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1. 发明申请

US20190314045A1 TARGETING METHODS AND DEVICES FOR NON-INVASIVE THERAPY DELIVERY 审中-公开
公开(公告)号：US20190314045A1
公开(公告)日：2019-10-17
申请号：US16383386
申请日：2019-04-12
申请人： Bryan Cunitz , Kennedy Hall , Mathew Sorenson , Michael R. Bailey , Adam D. Maxwell , Barbrina Dunmire , Oren Levy , Doug Corl , Paul Fasolo
发明人： Bryan Cunitz , Kennedy Hall , Mathew Sorenson , Michael R. Bailey , Adam D. Maxwell , Barbrina Dunmire , Oren Levy , Doug Corl , Paul Fasolo
IPC分类号： A61B17/22 , A61B8/08 , A61B5/00 , A61B8/00
摘要： Targeting methods and devices for non-invasive therapy delivery are disclosed. In one embodiment, a method for targeting an object in a body using ultrasound includes: producing a therapy ultrasound waveform configured to fragment or comminute the object in the body using a therapy transducer of an ultrasound probe; and acquiring a sound waveform by a receiver. The sound waveform is at least in part caused by interactions of the therapy ultrasound with the object. The method also includes generating an indication of a targeting accuracy based on the acquired sound waveform.

2. 发明授权

US09198635B2 Method and apparatus for preparing organs and tissues for laparoscopic surgery 有权
标题翻译：用于腹腔镜手术的器官和组织的制备方法和装置
公开(公告)号：US09198635B2
公开(公告)日：2015-12-01
申请号：US11464118
申请日：2006-08-11
申请人： Lawrence A. Crum , Peter J. Kaczkowski , Stuart B. Mitchell , Michael R. Bailey
发明人： Lawrence A. Crum , Peter J. Kaczkowski , Stuart B. Mitchell , Michael R. Bailey
IPC分类号： A61B8/00 , A61B8/12 , A61B8/06 , A61F7/02 , A61B8/13 , A61B17/32 , A61B17/00
CPC分类号： A61B8/12 , A61B8/06 , A61B8/13 , A61B8/4272 , A61B17/320092 , A61B2017/00243 , A61B2017/00575 , A61F7/02
摘要： High intensity ultrasound (HIU) is used to facilitate surgical procedures, such as a laparoscopic partial nephrectomy, with minimal bleeding. An apparatus is configured to emit HIU from one or more transducers that are attached to a minimally invasive surgical instrument. Such a tool preferably can provide sufficient clamping pressure to collapse blood vessels' walls, so that they will be sealed by the application of the HIU, and by the resulting thermal ablation and tissue cauterization. Such an instrument can provide feedback to the user that the lesion is completely transmural and that blood flow to the region distal of the line of thermal ablation has ceased. Similar instruments having opposed arms can be configured for use in conventional surgical applications as well. Instruments can be implemented with transducers on only one arm, and an ultrasound reflective material disposed on the other arm.
摘要翻译：高强度超声（HIU）用于促进外科手术，如腹腔镜部分肾切除术，出血少。一种装置被配置为从附接到微创外科器械的一个或多个换能器发射HIU。这种工具优选地可以提供足够的夹紧压力来折叠血管的壁，使得它们将通过施加HIU而被密封，并且通过所得到的热消融和组织烧灼。这样的仪器可以向使用者提供病变完全透壁并且到达热消融线的远端区域的血液流动已经停止的反馈。具有相对臂的类似器械也可以被配置为用于常规外科应用。仪器可以在仅一个臂上的换能器和设置在另一个臂上的超声反射材料实现。

