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1. 发明申请

US20080221448A1 Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions 审中-公开
标题翻译：以图像为导向的治疗工具，提供微创手术和干预措施
公开(公告)号：US20080221448A1
公开(公告)日：2008-09-11
申请号：US12072906
申请日：2008-02-27
申请人： Butrus T. Khuri-Yakub , Omer Oralkan , Goksen G. Yaralioglu
发明人： Butrus T. Khuri-Yakub , Omer Oralkan , Goksen G. Yaralioglu
IPC分类号： A61B8/00 , A61B18/20 , A61N7/00
CPC分类号： B06B1/0292 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4483 , A61B8/4488 , A61B8/483 , A61B10/04 , A61B18/24 , A61B90/36 , A61B2090/3782 , A61B2562/028 , A61N7/022
摘要： Imaged-guided therapy for minimally invasive surgeries and interventions is provided. An image-guided device includes an elongate tubular member, such as a catheter, an annular array of capacitive micromachined ultrasound transducers (cMUTs) for real-time three-dimensional forward-looking acoustic imaging, and a therapeutic tool. The therapeutic tool is positioned inside an inner lumen of the elongate tubular member and can be a device for tissue ablation, such as a high intensity focused ultrasound (HIFU) device or a laser. The HIFU device is operable at high frequencies to have a sufficiently small focus spot, thus a high focal intensity. The imaging annular array is also operable at high frequencies for good acoustic imaging resolution. The high resolution forward-looking imaging array, in combination with the high frequency HIFU transducer, provides a single image-guided therapy device for precise tissue ablation and real-time imaging feedback.
摘要翻译：提供了用于微创手术和干预措施的成像指导治疗。图像引导装置包括细长管状构件，例如导管，用于实时三维前瞻性声学成像的电容微加工超声换能器（cMUT）的环形阵列和治疗工具。治疗工具位于细长管状构件的内腔内，并且可以是用于组织消融的装置，例如高强度聚焦超声（HIFU）装置或激光。 HIFU装置可以在高频下操作以具有足够小的焦点，因此具有高焦距。成像环形阵列也可在高频下操作以获得良好的声学成像分辨率。高分辨率前瞻性成像阵列与高频HIFU传感器结合，提供了一个单一的图像引导治疗装置，用于精确的组织消融和实时成像反馈。

2. 发明申请

US20120259249A1 Noninvasive Ultrasound-Based Retinal Stimulator: Ultrasonic Eye 审中-公开
标题翻译：无创超声波视网膜刺激仪：超声眼
公开(公告)号：US20120259249A1
公开(公告)日：2012-10-11
申请号：US13441650
申请日：2012-04-06
申请人： Butrus T. Khuri-Yakub , Omer Oralkan , Stephen A. Baccus , Michael D. Menz
发明人： Butrus T. Khuri-Yakub , Omer Oralkan , Stephen A. Baccus , Michael D. Menz
IPC分类号： A61F9/08 , A61N7/00
CPC分类号： A61N7/022 , A61B8/0808
摘要： Focused ultrasound is a promising technology for neural stimulation that is non-invasive, and capable of passing through the skull. Here we use the isolated retina to characterize the effect of ultrasound on an intact neural circuit and compared these effects to those of visual stimulation of the same retinal ganglion cells. Ultrasound stimuli evoked precise, stable responses that looked qualitatively similar to strong visual responses but with shorter latency. We found that ultrasonic stimulation activates cells presynaptic to ganglion cells, which may include photoreceptors and interneurons. Ultrasonic stimulation is an effective and spatial-temporally precise method to activate the retina. Ultrasonic stimulation may have diagnostic potential to probe remaining retinal function in cases of photoreceptor degeneration, and therapeutic potential for use in a retinal prosthesis. In addition, ultrasound promises to be a useful tool to understand the dynamic activity in the interneuron population of the retina.
摘要翻译：聚焦超声波是一种有前途的神经刺激技术，非侵入性，能够通过颅骨。在这里，我们使用孤立的视网膜来表征超声对完整神经回路的影响，并将这些效应与同一视网膜神经节细胞的视觉刺激相比较。超声刺激诱发精确，稳定的反应，看起来质地与强视觉反应相似，但延迟较短。我们发现超声波刺激激活细胞突触前神经节细胞，其可能包括光感受器和中间神经元。超声波刺激是激活视网膜的有效和时空精确的方法。在光感受器变性的情况下，超声波刺激可能具有探测剩余视网膜功能的诊断潜力，以及用于视网膜假体的治疗潜力。此外，超声波有助于了解视网膜中间神经元群体的动态活动。

