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1. 发明申请

WO2007046819A2 BIOMARKER SENSORS AND METHOD FOR MULTI-COLOR IMAGING AND PROCESSING OF SINGLE-MOLECULE LIFE SIGNATURES 审中-公开
标题翻译：生物标记传感器和多色成像和单分子生命信号处理方法
公开(公告)号：WO2007046819A2
公开(公告)日：2007-04-26
申请号：PCT/US2005/041954
申请日：2005-11-15
申请人： CALIFORNIA INSTITUE OF TECHNOLOGY , WADE, Lawarence, A. , COLLIER, Charles, Patrick
发明人： WADE, Lawarence, A. , COLLIER, Charles, Patrick
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00
CPC分类号： G01Q60/42 , G01Q80/00
摘要： A device comprising an array of active regions for use in reacting one or more species in at least two of the active regions in a sequential process, e.g., sequential reactions. The device has a transparent substrate member, which has a surface region. The device has a silane material overlying the surface region. The device has a first active region formed overlying a first portion of the silane material. In a specific embodiment, the first active region has a first dimension of less than 1 micron in size and has one or more first molecules capable of binding to the first portion of the silane material. In a specific embodiment, the device has a second active region formed overlying a second portion of the silane material. The second active region has a second dimension of less than 1 micron in size and has one or more second molecules capable of binding to the second portion of the active region. In a specific embodiment, the device has a spatial distance separating the first active region and the second active region. In a preferred embodiment, the spatial distance is characterized by a dimension of 1 micron and less. The device has a fluid material in contact with the first active region, the second active region, and the spatial distance according to a specific embodiment. The device also has a reactant species within the fluid material. The reactant species is capable of spatially moving from the first active region to the second active region over the spatial distance of 1 micron and less within a time of less than 10 microseconds.
摘要翻译：一种包含活性区域阵列的装置，其用于在顺序过程（例如顺序反应）中使至少两个活性区域中的一种或多种物质反应。该装置具有透明基板部件，该基板部件具有表面区域。该装置具有覆盖表面区域的硅烷材料。该装置具有覆盖硅烷材料的第一部分的第一有源区。在具体实施方案中，第一有源区具有尺寸小于1微米的第一尺寸，并具有一个或多个能够结合硅烷材料的第一部分的第一分子。在具体实施方案中，该装置具有覆盖硅烷材料的第二部分的第二有源区。第二有源区具有尺寸小于1微米的第二维度，并且具有一个或多个能够结合活性区的第二部分的第二分子。在具体实施例中，该装置具有分隔第一有源区和第二有源区的空间距离。在优选实施例中，空间距离的特征在于1微米和更小的尺寸。根据具体实施例，该装置具有与第一有源区域，第二有源区域和空间距离接触的流体材料。该装置还在流体材料内具有反应物种类。反应物种能够在小于10微秒的时间内在空间距离为1微米以下的空间距离上从第一有源区域移动到第二有源区域。

2. 发明申请

WO2005076832A2 METHOD FOR MANUFACTURING SINGLE WALL CARBON NANOTUBE TIPS 审中-公开
标题翻译：制造单壁碳纳米管提示的方法
公开(公告)号：WO2005076832A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/002668
申请日：2005-02-01
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , COLLIER, Charles, Patrick , MA, Ziyang , QUAKE, Stephen, R. , SHAPIRO, Ian, R. , WADE, Lawrence, A.
发明人： COLLIER, Charles, Patrick , MA, Ziyang , QUAKE, Stephen, R. , SHAPIRO, Ian, R. , WADE, Lawrence, A.
IPC分类号： C01B31/02 , G01Q10/00 , G01Q60/24 , G01Q60/38 , G01Q70/10 , G01Q70/12 , G01R3/00 , G21K7/00
CPC分类号： C01B32/162 , C01B2202/02 , C01B2202/34 , C01B2202/36 , G01Q60/38 , G01Q70/12 , G01R3/00
摘要： A method for fabricating assembled structures. The method includes providing a tip structure, which has a first end, a second end, and a length defined between the first end and the second end. The second end is a free end. The method includes attaching a nano-sized structure along a portion of the length of the tip structure to extend a total length of the tip structure to include the length of the tip structure and a first length associated with the nano-sized structure. The method includes shortening the nano-sized structure from the first length to a second length. The method also includes pushing the nano-sized structure in a direction parallel to the second length to reduce the second length to a third length of the nano-sized structure along the direction parallel to the second length to cause the nano-sized structure to move along a portion of the length of the tip structure.
摘要翻译：一种组装结构的制造方法。该方法包括提供尖端结构，其具有第一端，第二端和限定在第一端和第二端之间的长度。第二端是自由端。该方法包括沿着尖端结构的长度的一部分附接纳米尺寸结构以延伸尖端结构的总长度以包括尖端结构的长度和与纳米尺寸结构相关联的第一长度。该方法包括将纳米尺寸结构从第一长度缩短到第二长度。该方法还包括沿平行于第二长度的方向推动纳米尺寸结构，以沿平行于第二长度的方向将纳米尺寸结构的第二长度减小到第三长度，以使纳米尺寸结构移动沿着尖端结构的长度的一部分。