3. 发明授权

US08876740B2 Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound therapy 有权
标题翻译：使用高强度聚焦超声治疗非侵入性治疗组织的方法和系统
公开(公告)号：US08876740B2
公开(公告)日：2014-11-04
申请号：US13085368
申请日：2011-04-12
申请人： Michael S. Canney , Michael R. Bailey , Lawrence A. Crum , Vera A. Khokhlova , Tatiana D. Khokhlova , Wayne Kreider , Joo Ha Hwang , Oleg A. Sapozhnikov
发明人： Michael S. Canney , Michael R. Bailey , Lawrence A. Crum , Vera A. Khokhlova , Tatiana D. Khokhlova , Wayne Kreider , Joo Ha Hwang , Oleg A. Sapozhnikov
IPC分类号： A61N7/02 , A61B17/00 , A61B19/00 , A61B18/00
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2018/00005 , A61B2090/374 , A61B2090/378
摘要： Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
摘要翻译：使用高强度聚焦超声（“HIFU”）治疗非侵入性治疗组织的方法和系统。例如，根据本技术的实施例的非侵入性治疗组织的方法可以包括将超声源的焦平面定位在组织中的目标部位。超声波源可被配置为发射HIFU波。该方法还可以包括将来自超声源的超声能量脉冲向目标部位，并在组织内产生冲击波，以在毫秒内诱导目标部位的组织沸腾。组织的沸腾至少基本上乳化组织。

4. 发明申请

US20120071795A1 DERATING METHOD FOR THERAPEUTIC APPLICATIONS OF HIGH INTENSITY FOCUSED ULTRASOUND 有权
标题翻译：高强度聚焦超声治疗应用的治疗方法
公开(公告)号：US20120071795A1
公开(公告)日：2012-03-22
申请号：US13236531
申请日：2011-09-19
申请人： Vera A. Khokhlova , Olga V. Bessonova , Michael S. Canney , Michael R. Bailey , Oleg A. Sapozhnikov , Lawrence A. Crum
发明人： Vera A. Khokhlova , Olga V. Bessonova , Michael S. Canney , Michael R. Bailey , Oleg A. Sapozhnikov , Lawrence A. Crum
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B2034/104
摘要： Methods of derating a nonlinear ultrasound field and associated systems are disclosed herein. A method of derating a nonlinear ultrasound field in accordance with an embodiment of the present technology can include, for example, calibrating an ultrasound source to a first source voltage (Vw) and generating a nonlinear acoustic wave from the ultrasound source into water. The method can further include measuring a focal waveform of the nonlinear acoustic wave and determining a second source voltage (Vt) of the ultrasound source that generates the same focal waveform in tissue.
摘要翻译：本文公开了降低非线性超声场和相关系统的方法。根据本技术的实施例的降低非线性超声场的方法可以包括例如将超声源校准为第一源极电压（Vw）并且从超声源产生非线性声波到水中。该方法还可以包括测量非线性声波的聚焦波形并确定在组织中产生相同焦点波形的超声源的第二源电压（Vt）。

5. 发明授权

US5705747A Methods and system for scaleable liquid display and control 失效
标题翻译：可扩展液体显示和控制的方法和系统
公开(公告)号：US5705747A
公开(公告)日：1998-01-06
申请号：US818291
申请日：1997-03-14
申请人： Michael R. Bailey
发明人： Michael R. Bailey
IPC分类号： G01F23/00 , G01F23/16 , G01F23/20 , G01F23/68 , G08B25/00
CPC分类号： G01F23/20 , G01F23/0069 , G01F23/16 , G01F23/168 , G01F23/68
摘要： Methods and systems for displaying a level of a liquid contained in a tank are disclosed, wherein the level of the liquid is measured using a sensing device. An embodiment of a system includes a user interface, a processor, and a display. The user interface allows a plurality of parameters, including a lower display level and an upper display level, to be modified. The processor communicates with the sensing device and the user interface to scale the level in dependence upon the lower display level and the upper display level. The display communicates with the processor to graphically display the level of the liquid scaled in dependence upon the lower display level and the upper display level.
摘要翻译：公开了用于显示容纳在罐中的液体水平的方法和系统，其中使用感测装置测量液体的液位。系统的实施例包括用户界面，处理器和显示器。用户界面允许修改包括较低显示级别和较高显示级别的多个参数。处理器与感测装置和用户界面通信，以根据较低的显示水平和较高的显示水平来缩放水平。显示器与处理器进行通信，以图形方式显示根据较低显示电平和上显示电平进行缩放的液位。

