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1. 发明申请

WO2004002445A3 NOVEL FLOATING DOSAGE FORM 审中-公开
标题翻译：新的浮动剂型
公开(公告)号：WO2004002445A3
公开(公告)日：2004-03-04
申请号：PCT/IN0300229
申请日：2003-06-25
申请人： CADILA HEALTHCARE LTD , LOHRAY BRAJ BHUSHAN , TIWARI SANDIP B , PAI RAVEENDRA M , MURTHY KRISHNA T , MEHTA PAVAK R
发明人： LOHRAY BRAJ BHUSHAN , TIWARI SANDIP B , PAI RAVEENDRA M , MURTHY KRISHNA T , MEHTA PAVAK R
IPC分类号： A61K9/00
CPC分类号： A61K9/0065
摘要： Present invention relates to a novel pharmaceutical composition containing an active ingredient(s) which is retained in the stomach or upper part of gastrointestinal tract for controlled delivery of medicament for improved local treatment, and/or better absorption from upper parts of gastrointestinal tract for effective therapeutic results. Present invention also provides a method for preparation of the said dosage form preferably in the form of a bilayer tablet, in which one layer constitutes for spatial control and the other being for temporal control.
摘要翻译：本发明涉及含有活性成分的新型药物组合物，所述活性成分保留在胃肠道或胃肠道的上部用于控制递送药物以改善局部治疗和/或从胃肠道上部更好地吸收以有效地治疗结果。本发明还提供了制备所述剂型的方法，其优选为双层片剂形式，其中一层构成空间控制而另一层构成时间控制。

2. 发明申请

WO2005123134A3 A CONTROLLED RELEASE DELIVERY SYSTEM FOR METFORMIN 审中-公开
标题翻译：用于METFORMIN的控制释放系统
公开(公告)号：WO2005123134A3
公开(公告)日：2006-04-27
申请号：PCT/IN2005000148
申请日：2005-05-05
申请人： CADILA HEALTHCARE LTD , LOHRAY BRAJ BHUSHAN , TIWARI SANDIP B
发明人： LOHRAY BRAJ BHUSHAN , TIWARI SANDIP B
IPC分类号： A61K9/20 , A61K31/155 , A61K47/00 , A61P3/10
CPC分类号： A61K9/2013 , A61K9/2054 , A61K31/155
摘要： The invention relates to a controlled release delivery system for Metformin comprising of (a) therapeutically effective amount of Metformin or pharmaceutically acceptable salts there of; (b) hydrophilic polymers and (c) hydrophobic lubricating agent(s). The invention also relates to a method of making the said solid dosage form.
摘要翻译：本发明涉及二甲双胍的控制释放递送系统，其包含（a）治疗有效量的二甲双胍或其药学上可接受的盐; （b）亲水性聚合物和（c）疏水性润滑剂。本发明还涉及制备所述固体剂型的方法。

3. 发明申请

WO2008035359A2 OXIMINOPHENOXYALKANOIC ACID AND PHENYLALKANOIC ACID DERIVATIVES 审中-公开
标题翻译：亚硝基羟基烷酸和苯甲酸衍生物
公开(公告)号：WO2008035359A2
公开(公告)日：2008-03-27
申请号：PCT/IN2007000226
申请日：2007-06-05
申请人： CADILA HEALTHCARE LTD , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PINGALI HARIKISHORE , PATEL PANKAJ RAMANBHAI
发明人： LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PINGALI HARIKISHORE , PATEL PANKAJ RAMANBHAI
IPC分类号： C07C251/48 , A61K31/15 , A61K31/216 , A61K31/517 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , C07C251/52 , C07D239/90
CPC分类号： C07D239/90 , C07C251/48 , C07C251/52 , C07C2601/08 , C07C2601/14 , C07D207/333 , C07D209/08 , C07D209/86 , C07D231/12 , C07D263/24 , C07D263/32 , C07D265/36 , C07D265/38 , C07D277/24 , C07D333/22
摘要： The present invention discloses oximinophenoxyalkanoic acid and phenylalkanoic acid of the general formula (I) their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译：本发明公开了通式（I）的肟基苯氧基链烷酸和苯基链烷酸的互变异构形式，它们的立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及涉及它们的中间体制备。