3. 发明申请

US20130023752A1 Medical Screening and Diagnostics Based on Air-Coupled Photoacoustics 有权
标题翻译：基于空气耦合光声学的医学筛查和诊断
公开(公告)号：US20130023752A1
公开(公告)日：2013-01-24
申请号：US13554985
申请日：2012-07-20
申请人： Butrus T. Khuri-Yakub , Omer Oralkan
发明人： Butrus T. Khuri-Yakub , Omer Oralkan
IPC分类号： A61B6/00
CPC分类号： A61B5/0095 , A61B5/0507
摘要： Surface selective photoacoustic (PA) medical imaging is introduced. Surface selective PA imaging is responsive to surface features and does not image sub-surface features, in contrast to conventional PA imaging. The surface PA signal can be considerably larger than the bulk PA signal, for an air-coupled (or gas-coupled) acoustic transducer. Distinguishing these two signals based on time of arrival at the transducer can further distinguish the two signals. This approach provides numerous advantages.Non-contact imaging simplifies and expedites imaging, and can serve as a replacement for visual inspection by physicians. Applications include skin screening and endoscopy.
摘要翻译：介绍了表面选择性光声（PA）医学成像。与传统的PA成像相比，表面选择性PA成像对表面特征有反应，并且不影像亚表面特征。对于空气耦合（或气体耦合）的声换能器，表面PA信号可以大大地大于体积PA信号。基于到达换能器的时间区分这两个信号可以进一步区分两个信号。这种方法提供了许多优点。非接触式成像简化并加速成像，可作为医生进行视觉检查的替代品。应用包括皮肤筛查和内窥镜检查。

4. 发明授权

US08852104B2 Method and apparatus for ultrasound assisted local delivery of drugs and biomarkers 有权
标题翻译：用于超声辅助局部递送药物和生物标志物的方法和装置
公开(公告)号：US08852104B2
公开(公告)日：2014-10-07
申请号：US12798982
申请日：2010-04-14
申请人： Omer Oralkan , Butrus T. Khuri-Yakub
发明人： Omer Oralkan , Butrus T. Khuri-Yakub
IPC分类号： A61B5/05 , A61B5/00 , A61M37/00
CPC分类号： A61B5/0095 , A61B5/0068 , A61B5/0084 , A61B8/4281 , A61B8/4483 , A61M37/0092
摘要： The current invention provides an ultrasound-assisted delivery device, that includes a focused ultrasound transducer having an ultrasound focal point, a real-time imaging device having an imaging focal point, and a therapeutic delivery device, where the transducer and the imaging device are integrated with the delivery device, and the ultrasound focal point coincides with the imaging focal point, where the delivery device and transducer are disposed to provide an unobstructed imaging path for the real-time imaging device. The invention further includes a scanning optical or laser beam having a focal point disposed to sweep across the target, where the delivery device is disposed to deliver an optical contrast material to the target, and the scanning focal point coincides with the ultrasound and imaging focal points, where the target or the optical contrast material react to the scanning beam to generate at least one interface signal.
摘要翻译：本发明提供了一种超声辅助输送装置，其包括具有超声焦点的聚焦超声换能器，具有成像焦点的实时成像装置和治疗递送装置，其中所述换能器和成像装置被集成并且超声焦点与成像焦点重合，其中输送装置和换能器被设置成为实时成像装置提供无障碍的成像路径。本发明还包括扫描光学或激光束，其具有设置成扫过靶的焦点，其中输送装置设置成将光学对比材料输送到靶，并且扫描焦点与超声波和成像焦点重合，其中所述目标或所述光学对比材料对所述扫描光束起反应以产生至少一个接口信号。

5. 发明授权

US08843190B2 Medical screening and diagnostics based on air-coupled photoacoustics 有权
标题翻译：基于空气耦合光声学的医学筛查和诊断
公开(公告)号：US08843190B2
公开(公告)日：2014-09-23
申请号：US13554985
申请日：2012-07-20
申请人： Butrus T. Khuri-Yakub , Omer Oralkan
发明人： Butrus T. Khuri-Yakub , Omer Oralkan
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/0095 , A61B5/0507
摘要： Surface selective photoacoustic (PA) medical imaging is introduced. Surface selective PA imaging is responsive to surface features and does not image sub-surface features, in contrast to conventional PA imaging. The surface PA signal can be considerably larger than the bulk PA signal, for an air-coupled (or gas-coupled) acoustic transducer. Distinguishing these two signals based on time of arrival at the transducer can further distinguish the two signals. This approach provides numerous advantages. Non-contact imaging simplifies and expedites imaging, and can serve as a replacement for visual inspection by physicians. Applications include skin screening and endoscopy.
摘要翻译：介绍了表面选择性光声（PA）医学成像。与传统的PA成像相比，表面选择性PA成像对表面特征有反应，并且不影像亚表面特征。对于空气耦合（或气体耦合）的声换能器，表面PA信号可以大大地大于体积PA信号。基于到达换能器的时间区分这两个信号可以进一步区分两个信号。这种方法提供了许多优点。非接触式成像简化并加速成像，可作为医生进行视觉检查的替代品。应用包括皮肤筛查和内窥镜检查。

