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1. 发明授权

US07890210B2 Network-based robot control system and robot velocity control method in the network-based robot control system 有权
标题翻译：基于网络的机器人控制系统和机器人速度控制方法在基于网络的机器人控制系统中
公开(公告)号：US07890210B2
公开(公告)日：2011-02-15
申请号：US11395768
申请日：2006-03-31
申请人： Byung-Kwon Choi , Hyun-Sik Shim , Joon-Koo Kim
发明人： Byung-Kwon Choi , Hyun-Sik Shim , Joon-Koo Kim
IPC分类号： G06F19/00
CPC分类号： B25J9/1689 , G05B2219/40174
摘要： Provided are a network-based robot control system and a robot velocity control method in the network-based robot control system. A client calculates a robot control velocity according to its reception state of video data frames captured by a robot, generates a robot control message including the calculated robot control velocity, and transmits the robot control message to the robot. The robot then changes its velocity according to the robot control velocity included in the received robot control message. In this way, the velocity of the robot is controlled according to the video data reception state of the client, thereby allowing a user to easily control the robot regardless of the performance of the client.
摘要翻译：提供了一种基于网络的机器人控制系统和基于网络的机器人控制系统中的机器人速度控制方法。客户端根据机器人捕获的视频数据帧的接收状态来计算机器人控制速度，生成包含所计算的机器人控制速度的机器人控制消息，并将机器人控制消息发送给机器人。然后机器人根据包含在接收的机器人控制消息中的机器人控制速度改变其速度。以这种方式，根据客户端的视频数据接收状态来控制机器人的速度，从而允许用户容易地控制机器人，而不管客户端的性能如何。

2. 发明申请

US20060271238A1 Network-based robot control system and robot velocity control method in the network-based robot control system 有权
标题翻译：基于网络的机器人控制系统和机器人速度控制方法在基于网络的机器人控制系统中
公开(公告)号：US20060271238A1
公开(公告)日：2006-11-30
申请号：US11395768
申请日：2006-03-31
申请人： Byung-Kwon Choi , Hyun-Sik Shim , Joon-Koo Kim
发明人： Byung-Kwon Choi , Hyun-Sik Shim , Joon-Koo Kim
IPC分类号： G06F19/00
CPC分类号： B25J9/1689 , G05B2219/40174
摘要： Provided are a network-based robot control system and a robot velocity control method in the network-based robot control system. A client calculates a robot control velocity according to its reception state of video data frames captured by a robot, generates a robot control message including the calculated robot control velocity, and transmits the robot control message to the robot. The robot then changes its velocity according to the robot control velocity included in the received robot control message. In this way, the velocity of the robot is controlled according to the video data reception state of the client, thereby allowing a user to easily control the robot regardless of the performance of the client.
摘要翻译：提供了一种基于网络的机器人控制系统和基于网络的机器人控制系统中的机器人速度控制方法。客户端根据机器人捕获的视频数据帧的接收状态来计算机器人控制速度，生成包含所计算的机器人控制速度的机器人控制消息，并将机器人控制消息发送给机器人。然后机器人根据包含在接收的机器人控制消息中的机器人控制速度改变其速度。以这种方式，根据客户端的视频数据接收状态来控制机器人的速度，从而允许用户容易地控制机器人，而不管客户端的性能如何。

3. 发明申请

US20080066065A1 SOFTWARE ROBOT APPARATUS 有权
标题翻译：软件机器人装置
公开(公告)号：US20080066065A1
公开(公告)日：2008-03-13
申请号：US11852047
申请日：2007-09-07
申请人： Joon Koo Kim , Kwang-Choon Kim , Byung-Kwon Choi
发明人： Joon Koo Kim , Kwang-Choon Kim , Byung-Kwon Choi
IPC分类号： G06F9/44
CPC分类号： G06N3/004 , G06F8/65 , G06N3/126
摘要： A software robot apparatus (sobot apparatus) with a genetic code is disclosed. The sobot apparatus includes an application module, an artificial animated object engine, a sobot protocol module, an update agent, an update protocol module, a network interface, a sobot player, a script engine, a player database, a repository interface, a sobot graphic/audio interface, a 3D engine, a system software, a memory device, a display part, and an audio output part.
摘要翻译：公开了具有遗传密码的软件机器人装置（sobot装置）。 sobot装置包括应用模块，人造动画对象引擎，sobot协议模块，更新代理，更新协议模块，网络接口，sobot玩家，脚本引擎，玩家数据库，存储库界面，sobot 图形/音频接口，3D引擎，系统软件，存储设备，显示部分和音频输出部分。

