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1. 发明申请

WO2011028248A2 ELECTRONIC SELF-HEALING METHODS FOR RADIO-FREQUENCY RECEIVERS 审中-公开
标题翻译：用于无线电频率接收器的电子自愈方法
公开(公告)号：WO2011028248A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/002322
申请日：2010-08-24
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , BOHN, Florian , HAJIMIRI, Seyed, Ali , WANG, Hua , WANG, Yu-Jiu
发明人： BOHN, Florian , HAJIMIRI, Seyed, Ali , WANG, Hua , WANG, Yu-Jiu
IPC分类号： H03L7/00 , H04B7/08
CPC分类号： H04B1/40 , H04B17/0085
摘要： Systems and methods for providing self-healing integrated circuits. The method is characterized in that the behavior of a circuit or a device in response to an input signal is observed. One or more operational parameters or characteristics of the circuit or the device are derived. A corrective action to bring the operational parameters or characteristics of the circuit or device within a desired range is deduced, if needed. The corrective action can be the application of a correction signal or a modification of one or more parameters or characteristics of an element in the circuit. The calculated corrective action, if needed, is applied to bring the operational parameters or characteristics of the circuit or device within the desired range. Optionally, the operational parameters or characteristics of the circuit or the device after the correction is effectuated can be checked.
摘要翻译：用于提供自修复集成电路的系统和方法
该方法的特征在于观察响应于输入信号的电路或装置的行为。导出电路或设备的一个或多个操作参数或特性。如果需要，推导出将电路或设备的操作参数或特性带入期望范围内的校正措施。纠正措施可以是应用修正信号或修改电路中元件的一个或多个参数或特性。如果需要的话，计算出的校正动作被应用以使电路或装置的操作参数或特性在期望的范围内。可选地，可以检查修正后的电路或设备的操作参数或特性。

2. 发明申请

WO2010121223A2 ELECTROMAGNETIC MOLECULAR SENSORS AND METHODS OF USING SAME 审中-公开
标题翻译：电磁分子传感器及其使用方法
公开(公告)号：WO2010121223A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031517
申请日：2010-04-16
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , HAJIMIRI, Seyed, Ali , WANG, Hua
发明人： HAJIMIRI, Seyed, Ali , WANG, Hua
IPC分类号： G01N27/72 , G01N33/53 , C12Q1/68
CPC分类号： G01N27/745 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6832 , C12Q1/6834 , C12Q2525/161 , C12Q2525/197 , C12Q2525/301 , C12Q2563/143 , C12Q2565/519 , G01N27/3278 , G01N27/72 , G01N33/54326 , G01N33/54333 , G01N2446/00 , Y10T436/143333
摘要： Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors, and a binding moiety. The device can include an electromagnetic material that can be detected by the detector. The device is configured such that binding of an analyte to the binding moiety changes the relationship between the electromagnetic detector and the electromagnetic material such that a change in electromagnetic field is detected by the electromagnetic detector.
摘要翻译：公开了具有用于检测分析物的电磁检测器的装置。这些装置包括电磁检测器，包括有效的电感变化磁性检测器和结合部分。该装置可以包括可由检测器检测的电磁材料。该装置被配置为使得分析物与结合部分的结合改变了电磁检测器和电磁材料之间的关系，使得电磁检测器检测到电磁场的变化。

