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1. 发明申请

WO2011163526A3 SIGNAL ACTIVATED MOLECULAR DELIVERY 审中-公开
标题翻译：信号激活分子递送
公开(公告)号：WO2011163526A3
公开(公告)日：2012-04-12
申请号：PCT/US2011041703
申请日：2011-06-23
申请人： CALIFORNIA INST OF TECHN , HAN SI-PING , GODDARD WILLIAM A III , SCHERER LISA , ROSSI JOHN J , HOPE CITY
发明人： HAN SI-PING , GODDARD WILLIAM A III , SCHERER LISA , ROSSI JOHN J
IPC分类号： C12N15/11 , C12N15/87 , C12Q1/25 , C12Q1/68
CPC分类号： C12N15/87 , C12N15/111 , C12N2310/14 , C12N2310/3519 , C12N2320/32 , C12N2320/50
摘要： Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.
摘要翻译：本文提供了用于酶辅助递送分子和相关组分的信号激活分子构建体，例如传感器结构域，组合物，方法和系统。

2. 发明申请

WO2005031850A3 DETECTION AND REDUCTION OF DIELECTRIC BREAKDOWN IN SEMICONDUCTOR DEVICES 审中-公开
标题翻译：在半导体器件中的电介质断开的检测和减少
公开(公告)号：WO2005031850A3
公开(公告)日：2006-01-05
申请号：PCT/US2004031589
申请日：2004-09-24
申请人： CALIFORNIA INST OF TECHN , GODDARD WILLIAM A III , MIYATA MASAYASU , TAHIR-KHELI JAMIL
发明人： GODDARD WILLIAM A III , MIYATA MASAYASU , TAHIR-KHELI JAMIL
IPC分类号： G01N21/66 , H01L21/66
CPC分类号： G01N21/66 , H01L22/00 , H01L22/24
摘要： Methods for detecting the breakdown potential of a semiconductor device having a thin dielectric layer are disclosed. The method includes measuring a spectroscopy of the thin dielectric layer and determining whether the spectroscopy exhibits the presence of a breakdown precursor (H 2 , H interstitial radical, H attached radical, and H attached dimer). Preferably, the method is carried out in the presence of a substantially significant applied electric field across dielectric layer. A semiconductor device tested in accordance with this method is also disclosed. Additionally, methods for reducing dielectric breakdown of a semiconductor device having a thin dielectric layer involving the substitution of a second molecule for H 2 molecules present in the dielectric. This second molecule preferably does not react with Si or O to form an undesired attached state and may be an inert gas having a molecular size approximating that of a Hydrogen atom, such as Helium. A semiconductor device made using this method is also disclosed.
摘要翻译：公开了一种用于检测具有薄介电层的半导体器件的击穿电位的方法。该方法包括测量薄介电层的光谱，并确定光谱是否表现出分解前体（H 2 H 2，H间隙自由基，H连接基团和H连接的二聚体）的存在。优选地，该方法在跨介电层的基本上有效的施加电场的存在下进行。还公开了根据该方法测试的半导体器件。另外，用于减小具有薄介电层的半导体器件的电介质击穿的方法涉及电介质中存在的H 2 H 2分子的第二分子。该第二分子优选不与Si或O反应以形成不期望的附着状态，并且可以是分子大小接近氢原子如氦的惰性气体。还公开了使用该方法制造的半导体器件。

3. 发明申请

WO2011160093A3 METHODS AND SYSTEMS FOR MODULATING HORMONES AND RELATED METHODS, AGENTS AND COMPOSITIONS 审中-公开
标题翻译：用于调制HORMONES的方法和系统及相关方法，试剂和组合物
公开(公告)号：WO2011160093A3
公开(公告)日：2012-04-26
申请号：PCT/US2011040994
申请日：2011-06-17
申请人： CALIFORNIA INST OF TECHN , GODDARD WILLIAM A III , MENNA MARK , PANDOL STEPHEN , ABROL RAVINDER
发明人： GODDARD WILLIAM A III , MENNA MARK , PANDOL STEPHEN , ABROL RAVINDER
IPC分类号： A61K31/145 , A61K31/136 , A61K31/505 , A61K31/702 , A61P3/04 , A61P3/10
CPC分类号： G01N33/566 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/167 , A61K31/17 , A61K31/205 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/513 , A61K31/7016 , A61K31/704 , A61K47/61 , G01N2333/705
摘要： Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
摘要翻译：本文提供了苦味味受体配体，相关试剂，组合，组合物，方法和系统，用于在个体的胃肠道的细胞体外或体内调节代谢激素的释放。

4. 发明申请

WO0171347A8 METHOD AND APPARATUS FOR PREDICTING LIGAND BINDING INTERACTIONS 审中-公开
标题翻译：用于预测配对绑定交互的方法和装置
公开(公告)号：WO0171347A8
公开(公告)日：2002-02-21
申请号：PCT/US0109402
申请日：2001-03-23
申请人： CALIFORNIA INST OF TECHN , FLORIANO WELY B , VAIDEHI NAGARAJAN , GODDARD WILLIAM A III
发明人： FLORIANO WELY B , VAIDEHI NAGARAJAN , GODDARD WILLIAM A III
IPC分类号： G01N33/68 , G06F19/16 , G01N33/48
CPC分类号： G06F19/16 , G01N33/6803
摘要： Computer-implemented methods and apparatus implement a hierarchy of molecular modeling techniques for predicting binding sites of ligands in proteins, designing new pharmaceuticals and understanding the interactions of proteins involved in microbial pathogens. The techniques employ a hierarchical strategy ranging from coarse grain to fine grain conformational search methods combined with hierarchical levels of accuracy in scoring functions.
摘要翻译：计算机实现的方法和装置实现了分子建模技术的层次结构，用于预测蛋白质中配体的结合位点，设计新的药物并了解微生物病原体参与的蛋白质的相互作用。该技术采用分级策略，从粗粒到精细粒子构象搜索方法结合评分函数的分级准确度。

