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1. 发明授权

US07517654B2 Peptide and a derivative thereof promoting cell adhesion and spreading 有权
标题翻译：肽及其衍生物促进细胞粘附和扩散
公开(公告)号：US07517654B2
公开(公告)日：2009-04-14
申请号：US10555590
申请日：2005-07-08
申请人： Byung-Moo Min , Jin-Man Kim
发明人： Byung-Moo Min , Jin-Man Kim
IPC分类号： G01N33/53 , A61K38/04 , A61K39/00 , A61K38/00
CPC分类号： C07K14/78
摘要： The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3 chain LG3 domain, mediating integrin α3β1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments and derivatives thereof can be used effectively for research on cell adhesion activity, wound care, tissue regeneration, inhibition of cancer metastesis etc. mediated by various extracellular matrix protein including laminin.
摘要翻译：本发明涉及促进细胞粘附和扩散的肽，其片段及其衍生物，更具体地涉及人层粘连蛋白-5α3链LG3结构域中的整联蛋白α3β1依赖性肽，介导整合素α3beta1结合和细胞粘附和扩散，片段和衍生物。本发明的肽，其片段和衍生物可以有效地用于研究由包括层粘连蛋白在内的各种细胞外基质蛋白介导的细胞粘附活性，伤口护理，组织再生，抑制癌症转移等。

2. 发明申请

US20080096792A1 Peptide and a Derivative Thereof Promoting Cell Adhesion and Spreading 有权
标题翻译：肽及其衍生物促进细胞粘附和扩散
公开(公告)号：US20080096792A1
公开(公告)日：2008-04-24
申请号：US10555590
申请日：2005-07-08
申请人： Byung-Moo Min , Jin-Man Kim
发明人： Byung-Moo Min , Jin-Man Kim
IPC分类号： A61K38/00 , A61P17/02 , C07K16/00
CPC分类号： C07K14/78
摘要： The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3 chain LG3 domain, mediating integrin α3β1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments and derivatives thereof can be used effectively for research on cell adhesion activity, wound care, tissue regeneration, inhibition of cancer metastesis etc. mediated by various extracellular matrix protein including laminin.
摘要翻译：本发明涉及促进细胞粘附和扩散的肽，其片段及其衍生物，更具体地涉及人层粘连蛋白-5α3链LG3结构域中的整联蛋白α3β1依赖性肽，介导整合素α3β1结合和细胞粘附和扩散，片段及其衍生物。本发明的肽，其片段和衍生物可以有效地用于研究由包括层粘连蛋白在内的各种细胞外基质蛋白介导的细胞粘附活性，伤口护理，组织再生，抑制癌症转移等。

3. 发明授权

US07265705B1 Opamp and capacitor sharing scheme for low-power pipeline ADC 有权
标题翻译：低功耗管线ADC的运算放大器和电容器共享方案
公开(公告)号：US07265705B1
公开(公告)日：2007-09-04
申请号：US11463813
申请日：2006-08-10
申请人： Byung-Geun Lee , Byung-Moo Min
发明人： Byung-Geun Lee , Byung-Moo Min
IPC分类号： H03M1/34
CPC分类号： H03M1/145
摘要： A first stage circuit for a high-speed, high-resolution pipeline analog-to-digital converter (ADC) implements operational amplifier (opamp) sharing and capacitor sharing to combine the sample-and-hold (SAH) and the MDAC (multiplying digital to analog converter) functions in the first residue stage of the pipeline ADC. In one embodiment, the first stage circuit includes a sampling capacitor, an amplifier, a feedback capacitor array and a comparator. The sampling capacitor and the feedback capacitor array are configured by switches to operate in a sampling/MDAC mode, a discharge mode and a hold mode. In this manner, the sample-and-hold operation and the MDAC operation are merged into the first stage circuit of the pipeline ADC to achieve low power and high speed of operation.
摘要翻译：用于高速，高分辨率管线模数转换器（ADC）的第一级电路实现运算放大器（opamp）共享和电容器共享，以组合采样保持（SAH）和MDAC（乘法数字到模拟转换器）在流水线ADC的第一个残余级中起作用。在一个实施例中，第一级电路包括采样电容器，放大器，反馈电容器阵列和比较器。采样电容器和反馈电容器阵列由开关配置，以采样/ MDAC模式，放电模式和保持模式工作。以这种方式，采样保持操作和MDAC操作被合并到流水线ADC的第一级电路中，以实现低功率和高速运行。

