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1. 发明申请

WO2011092469A8 1-(5-TERT-BUTYL-2-PHENYL-2H-PYRAZOL-3-YL)-3-[2-FLUORO-4-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-7-YLOXY)-PHENYL]-UREA AND RELATED COMPOUNDS AND THEIR USE IN THERAPY 审中-公开
标题翻译： 1-（5-叔丁基-2-苯基-2H-吡唑-3-基）-3- [2-氟-4-（1-甲基-2-氧代-2,3-二氢-1H-咪唑并[ 4,5-B]吡啶-7-YLOXY） - 苯基] - 及其相关化合物及其在治疗中的用途
公开(公告)号：WO2011092469A8
公开(公告)日：2012-08-16
申请号：PCT/GB2011000106
申请日：2011-01-27
申请人： CANCER REC TECH LTD , CANCER RES INST ROYAL , SPRINGER CAROLINE , NICULESCU-DUVAZ ION , MARAIS RICHARD , NICULESCU-DUVAZ DAN , ZAMBON ALFONSO , MENARD DELPHINE
发明人： SPRINGER CAROLINE , NICULESCU-DUVAZ ION , MARAIS RICHARD , NICULESCU-DUVAZ DAN , ZAMBON ALFONSO , MENARD DELPHINE
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： A61K31/437 , A61K31/4353 , C07D401/02 , C07D471/04
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (I) (for convenience, collectively referred to herein as "IP compounds"), which, inter alia, are useful in the treatment of cancer, e.g., cancer characterised by (e.g., driven by) mutant RAS ("mutant RAS cancer"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions in the treatment of cancer, e.g., mutant RAS cancer.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及下列通式（I）的某些化合物（为了方便起见，统称为“IP化合物”），其特别可用于治疗癌症，例如以突变RAS（“突变RAS癌症”）为特征的癌症。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在治疗癌症中的用途，例如突变RAS癌症。

2. 发明专利

ES2469367T3 1-(5-Terc-butil-2-fenil-2H-pirazol-3-il)-3-[2-fluoro-4-(1-metil-2-oxo-2,3-dihidro-1H-imidazo[4,5-b]piridin-7-iloxi)-fenil]-urea y compuestos relacionados y su uso en terapia 未知
公开(公告)号：ES2469367T3
公开(公告)日：2014-06-18
申请号：ES11701856
申请日：2011-01-27
申请人： CANCER REC TECH LTD , CANCER RES INST ROYAL
发明人： SPRINGER CAROLINE , NICULESCU-DUVAZ ION , MARAIS RICHARD , NICULESCU-DUVAZ DAN , ZAMBON ALFONSO , MENARD DELPHINE
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Un compuesto seleccionado entre los compuestos de la siguiente fórmula, y sales, hidratos y solvatos farmacéuticamente aceptables de los mismos:**Fórmula** en la que -J- es independientemente: o**Fórmula** y en la que -R es independientemente: -H, -Me, -F, -Cl, -Br o -I; y en la que -R se sitúa en posiciones meta- o para- en el anillo fenilo.

3. 发明专利

NZ601085A 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy 未知
公开(公告)号：NZ601085A
公开(公告)日：2015-04-24
申请号：NZ60108511
申请日：2011-01-27
申请人： CANCER REC TECH LTD , CANCER RES INST ROYAL
发明人： ZAMBON ALFONSO , NICULESCU-DUVAZ DAN , MENARD DELPHINE , MARAIS RICHARD , SPRINGER CAROLINE , NICULESCU-DUVAZ ION
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed herein is 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-N-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea and related RA substituted compounds, and the use thereof in the treatment of cancer, such as mutant RAS cancer, more specifically pancreatic cancer; thyroid (e.g., follicular; undifferentiated papillary) cancer; colorectal cancer; seminoma; myelodysplastic syndrome (MDS); lung cancer (e.g., lung adenocarcinoma); liver cancer; leukemia (e.g., acute myelogenous leukemia (AML)); melanoma; bladder cancer; kidney cancer; breast cancer, ovarian cancer, bile duct cancer, or glioma.

5. 发明专利

NZ706154A 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy 未知
公开(公告)号：NZ706154A
公开(公告)日：2016-09-30
申请号：NZ70615411
申请日：2011-01-27
申请人： CANCER REC TECH LTD , CANCER RES INST ROYAL
发明人： NICULESCU-DUVAZ DAN , SPRINGER CAROLINE , NICULESCU-DUVAZ ION , ZAMBON ALFONSO , MENARD DELPHINE , MARAIS RICHARD
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed herein is the compound 1-(3-Tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)naphthalen-1-yl)urea and phenyl substituted derivatives thereof and their use in the treatment of cancer, including pancreatic cancer; thyroid cancer; colorectal cancer; seminoma; myelodysplastic syndrome (MDS); lung cancer; liver cancer; leukemia; melanoma; bladder cancer; kidney cancer; breast cancer, ovarian cancer, bile duct cancer, or glioma.

