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1. 发明申请

US20160067706A1 MANIPULATION OF OBJECTS IN MICROFLUIDIC DEVICES USING EXTERNAL ELECTRODES 审中-公开
标题翻译：使用外部电极处理微流体装置中的物体的操作
公开(公告)号：US20160067706A1
公开(公告)日：2016-03-10
申请号：US14942166
申请日：2015-11-16
申请人： Caliper Life Sciences, Inc.
发明人： Joshua I. Molho , Daniel G. Stearns , I-Jane Chen , Danh Tran , Bradley W. Rice , Tobias Daniel Wheeler
IPC分类号： B01L3/00
摘要： The invention provides microfluidic devices, systems, and methods for manipulating an object within a channel of a microfluidic device using an external electrode. The device has a channel disposed within the device, the channel having no included electrodes. The channel has a wall, at least a portion of which is penetrable by an electric field generated external to the device, the wall being penetrable such that the electric field extends through the wall portion and into a region within the channel. The system includes the microfluidic device and an electrode external to and not bonded to the device. In the method, the external electrode is placed adjacent to the device and energized to generate an electric field that extends through the wall of the device and into the channel, thereby manipulating an object within the channel.
摘要翻译：本发明提供了使用外部电极来操纵微流体装置的通道内的物体的微流体装置，系统和方法。该装置具有设置在该装置内的通道，该通道不包括电极。通道具有壁，其至少一部分可由在该装置外部产生的电场穿透，该壁可穿透，使得电场延伸通过该壁部并进入通道内的区域。该系统包括微流体装置和外部并未结合到装置的电极。在该方法中，外部电极被放置在与器件相邻并被激励以产生延伸穿过器件的壁并进入通道的电场，从而操纵通道内的物体。

2. 发明授权

US09770220B2 Integrated microtomography and optical imaging systems 有权
公开(公告)号：US09770220B2
公开(公告)日：2017-09-26
申请号：US15098819
申请日：2016-04-14
申请人： Caliper Life Sciences, Inc.
发明人： Daniel G. Stearns , David G. Nilson , Bradley W. Rice
IPC分类号： A61B6/00 , G01N23/04 , A61B6/03 , A61B6/04 , A61B5/00 , G01N21/76
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0073 , A61B6/032 , A61B6/035 , A61B6/0457 , A61B6/4405 , A61B6/508 , A61B6/5247 , A61B2503/40 , G01N21/763 , G01N23/046 , G01N2223/419
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.

3. 发明授权

US09297784B2 Device and method for extracting target objects from a sample 有权
标题翻译：从样本中提取目标对象的设备和方法
公开(公告)号：US09297784B2
公开(公告)日：2016-03-29
申请号：US13838338
申请日：2013-03-15
申请人： CALIPER LIFE SCIENCES, INC.
发明人： Joshua I. Molho , Daniel G. Stearns , I-Jane Chen , Danh Tran , Bradley W. Rice , Tobias Daniel Wheeler , Alexander V. Dukhovny
IPC分类号： G01N27/447 , B01L3/00
CPC分类号： G01N27/44756 , B01L3/502738 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0864 , B01L2400/0622
摘要： The invention provides devices, systems, and methods for extracting target objects from a sample. In the method, a stream of sample containing a plurality of target and non-target objects is directed by first and second streams of buffer through a sample inlet channel into a fluid junction and through the fluid junction into a sample waste channel. In response to detecting a target object within the stream of sample, an actuator is energized to close a normally open valve, resulting in a transient burst of cross-flow into the fluid junction that briefly diverts the flow of sample within the fluid junction and results in an aliquot of sample being directed into an aliquot delivery channel. The combination of the valve and the actuator acts as a self-limiting pulse generator.
摘要翻译：本发明提供了用于从样本提取目标对象的设备，系统和方法。在该方法中，包含多个目标物体和非目标物体的样品流由第一和第二缓冲液流通过样品入口通道引导到流体结中并通过流体连接引入样品废物通道。响应于检测到样品流内的目标物体，致动器被通电以关闭常开阀，导致横向流入流体结的瞬时突发，其短暂地转移流体结内的样品流和结果在样品的等分试样被导入等分输送通道中。阀和执行器的组合用作自限制脉冲发生器。

4. 发明授权

US10717081B2 Manipulation of objects in microfluidic devices using external electrodes 有权
公开(公告)号：US10717081B2
公开(公告)日：2020-07-21
申请号：US14942166
申请日：2015-11-16
申请人： Caliper Life Sciences, Inc.
发明人： Joshua I. Molho , Daniel G. Stearns , I-Jane Chen , Danh Tran , Bradley W. Rice , Tobias Daniel Wheeler
IPC分类号： B01L3/00 , B03C5/02 , B03C5/00
摘要： The invention provides microfluidic devices, systems, and methods for manipulating an object within a channel of a microfluidic device using an external electrode. The device has a channel disposed within the device, the channel having no included electrodes. The channel has a wall, at least a portion of which is penetrable by an electric field generated external to the device, the wall being penetrable such that the electric field extends through the wall portion and into a region within the channel. The system includes the microfluidic device and an electrode external to and not bonded to the device. In the method, the external electrode is placed adjacent to the device and energized to generate an electric field that extends through the wall of the device and into the channel, thereby manipulating an object within the channel.

