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    • 8. 发明授权
    • Stem cell growth factor-like polypeptide
    • 干细胞生长因子样多肽
    • US06667391B1
    • 2003-12-23
    • US09764325
    • 2001-01-16
    • Radoje T. DrmanacIvan LabatY. Tom TangCheng-Chi ChaoNancy K. MizeJohn Childs
    • Radoje T. DrmanacIvan LabatY. Tom TangCheng-Chi ChaoNancy K. MizeJohn Childs
    • C07K200
    • C07K14/475A61K38/00A61K2039/505C07K14/47Y10S435/81Y10S435/975
    • The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human fetal liver spleen (Hyseq clone identification number 6118092), ovary (Hyseq clone identification number 8375786), adult brain (Hyseq clone identification numbers 701734, 15327638, 15741682, 15954941, 15955015), lung tumor (Hyseq clone identification number 11047146 and 10280328), spinal cord (Hyseq clone identification number 10102150), cervix (Hyseq clone identification numbers 10022437 and 14029194), ovary (Hyseq clone identification number 8319153), endothelial cells (Hyseq clone identification number 13815744), umbilical cord (Hyseq clone identification number 18568149), lymphocyte (Hyseq clone identification number 10257378), lung fibroblast (Hyseq clone identification number 17116257), fetal brain (Hyseq clone identification number 15266959), and testis. Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
    • 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿肝脏脾脏(Hyseq克隆鉴定号6118092),卵巢(Hyseq克隆鉴定号8375786),成年脑(Hyseq克隆鉴定号701734,15327638,15741682,15954941,15955015)分离的核酸序列, 肺癌(Hyseq克隆鉴定号11047146和10280328),脊髓(Hyseq克隆鉴定号10102150),宫颈(Hyseq克隆鉴定号10022437和14029194),卵巢(Hyseq克隆鉴定号8319153),内皮细胞(Hyseq克隆鉴定号13815744 ),脐带(Hyseq克隆鉴定号18568149),淋巴细胞(Hyseq克隆鉴定号10257378),肺成纤维细胞(Hyseq克隆鉴定号17116257),胎儿脑(Hyseq克隆鉴定号码15266959)和睾丸。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。