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1. 发明申请

US20050259934A1 Photonic crystal fibers and medical systems including photonic crystal fibers 有权
标题翻译：光子晶体纤维和医疗系统，包括光子晶体纤维
公开(公告)号：US20050259934A1
公开(公告)日：2005-11-24
申请号：US11102258
申请日：2005-04-08
申请人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink , Gokhan Ulu
发明人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink , Gokhan Ulu
IPC分类号： A61B18/20 , A61B18/22 , A61F9/008 , G02B6/02 , G02B6/26 , G02B6/20
CPC分类号： A61B18/22 , A61B1/0017 , A61B18/203 , A61B2018/00452 , A61B2018/00476 , A61B2018/2272 , A61F9/008 , A61F2009/00842 , A61F2009/00863 , A61F2009/00891 , G02B6/02304 , G02B6/02385 , G02B6/262
摘要： In general, in one aspect, the invention features apparatus that include an assembly including a radiation input port configured to receive radiation from a radiation source and an output port configured to couple the radiation to a photonic crystal fiber, the assembly further including a retardation element positioned to modify a polarization state of the radiation received from the radiation source before it is coupled to the photonic crystal fiber.
摘要翻译：通常，在一个方面，本发明的特征在于，设备包括：组件，其包括被配置为接收来自辐射源的辐射的辐射输入端口和被配置为将辐射耦合到光子晶体光纤的输出端口，该组件还包括延迟元件定位成在辐射源耦合到光子晶体光纤之前修改从辐射源接收的辐射的偏振状态。

2. 发明申请

US20050259933A1 Photonic crystal fibers and medical systems including photonic crystal fibers 有权
标题翻译：光子晶体纤维和医疗系统，包括光子晶体纤维
公开(公告)号：US20050259933A1
公开(公告)日：2005-11-24
申请号：US11101915
申请日：2005-04-08
申请人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink
发明人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink
IPC分类号： A61B1/018 , A61B18/22 , G02B6/02 , G02B6/06
CPC分类号： G02B6/02304 , A61B1/018 , A61B18/201 , A61B18/22 , A61B2018/2272 , A61F9/008 , A61F9/00802 , A61F9/00821 , A61F9/00825 , A61F2009/00863 , A61F2009/00891 , C03B2201/86 , C03B2203/12 , C03B2203/14 , C03B2203/16 , C03B2203/18 , C03B2203/42 , G02B6/023 , G02B6/02385 , G02B6/03622 , G02B6/03638 , G02B6/03694 , Y02P40/57
摘要： In general, in one aspect, the invention features systems, including a photonic crystal fiber including a core extending along a waveguide axis and a dielectric confinement region surrounding the core, the dielectric confinement region being configured to guide radiation along the waveguide axis from an input end to an output end of the photonic crystal fiber. The systems also includes a handpiece attached to the photonic crystal fiber, wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient.
摘要翻译：通常，在一个方面，本发明的特征在于系统，其包括光子晶体光纤，其包括沿着波导轴延伸的芯和围绕该芯的介电限制区，所述介电限制区被配置为沿着波导轴从输入引导辐射结束于光子晶体光纤的输出端。所述系统还包括附接到光子晶体光纤的手持件，其中所述手持件允许操作者控制所述输出端的取向以将所述辐射引导到患者的目标位置。

3. 发明申请

US20070122096A1 Photonic crystal fibers and medical systems including photonic crystal fibers 审中-公开
标题翻译：光子晶体纤维和医疗系统，包括光子晶体纤维
公开(公告)号：US20070122096A1
公开(公告)日：2007-05-31
申请号：US11584167
申请日：2006-10-20
申请人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink
发明人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink
IPC分类号： G02B6/02 , G02B6/036
CPC分类号： A61B18/24 , A61B18/201 , A61B18/22 , A61B2018/00017 , A61B2018/2288 , G02B6/02304 , G02B6/02385 , G02B6/032 , G02B6/42
摘要： In general, in one aspect, the invention features methods that include directing radiation to a target location of a patient through a photonic crystal fiber, the photonic crystal fiber having a hollow core and flowing a fluid through the hollow core to the target location of the patient.
摘要翻译：通常，在一个方面，本发明的特征在于包括通过光子晶体光纤将辐射引导到患者的目标位置的方法，所述光子晶体光纤具有中空芯并且使流体通过中空芯流动到达所述靶的位置患者。