4. 发明授权

US07890446B2 Software robot apparatus 有权
标题翻译：软体机器人装置
公开(公告)号：US07890446B2
公开(公告)日：2011-02-15
申请号：US11852047
申请日：2007-09-07
申请人： Joon Koo Kim , Kwang-Choon Kim , Byung-Kwon Choi
发明人： Joon Koo Kim , Kwang-Choon Kim , Byung-Kwon Choi
IPC分类号： G06N5/00
CPC分类号： G06N3/004 , G06F8/65 , G06N3/126
摘要： A software robot apparatus (sobot apparatus) with a genetic code is disclosed. The sobot apparatus includes an application module, an artificial animated object engine, a sobot protocol module, an update agent, an update protocol module, a network interface, a sobot player, a script engine, a player database, a repository interface, a sobot graphic/audio interface, a 3D engine, a system software, a memory device, a display part, and an audio output part.
摘要翻译：公开了具有遗传密码的软件机器人装置（sobot装置）。 sobot装置包括应用模块，人造动画对象引擎，sobot协议模块，更新代理，更新协议模块，网络接口，sobot玩家，脚本引擎，玩家数据库，存储库界面，sobot 图形/音频接口，3D引擎，系统软件，存储设备，显示部分和音频输出部分。

5. 发明授权

US08445227B2 N-acetylglucosaminyltransferase III expression in lower eukaryotes 有权
公开(公告)号：US08445227B2
公开(公告)日：2013-05-21
申请号：US12540849
申请日：2009-08-13
申请人： Piotr Bobrowicz , Stephen R. Hamilton , Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Robert C. Davidson
发明人： Piotr Bobrowicz , Stephen R. Hamilton , Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Robert C. Davidson
IPC分类号： C12N15/00
CPC分类号： C07K14/39 , A61K38/00 , C07K2319/05 , C12N9/1051 , C12P21/005 , Y02A50/396
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified lipid-linked oligosaccharides are created or selected. N-glycans made in the engineered host cells exhibit GnTIII activity, which produce bisected N-glycan structures and may be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.

6. 发明授权

US07795002B2 Production of galactosylated glycoproteins in lower eukaryotes 有权
标题翻译：低等真核生物中半乳糖基化糖蛋白的产生
公开(公告)号：US07795002B2
公开(公告)日：2010-09-14
申请号：US11108088
申请日：2005-04-15
申请人： Robert Davidson , Tillman Ulf Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen Robin Hamilton
发明人： Robert Davidson , Tillman Ulf Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen Robin Hamilton
IPC分类号： C12N15/04 , A61K38/00
CPC分类号： C12P21/005 , C12N9/1051 , C12N15/1082 , C12N15/79 , Y10S435/911
摘要： The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.
摘要翻译：本发明提供了一种产生人类糖蛋白的新型低级真核宿主细胞，其特征在于具有末端半乳糖残基并且基本上缺乏岩藻糖和唾液酸残基。本发明还提供了一种催化将半乳糖残基从UDP-半乳糖转移到可用作治疗性糖蛋白的重组低等真核宿主细胞中的受体底物上的方法。

7. 发明申请

US20100016561A1 N-Acetylglucosaminyltransferase III Expression in Lower Eukaryotes 有权
公开(公告)号：US20100016561A1
公开(公告)日：2010-01-21
申请号：US12540849
申请日：2009-08-13
申请人： Piotr Bobrowicz , Stephen R. Hamilton , Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Robert C. Davidson
发明人： Piotr Bobrowicz , Stephen R. Hamilton , Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Robert C. Davidson
IPC分类号： C07K14/00 , C12P21/06
CPC分类号： C07K14/39 , A61K38/00 , C07K2319/05 , C12N9/1051 , C12P21/005 , Y02A50/396
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified lipid-linked oligosaccharides are created or selected. N-glycans made in the engineered host cells exhibit GnTIII activity, which produce bisected N-glycan structures and may be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.

