专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090301434A1 Method for operating an internal combustion engine 审中-公开
标题翻译：操作内燃机的方法
公开(公告)号：US20090301434A1
公开(公告)日：2009-12-10
申请号：US11989028
申请日：2006-09-22
申请人： Burkhard Hiller , Christina Sauer , Andre F. Casal Kulzer , Santosh Rao , Thomas Blank
发明人： Burkhard Hiller , Christina Sauer , Andre F. Casal Kulzer , Santosh Rao , Thomas Blank
IPC分类号： F02D13/00 , F01L1/34
CPC分类号： F02D13/0215 , F02D13/0265 , F02D13/0273 , F02D41/0002 , F02D41/3035 , F02D41/3047 , F02D41/402 , F02M26/01 , Y02T10/18 , Y02T10/42 , Y02T10/44
摘要： In a method for operating an internal combustion engine, particularly an Otto engine having direct gasoline injection in controlled self-ignition, the internal combustion engine including a combustion chamber, at least one intake valve and at least one exhaust valve, whose opening times are variable, and a fuel-air-exhaust gas mixture is introduced into a combustion chamber and is compressed in a compression stroke; the fuel-air mixture self-igniting towards the end of the compression stroke, a controlled self-ignition is made possible in wide load ranges by varying the opening times of the intake valve and the exhaust valve as a function of the load.
摘要翻译：在用于操作内燃机的方法中，特别是在受控自点火中具有直接汽油喷射的奥托发动机，该内燃机包括燃烧室，至少一个进气门和至少一个排气门，其开启时间是可变的并且将燃料 - 空气 - 废气混合物引入燃烧室并在压缩冲程中被压缩; 燃料 - 空气混合物在压缩行程结束时自燃，通过根据负载改变进气门和排气门的打开时间，在宽负载范围内可控自燃。

2. 发明申请

US20070179367A1 Method and Apparatus for Noninvasively Estimating a Property of an Animal Body Analyte from Spectral Data 审中-公开
标题翻译：用于从光谱数据非侵入性估计动物体分析物的性质的方法和装置
公开(公告)号：US20070179367A1
公开(公告)日：2007-08-02
申请号：US11564741
申请日：2006-11-29
申请人： Timothy Ruchti , Thomas Blank , Alexander Lorenz
发明人： Timothy Ruchti , Thomas Blank , Alexander Lorenz
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/7267 , G16H50/20
摘要： A method and apparatus for calibration development using clustering is disclosed. More particularly, the invention relates to subsequent calibration development using clusters that are individually interference compensated and to subsequent estimation. Estimation of analyte property values from data, such as noninvasive spectra, is improved by a calibration method that uses clusters that are individually interference-compensated.
摘要翻译：公开了一种使用聚类进行校准开发的方法和装置。更具体地说，本发明涉及使用单独干扰补偿的群集和随后的估计的随后的校准开发。通过使用单独进行干扰补偿的簇的校准方法来改进来自诸如非侵入光谱的数据的分析物质性值的估计。

3. 发明申请

US20060206018A1 Method and apparatus for noninvasive targeting 审中-公开
标题翻译：非侵入性靶向的方法和装置
公开(公告)号：US20060206018A1
公开(公告)日：2006-09-14
申请号：US11368234
申请日：2006-03-03
申请人： Alan Abul-Haj , Thomas Blank , Kevin Hazen , James Henderson , Timothy Ruchti , Josh Hope
发明人： Alan Abul-Haj , Thomas Blank , Kevin Hazen , James Henderson , Timothy Ruchti , Josh Hope
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/7264 , A61B2562/0242 , A61B2562/146
摘要： The invention relates to noninvasive sampling. In one embodiment, the invention relates to a sample probe interface method and apparatus for targeting a tissue depth and/or pathlength that is used in conjunction with a noninvasive analyzer to control spectral variation. In a second embodiment, a signal from a sample or target probe of a tissue feature or volume is used in positioning a portion of a measuring system relative to the sample. The system is optionally used in conjunction with a targeting system used to control the sampling location of the measuring system.
摘要翻译：本发明涉及无创取样。在一个实施例中，本发明涉及用于靶向与非侵入性分析仪结合使用以控制光谱变化的组织深度和/或光程长度的样本探针接口方法和装置。在第二实施例中，来自组织特征或体积的样本或目标探针的信号用于相对于样本定位测量系统的一部分。该系统可选地与用于控制测量系统的采样位置的瞄准系统结合使用。

