会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 8. 发明申请
    • NOVEL USE OF DIMETHYLFUMARATE
    • 二甲基丙酸的新用途
    • US20100324327A1
    • 2010-12-23
    • US12677089
    • 2008-09-10
    • In Kyu Lee
    • In Kyu Lee
    • C07C69/60
    • A61K31/225
    • Disclosed are a pharmaceutical composition for inhibiting vascular smooth muscle cell proliferation comprising dimethyl fumarate as an effective ingredient, use of dimethyl fumarate for inhibiting vascular smooth muscle cell proliferation, and a method of inhibiting vascular smooth muscle cell proliferation employing the same. Through the present invention, it was found that dimethyl fumarate could inhibit vascular smooth muscle cell proliferation by increasing the activity of AMPK. Accordingly, dimethyl fumarate can be usefully used as an effective ingredient of a medicine for inhibiting vascular smooth muscle cell proliferation.
    • 公开了一种用于抑制血管平滑肌细胞增殖的药物组合物,其包含富马酸二甲酯作为有效成分,使用富马酸二甲酯抑制血管平滑肌细胞增殖,以及使用该药物组合物抑制血管平滑肌细胞增殖的方法。 通过本发明,通过增加AMPK的活性,发现富马酸二甲酯可以抑制血管平滑肌细胞增殖。 因此,富马酸二甲酯可有效地用作抑制血管平滑肌细胞增殖的药物的有效成分。
    • 9. 发明授权
    • Processes for the preparation of cephalosporin derivatives
    • 制备头孢菌素衍生物的方法
    • US07622577B2
    • 2009-11-24
    • US10577551
    • 2004-10-30
    • Dae Won SeoIn Hwa ChungKi Bong LeeIn Kyu Lee
    • Dae Won SeoIn Hwa ChungKi Bong LeeIn Kyu Lee
    • C07D501/22
    • C07D501/00Y02P20/55
    • Provided is a process for preparing a compound of formula 1 or its salt, which comprises reacting a compound represented by the following formula 4 with acetaldehyde in a mixed solvent comprising water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the presence of a first base to stereospecifically prepare a compound represented by the following formula 3′; and reacting the compound of the formula 3′ with an anhydrous compound represented by the following formula 2 in the presence of a second base: wherein R1 is a hydrogen or an amino protecting group, R2 is a hydrogen or a carboxyl protecting group, and R3 is a hydrogen or an amino protecting group consisting of phenylacetyl group, wherein when R3 is a phenylacetyl group, R2 is not a hydrogen in formula 3′; and wherein, when at least one of R2 and R3 is a protecting group, all such protecting groups are removed from formula 3′, thereby producing a compound represented by formula 6 prior to reacting it with the compound of formula 2.
    • 本发明提供制备式1化合物或其盐的方法,该方法包括使下式4表示的化合物与乙醛在含有水,异丙醇和二氯甲烷的混合溶剂中以体积比为1:3-6:3的比例反应, 11-14在第一碱的存在下,立体选择性地制备由下式3'表示的化合物; 并使式3'化合物与下式2表示的无水化合物在第二碱存在下反应:其中R1是氢或氨基保护基,R2是氢或羧基保护基,R3是 是由苯乙酰基组成的氢或氨基保护基,其中当R3是苯乙酰基时,R2不是式3'中的氢; 并且其中当R 2和R 3中的至少一个是保护基时,从式3'中除去所有这些保护基,从而在与式2化合物反应之前制备由式6表示的化合物。