6. 发明专利

AU2011209586A1 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro- 4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo [4,5-b]pyridin-7-yloxy)-phenyl] -urea and related compounds and their use in therapy 未知
公开(公告)号：AU2011209586A1
公开(公告)日：2012-08-09
申请号：AU2011209586
申请日：2011-01-27
申请人： CANCER RES INST ROYAL , CANCER REC TECH LTD
发明人： SPRINGER CAROLINE , NICULESCU-DUVAZ ION , MARAIS RICHARD , NICULESCU-DUVAZ DAN , ZAMBON ALFONSO , MENARD DELPHINE
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (I) (for convenience, collectively referred to herein as "IP compounds"), which, , are useful in the treatment of cancer, e.g., cancer characterised by (e.g., driven by) mutant RAS ("mutant RAS cancer"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions in the treatment of cancer, e.g., mutant RAS cancer.

7. 发明专利

CA2786834A1 1-(5-TERT-BUTYL-2-PHENYL-2H-PYRAZOL-3-YL)-3-[2-FLUORO-4-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-7-YLOXY)-PHENYL]-UREA AND RELATED COMPOUNDS AND THEIR USE IN THERAPY 未知
公开(公告)号：CA2786834A1
公开(公告)日：2011-04-08
申请号：CA2786834
申请日：2011-01-27
申请人： CANCER REC TECH LTD , CANCER RES INST ROYAL
发明人： SPRINGER CAROLINE , NICULESCU-DUVAZ ION , MARAIS RICHARD , NICULESCU-DUVAZ DAN , ZAMBON ALFONSO , MENARD DELPHINE
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (I) (for convenience, collectively referred to herein as "IP compounds"), which, inter alia, are useful in the treatment of cancer, e.g., cancer characterised by (e.g., driven by) mutant RAS ("mutant RAS cancer"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions in the treatment of cancer, e.g., mutant RAS cancer.

8. 发明专利

CA2915425A1 VACCINIA VIRUS FOR GENE-DIRECTED ENZYME PRODRUG THERAPY 未知
公开(公告)号：CA2915425A1
公开(公告)日：2014-12-24
申请号：CA2915425
申请日：2014-06-18
申请人： CANCER RES INST ROYAL
发明人： MARAIS RICHARD , SPRINGER CAROLINE , TOMMASINI SERENA
IPC分类号： A61K35/76 , A61K31/135 , A61K38/48 , A61P35/00
摘要： Methods of making vaccinia viruses for gene-directed prodrug therapy are disclosed and their use in the treatment of disease is provided. In particular, the anti-tumour effects of vaccinia viruses that are modified to express a prodrug-activating enzyme are disclosed.

