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1. 发明申请

US20110229913A1 Method for Amplification of Signal in Immunochromatographic Assay and Immunochromatographic Kit Using the Method 审中-公开
公开(公告)号：US20110229913A1
公开(公告)日：2011-09-22
申请号：US13131711
申请日：2008-11-28
申请人： Byeong-Woo Bae , Sung-Dong Lee , Min-Gon Kim , Yong-Beom Shin , Jin-Hee Jang , Ji-Hun Shin
发明人： Byeong-Woo Bae , Sung-Dong Lee , Min-Gon Kim , Yong-Beom Shin , Jin-Hee Jang , Ji-Hun Shin
IPC分类号： G01N33/569 , G01N33/558 , G01N33/566 , C12M1/34 , B82Y99/00
CPC分类号： G01N33/558 , G01N33/585
摘要： The present invention relates to a method for amplifying a signal in an immunochro-matographic assay for high-sensitivity detection of an analyte and an immunochromatographic kit using the method, which amplifies a signal by controlling a flow rate by discrimination between the size of a first indicator and the size of a second indicator. According to an aspect of the present invention, a method for amplifying a signal in an immunochromatographic assay includes: binding a primary conjugate body, which has a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, to the analyte; binding the analyte bound to the primary conjugate body to an immobilized second antibody binding specifically to a second epitope of the analyte; and binding a secondary conjugate body, which has a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, to the connector of the primary conjugate body, wherein the primary conjugate body is disposed nearer to the immobilized second antibody than the secondary conjugate body, and the particle of the second indicator is larger than the particle of the first indicator, so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body. According to another aspect of the present invention, an immunochromatographic kit includes: a sample pad to which a liquid sample containing an analyte is applied; a conjugate pad including a primary conjugate body having a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, and a secondary conjugate body having a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, wherein the primary conjugate body is disposed nearer to an immobilized second antibody than the secondary conjugate body and the second indicator is larger than the first indicator so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body; a membrane including a detection site immobilizing thereto the second antibody binding specifically to a second epitope of the analyte to which the primary conjugate body is bound, and a control site for error detection; and an absorbing pad absorbing the liquid sample by a capillary phenomenon. Thus, the present invention can perform signal amplification without separate mechanical control or artificial step-by-step reaction.

2. 发明申请

US20120070822A1 METHOD FOR SIGNAL AMPLIFICATION DURING LATERAL-FLOW ANALYSIS 审中-公开
标题翻译：在流动分析期间信号放大的方法
公开(公告)号：US20120070822A1
公开(公告)日：2012-03-22
申请号：US13322691
申请日：2010-05-06
申请人： Byeong-Woo Bae , Sung-Dong Lee , Min-Gon Kim , Youn-Beom Shin , Jin-Hee Jang , Ji-Hun Shin , Seok-Ki Lee
发明人： Byeong-Woo Bae , Sung-Dong Lee , Min-Gon Kim , Youn-Beom Shin , Jin-Hee Jang , Ji-Hun Shin , Seok-Ki Lee
IPC分类号： C12Q1/70 , C12M1/34 , G01N33/566 , B82Y15/00
CPC分类号： G01N33/558 , G01N33/54346
摘要： Provided is a signal amplifying method in a lateral flow analysis with high sensitivity, in which gold ions and a reductant are added and react to a seed of gold nano particles to amplify a signal, and a lateral flow analysis device using the same.
摘要翻译：提供了一种高灵敏度的横向流动分析中的信号放大方法，其中加入金离子和还原剂并与金纳米颗粒的种子反应以放大信号，以及使用该离子流分析装置。

3. 发明申请

US20120088253A1 METHOD FOR MEASURING GLYCATED HEMOGLOBIN 有权
标题翻译：测量糖化血红蛋白的方法
公开(公告)号：US20120088253A1
公开(公告)日：2012-04-12
申请号：US13329689
申请日：2011-12-19
申请人： Byeong-Woo Bae , Sung-Dong Lee , Hyong-Soo Kim
发明人： Byeong-Woo Bae , Sung-Dong Lee , Hyong-Soo Kim
IPC分类号： G01N33/72
CPC分类号： G01N33/723
摘要： Provided is a method for measuring glycated hemoglobin. The method includes a hemolysis step of hemolyzing a blood sample with a hemolysate, a reaction step of reacting the hemolyzed blood sample with bead conjugates in which beads are conjugated with glycated hemoglobin binding materials, a first measuring step of measuring the amount of total hemoglobin in blood, an isolation step of isolating normal hemoglobin from the glycated hemoglobin conjugated with the bead conjugates, a second measuring step of measuring the amount of glycated hemoglobin in blood, and a calculation step of calculating the concentration of glycated hemoglobin in the blood sample based on the measured amounts of total hemoglobin and glycated hemoglobin in the blood sample.
摘要翻译：提供了测定糖化血红蛋白的方法。该方法包括使溶血液溶血血液样品的溶血步骤，使溶血的血液样品与珠粒与糖化血红蛋白结合材料共轭的珠缀合物反应的反应步骤，测量总血红蛋白量的第一测量步骤血液，从与珠缀合物缀合的糖化血红蛋白分离正常血红蛋白的分离步骤，测定血液中糖化血红蛋白量的第二测定步骤，计算血液样品中糖化血红蛋白浓度的计算步骤，基于血样中总血红蛋白和糖化血红蛋白的测定量。