6. 发明申请

US20090292208A1 Automated detection of asymptomatic carotid stenosis 审中-公开
标题翻译：自动检测无症状颈动脉狭窄
公开(公告)号：US20090292208A1
公开(公告)日：2009-11-26
申请号：US12380889
申请日：2009-03-03
申请人： R. Brooke Jeffrey, JR. , Butrus T. Khuri-Yakub , Sandy A. Napel , Omer Oralkan
发明人： R. Brooke Jeffrey, JR. , Butrus T. Khuri-Yakub , Sandy A. Napel , Omer Oralkan
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B5/02007 , G01S15/8927 , G01S15/8979 , G01S15/8984
摘要： Peak blood velocity measurement for automated stenosis detection is provided. Ultrasound measurements of the peak blood velocity are corrected by a calculation of the Doppler angle, which exists from misalignment of the ultrasound transducer axis and the true blood velocity. The direction of the blood velocity and the Doppler angle are found by imaging a set of planar cross-sections of a blood vessel, such as the carotid artery, to obtain velocity maps of the blood flowing in the blood vessel. Peak blood velocity can be correlated with an amount of stenosis therefore accurate peak blood velocity measurements are necessary for medical diagnosis. Automated stenosis detection allows for implementation in many medical settings. A capacitive micromachined ultrasound transducer array is also provided to measure the planar cross-sectional images.
摘要翻译：提供自动狭窄检测的峰值血液速度测量。通过计算由超声换能器轴的未对准和真实血液速度存在的多普勒角来校正峰值血液速度的超声测量。通过对血管如颈动脉的一组平面横截面进行成像来获得血液速度和多普勒角的方向，以获得在血管中流动的血液的速度图。峰值血流速度可以与狭窄量相关，因此精确的峰值血液速度测量对于医学诊断是必需的。自动狭窄检测允许在许多医疗设置中实现。还提供电容微加工超声换能器阵列以测量平面横截面图像。

7. 发明申请

US20100268152A1 Method and apparatus for ultrasound assisted local delivery of drugs and biomarkers 有权
标题翻译：用于超声辅助局部递送药物和生物标志物的方法和装置
公开(公告)号：US20100268152A1
公开(公告)日：2010-10-21
申请号：US12798982
申请日：2010-04-14
申请人： Omer Oralkan , Butrus T. Khuri-Yakub
发明人： Omer Oralkan , Butrus T. Khuri-Yakub
IPC分类号： A61M5/00
CPC分类号： A61B5/0095 , A61B5/0068 , A61B5/0084 , A61B8/4281 , A61B8/4483 , A61M37/0092
摘要： The current invention provides an ultrasound-assisted delivery device, that includes a focused ultrasound transducer having an ultrasound focal point, a real-time imaging device having an imaging focal point, and a therapeutic delivery device, where the transducer and the imaging device are integrated with the delivery device, and the ultrasound focal point coincides with the imaging focal point, where the delivery device and transducer are disposed to provide an unobstructed imaging path for the real-time imaging device. The invention further includes a scanning optical or laser beam having a focal point disposed to sweep across the target, where the delivery device is disposed to deliver an optical contrast material to the target, and the scanning focal point coincides with the ultrasound and imaging focal points, where the target or the optical contrast material react to the scanning beam to generate at least one interface signal.
摘要翻译：本发明提供了一种超声辅助输送装置，其包括具有超声焦点的聚焦超声换能器，具有成像焦点的实时成像装置和治疗递送装置，其中所述换能器和成像装置被集成并且超声焦点与成像焦点重合，其中输送装置和换能器被设置成为实时成像装置提供无障碍的成像路径。本发明还包括扫描光学或激光束，其具有设置成扫过靶的焦点，其中输送装置设置成将光学对比材料输送到靶，并且扫描焦点与超声波和成像焦点重合，其中所述目标或所述光学对比材料对所述扫描光束起反应以产生至少一个接口信号。

