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1. 发明申请

WO2006071470A2 MICROFLUIDIC DEVICES WITH CHEMICAL REACTION CIRCUITS 审中-公开
标题翻译：具有化学反应电路的微流体装置
公开(公告)号：WO2006071470A2
公开(公告)日：2006-07-06
申请号：PCT/US2005044072
申请日：2005-12-05
申请人： CALIFORNIA INST OF TECHN , FLUIDIGM CORP , UNIV CALIFORNIA , SIEMENS CORP , LEE CHUNG-CHENG , SUI GUODONG , ELIZAROV ARKADIJ , KOLB HARTMUTH C , HUANG JIANG , HEATH JAMES R , PHELPS MICHAEL E , QUAKE STEPHEN R , TSENG HSIAN-RONG , WYATT PAUL , DARIDON ANTOINE
发明人： LEE CHUNG-CHENG , SUI GUODONG , ELIZAROV ARKADIJ , KOLB HARTMUTH C , HUANG JIANG , HEATH JAMES R , PHELPS MICHAEL E , QUAKE STEPHEN R , TSENG HSIAN-RONG , WYATT PAUL , DARIDON ANTOINE
CPC分类号： B01J19/0093 , B01F11/0042 , B01F13/0059 , B01F2215/0404 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01L3/5027 , B33Y80/00 , C07B59/00
摘要： New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.
摘要翻译：提供了用于进行化学反应的新型微流体装置。该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。

3. 发明公开

EP1287532A4 METHOD FOR PRODUCING ?18 F|FLUORIDE ION 审中-公开
标题翻译： VERFAHREN ZUR ERZEUGUNG EINESü18ùF| -FLUORIDIONS
公开(公告)号：EP1287532A4
公开(公告)日：2006-10-25
申请号：EP01941492
申请日：2001-05-16
申请人： UNIV CALIFORNIA
发明人： BARRIO JORGE R , SATYAMURTHY NAGICHETTIAR , PHELPS MICHAEL E
IPC分类号： C01B7/20 , C07D471/10 , C07D473/18 , C07H5/02 , C07H19/06 , G21G1/10 , G21G4/08
CPC分类号： G21G1/10
摘要： A method for producing [ F] fluoride ion comprises loading an enclosed chamber (16) of a metal target with [ O]oxygen gas. The [ O] oxygen gas is irradiated in the enclosed chamber (16) to produce [ F] fluoride ion in the chamber (16). The produced[ F]fluoride ion is removed from the chamber (16) without opening the target, preferably by introducing a solubilizing agent into the enclosed chamber (16) to solubilize produced [ F] ion from the enclosed chamber (16) without opening the target. The remaining [ O]oxygen gas is removed from the chamber (16) for reuse prior to removing the [ F]fluoride ion from the chamber (16). The produced [ F]fluoride ion is reactive and can be used to produce radiolabeled compounds such as 2-deoxy-2[ F]fluoro-D-glucose.
摘要翻译：生产[18 F]氟化物离子的方法包括用[18 O]氧气装载金属靶的封闭室（16）。在封闭室（16）中照射[18 O]氧气以在室（16）中产生[18 F]氟化物离子。产生的[18 F]氟化物离子在不打开靶的情况下从腔室（16）中移除，优选通过将增溶剂引入封闭腔室（16）中以从封闭腔室中溶解所产生的[18 F]离子（16）而不打开目标。在从腔室（16）移除[18 F]氟化物离子之前，将剩余的[18 O]氧气从腔室（16）移除以重新使用。产生的[18 F]氟化物离子是反应性的并且可以用于产生放射性标记的化合物如2-脱氧-2 [18 F]氟-D-葡萄糖。

4. 发明专利

AU2003226317A1 CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS 未知
公开(公告)号：AU2003226317A1
公开(公告)日：2003-11-03
申请号：AU2003226317
申请日：2003-04-08
申请人： UNIV CALIFORNIA
发明人： PHELPS MICHAEL E , BARRIO JORGE R , TOYOKUNI TATSUSHI , SATYAMURTHY NAGICHETTIAR , HERSCHMAN HARVEY R
IPC分类号： A61K49/10 , A61K51/04 , A61K51/00 , A61B5/055
摘要： This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

5. 发明专利

AU7484301A Method for producing(¹⁸F)fluoride ion 未知
公开(公告)号：AU7484301A
公开(公告)日：2001-11-26
申请号：AU7484301
申请日：2001-05-16
申请人： UNIV CALIFORNIA
发明人： BARRIO JORGE R , SATYAMURTHY NAGICHETTIAR , PHELPS MICHAEL E
IPC分类号： C01B7/20 , C07D471/10 , C07D473/18 , C07H5/02 , C07H19/06 , G21G1/10 , G21G4/08

6. 发明申请

WO0187235A3 METHOD FOR PRODUCING[<18>F]FLUORIDE ION 审中-公开
标题翻译：生产[18 F]氟化物离子的方法
公开(公告)号：WO0187235A3
公开(公告)日：2002-05-30
申请号：PCT/US0115921
申请日：2001-05-16
申请人： UNIV CALIFORNIA
发明人： BARRIO JORGE R , SATYAMURTHY NAGICHETTIAR , PHELPS MICHAEL E
IPC分类号： C01B7/20 , C07D471/10 , C07D473/18 , C07H5/02 , C07H19/06 , G21G1/10 , G21G4/08
CPC分类号： G21G1/10
摘要： A method for producing [ F] fluoride ion comprises loading an enclosed chamber (16) of a metal target with [ O]oxygen gas. The [ O] oxygen gas is irradiated in the enclosed chamber (16) to produce [ F] fluoride ion in the chamber (16). The produced[ F]fluoride ion is removed from the chamber (16) without opening the target, preferably by introducing a solubilizing agent into the enclosed chamber (16) to solubilize produced [ F] ion from the enclosed chamber (16) without opening the target. The remaining [ O]oxygen gas is removed from the chamber (16) for reuse prior to removing the [ F]fluoride ion from the chamber (16). The produced [ F]fluoride ion is reactive and can be used to produce radiolabeled compounds such as 2-deoxy-2[ F]fluoro-D-glucose.
摘要翻译：用于生产[18 F]氟离子的方法包括用[18 O]氧气装载金属靶的封闭室（16）。在封闭室（16）中照射[18 O]氧气，以在室（16）中产生[18 F]氟化物离子。所产生的[18 F]氟化物离子不会打开靶，从腔室（16）中排出，优选通过将增溶剂引入封闭室（16）中以从封闭室中溶解产生的[18 F]离子（16），而不打开目标。在从室（16）中除去[18 F]氟化物离子之前，剩余的[18 O]氧气从室（16）中除去以便重新使用。产生的[18 F]氟离子是反应性的，可用于产生放射性标记的化合物，例如2-脱氧-2 [18 F]氟-D-葡萄糖。

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