5. 发明授权

US10130318B2 Integrated microtomography and optical imaging systems 有权
公开(公告)号：US10130318B2
公开(公告)日：2018-11-20
申请号：US15679252
申请日：2017-08-17
申请人： Caliper Life Sciences, Inc.
发明人： Daniel G. Stearns , David G. Nilson , Bradley W. Rice
IPC分类号： G01N23/00 , A61B6/00 , A61B5/00 , A61B6/03 , A61B6/04 , G01N21/76 , G01N23/046
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.

6. 发明申请

US20180008218A1 INTEGRATED MICROTOMOGRAPHY AND OPTICAL IMAGING SYSTEMS 审中-公开
公开(公告)号：US20180008218A1
公开(公告)日：2018-01-11
申请号：US15679252
申请日：2017-08-17
申请人： Caliper Life Sciences, Inc.
发明人： Daniel G. Stearns , David G. Nilson , Bradley W. Rice
IPC分类号： A61B6/00 , A61B6/04 , G01N23/04 , G01N21/76 , A61B5/00 , A61B6/03
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0073 , A61B6/032 , A61B6/035 , A61B6/0457 , A61B6/4405 , A61B6/508 , A61B6/5247 , A61B2503/40 , G01N21/763 , G01N23/046 , G01N2223/419
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.

7. 发明申请

US20160228079A1 INTEGRATED MICROTOMOGRAPHY AND OPTICAL IMAGING SYSTEMS 有权
标题翻译：综合微电影和光学成像系统
公开(公告)号：US20160228079A1
公开(公告)日：2016-08-11
申请号：US15098819
申请日：2016-04-14
申请人： Caliper Life Sciences, Inc.
发明人： Daniel G. Stearns , David G. Nilson , Bradley W. Rice
IPC分类号： A61B6/00 , A61B6/04 , A61B6/03
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0073 , A61B6/032 , A61B6/035 , A61B6/0457 , A61B6/4405 , A61B6/508 , A61B6/5247 , A61B2503/40 , G01N21/763 , G01N23/046 , G01N2223/419
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.
摘要翻译：集成的微影像学和光学成像系统包括支持成像对象的旋转台，光学平台以及单独的光学和微影像成像系统。在组合的微影像学和光学成像过程期间，桌子将成像对象围绕其穿过的垂直轴旋转到多个不同的旋转位置。光学舞台可以是反照，外照明或生物发光阶段。光学成像系统包括垂直地位于成像对象上方的照相机。微图像系统包括相对于成像对象水平定位的x射线源。当成像对象保持在旋转台上的适当位置时，都获得光学和X射线图像。舞台和桌子包括在成像室内，所有组件都包含在便携式机柜中。可以同时对多个成像对象进行成像，并且侧视镜可以向顶置摄像机提供对象的侧视图。

8. 发明申请

US20140151229A1 MANIPULATION OF OBJECTS IN MICROFLUIDIC DEVICES USING EXTERNAL ELECTRODES 审中-公开
标题翻译：使用外部电极处理微流体装置中的物体的操作
公开(公告)号：US20140151229A1
公开(公告)日：2014-06-05
申请号：US13705670
申请日：2012-12-05
申请人： CALIPER LIFE SCIENCES, INC.
发明人： Joshua I. Molho , Daniel G. Stearns , I-Jane Chen , Danh Tran , Bradley W. Rice , Tobias Daniel Wheeler
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502792 , B01L2200/0647 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2400/0424 , B01L2400/0427 , B01L2400/0487 , B03C5/005 , B03C5/026 , B03C2201/26
摘要： The invention provides microfluidic devices, systems, and methods for manipulating an object within a channel of a microfluidic device using an external electrode. The device has a channel disposed within the device, the channel having no included electrodes. The channel has a wall, at least a portion of which is penetrable by an electric field generated external to the device, the wall being penetrable such that the electric field extends through the wall portion and into a region within the channel. The system includes the microfluidic device and an electrode external to and not bonded to the device. In the method, the external electrode is placed adjacent to the device and energized to generate an electric field that extends through the wall of the device and into the channel, thereby manipulating an object within the channel.
摘要翻译：本发明提供了使用外部电极来操纵微流体装置的通道内的物体的微流体装置，系统和方法。该装置具有设置在该装置内的通道，该通道不包括电极。通道具有壁，其至少一部分可由在该装置外部产生的电场穿透，该壁可穿透，使得电场延伸通过该壁部并进入通道内的区域。该系统包括微流体装置和外部并未结合到装置的电极。在该方法中，外部电极被放置在与器件相邻并被激励以产生延伸穿过器件的壁并进入通道的电场，从而操纵通道内的物体。

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