5. 发明专利

NO20074827L 未知
公开(公告)号：NO20074827L
公开(公告)日：2007-09-21
申请号：NO20074827
申请日：2007-09-21
申请人： GODDARD WILLIAM A III
发明人： PERIANA ROY A , GODDARD WILLIAM A III
IPC分类号： B01J31/26 , B01J38/12 , C07C27/12
摘要： This invention discloses methods and processes for selectively converting hydrocarbons such as methane to materials such as alcohols or other materials containing more reactive functionalities.

6. 发明专利

NO20074827A 未知
公开(公告)号：NO20074827A
公开(公告)日：2007-09-21
申请号：NO20074827
申请日：2007-09-21
申请人： GODDARD WILLIAM A III
发明人： PERIANA ROY A , GODDARD WILLIAM A III
IPC分类号： B01J31/26 , B01J38/12 , C07C27/12
CPC分类号： C07C29/48 , B01J27/0573 , B01J31/1805 , C07B33/00 , C07C37/58 , C07C37/60 , Y02P20/52 , C07C31/04 , C07C39/04

7. 发明专利

CA2598699A1 NEW CATALYTIC SYSTEMS FOR THE CONVERSION OF HYDROCARBONS TO FUNCTIONALIZED PRODUCTS 未知
公开(公告)号：CA2598699A1
公开(公告)日：2006-08-31
申请号：CA2598699
申请日：2006-02-24
申请人： GODDARD WILLIAM A III , PERIANA ROY A
发明人： GODDARD WILLIAM A III , PERIANA ROY A
IPC分类号： C07C27/12 , C07C37/58
摘要： This invention discloses methods and processes for selectively converting hydrocarbons such as methane to materials such as alcohols or other materials containing more reactive functionalities.

8. 发明公开

EP2582367A4 METHODS AND SYSTEMS FOR MODULATING HORMONES AND RELATED METHODS, AGENTS AND COMPOSITIONS 无效
标题翻译：的主动和组合物的方法和系统进行调制激素及相关方法
公开(公告)号：EP2582367A4
公开(公告)日：2013-11-27
申请号：EP11796562
申请日：2011-06-17
申请人： CALIFORNIA INST OF TECHN
发明人： GODDARD WILLIAM A III , MENNA MARK , PANDOL STEPHEN , ABROL RAVINDER
IPC分类号： A61K31/145 , A61K9/00 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/136 , A61K31/167 , A61K31/205 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/7016 , A61K31/702 , A61K47/48 , A61P3/04 , A61P3/10 , G01N33/566
CPC分类号： G01N33/566 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/167 , A61K31/17 , A61K31/205 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/513 , A61K31/7016 , A61K31/704 , A61K47/61 , G01N2333/705
摘要： Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.

9. 发明公开

EP0920455A4 GROUP IV ZWITTERION ANSA METALLOCENE (ZAM) CATALYSTS FOR ALPHA-OLEFIN POLYMERIZATION 失效
标题翻译：催化剂基于两性离子安莎茂金属GROUP IV用于α-烯烃的聚合
公开(公告)号：EP0920455A4
公开(公告)日：2000-06-14
申请号：EP97938137
申请日：1997-08-08
申请人： CALIFORNIA INST OF TECHN
发明人： GODDARD WILLIAM A III , BRANDOW CHRISTOPHER G
IPC分类号： B01J31/00 , C07F7/24 , C07F9/00 , C07F11/00 , C07F15/00 , C07F17/00 , C08F4/06 , C08F4/44 , C08F4/639 , C08F10/00
CPC分类号： C07F17/00 , C08F4/63908 , C08F10/00 , C08F4/63927
摘要： Single component metallocene catalysts for α-olefin polymerization are disclosed. Prior art cation metallocene catalysts have required a separate anion co-catalyst like methyl aluminoxane (MAO). However, because the inventive zwitterion ansa metallocene (ZAM) catalysts have a 'built-in' anion co-catalyst functionality, the need for a separate anion co-catalyst is eliminated.

10. 发明申请

WO2006091849A2 NEW CATALYTIC SYSTEMS FOR THE CONVERSION OF HYDROCARBONS TO FUNCTIONALIZED PRODUCTS 审中-公开
标题翻译：用于将碳氢化合物转化为功能化产品的新催化体系
公开(公告)号：WO2006091849A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006656
申请日：2006-02-24
申请人： PERIANA ROY A , GODDARD WILLIAM A III
发明人： PERIANA ROY A , GODDARD WILLIAM A III
IPC分类号： C07C27/12 , C07C37/58
CPC分类号： C07C29/48 , B01J27/0573 , B01J31/1805 , C07B33/00 , C07C37/58 , C07C37/60 , Y02P20/52 , C07C31/04 , C07C39/04
摘要： This invention discloses methods and processes for selectively converting hydrocarbons such as methane to materials such as alcohols or other materials containing more reactive functionalities.
摘要翻译：本发明公开了用于选择性地将诸如甲烷的烃转化为诸如醇或其它含有更多反应性官能团的材料的材料的方法和方法。

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