9. 发明专利

ES2385103T3 Compuestos de imidazo[4,5-b]piridin-2-ona y análogos de los mismos como compuestos terapéuticos contra el cáncer 未知
公开(公告)号：ES2385103T3
公开(公告)日：2012-07-18
申请号：ES07732571
申请日：2007-04-26
申请人： CANCER REC TECH LTD , INST OF CANCER RES THE ROYAL CANCER HOSPITAL , ASTEX THERAPEUTICS LTD
发明人： NICULESCU-DUVAZ DAN , SPRINGER CAROLINE , MARAIS RICHARD , DIJKSTRA HARMEN , MENARD DELPHINE , NICULESCU-DUVAZ ION , DAVIES LAWRENCE , NOURRY ARNAUD
IPC分类号： C07D471/04 , A61K31/437 , A61K31/44 , A61K31/5377 , A61P35/00
摘要： Un compuesto seleccionado de compuestos de la siguiente fórmula, y sales farmacéuticamente aceptables y solvatos de los mismos: en la que: J es independientemente -NRN1-; RN1 es independientemente -H o -Me; RN2 es independientemente -H o -Me; Y es independientemente -CH >= ; Q es independientemente -O-; cada uno de RP1, RP2, RP5 y RP4 es independientemente -H, -Me, -CF3, -F o -Cl; el grupo A-L- es independientemente A-NH-C( >= O)-NH-, A-C( >= O)-NH- o A-N H-C( >= O)-; A es independientemente fenilo o pirazolilo, y está independientemente sin sustituir o sustituido con uno o más grupos seleccionados de: -(C >= O)NH2, -(C >= O)NMe2, -(C >= O)NEt2, -(C >= O)N(iPr)2, -(C >= O)N(CH2CH2OH)2, -(C >= O)-morfolino, -(C >= O)NHPh, -(C >= O)NHCH2Ph, -F, -Cl, -Br, -I, -CN, -OH, -OMe, -OEt, -O(iPr), -O(tBu), -OPh, -OCH2Ph, -OCF3, -OCH2CF3, -OCF2CF2H, -OCH2CH2OH, -OCH2CH2OMe -OCH2CH2OEt, -OCH2CH2NH2, -20 OCH2CH2NMe2, -OCH2CH2N(iPr)2, -OCH2CH2-morfolino, -OCH2CH2-piperazino, -OCH2CH2-pirrolidino, -OPh-Me, -OPh-OH, -OPh-OMe, -OPh-F, -OPh-Cl, -OPh-Br, -OPh-I, -NH2, -NHMe, -NHEt, -NH(iPr), -NMe2, -NEt2, -N(iPr)2, -N(CH2CH2OH)2, -NHPh, -NHCH2Ph, piperidino, piperazino, morfolino, -NH(C >= O)Me, -NH(C >= O)Et, -NH(C >= O)nPr, -NH(C >= O)Ph, -NHC( >= O)CH2Ph, -NMe(C >= O)Me, -NMe(C >= O)Et, -NMe(C >= O)Ph, -NMeC( >= O)CH2Ph, -SO2Me, -SO2CF3, -SO2Et, -SO2Ph, -SO2PhMe, -SO2CH2Ph, -SO2NH2, O2NHMe, -SO2NHEt, -SO2NMe2 -SO2NEt2 -SO2-25 morfolino, -SO2NHPh, -SO2NHCH2Ph, -CH2Ph, -CH2Ph-Me, -CH2Ph-OH, -CH2Ph-F, -CH2Ph-Cl, -Ph, -Ph-Me, -Ph-OH, -Ph-OMe, -Ph-NH2, -Ph-F, -Ph-Cl, -Ph-Br, -Ph-I, piridilo, pirazinilo, pirimidinilo, piridazinilo, furanilo, tiofenilo, pirrolilo, imidazolilo, pirazolilo, oxazolilo, tiazolilo, tiadiazolilo, pirrolidinilo, imidazolidinilo, pirazolidinilo, piperidinilo, piperazinilo, azepinilo, tetrahidrofuranilo, tetrahidropiranilo, morfolinilo, azetidinilo, -Me, -Et, -nPr, -iPr, -nBu, -iBu, -sBu, -tBu, -nPe, -iPe, ter-Pe, neo-Pe, -cPr, -cHex, -CH >= CH2, -CH2-CH >= CH2, -CF3, -CHF2, -CH2F, -CCl3, -CBr3, -30 CH2CH2F, -CH2CHF2, H2CF3, -CH2OH, -CH2OMe, -CH2OEt, -CH2NH2, -CH2NMe2, -CH2CH2OH, -CH2CH2OMe -CH2CH2OEt, -CH2CH2CH2NH2, -CH2CH2NMe2, -CH2CH2-morfolino, -CH2CH2-piperazino, -CH2CH2-pirrolidino, y >= O; o: A es un grupo pirazolilo seleccionado de grupos de las siguientes fórmulas: en las que: RPY es independientemente alquilo C1-7 saturado; y RN3 es independientemente fenilo, y está independientemente sin sustituir o sustituido con uno o más sustituyentes seleccionados de -F, -Cl, -Br, -I, -OMe, -OCF3, -Me y -CF3.

10. 发明专利

AT349534T 未知
公开(公告)号：AT349534T
公开(公告)日：2007-01-15
申请号：AT92921908
申请日：1992-10-23
申请人： CANCER REC TECH LTD
发明人： ANLEZARK GILLIAN , MELTON ROGER , SHERWOOD ROGER , CONNORS THOMAS , FRIEDLOS FRANK , JARMAN MICHAEL , KNOX RICHARD , MAUGER ANTHONY , SPRINGER CAROLINE
IPC分类号： C12N9/12 , A61K38/00 , C07C219/34 , C07C271/18 , C07D203/14 , C07D487/14 , C07H15/252 , C07H19/048 , C07K7/06 , C12N9/02 , C12N15/00 , C12N15/09 , C12N15/53 , C12P17/10 , C12P21/08 , C12R1/01 , C12R1/07 , C12R1/19 , G01N33/53 , G01N33/573 , C12P7/10

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