3. 发明申请

WO2005034206A2 SELECTIVE FUNCTIONALIZATION OF CARBON NANOTUBE TIPS ALLOWING FABRICATION OF NEW CLASSES OF NANOSCALE SENSING AND MANIPULATION TOOLS 审中-公开
标题翻译：碳纳米管选择性功能化，允许制造新型纳米级感应和操作工具
公开(公告)号：WO2005034206A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/005193
申请日：2004-02-20
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , WADE, Lawrence, A. , SHAPIRO, Ian, R. , COLLIER, Charles, Patrick , ESPLANDIU, Maria, J. , BITTNER, JR., Vern, Garrett
发明人： WADE, Lawrence, A. , SHAPIRO, Ian, R. , COLLIER, Charles, Patrick , ESPLANDIU, Maria, J. , BITTNER, JR., Vern, Garrett
IPC分类号： H01L
CPC分类号： G01Q70/12
摘要： Embodiments in accordance with the present invention relate to techniques for the growth and attachment of single wall carbon nanotubes (SWNT), facilitating their use as robust and well-characterized tools for AFM imaging and other applications. In accordance with one embodiment, SWNTs attached to an AFM tip can function as a structural scaffold for nanoscale device fabrication on a scanning probe. Such a probe can trigger, with nanometer precision, specific biochemical reactions or conformational changes in biological systems. The consequences of such triggering can be observed in real time by single-molecule fluorescence, electrical, and/or AFM sensing. Specific embodiments in accordance with the present invention utilize sensing and manipulation of individual molecules with carbon nanotubes, coupled with single-molecule fluorescence imaging, to allow observation of spectroscopic signals in response to mechanically induced molecular changes. Biological macromolecules such as proteins or DNA can be attached to nanotubes to create highly specific single-molecule probes for investigations of intermolecular dynamics, for assembling hybrid biological and nanoscale materials, or for developing molecular electronics. In one example, electrical wiring of single redox enzymes to carbon nanotube scanning probes allows observation and electrochemical control over single enzymatic reactions by monitoring fluorescence from a redox-active cofactor or the formation of fluorescent products. Enzymes "nanowired" to the tips of carbon nanotubes in accordance with embodiments of the present invention, may enable extremely sensitive probing of biological stimulus-response with high spatial resolution, including product-induced signal transduction.
摘要翻译：根据本发明的实施方案涉及用于生长和附着单壁碳纳米管（SWNT）的技术，便于将其用作用于AFM成像和其它应用的鲁棒且良好表征的工具。根据一个实施例，附接到AFM尖端的SWNT可以用作扫描探针上的纳米级器件制造的结构支架。这样的探针可以以纳米精度触发生物系统中的特定生化反应或构象变化。这种触发的后果可以通过单分子荧光，电学和/或AFM感测实时观察到。根据本发明的具体实施方案利用与单分子荧光成像耦合的碳纳米管的单个分子的感测和操纵，以便响应于机械诱导的分子变化观察光谱信号。生物大分子如蛋白质或DNA可以连接到纳米管上，以产生用于分子间动力学研究的高度特异性单分子探针，用于组装混合生物和纳米级材料，或用于开发分子电子学。在一个实例中，单个氧化还原酶与碳纳米管扫描探针的电气配线允许通过监测来自氧化还原活性辅助因子的荧光或荧光产物的形成来观察和电化学控制单个酶反应。根据本发明的实施方案，“纳米线”纳米线对碳纳米管的尖端可以实现具有高空间分辨率（包括产物诱导的信号转导）的生物刺激反应的极度敏感的探测。

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