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1. 发明申请

WO2007132211A1 ACOUSTIC WAVE TRANSDUCER SUBSTRATE AND MEASUREMENTS USING THE SAME 审中-公开
标题翻译：声波传感器基板和使用它的测量
公开(公告)号：WO2007132211A1
公开(公告)日：2007-11-22
申请号：PCT/GB2007/001749
申请日：2007-05-11
申请人： CAMBRIDGE ENTERPRISE LIMITED , WELLAND, Mark , DOBSON, Christopher , KNOWLES, Tuomas
发明人： WELLAND, Mark , DOBSON, Christopher , KNOWLES, Tuomas
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/543 , G01N2333/4709 , G01N2500/00
摘要： An acoustic wave transducer substrate is provided, the substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites. The growth-promotion sites are preferably for promoting fibril formation. The invention also provides a method of screening a candidate compound for an effect on fibril growth, including the steps of: providing an acoustic wave transducer substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites; causing oscillation of the substrate; contacting the substrate surface with a sample fluid comprising polypeptide molecules and a candidate compound; and measuring one or more parameters of the substrate oscillation to monitor the accumulation of said polypeptide molecules of interest in the presence and absence of said candidate compound. Alteration of the accumulation of said polypeptide molecules of interest in the presence of said candidate compound as compared with that in the absence of said candidate compound indicates that the candidate compound has an effect of fibril growth.
摘要翻译：提供了一种声波换能器基底，该基底具有多个生长促进位点的表面，用于促进多肽分子在所述位点的积聚。生长促进位点优选用于促进原纤维形成。本发明还提供筛选候选化合物以对原纤维生长产生影响的方法，包括以下步骤：提供具有多个生长促进位点的表面的声波换能器底物，以促进多肽分子在所述位点的积聚; 引起基板的振荡; 使衬底表面与包含多肽分子和候选化合物的样品流体接触; 以及测量所述底物振荡的一个或多个参数，以监测所述候选化合物存在和不存在的所述目的多肽分子的积累。与不存在所述候选化合物相比，在所述候选化合物存在下，所述目的多肽分子的积累的改变表明候选化合物具有原纤维生长的作用。

2. 发明申请

WO2010041009A1 POLYMER COMPOSITE AND METHOD FOR ITS MANUFACTURE 审中-公开
标题翻译：聚合物复合材料及其制造方法
公开(公告)号：WO2010041009A1
公开(公告)日：2010-04-15
申请号：PCT/GB2009/002398
申请日：2009-10-07
申请人： CAMBRIDGE ENTERPRISE LIMITED , KNOWLES, Tuomas , LACOUR, Stéphanie , WELLAND, Mark
发明人： KNOWLES, Tuomas , LACOUR, Stéphanie , WELLAND, Mark
IPC分类号： C08L101/00
CPC分类号： C08J5/045 , C08J2383/04 , C08L89/00 , C08L101/00 , C08L2666/26
摘要： A composite material is disclosed, having a matrix component and a stiffening component. The matrix component includes a polymer such as a silicone polymer (polysiloxane). The stiffening component includes filamentous peptide- or protein-based structures formed from peptides or proteins with an average number of amino acids in the range 2-250. The filamentous structures may be self-assembled structures such as amyloid fibrils.
摘要翻译：公开了一种具有基体组分和加强组分的复合材料。基质组分包括聚合物如硅氧烷聚合物（聚硅氧烷）。硬化组分包括由肽或蛋白质形成的丝状肽或蛋白质结构，平均氨基酸数目在2-250范围内。丝状结构可以是自组装结构，例如淀粉样蛋白原纤维。

3. 发明公开

EP2016411A1 ACOUSTIC WAVE TRANSDUCER SUBSTRATE AND MEASUREMENTS USING THE SAME 审中-公开
标题翻译：声波转化器基底和测量SO
公开(公告)号：EP2016411A1
公开(公告)日：2009-01-21
申请号：EP07732774.0
申请日：2007-05-11
申请人： Cambridge Enterprise Limited
发明人： WELLAND, Mark , DOBSON, Christopher , KNOWLES, Tuomas
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/543 , G01N2333/4709 , G01N2500/00
摘要： An acoustic wave transducer substrate is provided, the substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites. The growth-promotion sites are preferably for promoting fibril formation. The invention also provides a method of screening a candidate compound for an effect on fibril growth, including the steps of: providing an acoustic wave transducer substrate having a surface with a plurality of growth promotion sites for promoting the accumulation of polypeptide molecules at said sites; causing oscillation of the substrate; contacting the substrate surface with a sample fluid comprising polypeptide molecules and a candidate compound; and measuring one or more parameters of the substrate oscillation to monitor the accumulation of said polypeptide molecules of interest in the presence and absence of said candidate compound. Alteration of the accumulation of said polypeptide molecules of interest in the presence of said candidate compound as compared with that in the absence of said candidate compound indicates that the candidate compound has an effect of fibril growth.

4. 发明申请

WO2016059391A1 POLYMER COMPOSED OF REPEAT UNITS HAVING A BIOLOGICALLY ACTIVE MOLECULE ATTACHED THERETO VIA A PH-SENSITIVE BOND 审中-公开
标题翻译：具有生物活性分子的重复单元的聚合物通过敏感性粘合剂
公开(公告)号：WO2016059391A1
公开(公告)日：2016-04-21
申请号：PCT/GB2015/053007
申请日：2015-10-13
申请人： OUBERAI, Myriam Marie , WELLAND, Mark
发明人： OUBERAI, Myriam Marie , WELLAND, Mark
IPC分类号： A61K47/48 , A61K45/06 , A61K9/51 , A61K31/4409 , A61K31/496 , C08G63/16 , C08G63/672 , C08G63/685
CPC分类号： A61K31/573 , A61K9/5031 , A61K9/5146 , A61K31/13 , A61K31/133 , A61K31/138 , A61K31/4409 , A61K31/496 , A61K45/06 , A61K47/482 , A61K47/593 , C08G63/16 , C08G63/672 , C08G63/6856 , C08G63/916 , C12P7/62 , C12Y301/01003 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： There is provided a polymer comprising: (i) a repeat unit derived from a compound of formula (I) (Formula (I)) wherein, R 1 and R 2 are each independently selected from OH, OR', SH, SR', NH 2 , NHR' and NR' 2 ; R' is C 1-20 hydrocarbyl; each n is independently 0 or an integer between 1 and 6; each m is independently 0 or an integer between 1 and 4, and preferably at least one m is 1; and q is an integer between 1 and 8; and; (ii) a biologically active molecule, wherein said biologically active molecule is covalently bonded to said repeat unit; as well as methods for preparing such polymers, particles comprising said polymers and uses of said polymers and particles including use in the treatment of disease.
摘要翻译：提供聚合物，其包括：（i）衍生自式（I）化合物（式（I））的重复单元，其中R 1和R 2各自独立地选自OH，OR'，SH，SR'，NH 2， NHR'和NR'2; R'是C 1-20烃基; 每个n独立地为0或1至6之间的整数; 每个m独立地为0或1至4之间的整数，优选至少1m为1; q为1〜8之间的整数; 和; （ii）生物活性分子，其中所述生物活性分子共价键合到所述重复单元; 以及制备这种聚合物的方法，包含所述聚合物的颗粒以及包括用于治疗疾病的所述聚合物和颗粒的用途。

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