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1. 发明授权

US10261223B2 System and method for fabrication of miniature endoscope using nanoimprint lithography 有权
公开(公告)号：US10261223B2
公开(公告)日：2019-04-16
申请号：US15115206
申请日：2015-01-30
申请人： CANON U.S.A., INC. , THE GENERAL HOSPITAL CORPORATION , Guillermo J Tearney , Dongkyun Kang , Mitsuhiro Ikuta , George M. Whitesides , Ramses V. Martinez
发明人： Guillermo J Tearney , Dongkyun Kang , Mitsuhiro Ikuta , George M. Whitesides , Ramses V. Martinez
IPC分类号： G02B5/18 , B29D11/00 , G02B23/24 , G02B27/42 , B29K105/00
摘要： Exemplary method and system for providing a diffractive configuration in an optical arrangement are provided. For example, a material can be provided with at least one patterned surface having a very high aspect ratio. The material can be connected with at least one portion of a waveguide arrangement using a pre-polymer adhesive composition. Further, the pre-polymer adhesive composition can be caused to polymerize so as to form the diffractive configuration which at least approximately replicates a structure or at least one feature of the patterned surface.

2. 发明申请

US20160349417A1 SYSTEM AND METHOD FOR FABRICATION OF MINIATURE ENDOSCOPE USING NANOIMPRINT LITHOGRAPHY 审中-公开
标题翻译：使用NANOIMPRINT LITHOGRAPHY制造微小内窥镜的系统和方法
公开(公告)号：US20160349417A1
公开(公告)日：2016-12-01
申请号：US15115206
申请日：2015-01-30
申请人： Guillermo J. TEARNEY , Dongkyun KANG , Mitsuhiro IKUTA , George M. WHITESIDES , Ramses V. MARTINEZ , CANON U.S.A., INC. , THE GENERAL HOSPITAL CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Guillermo J Tearney , Dongkyun Kang , Mitsuhiro Ikuta , George M. Whitesides , Ramses V. Martinez
IPC分类号： G02B5/18 , G02B23/24 , B29D11/00 , G02B27/42
CPC分类号： G02B5/1852 , B29D11/00769 , B29K2105/0002 , B29K2995/0027 , G02B5/1814 , G02B5/1847 , G02B23/2423 , G02B23/2469 , G02B27/4244
摘要： Exemplary method and system for providing a diffractive configuration in an optical arrangement are provided. For example, a material can be provided with at least one patterned surface having a very high aspect ratio. The material can be connected with at least one portion of a waveguide arrangement using a pre-polymer adhesive composition. Further, the pre-polymer adhesive composition can be caused to polymerize so as to form the diffractive configuration which at least approximately replicates a structure or at least one feature of the patterned surface.
摘要翻译：提供了用于在光学装置中提供衍射构造的示例性方法和系统。例如，材料可以设置有具有非常高的纵横比的至少一个图案化表面。该材料可以使用预聚物粘合剂组合物与波导布置的至少一部分连接。此外，可以使预聚物粘合剂组合物聚合以形成至少近似复制图案化表面的结构或至少一个特征的衍射构型。

3. 发明授权

US10578422B2 Devices, systems, methods and storage mediums using full range optical coherence tomography 有权
公开(公告)号：US10578422B2
公开(公告)日：2020-03-03
申请号：US15617928
申请日：2017-06-08
申请人： Canon U.S.A. Inc. , The General Hospital Corporation
发明人： Daisuke Yamada , Guillermo J Tearney
IPC分类号： G01B9/02 , A61B5/00
摘要： One or more devices, systems, methods and storage mediums for performing continuously, full range optical coherence tomography (OCT) without losing A-lines are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes (e.g., common path probes), catheters, endoscopes, phase shift units (e.g., galvanometer scanner) and bench top systems. Preferably, the OCT devices, systems methods and storage mediums include or involve a phase shift device including at least a galvanometer scanner. The galvanometer scanner is preferably applied with or to a voltage with a triangle shape, the voltage having continuity or absolute constant frequency to obtain continuous images without losing any A-lines. The method(s) may include background subtraction, image shifting to compensate phase shifts and a DC noise reduction algorism.