4. 发明申请

US20050259942A1 Photonic crystal fibers and medical systems including photonic crystal fibers 有权
标题翻译：光子晶体纤维和医疗系统，包括光子晶体纤维
公开(公告)号：US20050259942A1
公开(公告)日：2005-11-24
申请号：US11102299
申请日：2005-04-08
申请人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Jesse Rusk , Robert Payne , Yoel Fink
发明人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Jesse Rusk , Robert Payne , Yoel Fink
IPC分类号： A61B18/20 , A61B18/22 , G02B6/00 , G02B6/02 , G02B6/42
CPC分类号： A61B18/201 , A61B18/22 , A61B18/24 , G02B6/02304 , G02B6/02385 , G02B6/032 , G02B6/42
摘要： In general, in one aspect, the invention features methods that include directing radiation to a target location of a patient through a photonic crystal fiber, the photonic crystal fiber having a hollow core and flowing a fluid through the hollow core to the target location of the patient.
摘要翻译：通常，在一个方面，本发明的特征在于包括通过光子晶体光纤将辐射引导到患者的目标位置的方法，所述光子晶体光纤具有中空芯并且使流体通过中空芯流动到达所述靶的位置患者。

5. 发明申请

US20070147752A1 Photonic crystal fibers and systems using photonic crystal fibers 审中-公开
标题翻译：光子晶体光纤和使用光子晶体光纤的系统
公开(公告)号：US20070147752A1
公开(公告)日：2007-06-28
申请号：US11449947
申请日：2006-06-09
申请人： Ori Weisberg , Gregor Dellemann , Uri Kolodny , David Torres , Charalambos Anastassiou , Steven Jacobs , Gil Shapira , Burak Temelkuran , Aaron Micetich , Rokan Ahmad , Ytshak Avrahami , Yelena Kann , Max Shurgalin , Yoel Fink , Tairan Wang
发明人： Ori Weisberg , Gregor Dellemann , Uri Kolodny , David Torres , Charalambos Anastassiou , Steven Jacobs , Gil Shapira , Burak Temelkuran , Aaron Micetich , Rokan Ahmad , Ytshak Avrahami , Yelena Kann , Max Shurgalin , Yoel Fink , Tairan Wang
IPC分类号： G02B6/032
CPC分类号： A61B18/22 , A61B18/201 , A61B2018/207 , A61B2018/2244 , G02B6/02304 , G02B6/02385 , G02B6/03638 , G02B6/03661
摘要： In general, in one aspect, the invention features methods that include guiding radiation at a first wavelength, λ1, through a core of a photonic crystal fiber and guiding radiation at a second wavelength, λ2, through the photonic crystal fiber, wherein |λ1−λ2|>100 nm.
摘要翻译：通常，在一个方面，本发明的特征在于方法包括通过光子晶体光纤的芯引导第一波长λ1的辐射，并引导第二波长λλ的辐射，通过光子晶体光纤，其中λ1→λ2→100nm。

6. 发明申请

US20070053640A1 Photonic crystal fibers having a preferred bending plane and systems that use such fibers 有权
标题翻译：具有优选弯曲面的光子晶体纤维和使用这种纤维的系统
公开(公告)号：US20070053640A1
公开(公告)日：2007-03-08
申请号：US11366345
申请日：2006-03-02
申请人： James Goell , Marin Soljacic , Steven Jacobs , Tairan Wang , Gokhan Ulu , Burak Temelkuran , Steven Johnson
发明人： James Goell , Marin Soljacic , Steven Jacobs , Tairan Wang , Gokhan Ulu , Burak Temelkuran , Steven Johnson
IPC分类号： G02B6/02
CPC分类号： G02B6/02304 , A61B1/018 , A61B18/201 , A61B18/22 , A61B2018/2272 , A61F9/008 , A61F9/00802 , A61F9/00821 , A61F9/00825 , A61F2009/00863 , A61F2009/00891 , C03B2201/86 , C03B2203/12 , C03B2203/14 , C03B2203/16 , C03B2203/18 , C03B2203/42 , G02B6/023 , G02B6/02385 , G02B6/03622 , G02B6/03638 , G02B6/03694 , Y02P40/57
摘要： In general, in a first aspect, the invention features photonic crystal fibers that include a core extending along a waveguide axis, a confinement region extending along the waveguide axis surrounding the core, and a cladding extending along the waveguide axis surrounding the confinement region, wherein the cladding has an asymmetric cross-section.
摘要翻译：通常，在第一方面，本发明的特征在于光子晶体光纤，其包括沿着波导轴延伸的芯，沿着围绕芯的波导轴延伸的约束区域以及沿着围绕限制区域的波导轴延伸的包层，其中包层具有不对称的横截面。