4. 发明授权

US09307937B2 Apparatus and method for measuring biomedical data using algorithm for improving reproducibility 有权
标题翻译：使用用于提高重现性的算法来测量生物医学数据的装置和方法
公开(公告)号：US09307937B2
公开(公告)日：2016-04-12
申请号：US12722110
申请日：2010-03-11
申请人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung , Yooh-Hee Lee
发明人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung , Yooh-Hee Lee
IPC分类号： G01N33/50 , A61B5/145 , G06F19/00 , A61B5/1455 , G01N33/487 , G06G7/58
CPC分类号： A61B5/14546 , A61B5/1455 , G01N33/48785 , G06F19/00 , G06F19/30 , G06F19/34 , G16H40/63
摘要： Disclosed herein is a method and apparatus for measuring biomedical data. The method of measuring biomedical data using a biochemical reaction includes determining reaction termination time at which the biochemical reaction has been stabilized based on an average variation in a predetermined period in an early stage of measurement, and obtaining a final measured value by adding a correction value to a value measured at the determined reaction termination time.
摘要翻译：本文公开了一种用于测量生物医学数据的方法和装置。使用生物化学反应测定生物医学数据的方法包括：根据测定初期的规定期间的平均变化量，确定生物化学反应已稳定的反应终止时间，通过加入校正值得到最终测定值到在确定的反应终止时间测量的值。

5. 发明授权

US08883086B2 Apparatus and method for measuring biomedical data and measurement strip 有权
标题翻译：用于测量生物医学数据和测量条的装置和方法
公开(公告)号：US08883086B2
公开(公告)日：2014-11-11
申请号：US12722252
申请日：2010-03-11
申请人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung
发明人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung
IPC分类号： G01N33/52 , A61B5/145 , G01N21/00 , G01N21/17 , G01N33/92 , G01N33/487 , G01N33/49 , G01N21/84 , A61B5/1455
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/1455 , A61B2560/0431 , A61B2560/0462 , A61B2562/0295 , A61B2562/063 , B01L2200/025 , B01L2300/021 , B01L2300/024 , B01L2300/025 , B01L2300/0816 , B01L2300/0825 , G01N21/00 , G01N21/17 , G01N21/8483 , G01N33/48771 , G01N33/49 , G01N33/92 , Y10S435/805 , Y10S435/808 , Y10S435/97
摘要： Disclosed herein are an apparatus and method for measuring biomedical data and a measurement strip. The apparatus includes a plurality of detection units arranged within a strip reception area on a plane and spaced apart from each other, a measurement type determination unit for determining whether reactive portions are present in areas of the measurement strip corresponding to the plurality of detection units based on detection results obtained by the detection units and determining a type of measurement based on results of the determination, a biomedical data measurement unit for activating part or all of the detection units according to the type of measurement determined by the measurement type determination unit, and measuring the biomedical data using the activated detection units, and an output unit for outputting the measured biomedical data to an outside.
摘要翻译：本文公开了一种用于测量生物医学数据和测量条的装置和方法。该装置包括多个检测单元，布置在平面上的条带接收区域中并彼此间隔开;测量类型确定单元，用于确定反应部分是否存在于与多个检测单元相对应的测量条带的区域中根据由检测单元获得的检测结果，并且基于确定结果确定测量类型;生物医学数据测量单元，用于根据由测量类型确定单元确定的测量类型激活部分或全部检测单元;以及使用激活的检测单元测量生物医学数据，以及用于将测量的生物医学数据输出到外部的输出单元。