4. 发明申请

US20060167350A1 Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction 审中-公开
标题翻译：开发用于非侵入性血液分析物预测的局部校准模型的多层方法
公开(公告)号：US20060167350A1
公开(公告)日：2006-07-27
申请号：US11065223
申请日：2005-02-23
申请人： Stephen Monfre , Thomas Blank , Timothy Ruchti , Suresh Thennadil
发明人： Stephen Monfre , Thomas Blank , Timothy Ruchti , Suresh Thennadil
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B5/7264
摘要： A method of multi-tier classification and calibration in noninvasive blood analyte prediction is provided that minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in-vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters that have a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information, and other device measurements suitable for developing tissue classifications. The multi-tier classification approach to calibration uses multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
摘要翻译：提供了一种在非侵入性血液分析物预测中进行多层次分类和校准的方法，通过限制共同变化的光谱干扰物来最小化预测误差。组织样本根据受试者的人口统计学和仪器皮肤测量进行分类，包括体内近红外光谱测量。多层智能图案分类序列将光谱数据组织成具有组织性质内部一致性高度的簇。在每个层次中，使用主题人口统计学，光谱测量信息和适合于开发组织分类的其它装置测量法来连续地改进类别。多级分类校准方法使用多变量统计学参数和使用光谱特征的多层次分类。用于多层分类的变量可以是皮肤表面水合，皮肤表面温度，组织体积水合，以及近红外脂肪带对真皮的相对光学厚度的评估。使用沿关键波长段的NIR光谱信号评估所有组织参数。

5. 发明申请

US20050203358A1 Method and apparatus for using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers 审中-公开
标题翻译：使用替代部位葡萄糖测定来校准和维护非侵入性和可植入分析仪的方法和设备
公开(公告)号：US20050203358A1
公开(公告)日：2005-09-15
申请号：US11122921
申请日：2005-05-04
申请人： Stephen Monfre , Kevin Hazen , Timothy Ruchti , Thomas Blank , James Henderson
发明人： Stephen Monfre , Kevin Hazen , Timothy Ruchti , Thomas Blank , James Henderson
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495 , G01N21/27 , G01N21/35 , G01N21/49
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , G01N21/274 , G01N21/359 , G01N21/49
摘要： A method and apparatus for calibrating noninvasive or implantable glucose analyzers uses either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variations that are built into the calibration model. An additional embodiment uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The invention provides a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.
摘要翻译：用于校准无创或可植入的葡萄糖分析仪的方法和装置使用替代的侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。在校准中使用替代入侵或非侵入性葡萄糖测定可以最大限度地减少由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。另外的实施方案使用非侵入性和替代性侵入性葡萄糖测定与传统的侵入性葡萄糖测定之间的统计学相关性来调整对于传统侵入性葡萄糖浓度的非侵入性或替代性侵入性葡萄糖浓度。本发明提供了一种用于基于反映观察到的基质的葡萄糖测定和由分析仪更仔细测量的变量进行校准的方法。葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

6. 发明申请

US20050187439A1 Sampling interface system for in-vivo estimation of tissue analyte concentration 审中-公开
标题翻译：用于体内估计组织分析物浓度的采样界面系统
公开(公告)号：US20050187439A1
公开(公告)日：2005-08-25
申请号：US11031103
申请日：2005-01-06
申请人： Thomas Blank , George Acosta , Stephen Monfre , Roxanne Abul-Haj , Kevin Hazen , Sedar Brown , Benjamin Richie , James Henderson , Barry Elliott , Josh Hope
发明人： Thomas Blank , George Acosta , Stephen Monfre , Roxanne Abul-Haj , Kevin Hazen , Sedar Brown , Benjamin Richie , James Henderson , Barry Elliott , Josh Hope
IPC分类号： A61B5/00 , G01N21/35
CPC分类号： G01N21/359 , A61B5/0075 , A61B5/14532 , A61B5/1455 , A61B2562/146
摘要： Sampling is controlled to enhance analyte concentration estimation derived from noninvasive sampling. Means of assuring that the same tissue sample volume is repeatably sampled are presented, thus minimizing sampling errors due to mechanical tissue distortion, specular reflectance, and probe placement. In a first embodiment of the invention, sampling is controlled using automated delivery of a coupling fluid to a region between a tip of a sample probe and a tissue measurement site in a manner requiring minimal user interaction. In a second embodiment of the invention, sampling is controlled by controlling temperature variations, preferably with a coupling fluid, at a region about the tip of a sample probe and a sample site. In a third embodiment, sampling is procedurally controlled via timing and location of coupling fluid delivery to a sample site.
摘要翻译：控制采样以增强从无创采样得到的分析物浓度估计。呈现确保相同组织样本体积被重复采样的方法，从而最小化由于机械组织变形，镜面反射率和探针放置引起的采样误差。在本发明的第一实施例中，采用自动化方式将耦合流体以需要最少用户相互作用的方式自动传送到样品探针的尖端和组织测量部位之间的区域进行控制。在本发明的第二实施例中，通过在围绕样品探针的尖端的区域和样品位置处控制温度变化来控制采样，优选地通过耦合流体进行控制。在第三实施例中，通过将流体输送到样品位置的定时和位置程序地控制采样。