7. 发明申请

US20050271340A1 Photonic crystal waveguides and systems using such waveguides 有权
标题翻译：光子晶体波导和使用这种波导的系统
公开(公告)号：US20050271340A1
公开(公告)日：2005-12-08
申请号：US10978605
申请日：2004-11-01
申请人： Ori Weisberg , Steven Jacobs , Maksim Skorobogatiy , Steven Johnson , Uri Kolodny
发明人： Ori Weisberg , Steven Jacobs , Maksim Skorobogatiy , Steven Johnson , Uri Kolodny
IPC分类号： G02B6/02 , G02B6/036
CPC分类号： G02B6/02304 , G02B6/02328 , G02B6/02361 , G02B6/03622 , G02B6/03688 , G02B6/03694
摘要： In general, in one aspect, the invention features an apparatus that includes a photonic crystal fiber configured to guide a mode of electromagnetic radiation at a wavelength, λ, along a waveguide axis. The fiber includes a core extending along the waveguide axis, and a confinement region extending along the waveguide axis and surrounding the core. The confinement region includes alternating layers of a first and a second dielectric material having thicknesses d1 and d2 and different refractive indices n1 and n2, respectively. The thickness of at least one of the alternating layers of the first material_differs from thickness d1QW or at least one of the alternating layers of the second material_differs from thickness d2QW, where d1QW and d2QW correspond to a quarter-wave condition for the two dielectric materials given by d1QW=λ/(4{square root}{square root over (n12−1)}) and d2QW=λ/(4{square root}{square root over (n22−1)}), respectively. The photonic crystal fiber has an attenuation for the guided mode at the wavelength λ that is reduced by a factor of about two or more relative to an attenuation for a reference fiber that is identical to the photonic crystal fiber except that the reference fiber has alternating layer thicknesses corresponding to the quarter-wave condition.
摘要翻译：通常，在一个方面，本发明的特征在于一种装置，其包括光子晶体光纤，其被配置为沿波导轴引导波长λ的电磁辐射模式。光纤包括沿波导轴延伸的芯，以及沿着波导轴线延伸并围绕芯的约束区域。限制区域包括具有厚度d 1和2 2的不同折射率n 1和n 2的第一和第二电介质材料的交替层，n 2 。第一材料的至少一个交替层的厚度来自厚度d <1> QW /或第二材料的至少一个交替层，厚度d _{，其中d <1> QW 和D <2> QW >对应于由d 1 / Q Q（λ）=λ/（4 {平方根} {平方根（n> 1）给出的两个介电材料的四分之一波长条件， 1 2 -1）}）和d 2 QW =λ/（4 {平方根} {平方根超过（ 2 2 -1）}）。光子晶体光纤对于在波长λ处的导模的衰减相对于与光子晶体光纤相同的参考光纤的衰减相比减小约两倍或更多的因子，除了参考光纤具有交替层厚度对应于四分之一波长条件。}

8. 发明授权

US09746885B2 Computing system including a first and second housing and polar magnets 有权
公开(公告)号：US09746885B2
公开(公告)日：2017-08-29
申请号：US14355030
申请日：2012-02-27
申请人： Michael Delpier , Stacy L Wolff , Kevin L Massaro , Daniel Koelker , Steven Jacobs , Dimitre Mehandjiysky
发明人： Michael Delpier , Stacy L Wolff , Kevin L Massaro , Daniel Koelker , Steven Jacobs , Dimitre Mehandjiysky
IPC分类号： G06F1/16
摘要： A first housing with a polar magnet on a first side. The first housing can include an opening on the first side. A second housing can include a sliding latch. An opposite polar magnet attached to the sliding latch. The polar magnet attracts the opposite polar magnet on the sliding latch to move the sliding latch to a latched position.

9. 发明授权

US09200273B2 Fibronectin type III repeat based protein scaffolds with alternative binding surfaces 有权
标题翻译：具有替代结合表面的纤连蛋白III型重复基于蛋白质支架
公开(公告)号：US09200273B2
公开(公告)日：2015-12-01
申请号：US13628393
申请日：2012-09-27
申请人： Michael Diem , Steven Jacobs
发明人： Michael Diem , Steven Jacobs
IPC分类号： C40B50/06 , C12N15/10 , C40B40/08
CPC分类号： G01N33/6845 , C12N15/1044 , C40B30/04 , C40B40/08 , C40B50/06 , G01N2333/78
摘要： Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
摘要翻译：基于具有替代结合表面设计的纤连蛋白III型（FN3）重复的蛋白质支架和支架文库，编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备方法可用于产生治疗分子和治疗和疾病和病症的诊断。

10. 发明授权

US08293482B2 Fibronectin type III domain based scaffold compositions, methods and uses 有权
标题翻译：纤连蛋白III型结构域的支架组合物，方法和用途
公开(公告)号：US08293482B2
公开(公告)日：2012-10-23
申请号：US12704824
申请日：2010-02-12
申请人： Steven Jacobs , Karyn O'Neil
发明人： Steven Jacobs , Karyn O'Neil
IPC分类号： C07K16/00 , G01N33/53
CPC分类号： C12N15/1044 , A61K38/00 , C07K14/78 , C40B40/08 , C40B50/06
摘要： A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.
摘要翻译：基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。

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