6. 发明授权

US08293189B2 Test strip designed to improve spreadability of blood 有权
标题翻译：试纸条旨在提高血液的铺展性
公开(公告)号：US08293189B2
公开(公告)日：2012-10-23
申请号：US12722183
申请日：2010-03-11
申请人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung
发明人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung
IPC分类号： G01N31/22
CPC分类号： G01N33/525 , C12Q1/60 , G01N33/92
摘要： Disclosed is a test strip for measuring medical data, in which a hydrophilic material is introduced to improve the spreadability of blood. Having the structure comprising a blood-filtering layer designed to filter off either or both of erythrocytes and low-density lipoprotein (LDL) cholesterol from an applied blood sample; a reaction layer in which the blood sample free of erythrocytes and/or low-density lipoprotein (LDL) cholesterol is reacted with an reagent, and a hydrophilic material, intercalated between the blood-filtering layer and the reaction layer, for uniformly spreading the blood sample filtered through the filtering layer, the blood-filtering layer and the reaction layer being stacked between the lower support and the upper cover, the test strip prevents the infiltration of erythrocytes into the reaction layer and improves the spreadability of blood to reduce measurement errors, thus bringing about higher reproducibility.
摘要翻译：公开了一种用于测量医疗数据的测试条，其中引入亲水材料以改善血液的铺展性。具有包括血液过滤层的结构，设计用于从施用的血液样品中过滤掉红细胞和低密度脂蛋白（LDL）胆固醇中的任一者或两者; 将没有红细胞和/或低密度脂蛋白（LDL）胆固醇的血液样品与试剂反应的反应层和插入血液过滤层和反应层之间的亲水材料，以均匀地分散血液样品通过过滤层过滤，血液过滤层和反应层堆叠在下支撑体和上盖之间，试纸片防止红细胞浸入反应层，提高血液的铺展性，减少测量误差，从而带来更高的再现性。

7. 发明授权

US08221703B2 Device for collecting sample 有权
标题翻译：收集样品的装置
公开(公告)号：US08221703B2
公开(公告)日：2012-07-17
申请号：US12722165
申请日：2010-03-11
申请人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung , Ku-Cheol Ahn
发明人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung , Ku-Cheol Ahn
IPC分类号： A61B10/00
CPC分类号： G01N33/4875 , A61B5/14532 , A61B5/1468 , A61B5/15 , A61B5/150022 , A61B5/150259 , A61B5/150343 , A61B5/150358 , A61B5/157 , A61B2562/0295 , B01L3/5023
摘要： Disclosed herein is a device for collecting a sample, which is intended to dispense a received sample onto a measurement strip. The device includes a main body and a pair of receiving pieces. The receiving pieces protrude from a first end of the main body in such a way as to be spaced apart from each other while facing each other, and receive the sample by capillary force acting on a space which is defined between the receiving pieces and which is open on right, left and bottom sides. The device allows the received sample to be easily transferred to a reaction zone of a measurement strip, and enables the sample to be completely absorbed by the reaction zone because of capillary force in a receiving area when the device comes into contact with the reaction zone of the strip.
摘要翻译：本文公开了一种用于收集样品的装置，其旨在将接收的样品分配到测量条上。该装置包括主体和一对接收件。接收件从主体的第一端以彼此相对的方式突出，并且通过作用在限定在接收件之间的空间的毛细作用力接收样品，在右侧，左侧和底侧打开。该装置允许所接收的样品容易地转移到测量条的反应区，并且使得样品在接收区域中由于毛细管力而被反应区完全吸收，当装置与反应区接触时带子。

8. 发明授权

US08377684B2 Test strip and method for measuring blood cholesterol level using the same 有权
标题翻译：测试条和使用其测量血液胆固醇水平的方法
公开(公告)号：US08377684B2
公开(公告)日：2013-02-19
申请号：US12722147
申请日：2010-03-11
申请人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung
发明人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung
IPC分类号： C12M1/34
CPC分类号： G01N33/526 , C12Q1/60 , G01N33/92
摘要： Disclosed are a test strip and a method for measuring medical data. The test strip comprises an upper cover having one or more application holes; a lower support having one or more detected parts at positions corresponding to detecting units of the measuring apparatus; an erythrocyte and LDL cholesterol-filtering layer designed to filter off both of erythrocytes and LDL cholesterol from an applied blood sample by agglutinating erythrocytes and precipitating LDL cholesterol; and a reaction layer in which the blood sample free of erythrocytes and LDL cholesterol is reacted with an reagent, the filtering layer and the reaction layer being stacked between the lower support and the upper cover. Structured to filter off erythrocytes and low-density lipoprotein (LDL) cholesterol from a blood sample in a single layer, the test strip of the present invention can be made to be slim and allows a low volume of blood to be analyzed.
摘要翻译：公开了一种测试条和用于测量医疗数据的方法。测试条包括具有一个或多个施加孔的上盖; 在与测量装置的检测单元相对应的位置处具有一个或多个检测到的部分的下支撑件; 红细胞和低密度脂蛋白胆固醇过滤层设计用于通过凝集红细胞和沉淀LDL胆固醇从应用的血液样品中过滤掉红细胞和低密度脂蛋白胆固醇; 将没有红细胞和低密度脂蛋白胆固醇的血液样品与试剂反应的反应层，过滤层和反应层堆叠在下支撑体和上盖之间。结构化从单层血液样品中过滤掉红细胞和低密度脂蛋白（LDL）胆固醇，本发明的测试条可以使其细小，并允许分析低体积的血液。

