行遗传和/或生化测试以鉴定患者是否携带所公开的多态变体之一。基于患者携带的多态变体，医师可以施用适当的治疗，例如沉默调节蛋白激活剂。

5. 发明申请

WO2006076681A2 NOVEL COMPOSITIONS FOR PREVENTING AND TREATING NEURODEGENERATIVE AND BLOOD COAGULATION DISORDERS 审中-公开
标题翻译：用于预防和治疗神经损伤和血液凝血障碍的新型组合物
公开(公告)号：WO2006076681A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/001428
申请日：2006-01-13
申请人： SIRTRIS PHARMACEUTICALS, INC. , MILBURN, Michael , MILNE, Jill , WESTPHAL, Christopher, H. , NORMINGTON, Karl, D. , FUJII, Jennifer , DIPP, Michelle , ELLIOT, Peter
发明人： MILBURN, Michael , MILNE, Jill , WESTPHAL, Christopher, H. , NORMINGTON, Karl, D. , FUJII, Jennifer , DIPP, Michelle , ELLIOT, Peter
CPC分类号： A61K31/065 , A61K31/05 , A61K31/353 , A61K31/7048
摘要： Provided herein are methods and compositions for treating or preventing neurodegenerative disorders or blood coagulation disorders. Methods may comprise modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as nicotinamide.
摘要翻译：本文提供了用于治疗或预防神经变性疾病或血液凝固障碍的方法和组合物。方法可以包括调节sirtuin的活性或水平，例如SIRT1或Sir2。示例性方法包括使细胞与沉默调节蛋白激活化合物如黄酮，芪，黄酮酮，异黄酮，儿茶素，查耳酮，单宁或花色素接触; 或抑制性化合物，例如烟酰胺。

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