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1. 发明申请

WO2007148095A2 METHODS FOR DETERMINING A PROGNOSIS OF COLORECTAL CANCER 审中-公开
标题翻译：确定色素性癌症的方法
公开(公告)号：WO2007148095A2
公开(公告)日：2007-12-27
申请号：PCT/GB2007/002316
申请日：2007-06-21
申请人： CANCER RESEARCH TECHNOLOGY LIMITED , HUTCHISON, Christopher , COX, Thomas , WILSON, Robert , PRZYBORSKI, Stefan , VAN ENGELAND, Manon , DE BRUINE, Adrian
发明人： HUTCHISON, Christopher , COX, Thomas , WILSON, Robert , PRZYBORSKI, Stefan , VAN ENGELAND, Manon , DE BRUINE, Adrian
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The invention provides methods for determining a prognosis of colorectal cancer in an individual comprising determining an A-type lamin status of an individual and using the A-type lamin status to determine the prognosis of the colorectal cancer, and more particularly for predicting outcomes of colorectal cancer in the individual such as the survival or mortality of the individual or the likelihood of recurrence of the colorectal cancer. Kits for use in carrying out these methods are also provided.
摘要翻译：本发明提供了确定个体中结肠直肠癌预后的方法，其包括确定个体的A型层状态，并使用A型层状态来确定结肠直肠癌的预后，更具体地，用于预测结肠直肠的结果个体中的癌症如个体的存活或死亡或结肠直肠癌复发的可能性。还提供了用于实施这些方法的试剂盒。

2. 发明公开

EP2044439A2 METHODS FOR DETERMINING A PROGNOSIS OF COLORECTAL CANCER 审中-公开
标题翻译：确定大肠癌预后的方法
公开(公告)号：EP2044439A2
公开(公告)日：2009-04-08
申请号：EP07733312.8
申请日：2007-06-21
申请人： Cancer Research Technology Limited
发明人： HUTCHISON, Christopher , COX, Thomas , WILSON, Robert , PRZYBORSKI, Stefan , VAN ENGELAND, Manon , DE BRUINE, Adrian
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The invention provides methods for determining a prognosis of colorectal cancer in an individual comprising determining an A-type lamin status of an individual and using the A-type lamin status to determine the prognosis of the colorectal cancer, and more particularly for predicting outcomes of colorectal cancer in the individual such as the survival or mortality of the individual or the likelihood of recurrence of the colorectal cancer. Kits for use in carrying out these methods are also provided.
摘要翻译：本发明提供了用于确定个体中结肠直肠癌预后的方法，包括确定个体的A型核纤层蛋白状态并使用A型核纤层蛋白状态来确定结直肠癌的预后，并且更具体地用于预测结肠直肠癌个体中的癌症例如个体的存活或死亡或结直肠癌复发的可能性。还提供了用于实施这些方法的试剂盒。

3. 发明申请

WO2015114377A1 EXERCISE APPARATUS 审中-公开
标题翻译：锻炼装置
公开(公告)号：WO2015114377A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/050257
申请日：2015-01-30
申请人： COX, Thomas
发明人： COX, Thomas
IPC分类号： A63B21/00 , A63B22/18 , A63B23/035 , A63B23/12 , A63B26/00 , A63B21/055 , A63B21/16
CPC分类号： A63B23/1236 , A63B21/0442 , A63B21/0552 , A63B21/0557 , A63B21/068 , A63B21/072 , A63B21/4035 , A63B21/4043 , A63B22/0002 , A63B22/18 , A63B23/02 , A63B23/03541 , A63B23/1272 , A63B26/003 , A63B2022/0092 , A63B2071/0072 , A63B2071/027 , A63B2210/50
摘要： Exercise apparatus, comprising a pair of handle elements, and a pair of housing elements, each handle element comprises a manually grippable bar and a base portion presenting a substantially spherical contact surface, each housing element is substantially hemispherical and defines a substantially central window, and each handle element is releasably locatable within a housing element to form a substantially hemispherical handle body in which the contact surface of the handle element is presented within the window of the housing element and provides a contact point about which the housing body is rotatable when located on a support surface.
摘要翻译：包括一对把手元件和一对外壳元件的锻炼设备，每个手柄元件包括手动可抓握杆和呈现基本上球形的接触表面的基部，每个壳体元件基本上是半球形的并且限定了大致中央的窗口，并且每个手柄元件可释放地定位在壳体元件内以形成大致半球状的手柄主体，其中手柄元件的接触表面呈现在壳体元件的窗口内，并提供接触点，壳体主体可位于该接触点处支撑面。