4. 发明申请

US20080287808A1 APPARATUS, PROBE AND METHOD FOR PROVIDING DEPTH ASSESSMENT IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：在解剖结构中提供深度评估的装置，探针和方法
公开(公告)号：US20080287808A1
公开(公告)日：2008-11-20
申请号：US11854199
申请日：2007-09-12
申请人： Guillermo J Tearney , Brett Eugene Bouma
发明人： Guillermo J Tearney , Brett Eugene Bouma
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/445 , A61B2562/0242
摘要： Apparatus and method can be provided for obtaining information regarding at least one portion of an anatomical structure. For example, using at least one first arrangement, it is possible to forward at least one first electromagnetic radiation to the at least one portion. In addition, using at least one second arrangement, it is possible to detect at least one second electromagnetic radiation from the sample, the second electromagnetic radiation being related to the first electromagnetic radiation. The second arrangement can be used to obtain data associated with the second electromagnetic radiation at a plurality of integration times. Further, with at least one third arrangement, it is possible to determine at least one motion characteristic as a function of depth within the portion using the second electromagnetic radiation. The motion characteristic can be determined by obtaining data associated with the second electromagnetic radiation. The data can be speckle data detected by the second arrangement. In addition, using the third arrangement, it is possible to determine optical properties of the portion based on the data. Furthermore, with a fourth arrangement, it is possible to receive the first electromagnetic radiation and generate a plurality of third electromagnetic radiations to irradiate multiple points on the portion. The second arrangement can be used to detect the second electromagnetic radiation from the sample based on the third electromagnetic radiations, and the third arrangement can also be used to determine a plurality of motion characteristics as a function of depth for a plurality of location of the at least one portion as a function of the second electromagnetic radiation.
摘要翻译：可以提供装置和方法来获得关于解剖结构的至少一部分的信息。例如，使用至少一个第一布置，可以将至少一个第一电磁辐射转发到至少一个部分。另外，使用至少一个第二布置，可以检测来自样品的至少一个第二电磁辐射，第二电磁辐射与第一电磁辐射有关。第二布置可以用于在多个积分时间获得与第二电磁辐射相关联的数据。此外，利用至少一个第三布置，可以使用第二电磁辐射来确定作为深度的函数的至少一个运动特性。可以通过获得与第二电磁辐射相关联的数据来确定运动特性。数据可以是由第二布置检测到的斑点数据。另外，使用第三布置，可以基于数据来确定该部分的光学特性。此外，通过第四布置，可以接收第一电磁辐射并产生多个第三电磁辐射以照射该部分上的多个点。第二布置可以用于基于第三电磁辐射来检测来自样本的第二电磁辐射，并且第三布置还可以用于确定多个运动特性作为对于多个位置的at的深度的函数作为第二电磁辐射的函数的至少一部分。

5. 发明授权

US07796270B2 Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques 有权
标题翻译：基于一个或多个频谱编码的内窥镜技术产生数据的系统和方法
公开(公告)号：US07796270B2
公开(公告)日：2010-09-14
申请号：US11621694
申请日：2007-01-10
申请人： Dvir Yelin , Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J Tearney
发明人： Dvir Yelin , Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J Tearney
IPC分类号： G01B9/02 , G01J3/45 , G01N21/00
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/6852 , A61B5/7257 , A61B5/726 , G01B9/02002 , G01B9/02036 , G01B9/02037 , G01B9/02044 , G01B9/02091 , G01N21/359 , G01N2021/1782 , G01N2021/1787 , G01N2021/3595
摘要： Exemplary systems and methods for generating data associated with at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to provide a particular radiation using at least one first arrangement. The particular radiation can include at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement. The first radiation and/or the second radiation can comprise a plurality of wavelengths. The first electro-magnetic radiation can be spectrally dispersed along at least one portion of the sample. The second electro-magnetic radiation measured at two or more different lengths of the reference arrangement with respect to the first arrangement. Data can be generated which is associated with the first and second electro-magnetic radiations obtained at the two different lengths using at least one second arrangement which comprises a spectrometer arrangement.
摘要翻译：可以提供用于产生与样品的至少一部分相关联的数据的示例性系统和方法。例如，根据这样的系统和方法的一个示例性实施例，可以使用至少一个第一布置来提供特定的辐射。特定的辐射可以包括被引导至至少一个样品的至少一个第一电磁辐射和指向参考装置的至少一个第二电磁辐射。第一辐射和/或第二辐射可以包括多个波长。第一电磁辐射可沿样品的至少一部分光谱分散。在参考装置的两个或多个不同长度处相对于第一装置测量的第二电磁辐射。可以生成与使用包括光谱仪布置的至少一个第二布置在两个不同长度获得的第一和第二电磁辐射相关联的数据。

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