4. 发明授权

US5900921A Lens for diplopia and amblyopia and glasses using the same 失效
标题翻译：复视和弱视的镜片和使用相同的眼镜
公开(公告)号：US5900921A
公开(公告)日：1999-05-04
申请号：US9833
申请日：1998-01-20
申请人： Byung-Moo Min
发明人： Byung-Moo Min
IPC分类号： G02C7/02 , G02C7/10
CPC分类号： G02C7/02
摘要： Disclosed is a lens for treating the diplopia and amblyopia and glasses using the same including a concave and convex part wherein a concave part and a convex part are continuously and repeatedly formed on the overall surface of a lens body facing an eye ball of a person who wears the lens. Here, the concave pan has a radius of curvature of R and the convex part has a radius of curvature of r. The relation between R and r is R>>r. There is no esthetic defects ostensibly since an eye through the glasses using the lens look like a normal eye seen from the outside of the glasses and covers a normal eye on behalf of the conventional eye patch by hardly seeing an object of the outside seen from the inside of the glasses, thereby improving the eyesight of the patient suffering from the diplopia or the amblyopia.
摘要翻译：公开了一种用于治疗复视和弱视的晶状体及使用其的凹版和凸部的眼镜，其中凹部和凸部连续重复地形成在面对眼球的透镜体的整个表面上，戴镜头这里，凹盘的曲率半径为R，凸部的曲率半径为r。 R和r之间的关系为R >> r。没有表面上的美观缺陷，因为眼睛使用透镜的眼睛看起来像从眼镜外面看到的正常眼睛，并且通过几乎看不到从外部观察到的外部物体来代表常规眼睛斑块来覆盖正常眼睛在眼镜内部，从而改善患有复视或弱视的患者的视力。

5. 发明授权

US06566399B2 Inhibitor of replicative senescence of human keratinocytes containing retinoic acid as active ingredients 有权
标题翻译：含视黄酸作为活性成分的人角质形成细胞的复制衰老抑制剂
公开(公告)号：US06566399B2
公开(公告)日：2003-05-20
申请号：US09922070
申请日：2001-08-03
申请人： Byung-Moo Min
发明人： Byung-Moo Min
IPC分类号： A01N3700
CPC分类号： A61K31/203
摘要： Disclosed is an inhibitor of replicative senescence of human keratinocytes containing retinoic acid, including all-trans retinoic acid, 3,4-didehydroretinoic acid, and 9-cis retinoic acid, as active ingredients. The retinoic acid plays an important role in extending the in vitro life span and inhibiting replicative senescence of the human mucosal keratinocytes and the human epidermal keratinocytes, thereby being used for a prophylactic or therapeutic agent of various diseases attributed to replicative senescence of the human oral keratinocytes. In addition, the inhibitor containing the retinoic acid can be used for a cosmetic purpose and as a prophylactic or therapeutic agent for wound-caused dermatitis and ski senescence.
摘要翻译：公开了包含视黄酸（包括全反式视黄酸，3,4-二脱氢视黄酸和9-顺式视黄酸）作为活性成分的角质形成细胞的复制衰老抑制剂。视黄酸在延长人体粘膜角质形成细胞和人表皮角质形成细胞的体外寿命和抑制复制衰老方面起着重要的作用，从而被用于归因于人口腔角质形成细胞复制衰老的各种疾病的预防或治疗剂。此外，含有视黄酸的抑制剂可用于美容目的，并用作伤口引起的皮炎和滑雪衰老的预防或治疗剂。