3. 发明申请

WO2010099350A2 LOW COST BONDING TECHNIQUE FOR INTEGRATED CIRCUIT CHIPS AND PDMS STRUCTURES 审中-公开
标题翻译：用于集成电路板和PDMS结构的低成本接合技术
公开(公告)号：WO2010099350A2
公开(公告)日：2010-09-02
申请号：PCT/US2010/025456
申请日：2010-02-25
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , WANG, Hua , HAJIMIRI, Seyed, Ali
发明人： WANG, Hua , HAJIMIRI, Seyed, Ali
IPC分类号： H01L21/60
CPC分类号： G01R33/1269 , B81C1/0023 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/83 , H01L2224/45144 , H01L2224/48091 , H01L2224/48227 , H01L2224/49171 , H01L2224/83193 , H01L2224/83855 , H01L2924/01013 , H01L2924/01014 , H01L2924/01079 , H01L2924/10253 , H01L2924/14 , H01L2924/1461 , H01L2924/3011 , H01L2924/00014 , H01L2924/00
摘要： Methods of bonding a structure fabricated in polydimethylsiloxane (PDMS) and an integrated circuit chip. The procedures for bonding include providing a substrate, affixing the integrated circuit to the substrate, as needed preparing the surface of the integrated circuit chip to permit bonding, aligning the PDMS structure and the features of the integrated circuit chip, and applying a bonding agent. The bonding agent is cured by exposure to a thermal regime for a suitable length of time. Depending on relative sizes, in some cases, a plural number of PDMS structures can be attached to one chip, or a single PDMS structure can be bonded to multiple chips. In some cases, the integrated circuit chip operates wirelessly. In other situations, the substrate provides electrical communication from the integrated circuit chip to electronic components.
摘要翻译：将聚二甲基硅氧烷（PDMS）制造的结构与集成电路芯片结合的方法。接合的步骤包括提供基板，将集成电路固定到基板上，根据需要准备集成电路芯片的表面以允许粘合，对准PDMS结构和集成电路芯片的特征，以及施加粘合剂。粘合剂通过暴露于热状态固化适宜的时间长度。根据相对尺寸，在一些情况下，可以将多个PDMS结构附接到一个芯片，或者单个PDMS结构可以被结合到多个芯片。在某些情况下，集成电路芯片可以无线操作。在其他情况下，衬底提供从集成电路芯片到电子部件的电通信。

4. 发明申请

WO2009148668A2 EFFECTIVE-INDUCTANCE-CHANGE BASED MAGNETIC PARTICLE SENSING 审中-公开
标题翻译：基于有效电感变化的磁性粒子感测
公开(公告)号：WO2009148668A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/036368
申请日：2009-03-06
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , WANG, Hua , HAJIMIRI, Seyed, Ali , CHEN, Yan
发明人： WANG, Hua , HAJIMIRI, Seyed, Ali , CHEN, Yan
CPC分类号： G01R33/1269
摘要： The invention relates to an integrated measurement system to detect a quantity of magnetic particles in a sample. The measurement system includes a substrate. An electromagnetic (EM) structure disposed on the surface of the substrate is configured to receive a sample including the magnetic particles in proximity thereof. The integrated measurement system also includes an electrical current generator disposed on the surface of the substrate which is electro-magnetically coupled to the EM structure. The electrical current generator is configured to cause an electrical current to flow in the EM structure. The integrated measurement system also includes an effective inductance sensor disposed on the surface of the substrate which is configured to measure a selected one of an effective inductance and a change in effective inductance. The invention also relates to a method to determine the number of and/or the locations of the magnetic particles in a sample.
摘要翻译：本发明涉及一种用于检测样品中的磁性颗粒的量的综合测量系统。测量系统包括基板。设置在基板的表面上的电磁（EM）结构被配置为接收包括邻近的磁性颗粒的样品。集成测量系统还包括设置在基板的表面上的电流发生器，其电磁耦合到EM结构。电流发生器被配置为使得电流在EM结构中流动。集成测量系统还包括设置在衬底的表面上的有效电感传感器，其被配置为测量有效电感和有效电感的变化中选定的一个。本发明还涉及确定样品中磁性颗粒数量和/或位置的方法。

5. 发明申请

WO2010031016A2 A FREQUENCY-SHIFT CMOS MAGNETIC BIOSENSOR ARRAY WITH SINGLE BEAD SENSITIVITY AND NO EXTERNAL MAGNET 审中-公开
标题翻译：具有单磁感应和无外磁的频率转换CMOS磁敏生物传感器阵列
公开(公告)号：WO2010031016A2
公开(公告)日：2010-03-18
申请号：PCT/US2009/056887
申请日：2009-09-15
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , WANG, Hua , HAJIMIRI, Seyed, Ali
发明人： WANG, Hua , HAJIMIRI, Seyed, Ali
IPC分类号： G01N33/48
CPC分类号： G01N27/745 , G01N33/54326 , G01N33/5438
摘要： According to one aspect, an integrated magnetic particle measurement device for detecting a presence or absence of magnetic particles in a sample volume includes at least one sensor cell having a differential sensor pair. An active sensor oscillator frequency is responsive to one or more magnetic particles situated within a sample volume. The sensor cell is configured to be operative in the absence of an externally applied magnetic field. A frequency measurement circuit provides as a time-multiplexed output a first count representative of the active sensor oscillator frequency and a second count representative of the reference sensor oscillator frequency. A calculated difference between the first count and the second count is indicative of a presence or an absence of one or more magnetic particles within the sample volume. An integrated magnetic particle measurement system array and a method for detecting one or more magnetic particles are also described.
摘要翻译：根据一个方面，用于检测样本体积中磁性粒子的存在或不存在的集成磁性粒子测量装置包括具有差分传感器对的至少一个传感器单元。有源传感器振荡器频率响应位于样本体积内的一个或多个磁性粒子。传感器单元被配置为在没有外部施加的磁场的情况下工作。频率测量电路作为时分多路复用输出提供表示有源传感器振荡器频率的第一计数和表示参考传感器振荡器频率的第二计数。第一计数与第二计数之间的计算差值指示样本体积内存在或不存在一个或多个磁性粒子。还描述了集成的磁性粒子测量系统阵列和用于检测一个或多个磁性粒子的方法。