4. 发明申请

WO2014047447A2 FTO MODULATING COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译： FTO调节化合物及其使用方法
公开(公告)号：WO2014047447A2
公开(公告)日：2014-03-27
申请号：PCT/US2013/060934
申请日：2013-09-20
申请人： MIDWESTERN UNIVERSITY , OLSEN, Mark , ROWLES, Joie , IACOBAN, Paulina , TRIBBEY, Leah Mary , COX, Thomas
发明人： OLSEN, Mark , ROWLES, Joie , IACOBAN, Paulina , TRIBBEY, Leah Mary , COX, Thomas
IPC分类号： A61K31/34
CPC分类号： C07D417/04 , A61P35/00 , C07D307/32 , C07D307/66 , C07D405/04 , C07D405/12 , C07D409/04 , C12Q1/26
摘要： The present invention relates to compounds which modulate the level or activity of polypeptides having Fe(II) and 2-oxoglutarate (2QG)-dependent oxygenase activity in a cell, tissue, or subject, exemplified by the Fat Mass and Obesity Associated protein (FTO). Aspects relate to N-(3,4-dihydroxy-5-aryl-2-furanyl)-sulfonamides, methods for their synthesis, and methods of using these compounds to modulate the activity of FTO in a cell-free sample, a cell-based assay, and in a subject. Aspects are also directed to compositions comprising compounds which modulate the activity of FTO, including pharmaceutically-acceptable compositions, and to methods of preventing, ameliorating, or treating FTO-mediated conditions or diseases in a subject, including stroke, epilepsy, depression, and degenerative central nervous system disorders such as Alzheimer's and Parkinson's disease. Other aspects elate to use of the compounds to ameliorate or treat conditions associated with metabolic disorders, such as diabetes and obesity.
摘要翻译：本发明涉及调节在细胞，组织或受试者中具有Fe（II）和2-氧戊二酸（2QG） - 依赖性加氧酶活性的多肽的水平或活性的化合物，例如脂肪和肥胖相关蛋白（FTO ）。方面涉及N-（3,4-二羟基-5-芳基-2-呋喃基） - 磺酰胺，其合成方法以及使用这些化合物调节无细胞样品中FTO活性的方法，并且在受试者中。方面还涉及包含调节FTO的活性的化合物的组合物，包括药学上可接受的组合物，以及预防，改善或治疗受试者中的FTO介导的病症或疾病的方法，包括中风，癫痫，抑郁和退行性疾病中枢神经系统疾病如阿尔茨海默病和帕金森病。使用化合物改善或治疗与代谢紊乱如糖尿病和肥胖相关的病症的其它方面也是令人鼓舞的。

5. 发明申请

WO2009064805A1 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLUENZA 审中-公开
标题翻译：用于治疗和诊断流感病毒的组合物和方法
公开(公告)号：WO2009064805A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083265
申请日：2008-11-12
申请人： SPALTUDAQ CORPORATION , GRANDEA, Andres, G. , KING, Gordon , COX, Thomas , OLSEN, Ole , MITCHAM, Jennifer
发明人： GRANDEA, Andres, G. , KING, Gordon , COX, Thomas , OLSEN, Ole , MITCHAM, Jennifer
IPC分类号： C07K16/10 , G01N33/569 , A61K39/395 , A61P31/16 , C07K14/11
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies binding to conformational determinants of an M2 homotetramer and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译：本发明提供了与M2同四聚体的构象决定簇结合的新的人抗流感抗体以及相关的组合物和方法。这些抗体用于流感感染的诊断和治疗。

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