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1. 发明授权

US08569281B2 Compounds and their administration for treating a neurodegenerative disease as well as a method for identifying a compound capable of inhibiting a kinase, such as LRRK 失效
标题翻译：用于治疗神经变性疾病的化合物及其施用以及用于鉴定能够抑制激酶的化合物的方法，例如LRRK
公开(公告)号：US08569281B2
公开(公告)日：2013-10-29
申请号：US13238840
申请日：2011-09-21
申请人： Bryan K. Chan , Huifen Chen , Anthony Estrada , Daniel Shore , Zachary Sweeney , Edward Giles McIver
发明人： Bryan K. Chan , Huifen Chen , Anthony Estrada , Daniel Shore , Zachary Sweeney , Edward Giles McIver
IPC分类号： A61K31/5365 , A61K31/00 , A61K31/44 , C07D498/00 , C07D413/00 , C07D401/00 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to substituted pyrazolopyridine compounds, and pharmaceutically acceptable salts or esters thereof. The present invention further relates to therapeutic uses of pharmaceutical compositions comprising the substituted pyrazolopyridine compounds, for example, in cancer and neurodegenerative diseases.
摘要翻译：本发明涉及取代的吡唑并吡啶化合物及其药学上可接受的盐或酯。本发明还涉及包含取代的吡唑并吡啶化合物的药物组合物在癌症和神经变性疾病中的治疗用途。

2. 发明授权

US08354420B2 Aminopyrimidine derivatives as LRRK2 inhibitors 有权
标题翻译：氨基嘧啶衍生物作为LRRK2抑制剂
公开(公告)号：US08354420B2
公开(公告)日：2013-01-15
申请号：US13150929
申请日：2011-06-01
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
IPC分类号： A61K31/505 , C07D239/28
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式I化合物或其药学上可接受的盐，其中m，n。 X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

3. 发明申请

US20110301141A1 AMINOPYRIMIDINE DERIVATIVES AS LRRK2 INHIBITORS 有权
标题翻译：作为LRRK2抑制剂的氨基嘧啶衍生物
公开(公告)号：US20110301141A1
公开(公告)日：2011-12-08
申请号：US13150929
申请日：2011-06-01
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
IPC分类号： A61K31/5377 , C07D401/12 , C07D401/14 , A61P25/16 , A61K31/506 , A61K31/5386 , A61K31/553 , C07D413/12 , C07D403/12
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式I化合物或其药学上可接受的盐，其中m，n。 X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

4. 发明申请

US20050062239A1 Locking anti-motion suspension 有权
标题翻译：锁定防静电悬挂
公开(公告)号：US20050062239A1
公开(公告)日：2005-03-24
申请号：US10664568
申请日：2003-09-19
申请人： Daniel Shore
发明人： Daniel Shore
IPC分类号： B60G11/26 , B60G17/00 , B60G17/005 , B60G17/056
CPC分类号： B60G17/005 , B60G17/056 , B60G2202/154 , B60G2300/022
摘要： A skid steer vehicle has a suspension that includes a control arm pivotally coupled to the vehicle chassis that is supported by a hydraulic cylinder connected to an accumulator to provide springing. A hydraulic circuit coupled to the cylinder and accumulator permit the operator to raise and lower the chassis, to lock the suspension while the vehicle is loaded, and to automatically charge or discharge the accumulator to match the cylinder pressure during loading and unloading. In this manner, when the suspension is unlocked after loading, the vehicle chassis neither rises nor falls.
摘要翻译：滑行转向车辆具有悬架，其包括枢转地联接到车辆底架的控制臂，该控制臂由连接到蓄能器的液压缸支撑以提供弹簧。耦合到气缸和蓄电池的液压回路允许操作者升高和降低底盘，以在车辆被加载时锁定悬架，并且在装载和卸载期间自动对蓄能器进行充气或排放以匹配气缸压力。以这种方式，当在装载之后解除悬架时，车辆底盘既不升高也不下降。