6. 发明申请

WO2010096770A2 NOISE SUPPRESSION TECHNIQUES IN HIGH PRECISION LONG-TERM FREQUENCY/TIMING MEASUREMENTS 审中-公开
标题翻译：噪声抑制技术在高精度长期频率/时序测量
公开(公告)号：WO2010096770A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/024933
申请日：2010-02-22
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , HAJIMIRI, Seyed, Ali , WANG, Hua , KOUSAI, Shouhei
发明人： HAJIMIRI, Seyed, Ali , WANG, Hua , KOUSAI, Shouhei
IPC分类号： G01R23/20 , G01R23/02
CPC分类号： G01R29/26 , G01R31/31709
摘要： A frequency/timing measurement apparatus includes a reference source having a reference source output terminal. At least one target source has a target source output terminal. The at least one target source is communicatively coupled to the reference source. A frequency timing measurement block has a first input terminal electrically coupled to the reference source output terminal. A second input terminal is electrically coupled to the target source output terminal and at least one output terminal. The frequency timing measurement block is configured to perform a noise shaping technique to reduce measurement error attributable to a phase noise that is correlated between the reference source and the target source, and to provide a reduced correlated noise measurement at the at least one output terminal. A method to reduce correlated noise is also described.
摘要翻译：频率/定时测量装置包括具有参考源输出端的参考源。至少一个目标源具有目标源输出端。至少一个目标源通信地耦合到参考源。频率定时测量块具有电耦合到参考源输出端的第一输入端。第二输入端子电耦合到目标源极输出端子和至少一个输出端子。频率定时测量块被配置为执行噪声整形技术以减少归因于在参考源和目标源之间相关的相位噪声的测量误差，并且在至少一个输出端子处提供减小的相关噪声测量。还描述了一种降低相关噪声的方法。

7. 发明申请

WO2009148664A2 FULLY INTEGRATED TEMPERATURE REGULATOR FOR BIOCHEMICAL APPLICATIONS 审中-公开
标题翻译：全面综合温度调节器用于生物化学应用
公开(公告)号：WO2009148664A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/036288
申请日：2009-03-06
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , WANG, Hua , HAJIMIRI, Seyed, Ali
发明人： WANG, Hua , HAJIMIRI, Seyed, Ali
CPC分类号： G05D23/24 , G05D23/1906 , G05D23/22 , G05D23/27
摘要： The invention is an integrated temperature regulator that can be fabricated using conventional semiconductor processing technology. The integrated temperature regulator can include a reaction chamber, for example fabricated from PDMS, in which chemical or biochemical reactions of interest can be carried out. The temperature regular can also be used to regulate the temperature of some circuits, e.g. an effective-inductance-change based magnetic particle sensor, to achieve a stable operation performance, such as an improved sensitivity. The integrated temperature regulator includes as subcomponents a temperature sensing circuit that receives a thermal signal from the vicinity of the reaction chamber, a temperature reference circuit, and a temperature control circuit that controls a heater based at least in part on the difference between the sensed temperature and the reference temperature. The various subcomponents can be programmable.
摘要翻译：本发明是可以使用常规半导体处理技术制造的集成温度调节器。集成温度调节器可以包括例如由PDMS制造的反应室，其中可以进行感兴趣的化学或生物化学反应。温度常数也可用于调节某些电路的温度，例如基于有效电感变化的磁性粒子传感器，以实现稳定的操作性能，例如提高的灵敏度。集成温度调节器包括作为子部件的温度感测电路，其接收来自反应室附近的热信号，温度参考电路和温度控制电路，其至少部分地基于感测温度之间的差异来控制加热器和参考温度。各个子部件可以编程。