4. 发明申请

WO2007052300A3 PROCESSES FOR THE PREPARATION OF DIFFERENT FORMS OF (S)-(+)-CLOPIDOGREL BESYLATE 审中-公开
标题翻译：制备不同形式的（S） - （+） - 氯吡格雷乙酸酯的方法
公开(公告)号：WO2007052300A3
公开(公告)日：2007-07-12
申请号：PCT/IN2006000322
申请日：2006-08-28
申请人： CADILA HEALTHCARE LTD , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PANDEY BIPIN , DAVE MAYANK GHANSHYAMBHAI , DHOLAKIA PARIND NARENDRA
发明人： LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PANDEY BIPIN , DAVE MAYANK GHANSHYAMBHAI , DHOLAKIA PARIND NARENDRA
IPC分类号： C07D495/04 , A61K31/4365 , A61P9/10
CPC分类号： C07D495/04
摘要： Disclosed herein are the improved processes for the preparation of different forms of (S)-(+)-Clopidogrel besylate, pharmaceutical compositions containing them and their use in medicine.
摘要翻译：本文公开了制备不同形式的（S） - （+） - 苯磺酸氯吡格雷，含有它们的药物组合物及其在医学中的用途的改进方法。

5. 发明申请

WO2008059513A3 COMPOUNDS SUITABLE AS MODULATORS OF HDL 审中-公开
标题翻译：适合作为HDL调节剂的化合物
公开(公告)号：WO2008059513A3
公开(公告)日：2008-08-28
申请号：PCT/IN2007000321
申请日：2007-07-27
申请人： CADILA HEALTHCARE LTD , THOMBARE PRAVIN S , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PATEL PANKAJ RAMANBHAI
发明人： THOMBARE PRAVIN S , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PATEL PANKAJ RAMANBHAI
IPC分类号： C07D215/36 , A61K31/47 , C07C237/30 , C07D215/48 , C07D221/16 , C07D223/16 , C07D237/30 , C07D265/36 , C07D405/12
CPC分类号： C07C237/30 , C07C2601/14 , C07D215/48 , C07D405/12
摘要： Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
摘要翻译：在本发明的实施方案中公开的是适合作为具有通式（1）的HDL的调节剂的化合物，涉及其合成的新中间体，其药学上可接受的盐和含有它们的药物组合物。本发明还涉及制备通式（1）的化合物，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物和参与其合成的新中间体的方法。

6. 发明申请

WO2007017892A2 NOVEL COMPOUNDS AS GLP-I AGONISTS 审中-公开
标题翻译：新型化合物作为GLP-I激动剂
公开(公告)号：WO2007017892A2
公开(公告)日：2007-02-15
申请号：PCT/IN2006000154
申请日：2006-05-04
申请人： CADILA HEALTHCARE LTD , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , BAHEKAR RAJESH H
发明人： LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , BAHEKAR RAJESH H
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention describes a group of novel peptidomimetics useful for the treatment of diabetes. These compounds are defined by the general formula (I) as given below. A-X 1 - S 1 -Y-S 2 -X 2 -B (I)
摘要翻译：本发明描述了一组用于治疗糖尿病的新型肽模拟物。这些化合物由如下给出的通式（I）定义。 A-X 1 -S 1 -Y-S 2 -X 2 -B（I）

7. 发明申请

WO2005019224A3 NOVEL ANTIINFECTIVE COMPOUNDS 审中-公开
标题翻译：新型抗菌化合物
公开(公告)号：WO2005019224A3
公开(公告)日：2005-07-28
申请号：PCT/IN2004000155
申请日：2004-06-04
申请人： CADILA HEALTHCARE LTD , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , SRIVASTAVA BRIJESH KUMAR
发明人： LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , SRIVASTAVA BRIJESH KUMAR
IPC分类号： A61K31/435 , C07D491/04 , C07D495/04
CPC分类号： C07D495/04 , C07D491/04
摘要： The present invention describes novel antiinfective compounds of formula (I), process for their preparation and pharmaceutical compositions containing them.
摘要翻译：本发明描述了式（I）的新型抗感染化合物，其制备方法和含有它们的药物组合物。