8. 发明申请

US20070287912A1 Functional imaging using capacitive micromachined ultrasonic transducers 审中-公开
标题翻译：使用电容微加工超声换能器的功能成像
公开(公告)号：US20070287912A1
公开(公告)日：2007-12-13
申请号：US11803157
申请日：2007-05-11
申请人： Butrus Khuri-Yakub , Omer Oralkan , Ira Wygant , Srikant Valthllingam
发明人： Butrus Khuri-Yakub , Omer Oralkan , Ira Wygant , Srikant Valthllingam
IPC分类号： A61B8/00 , A61N5/067
CPC分类号： A61B5/0059 , A61B5/0095 , A61B8/08 , A61B8/4483 , A61B8/483 , A61B2562/028 , B06B1/0292 , G01N29/0618 , G01N29/0681 , G01N29/2406 , G01N29/2418 , G01N29/2431 , G01N2291/02475
摘要： The present invention provides an apparatus for functional imaging of an object that is compact, sensitive, and provides real-time three-dimensional images. The apparatus includes a source of non-ultrasonic energy, where the source induces generation of ultrasonic waves within the object. The source can provide any type of non-ultrasonic energy, including but not limited to light, heat, microwaves, and other electromagnetic fields. Preferably, the source is a laser. The apparatus also includes a single capacitive micromachined ultrasonic transducer (CMUT) device or an array of CMUTs. In the case of a single CMUT element, it can be mechanically scanned to simulate an array of any geometry. Among the advantages of CMUTs are tremendous fabrication flexibility and a typically wider bandwidth. Transducer arrays with high operating frequencies and with nearly arbitrary geometries can be fabricated. A method of functional imaging using the apparatus is also provided.
摘要翻译：本发明提供了一种用于对物体进行功能成像的装置，其是紧凑的，敏感的并且提供实时的三维图像。该装置包括非超声能量源，其中源引起在物体内产生超声波。源可以提供任何类型的非超声波能量，包括但不限于光，热，微波和其他电磁场。优选地，源是激光。该装置还包括单个电容微机械加速超声换能器（CMUT）装置或CMUT阵列。在单个CMUT元件的情况下，可以机械扫描以模拟任何几何的阵列。 CMUT的优点之一是巨大的制造灵活性和通常更宽的带宽。可以制造具有高工作频率和几乎任意几何形状的传感器阵列。还提供了使用该装置的功能成像的方法。

9. 发明授权

US09864190B2 Confocal microscope, system and method therefor 有权
公开(公告)号：US09864190B2
公开(公告)日：2018-01-09
申请号：US13403614
申请日：2012-02-23
申请人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T. C. Liu , Hyejun Ra , Jae Eun Hwang
发明人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T. C. Liu , Hyejun Ra , Jae Eun Hwang
IPC分类号： A61B10/04 , G02B26/10 , G02B21/00 , G02B23/24 , G02B23/26 , A61B1/00 , A61B1/04 , A61B5/00 , A61B8/12 , A61B8/00 , A61B8/08 , G02B17/08
CPC分类号： G02B26/101 , A61B1/00105 , A61B1/043 , A61B5/0068 , A61B8/12 , A61B8/4483 , A61B8/483 , G02B17/0808 , G02B21/0028 , G02B23/2423 , G02B23/26
摘要： Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.

10. 发明申请

US20120330157A1 CONFOCAL MICROSCOPE, SYSTEM AND METHOD THEREFOR 有权
标题翻译：共焦显微镜，其系统及方法
公开(公告)号：US20120330157A1
公开(公告)日：2012-12-27
申请号：US13403614
申请日：2012-02-23
申请人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T.C. Liu , Hyejun Ra , Jae Eun Hwang
发明人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T.C. Liu , Hyejun Ra , Jae Eun Hwang
IPC分类号： G02B26/10 , A61B8/13 , A61B1/07
CPC分类号： G02B26/101 , A61B1/00105 , A61B1/043 , A61B5/0068 , A61B8/12 , A61B8/4483 , A61B8/483 , G02B17/0808 , G02B21/0028 , G02B23/2423 , G02B23/26
摘要： Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.
摘要翻译：本发明的方面涉及使用一种或多种方式收集信息的装置，装置，系统和方法。与一个或多个实施例一致，装置包括具有不同扫描轴并且分别朝向不同方向的第一和第二扫描镜装置。第一扫描镜装置将源光和图像光引导成两条路径，第二扫描镜装置将来自目标的图像光引导到第一扫描反射镜装置。第一和第二扫描镜装置将来自第一扫描反射镜的源光和经由第二扫描镜的源光协同扫描至至少两个自由度的目标位置，以及来自目标位置的直接图像光。

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