8. 发明申请

WO2007019424A2 SPECTRAL-SCANNING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：光谱扫描磁共振成像
公开(公告)号：WO2007019424A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/030681
申请日：2006-08-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , AL HAJIMIRI, Seyed , HASSIBI, Arjang , WANG, Hua
发明人： AL HAJIMIRI, Seyed , HASSIBI, Arjang , WANG, Hua
IPC分类号： G01V3/00 , A61B5/05
CPC分类号： G01R33/3808 , G01R33/3607 , G01R33/3642 , G01R33/3657 , G01R33/446 , G01R33/5612 , G01R33/56383
摘要： Spectral scanning magnetic resonance imaging methods and systems. In preferred methods and systems of the invention, to measure the resonance spectrum of the target object (18), a plurality of excitation signals in different frequencies and/or waveform shapes are introduced simultaneously to the imaging volume through one or more excitation coils (12,12a), and the response spectrum is measured also in real-time and/or after excitation. Systems of the invention can be compact and portable, with small magnets (10) providing the deterministic inhomogeneous magnetic field. Preferred embodiments include integrated circuit transmitters (22) and receivers (20). Preferred systems of the invention are suitable, for example, for point of care medical diagnostics.
摘要翻译：光谱扫描磁共振成像方法和系统。在本发明的优选方法和系统中，为了测量目标物体（18）的共振谱，通过一个或多个激励线圈（12）将多个不同频率和/或波形形状的激励信号同时引入成像体积，12a），并且响应谱也是在实时和/或激发后测量的。本发明的系统可以紧凑且便于携带，其中提供确定性非均匀磁场的小磁体（10）。优选实施例包括集成电路发射器（22）和接收器（20）。本发明的优选系统例如适用于护理点医疗诊断。

9. 发明公开

EP2406641A2 NOISE SUPPRESSION TECHNIQUES IN HIGH PRECISION LONG-TERM FREQUENCY/TIMING MEASUREMENTS 审中-公开
标题翻译：降噪程序进行长期HOCHPRÄZISIONSFREQUENZ-/定时测量
公开(公告)号：EP2406641A2
公开(公告)日：2012-01-18
申请号：EP10744436.6
申请日：2010-02-22
申请人： California Institute of Technology
发明人： HAJIMIRI, Seyed, Ali , WANG, Hua , KOUSAI, Shouhei
IPC分类号： G01R23/20 , G01R23/02
CPC分类号： G01R29/26 , G01R31/31709
摘要： A frequency/timing measurement apparatus includes a reference source having a reference source output terminal. At least one target source has a target source output terminal. The at least one target source is communicatively coupled to the reference source. A frequency timing measurement block has a first input terminal electrically coupled to the reference source output terminal. A second input terminal is electrically coupled to the target source output terminal and at least one output terminal. The frequency timing measurement block is configured to perform a noise shaping technique to reduce measurement error attributable to a phase noise that is correlated between the reference source and the target source, and to provide a reduced correlated noise measurement at the at least one output terminal. A method to reduce correlated noise is also described.

10. 发明公开

EP2326950A2 A FREQUENCY-SHIFT CMOS MAGNETIC BIOSENSOR ARRAY WITH SINGLE BEAD SENSITIVITY AND NO EXTERNAL MAGNET 审中-公开
标题翻译：与频移和单珠灵敏度和无需外部磁铁CMOS MAGNETBIOSENSOR-ARRAY
公开(公告)号：EP2326950A2
公开(公告)日：2011-06-01
申请号：EP09813773.0
申请日：2009-09-15
申请人： California Institute of Technology
发明人： WANG, Hua , HAJIMIRI, Seyed, Ali
IPC分类号： G01N33/48
CPC分类号： G01N27/745 , G01N33/54326 , G01N33/5438
摘要： According to one aspect, an integrated magnetic particle measurement device for detecting a presence or absence of magnetic particles in a sample volume includes at least one sensor cell having a differential sensor pair. An active sensor oscillator frequency is responsive to one or more magnetic particles situated within a sample volume. The sensor cell is configured to be operative in the absence of an externally applied magnetic field. A frequency measurement circuit provides as a time-multiplexed output a first count representative of the active sensor oscillator frequency and a second count representative of the reference sensor oscillator frequency. A calculated difference between the first count and the second count is indicative of a presence or an absence of one or more magnetic particles within the sample volume. An integrated magnetic particle measurement system array and a method for detecting one or more magnetic particles are also described.

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