8. 发明申请

WO2004007490A2 A NOVEL PROCESS TO PREPARE PIOGLITAZONE VIA SEVERAL NOVEL INTERMEDIATES. 审中-公开
标题翻译：通过几个新的中介来制备PIOGLITAZONE的新过程。
公开(公告)号：WO2004007490A2
公开(公告)日：2004-01-22
申请号：PCT/IN0300241
申请日：2003-07-15
申请人： CADILA HEALTHCARE LTD , PANDEY BIPIN , LOHRAY VIDYA BHUSHAN , LOHRAY BRAJ BHUSHAN
发明人： PANDEY BIPIN , LOHRAY VIDYA BHUSHAN , LOHRAY BRAJ BHUSHAN
IPC分类号： C07D213/30 , C07D213/34 , C07D417/12 , C07D417/00
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, are described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
摘要翻译：描述了制备噻唑烷二酮类，优选吡格列酮的新方法。还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。

9. 发明申请

WO02059128A3 PROCESS FOR PREPARING CLOPIDOGREL 审中-公开
标题翻译：制备石蜡的方法
公开(公告)号：WO02059128A3
公开(公告)日：2002-12-19
申请号：PCT/IN0200012
申请日：2002-01-21
申请人： CADILA HEALTHCARE LTD , PANDEY BIPIN , LOHRAY VIDYA BHUSHAN , LOHRAY BRAJ BHUSHAN
发明人： PANDEY BIPIN , LOHRAY VIDYA BHUSHAN , LOHRAY BRAJ BHUSHAN
IPC分类号： A61K31/4365 , A61P7/02 , C07B55/00 , C07B57/00 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention discloses a process for the preparation of thieno[3,2-c]pyridine derivatives of general formula (I), in either racemic or optically active (+) or (-) forms and their salts, wherein X, the substituent on benzene ring represents either a hydrogen or halogen atom such as fluorine, chlorine, bromine or iodine. The present invention also describes a process for preparing the compounds of general formula (II), in either racemic or optically active (+) or (-) forms and their salts, where X, the substituent on benzene ring represents either a hydrogen or halogen atom such as fluorine, chlorine, bromine or iodine. The compounds represented by formulae (I) and (II) have one asymmetric carbon and hence, the optically active compounds of formula (I) or of formula (ii), may be obtained either by resolving the racemic intermediate/final product or using an optically active intermediate. The compounds of the invention are pharmacologically active and have significant anti-aggregating and anti-thrombotic properties.
摘要翻译：本发明公开了以外消旋或光学活性（+）或（ - ）形式制备通式（I）的噻吩并[3,2-c]吡啶衍生物及其盐的方法，其中X为取代基苯环表示氢或卤素原子，例如氟，氯，溴或碘。本发明还描述了以外消旋或光学活性（+）或（ - ）形式制备通式（II）化合物及其盐的方法，其中X，苯环上的取代基表示氢或卤素原子如氟，氯，溴或碘。由式（I）和（II）表示的化合物具有一个不对称碳，因此式（I）或式（ii）的光学活性化合物可以通过拆分外消旋中间体/最终产物或使用光学活性中间体。本发明的化合物具有药理活性并且具有显着的抗聚集和抗血栓形成性质。

10. 发明申请

WO2007099553A2 1,3-DIOXANE CARBOXYLIC ACIDS 审中-公开
标题翻译： 1,3-二氧代羧酸
公开(公告)号：WO2007099553A2
公开(公告)日：2007-09-07
申请号：PCT/IN2007000066
申请日：2007-02-19
申请人： CADILA HEALTHCARE LTD , PINGALI HARIKISHORE , MAKADIA PANKAJ MAGANLAL , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PATEL PANKAJ RAMANBHAI
发明人： PINGALI HARIKISHORE , MAKADIA PANKAJ MAGANLAL , LOHRAY BRAJ BHUSHAN , LOHRAY VIDYA BHUSHAN , PATEL PANKAJ RAMANBHAI
CPC分类号： C07D319/06
摘要： The present invention relates to novel 1,3-dioxane carboxylic acids of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
摘要翻译：本发明涉及通式（I）的新型1,3-二恶烷羧酸，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及中间体参与其制备。

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