5. 发明申请

US20060070746A1 Bulldozer autograding system 有权
标题翻译：推土机升级系统
公开(公告)号：US20060070746A1
公开(公告)日：2006-04-06
申请号：US10947002
申请日：2004-09-21
申请人： George Lumpkins , Peter Dix , Daniel Shore
发明人： George Lumpkins , Peter Dix , Daniel Shore
IPC分类号： A01B41/06
CPC分类号： E02F3/844 , E02F3/845
摘要： A dozer blade control system controls the position of a bulldozer blade, maintaining the blade at a constant position as the dozer travels through a worksite. The control system monitors the angle of the dozer blade with respect to the earth and when it senses that the dozer blade is tilting, it corrects the dozer blade's position by extending or retracting hydraulic cylinders that couple the dozer blade to the chassis of the crawler-tractor. When the dozer chassis pitches forwards, the blade begins to tilt forward and to drop closer to the ground. The control system senses this forward rotation of the blade and retracts the hydraulic cylinders that couple the blade to the chassis, causing the blade to return to and maintain its original position. Conversely, when the dozer chassis pitches backwards and the blade begins to tilt backward and rise higher above the ground, the control system extends the hydraulic cylinders coupling the blade to the chassis and lowers the blade, causing the blade to return to and maintain its original position with respect to the earth.
摘要翻译：推土机叶片控制系统控制推土机叶片的位置，当推土机穿过工地时将叶片保持在恒定的位置。控制系统监测推土机叶片相对于地球的角度，并且当其感测到推土铲叶片倾斜时，其通过将推土机叶片连接到履带的底盘上的液压缸来校正推土铲叶片的位置，拖拉机。当推土机底盘向前倾斜时，叶片开始向前倾斜并靠近地面。控制系统感测到叶片的正向旋转，并将连接叶片的液压缸缩回到底盘，导致叶片返回并保持其原始位置。相反，当推土机底盘向后倾斜并且叶片开始向后倾斜并且在地面上方升高时，控制系统将连接叶片的液压缸延伸到底盘并降低叶片，使得叶片返回并保持其原始相对于地球的位置。

6. 发明申请

US20050275184A1 Variable ride control 有权
标题翻译：可变驾驶控制
公开(公告)号：US20050275184A1
公开(公告)日：2005-12-15
申请号：US10854833
申请日：2004-05-27
申请人： Anthony Lamela , Troy Bateman , Brian Felsing , Peter Dix , Daniel Shore , Hong-Chin Lin
发明人： Anthony Lamela , Troy Bateman , Brian Felsing , Peter Dix , Daniel Shore , Hong-Chin Lin
IPC分类号： B60G9/04
CPC分类号： B60G17/0152 , B60G2202/154 , B60G2300/022 , B60G2400/204 , B60G2400/252 , B60G2400/60 , B60G2500/10
摘要： A skid steer vehicle has a chassis with four drive wheels suspended from the chassis that are damped by four damping cylinders. An electronic controller varies the damping of the cylinders in an automatic mode, based on certain operational parameters of the vehicle, and in a manual mode in response to operator selection of a desired degree of suspension damping.
摘要翻译：滑行转向车辆具有底盘，四个驱动轮悬挂在底盘上，四个阻尼缸被阻尼。电子控制器基于车辆的某些操作参数在自动模式下改变气缸的阻尼，并且响应于操作者选择期望的悬架阻尼程度来改变手动模式。

7. 发明申请

US20190139087A1 Systems and Methods for Acquiring Consent from a Party Subject to Online Advertisement 审中-公开
公开(公告)号：US20190139087A1
公开(公告)日：2019-05-09
申请号：US16182282
申请日：2018-11-06
申请人： David Dabbs , Daniel Shore , Mateen Moosa
发明人： David Dabbs , Daniel Shore , Mateen Moosa
IPC分类号： G06Q30/02 , G06F16/958 , G06F16/957 , G06F3/0482 , G06F3/0484
摘要： A method for gaining consent to target advertising to and to collect data from a subject to online advertising includes providing, to the subject to online advertising at a computing device associated with the subject to online advertising, instructions for a consent dialogue window, the consent dialogue window served to the subject. The consent dialogue window is presented to the subject as an overlay to a website. The consent dialogue window includes a non-consent affirmation box, which, if affirmatively indicated, indicates to the consent server that the subject to online advertising does not consent to targeted advertising and collection of data, and a media declaration which accurately informs the subject that if any affirmative indication is made outside indicatable areas, which include, at least, the non-consent affirmation box, then the subject to online advertising consents to online advertisement and data collection from the vendor server and partner vendor servers.

8. 发明申请

US20060125201A1 Locking anti-motion suspension 有权
公开(公告)号：US20060125201A1
公开(公告)日：2006-06-15
申请号：US11351038
申请日：2006-02-08
申请人： Daniel Shore
发明人： Daniel Shore
IPC分类号： B60G11/26
CPC分类号： B60G17/005 , B60G17/056 , B60G2202/154 , B60G2300/022
摘要： A skid steer vehicle has a suspension that includes a control arm pivotally coupled to the vehicle chassis that is supported by a hydraulic cylinder connected to an accumulator to provide springing. A hydraulic circuit coupled to the cylinder and accumulator permit the operator to raise and lower the chassis, to lock the suspension while the vehicle is loaded, and to automatically charge or discharge the accumulator to match the cylinder pressure during loading and unloading. In this manner, when the suspension is unlocked after loading, the vehicle chassis neither rises nor falls.

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