6. 发明授权

US09314510B2 Human laminin α2 chain LG3 domain and active peptides promoting cell adhesion, spreading, migration, and neurite outgrowth 有权
标题翻译：人类层粘连蛋白α2链LG3结构域和活性肽促进细胞粘附，扩散，迁移和神经突生长
公开(公告)号：US09314510B2
公开(公告)日：2016-04-19
申请号：US13418137
申请日：2012-03-12
申请人： Byung-Moo Min
发明人： Byung-Moo Min
IPC分类号： G01N33/567 , A01N1/00 , C12N5/077 , C12N5/0775 , C12N5/0789 , A61K35/28 , A61K35/30 , A61K38/39
CPC分类号： A61K38/39
摘要： The present invention relates to human laminin α2 chain LG3 domain and active peptides promoting cell adhesion, spreading, migration, and neurite outgrowth. More particularly, it was found that when nerve cells are incubated using human laminin α2 chain LG3 domain and active peptides in the LG3 domain, cell adhesion, spreading, migration, and neurite outgrowth of nerve cells promote and the promotion of cell adhesion, spreading, migration, and neurite outgrowth of nerve cells are integrin-mediated and achieved by the activation of PKCδ and FAK phosphorylation. Thus, the present invention can be very useful for researches on cell adhesion, spreading, migration, and neurite outgrowth activities of cells which are focused on nerve cells and mediated by various extracellular matrix proteins including laminin, manufacture of artificial nerve conduits, burns treatment, wounds treatment, and tissue regeneration.
摘要翻译：本发明涉及人层粘连蛋白α2链LG3结构域和促进细胞粘附，扩散，迁移和神经突生长的活性肽。更具体地说，发现当神经细胞在LG3结构域中使用人层粘连蛋白α2链LG3结构域和活性肽进行培养时，神经细胞的细胞粘附，扩散，迁移和神经突生长促进并促进细胞粘附，扩散，神经细胞迁移和神经突增生是整合素介导的，并通过激活PKCδ和FAK磷酸化实现。因此，本发明对于细胞的细胞粘附，扩散，迁移和神经突生长活性的研究非常有用，这些细胞主要集中在神经细胞上并由各种细胞外基质蛋白（包括层粘连蛋白，人造神经导管的制造，烧伤治疗，伤口治疗和组织再生。

7. 发明授权

US06954169B1 1/f noise, offset-voltage charge injection induced error cancelled op-amp sharing technique 有权
标题翻译： 1 / f噪声，失调电压电荷注入诱导误差消除运算放大器共享技术
公开(公告)号：US06954169B1
公开(公告)日：2005-10-11
申请号：US10269931
申请日：2002-10-11
申请人： Byung-Moo Min
发明人： Byung-Moo Min
IPC分类号： H03M1/06 , H03M1/12 , H03M1/44
CPC分类号： H03M1/0663 , H03M1/1225 , H03M1/442
摘要： The present invention provides an apparatus and method for reducing and canceling 1/f noise, offset voltage, and charge injection introduced in pipeline ADCs in conventional op-amp sharing techniques. The polarity of the residue signals is changed at each phase. During phase one, the residue signal of the operational amplifier is sampled on the capacitors with inverse polarity. During phase 2 the residue signal of the operational amplifier is sampled on the capacitors with the inverse polarity of phase one.
摘要翻译：本发明提供了一种用于在传统的运算放大器共享技术中减少和消除在管线ADC中引入的1 / f噪声，失调电压和电荷注入的装置和方法。残留信号的极性在各相变化。在第一阶段，运算放大器的残留信号在反相极性的电容上进行采样。在阶段2期间，运算放大器的残留信号在具有相位极性的电容器上进行采样。

8. 发明授权

US06275075B1 Current comparator 有权
标题翻译：电流比较器
公开(公告)号：US06275075B1
公开(公告)日：2001-08-14
申请号：US09459462
申请日：1999-12-13
申请人： Byung-Moo Min
发明人： Byung-Moo Min
IPC分类号： H03K5153
CPC分类号： G01R19/0038 , H03K17/302
摘要： The present invention provides a current comparator that reduces both input and output resistance. The current comparator positions a resistive feedback network in a first inverting amplifier of an input stage. The input stage according to the present invention can include a first and a second input terminal, an output terminal, a reference current source, a load circuit, a driving unit, and a resistive circuit. The reference current source supplies a reference current to the first input terminal. The load circuit supplies a first current to the output terminal. The first current is preferably equal to the reference current. The driving unit generates a prescribed output voltage by controlling the first current based on an input current applied to the second input terminal. The resistor is coupled between a control terminal of the driving unit, the second input terminal and the output terminal.
摘要翻译：本发明提供一种减小输入和输出电阻的电流比较器。电流比较器将电阻反馈网络定位在输入级的第一反相放大器中。根据本发明的输入级可以包括第一和第二输入端子，输出端子，参考电流源，负载电路，驱动单元和电阻电路。参考电流源向第一输入端提供参考电流。负载电路向输出端提供第一电流。第一电流优选等于参考电流。驱动单元通过基于施加到第二输入端子的输入电流来控制第一电流来产生规定的输出电压。电阻器耦合在驱动单元的控制端子，第二输入端子和输出端子之间。