9. 发明授权

US08557590B2 Method for measuring glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白的方法
公开(公告)号：US08557590B2
公开(公告)日：2013-10-15
申请号：US13329689
申请日：2011-12-19
申请人： Byeong-Woo Bae , Sung-Dong Lee , Hyong-Soo Kim
发明人： Byeong-Woo Bae , Sung-Dong Lee , Hyong-Soo Kim
IPC分类号： G01N33/72 , C12M1/34 , G01N33/543 , G01N1/18
CPC分类号： G01N33/723
摘要： A method for measuring glycated hemoglobin includes hemolyzing a blood sample with a hemolysate; reacting the hemolyzed blood sample with bead conjugates in which beads are conjugated with glycated hemoglobin binding materials; measuring the amount of total hemoglobin in the reacted blood sample; isolating normal hemoglobin from the glycated hemoglobin conjugated with the bead conjugates; measuring the amount of glycated hemoglobin isolated from the normal hemoglobin; and determining the percentage of the glycated hemoglobin in the blood sample on the basis of the measured amounts of total hemoglobin and glycated hemoglobin. The isolation of normal hemoglobin is performed by absorbing the normal hemoglobin using an absorption pad that is a porous pad having pores, each of which has a size greater than the size of the normal hemoglobin and smaller than the size of the bead.
摘要翻译：测定糖化血红蛋白的方法包括用溶血液溶血样品; 使溶血的血液样品与其中珠粒与糖化血红蛋白结合材料缀合的珠缀合物反应; 测量反应血样中总血红蛋白的量; 从与珠缀合物缀合的糖化血红蛋白分离正常血红蛋白; 测量从正常血红蛋白分离的糖化血红蛋白的量; 并且根据所测量的总血红蛋白和糖化血红蛋白的量确定血液样品中糖化血红蛋白的百分比。正常血红蛋白的分离是通过吸收正常血红蛋白来进行的，该吸收垫是具有孔的多孔垫的吸收垫，每个孔具有大于正常血红蛋白的尺寸并且小于珠的尺寸。

10. 发明授权

US08158080B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08158080B2
公开(公告)日：2012-04-17
申请号：US12722226
申请日：2010-03-11
申请人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung , Ku-Cheol Ahn
发明人： Byeong-Woo Bae , Sung-Dong Lee , Byung-Hoon Kho , Ji-Eon Ryu , Jin-Kyeong Kim , Hyou-Arm Joung , Ku-Cheol Ahn
IPC分类号： G01N31/22
CPC分类号： C12Q1/006
摘要： Disclosed herein is a biosensor. The biosensor includes a measuring layer configured to measure whether reaction to a biological sample has occurred. An upper cover is disposed on a top of the measuring layer, and is provided with an open window configured to allow a measurement area of the measuring layer to be exposed and an upper protrusion configured to protrude from an outer portion of the open window in a direction in which the upper protrusion is coupled to a lower panel. The lower panel is disposed below the measuring layer, and is provided with a lower protrusion which protrudes between the open window and the upper protrusion of the upper cover so that the lower protrusion is spaced apart from the upper protrusion by a gap and which presses the measuring layer so that a top of the measuring layer upwardly protrudes from the open window.
摘要翻译：本文公开了一种生物传感器。生物传感器包括测量层，其被配置为测量是否已经发生对生物样品的反应。上盖设置在测量层的顶部，并且设置有打开的窗口，其被构造成允许测量层的测量区域被暴露，并且上部突起被构造成在开口窗的外部部分中以上突起联接到下面板的方向。下面板设置在测量层的下方，并且设置有下突起，该突起在开窗和上盖的上突起之间突出，使得下突起与上突起间隔开间隙，并且按压测量层，使得测量层的顶部从打开的窗口向上突出。

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