7. 发明申请

US20050020892A1 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US20050020892A1
公开(公告)日：2005-01-27
申请号：US10820322
申请日：2004-04-07
申请人： George Acosta , James Henderson , N. Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
发明人： George Acosta , James Henderson , N. Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
IPC分类号： A61B5/00 , A61B5/103 , A61B5/107 , G01N21/35 , G01N21/47 , G01N21/49
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1495 , A61B5/441 , A61B5/4869 , A61B5/4872 , A61B5/6824 , A61B5/7203 , A61B5/726 , A61B2560/0233 , A61B2562/0233 , A61B2562/0242 , G01N21/359 , G01N21/474 , G01N21/49
摘要： A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneous layer of the sampled tissue so that interference from the adipose layer is minimized. The optical system includes at least one optical probe. Spacing between optical paths and detection fibers of each probe and between probes is optimized to minimize sampling of the adipose subcutaneous layer and to maximize collection of light backscattered from the cutaneous layer. Penetration depth is optimized by limiting range of distances between paths and detection fibers. Minimizing sampling of the adipose layer greatly reduces interference contributed by the fat band in the sample spectrum, increasing signal-to-noise ratio. Providing multiple probes also minimizes interference in the sample spectrum due to placement errors.
摘要翻译：基于近红外光谱仪的分析仪连续或半连续地连接到人类受试者并且收集用于确定采样组织中的生物学参数（诸如葡萄糖浓度）的光谱测量。该分析仪包括优化的靶向采样组织的皮肤层的光学系统，使得来自脂肪层的干扰最小化。光学系统包括至少一个光学探针。针对每个探针和探针之间的光路和检测纤维之间的间距进行优化，以最小化脂肪皮下层的取样，并最大限度地收集从皮肤层反射的光。穿透深度通过限制路径和检测光纤之间的距离范围进行优化。最小化脂肪层的取样大大减少了样品谱中脂肪带所造成的干扰，提高了信噪比。提供多个探针也可以最小化由于放置误差而导致的样品光谱干扰。

8. 发明申请

US20050010090A1 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US20050010090A1
公开(公告)日：2005-01-13
申请号：US10472856
申请日：2003-03-07
申请人： George Acosta , James Henderson , N. Abul Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
发明人： George Acosta , James Henderson , N. Abul Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/49 , G01N33/48
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyze is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

9. 发明授权

US06442408B1 Method for quantification of stratum corneum hydration using diffuse reflectance spectroscopy 失效
公开(公告)号：US06442408B1
公开(公告)日：2002-08-27
申请号：US09669781
申请日：2000-09-25
申请人： Brian J. Wenzel , Stephen L. Monfre , Timothy L. Ruchti , Ken Meissner , Frank Grochocki , Thomas Blank , Jessica Rennert
发明人： Brian J. Wenzel , Stephen L. Monfre , Timothy L. Ruchti , Ken Meissner , Frank Grochocki , Thomas Blank , Jessica Rennert
IPC分类号： A61B500
CPC分类号： A61B5/441 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01N21/274 , G01N21/359 , G01N21/4785 , G01N21/49
摘要： An apparatus and method for non-invasively quantifying the hydration of the stratum corneum of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting NIR absorption spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, a calibration model developed from an exemplary set of measurements is applied to predict the SC hydration for the sample. The method of SC hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. The stratum corneum hydration measurement is therefore suitable for further spectral analysis and the quantification of biological and chemical compounds, such as blood analytes.

10. 发明申请

US20100059345A1 BALL SWITCH IN A MULTIBALL SWITCH ARRANGEMENT 有权
标题翻译：球开关在多开关装置中
公开(公告)号：US20100059345A1
公开(公告)日：2010-03-11
申请号：US12518594
申请日：2007-11-17
申请人： Thomas Blank
发明人： Thomas Blank
IPC分类号： H01H35/14
CPC分类号： H01H35/141 , H01H35/02
摘要： A ball switch for a multi ball-switch arrangement includes a base plate and a metallic circular disk centrally disposed on the base plate. A first electrically-conductive contact track, which is co-planar with the circular disk, extends from the circular disk to a first edge of the base plate. A chamber plate having a through-bore is disposed opposite the base plate so as to form a chamber which concentrically circumscribes the circular disk. The chamber has a metallic inner wall with a circumferential first metallic annular strip disposed at a first end thereof at a first side of the chamber plate. A dielectric sealing ring which concentrically surrounds the circular disk is disposed between the first metallic annular strip and the base plate so as to seal the chamber. An electrically conductive ball is disposed in the chamber and has a diameter which prevents a further similar conductive ball from fitting into the chamber.
摘要翻译：用于多球开关装置的球开关包括基板和集中设置在基板上的金属圆盘。与圆盘共面的第一导电接触轨道从圆盘延伸到基板的第一边缘。具有通孔的室板与基板相对设置，以形成同心地围绕圆盘的室。所述腔室具有金属内壁，所述金属内壁具有在所述腔室板的第一侧处设置在其第一端处的周向第一金属环形带。同心地围绕圆盘的电介质密封环设置在第一金属环形带和基板之间，以便密封室。导电球设置在腔室中并且具有防止另外类似的导电球装入腔室的直径。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式