9. 发明授权

US07279940B1 Switched-capacitor circuit with time-shifted switching scheme 有权
标题翻译：具有时移切换方案的开关电容电路
公开(公告)号：US07279940B1
公开(公告)日：2007-10-09
申请号：US11258686
申请日：2005-10-25
申请人： Byung-Moo Min
发明人： Byung-Moo Min
IPC分类号： G11C27/02
CPC分类号： G11C27/026
摘要： A switched-capacitor circuit for sampling a pair of differential input signals includes a first bootstrapped switch and a first non-boosted switch connected in parallel between a first output terminal of an amplifier and a first feedback node of the switched-capacitor circuit to form a first feedback signal path and a second bootstrapped-switch and a second non-boosted switch connected in parallel between a second output terminal of the amplifier and a second feedback node of the switched-capacitor circuit to form a second feedback signal path. The first and second non-boosted switches are controlled by a first clock signal and the first and second bootstrapped switches are controlled by a second clock signal where the second clock signal is the first clock signal delayed by a predetermined amount.
摘要翻译：用于对一对差分输入信号进行采样的开关电容电路包括：第一自举开关和第一非升压开关，并联连接在放大器的第一输出端和开关电容电路的第一反馈节点之间，以形成第一反馈信号路径和第二自举开关和第二非升压开关并联连接在放大器的第二输出端子和开关电容器电路的第二反馈节点之间以形成第二反馈信号路径。第一和第二非升压开关由第一时钟信号控制，并且第一和第二自举开关由第二时钟信号控制，其中第二时钟信号是延迟预定量的第一时钟信号。

10. 发明授权

US07265621B1 Fully differential operational amplifier with fast settling time 有权
标题翻译：全差分运算放大器具有快速建立时间
公开(公告)号：US07265621B1
公开(公告)日：2007-09-04
申请号：US11181564
申请日：2005-07-13
申请人： Byung-Moo Min
发明人： Byung-Moo Min
IPC分类号： H03F3/45
CPC分类号： H03F3/45188 , H03F3/4565 , H03F3/45654 , H03F2203/45052 , H03F2203/45088 , H03F2203/45194 , H03F2203/45334 , H03F2203/45352 , H03F2203/45354 , H03F2203/45482
摘要： An operational amplifier includes a pair of differential input transistors, a pair of cascode transistors and a keep-alive circuit. The pair of differential input transistors is connected together at the source terminals and the gate terminals of the input transistors receive a pair of differential input signals. Each cascode transistor is connected to a respective input transistor to form a cascode. The drain terminals of the pair of cascode transistors provide a pair of differential output signals. The keep-alive circuit is connected to provide first and second bias currents to the source terminals of the pair of cascode transistors. In operation, each of the first and second bias currents is a variable current being a function of a voltage at the source terminal of the respective cascode transistor. The first and second bias currents keep the pair of cascode transistors alive during transient overload conditions.
摘要翻译：运算放大器包括一对差分输入晶体管，一对共源共栅晶体管和保持电路。一对差分输入晶体管在源极端子处连接在一起，并且输入晶体管的栅极端子接收一对差分输入信号。每个共源共栅晶体管连接到相应的输入晶体管以形成共源共栅。一对共源共栅晶体管的漏极端子提供一对差分输出信号。保持电路被连接以向该对共源共栅晶体管的源极端提供第一和第二偏置电流。在操作中，第一和第二偏置电流中的每一个是可变电流，其是相应共源共栅晶体管的源极端处的电压的函数。在瞬态过载条件下，第一和第二偏置电流保持该对共源共栅晶体管存活。

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