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1. 发明授权

US08772017B2 Integrated nucleic acid assays 有权
标题翻译：综合核酸测定
公开(公告)号：US08772017B2
公开(公告)日：2014-07-08
申请号：US13492612
申请日：2012-06-08
申请人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
发明人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
IPC分类号： C12M1/34
CPC分类号： C12Q1/6834 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , C12Q2563/131 , C12Q2525/197 , C12Q2563/143 , C12Q2565/629
摘要： Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
摘要翻译：公开了用于从临床样品进行核酸提取，扩增和检测的集成微流控柱。这些设备是单进入，卫生和一次性的。该装置能够进行单核或多重核酸靶标检测，例如：用于多种感染剂的测定板或癌细胞类型的测定板。还公开了在全自动气动控制装置中使用微流控盒的方法。

2. 发明授权

US08222023B2 Integrated nucleic acid assays 有权
标题翻译：综合核酸测定
公开(公告)号：US08222023B2
公开(公告)日：2012-07-17
申请号：US12207627
申请日：2008-09-10
申请人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
发明人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
IPC分类号： C12M1/34
CPC分类号： C12Q1/6834 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , C12Q2563/131 , C12Q2525/197 , C12Q2563/143 , C12Q2565/629
摘要： Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
摘要翻译：公开了用于从临床样品进行核酸提取，扩增和检测的集成微流控柱。这些设备是单进入，卫生和一次性的。该装置能够进行单核或多重核酸靶标检测，例如：用于多种感染剂的测定板或癌细胞类型的测定板。还公开了在全自动气动控制装置中使用微流控盒的方法。

3. 发明申请

US20090148933A1 INTEGRATED NUCLEIC ACID ASSAYS 有权
标题翻译：一体化核酸分析
公开(公告)号：US20090148933A1
公开(公告)日：2009-06-11
申请号：US12207627
申请日：2008-09-10
申请人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
发明人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
IPC分类号： C12M1/34
CPC分类号： C12Q1/6834 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , C12Q2563/131 , C12Q2525/197 , C12Q2563/143 , C12Q2565/629
摘要： Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
摘要翻译：公开了用于从临床样品进行核酸提取，扩增和检测的集成微流控柱。这些设备是单进入，卫生和一次性的。该装置能够进行单核或多重核酸靶标检测，例如：用于多种感染剂的测定板或癌细胞类型的测定板。还公开了在全自动气动控制装置中使用微流控盒的方法。

4. 发明申请

US20090325276A1 INTEGRATED MICROFLUIDIC ASSAY DEVICES AND METHODS 审中-公开
标题翻译：综合微流感测定装置及方法
公开(公告)号：US20090325276A1
公开(公告)日：2009-12-31
申请号：US12411020
申请日：2009-03-25
申请人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
发明人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
IPC分类号： C12M1/00
CPC分类号： G01N33/5302 , B01F11/0071 , B01F13/0059 , B01L3/502715 , B01L7/52 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , Y02A50/58
摘要： Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.
摘要翻译：提供了用于同时评估血清学和分子生物学靶标的微流体诊断测试模块的组合，并且包括在一次性使用的装置中对抗体（或抗原）和核酸靶标进行面板测试。这些改进旨在评估致病过程的总体进展和活动，而不仅仅是特定诊断标记的存在或不存在，这通常是不完整的或具有误导性的。

5. 发明授权

US08110392B2 Methods and devices for microfluidic point-of-care immunoassays 有权
标题翻译：用于微流控点免疫测定的方法和装置
公开(公告)号：US08110392B2
公开(公告)日：2012-02-07
申请号：US12341637
申请日：2008-12-22
申请人： C Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R Williford , John Clemmens
发明人： C Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R Williford , John Clemmens
IPC分类号： C12M1/36
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译：公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理而设计的系统中的混合和试剂和样品操作方面的改进。

6. 发明申请

US20090148847A1 RAPID MAGNETIC FLOW ASSAYS 审中-公开
标题翻译：快速磁流测定
公开(公告)号：US20090148847A1
公开(公告)日：2009-06-11
申请号：US12203779
申请日：2008-09-03
申请人： Mark Kokoris , Melud Nabavi , Wayne L. Breidford , John Gerdes , Stephen Mordue , C. Frederick Battrell
发明人： Mark Kokoris , Melud Nabavi , Wayne L. Breidford , John Gerdes , Stephen Mordue , C. Frederick Battrell
IPC分类号： C12Q1/68 , C07H21/04 , B01J19/00
CPC分类号： C12Q1/6834 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , C12Q2563/131 , C12Q2525/197 , C12Q2563/143 , C12Q2565/629
摘要： Disclosed is an improvement in methods for nucleic acid and immunological bioassays. The methods comprise a step for “sweeping” paramagnetic bead: target molecule complexes so as to capture them with an affinity capture agent on a test pad by moving a magnetic force field from outside to inside the test pad area so as to bring into contact the paramagnetic complexes with the capture agent, while sweeping any unbound paramagnetic material off the test pad by moving the magnetic field from inside to outside the test pad area. Surprisingly, the paramagnetic complexes are rapidly affinity-extracted from the moving magnetic field.
摘要翻译：披露了核酸和免疫生物测定方法的改进。所述方法包括用于“扫掠”顺磁珠：靶分子复合物的步骤，以便通过将磁力场从外部移动到测试垫区域的内部，将它们用亲和俘获剂捕获在测试垫上，以使其与与捕获剂的顺磁性复合物，同时通过将磁场从内部移动到测试焊盘区域外部，将任何未结合的顺磁材料从测试焊盘上扫除。令人惊奇的是，顺磁性络合物从移动磁场快速亲和提取。