8. 发明申请

US20090155847A1 Combinatorial DNA library for producing modified N-glycans in lower eukaryotes 有权
公开(公告)号：US20090155847A1
公开(公告)日：2009-06-18
申请号：US12291373
申请日：2008-11-07
申请人： Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen R. Hamilton , Robert C. Davidson
发明人： Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen R. Hamilton , Robert C. Davidson
IPC分类号： C12P21/00
CPC分类号： C12P21/005 , C07K14/47 , C12N9/1051 , C12N15/1082 , C12N15/79
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified oligosaccharides are created or selected. N-glycans made in the engineered host cells have a Man5GlcNAc2 core structure which may then be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.

9. 发明授权

US07449308B2 Combinatorial DNA library for producing modified N-glycans in lower eukaryotes 有权
标题翻译：用于在低等真核生物中生产修饰的N-聚糖的组合DNA文库
公开(公告)号：US07449308B2
公开(公告)日：2008-11-11
申请号：US10371877
申请日：2003-02-20
申请人： Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen R. Hamilton , Robert C. Davidson
发明人： Tillman U. Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen R. Hamilton , Robert C. Davidson
IPC分类号： C12N15/00
CPC分类号： C12P21/005 , C07K14/47 , C12N9/1051 , C12N15/1082 , C12N15/79
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified oligosaccharides are created or selected. N-glycans made in the engineered host cells have a Man5GlcNAc2 core structure which may then be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.
摘要翻译：本发明涉及具有修饰的寡糖的真核宿主细胞，其可以通过异源表达一组糖基转移酶，糖转运体和甘露糖苷酶进一步修饰，以成为用于产生哺乳动物例如人治疗性糖蛋白的宿主菌株。本发明提供核酸分子和组合文库，其可用于成功靶向和表达哺乳动物酶活性，例如参与糖基化的真核宿主细胞中的细胞内区室的那些。该方法提供了可用于表达和靶向参与糖基化的任何所需基因的工程化宿主细胞。建立或选择具有修饰寡糖的宿主细胞。在工程化的宿主细胞中制备的N-聚糖具有可以通过异源表达一种或多种酶（例如糖基转移酶）而进一步修饰的Man III / 糖转运蛋白和甘露糖苷酶，以产生人样糖蛋白。为了生产治疗性蛋白质，该方法可适用于工程化可能获得任何所需糖基化结构的细胞系。

10. 发明申请

US20060252096A1 Single chain antibody with cleavable linker 审中-公开
标题翻译：具有可切割连接子的单链抗体
公开(公告)号：US20060252096A1
公开(公告)日：2006-11-09
申请号：US11411436
申请日：2006-04-25
申请人： Dongxing Zha , Byung-Kwon Choi , Tillman Gerngross
发明人： Dongxing Zha , Byung-Kwon Choi , Tillman Gerngross
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C12N1/18 , C07K16/44 , C12N15/74
CPC分类号： G01N33/531 , C07K16/00 , C07K2317/41 , C07K2317/50 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/50
摘要： Disclosed are antibodies and methods for making antibodies with desired glycosylation and efficient production. Host cells transformed with a nucleic acid encoding a fusion protein comprising a signal sequence, light and heavy immunoglobulin chains, each comprising a variable region and a constant region and separated by a spacer peptide comprising at least one proteolytic cleavage site are cultured to express the nucleic acids and are cleaved by appropriate proteases to produce antibodies.
摘要翻译：公开了用于制备具有所需糖基化和有效生产的抗体的抗体和方法。培养用编码融合蛋白的核酸转化的宿主细胞，其包含信号序列轻链和重免疫球蛋白链，每个包含可变区和恒定区，并由包含至少一个蛋白水解切割位点的间隔肽分离，以表达核酸酸，并被适当的蛋白酶切割以产生抗体。

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