7. 发明申请

US20090181411A1 METHODS AND DEVICES FOR MICROFLUIDIC POINT-OF-CARE IMMUNOASSAYS 有权
标题翻译：微流感点免疫法的方法和装置
公开(公告)号：US20090181411A1
公开(公告)日：2009-07-16
申请号：US12341637
申请日：2008-12-22
申请人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
发明人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , G01N21/00 , G01N21/64 , G01N33/00
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译：公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理设计的系统中的混合和试剂和样品操作方面的改进。

8. 发明申请

US20120164627A1 METHODS AND DEVICES FOR MICROFLUIDIC POINT-OF-CARE IMMUNOASSAYS 审中-公开
标题翻译：微流感点免疫法的方法和装置
公开(公告)号：US20120164627A1
公开(公告)日：2012-06-28
申请号：US13342859
申请日：2012-01-03
申请人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
发明人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
IPC分类号： G01N33/53 , G01N33/569 , G01N21/75 , B01L3/00 , C12M1/40
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译：公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理设计的系统中的混合和试剂和样品操作方面的改进。

9. 发明申请

US20060246575A1 Microfluidic rare cell detection device 审中-公开
标题翻译：微流体稀有细胞检测装置
公开(公告)号：US20060246575A1
公开(公告)日：2006-11-02
申请号：US11331587
申请日：2006-01-13
申请人： Christy Lancaster , C. Battrell , Jason Capodanno , John Gerdes , Mark Kokoris , Melud Nabavi , Stephen Mordue , Robert McRuer , John Clemmens , Wayne Breidford
发明人： Christy Lancaster , C. Battrell , Jason Capodanno , John Gerdes , Mark Kokoris , Melud Nabavi , Stephen Mordue , Robert McRuer , John Clemmens , Wayne Breidford
IPC分类号： C12M1/34
CPC分类号： F16K99/0001 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L7/52 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , B01L2400/0633 , F16K99/0007 , F16K99/0034 , F16K99/0046 , F16K2099/008 , F16K2099/0084 , G01N1/34 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/0069 , G01N2015/1409 , G01N2015/1486 , G01N2015/149
摘要： The present invention relates to microfluidic devices and methods for detecting rare cells. The disclosed microfluidic devices and methods integrate and automate sample preparation, cell labeling, cell sorting and enrichment, and DNA/RNA analysis of sorted cells.
摘要翻译：本发明涉及用于检测稀有细胞的微流体装置和方法。所公开的微流体装置和方法将样品制备，细胞标记，细胞分选和富集以及分选细胞的DNA / RNA分析整合并自动化。

10. 发明申请

US20070042427A1 Microfluidic laminar flow detection strip 审中-公开
标题翻译：微流体层流检测条
公开(公告)号：US20070042427A1
公开(公告)日：2007-02-22
申请号：US11416791
申请日：2006-05-03
申请人： John Gerdes , C. Battrell , Denise Hoekstra , John Clemmens , Stephen Mordue
发明人： John Gerdes , C. Battrell , Denise Hoekstra , John Clemmens , Stephen Mordue
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/54386 , G01N33/54366
摘要： The present invention relates to microfluidic laminar flow detection strip devices and methods for using and making the same. The disclosed devices comprise: a first inlet; a microfluidic channel having a first end and a second end, wherein the first end is fluidly connected to the first inlet; a bellows pump fluidly connected to the second end of the microfluidic channel, wherein the bellows pump comprises an absorbent material disposed therein; a dried reagent zone within the microfluidic channel, wherein the dried reagent zone comprises a first reagent and a control reagent printed thereon, the first reagent comprising a first detection antibody conjugated to a dyed substrate bead or functionalized for colorimetric development, and the control reagent comprising a control detection antibody conjugated to a dyed substrate bead or functionalized for calorimetric development; a first bound antibody zone within the microfluidic channel, wherein the first bound antibody zone comprises a first bound antibody printed thereon; and a control zone within the microfluidic channel, wherein the control zone comprises a control bound antibody printed thereon.
摘要翻译：本发明涉及微流体层流检测带装置及其制造方法。所公开的装置包括：第一入口; 微流体通道，其具有第一端和第二端，其中所述第一端流体连接到所述第一入口; 流体连接到微流体通道的第二端的波纹管泵，其中波纹管泵包括设置在其中的吸收材料; 微流体通道内的干燥试剂区，其中干燥的试剂区包含印刷在其上的第一试剂和对照试剂，第一试剂包含与染色的底物珠缀合或用于比色显影官能化的第一检测抗体，并且所述对照试剂包含与染色的基质珠缀合的控制检测抗体或用于量热显影功能化的对照检测抗体; 所述微流体通道内的第一结合抗体区，其中所述第一结合抗体区包含印刷在其上的第一结合抗体; 和微流体通道内的对照区，其中控制区包含印刷在其上的对照结合抗体。

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