6. 发明授权

US09498651B2 Methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities and associated systems and devices 有权
标题翻译：使用气体或蒸气腔内的超声雾化机制和相关系统和装置的软组织乳化方法
公开(公告)号：US09498651B2
公开(公告)日：2016-11-22
申请号：US13444466
申请日：2012-04-11
申请人： Oleg A. Sapozhnikov , Michael R. Bailey , Lawrence A. Crum , Tatiana D. Khokhlova , Vera A. Khokhlova , Julianna C. Simon , Yak-Nam Wang
发明人： Oleg A. Sapozhnikov , Michael R. Bailey , Lawrence A. Crum , Tatiana D. Khokhlova , Vera A. Khokhlova , Julianna C. Simon , Yak-Nam Wang
IPC分类号： A61B8/00 , A61N7/02 , A61N7/00
CPC分类号： A61N7/02 , A61B8/00 , A61N2007/0039
摘要： The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue.
摘要翻译：本技术涉及使用在气体或蒸气腔内的超声雾化机理以及相关系统和装置的软组织乳化方法。在几个实施例中，例如，非侵入性治疗组织的方法包括将来自超声源的超声能量脉冲到组织中的靶位点。超声波源被配置为发射高强度聚焦超声（HIFU）波。靶位置包括位于组织内的气体或气体腔的压力释放界面。该方法继续通过在组织中产生冲击波以在靶位点处的组织中引起损伤。该方法还包括基于组织的机械或热消融中的至少一个程度来表征病变。

7. 发明授权

US07621873B2 Method and system to synchronize acoustic therapy with ultrasound imaging 有权
标题翻译：声学治疗与超声成像同步的方法和系统
公开(公告)号：US07621873B2
公开(公告)日：2009-11-24
申请号：US11206640
申请日：2005-08-17
申请人： Neil Owen , Michael R. Bailey , James Hossack
发明人： Neil Owen , Michael R. Bailey , James Hossack
IPC分类号： A61B17/22
CPC分类号： A61B8/00 , A61B8/4209 , A61B8/4281 , A61B8/543 , A61N7/02
摘要： Interference in ultrasound imaging when used in connection with high intensity focused ultrasound (HIFU) is avoided by employing a synchronization signal to control the HIFU signal. Unless the timing of the HIFU transducer is controlled, its output will substantially overwhelm the signal produced by ultrasound imaging system and obscure the image it produces. The synchronization signal employed to control the HIFU transducer is obtained without requiring modification of the ultrasound imaging system. Signals corresponding to scattered ultrasound imaging waves are collected using either the HIFU transducer or a dedicated receiver. A synchronization processor manipulates the scattered ultrasound imaging signals to achieve the synchronization signal, which is then used to control the HIFU bursts so as to substantially reduce or eliminate HIFU interference in the ultrasound image. The synchronization processor can alternatively be implemented using a computing device or an application-specific circuit.
摘要翻译：当与高强度聚焦超声（HIFU）结合使用时，超声成像的干扰通过采用同步信号来控制HIFU信号来避免。除非HIFU传感器的定时被控制，否则其输出将基本上压倒由超声成像系统产生的信号并使其产生的图像变得模糊。获得用于控制HIFU换能器的同步信号，而无需修改超声波成像系统。使用HIFU换能器或专用接收器收集对应于分散超声成像波的信号。同步处理器操纵散射的超声成像信号以实现同步信号，然后将该同步信号用于控制HIFU脉冲串，以便基本上减少或消除超声图像中的HIFU干扰。替代地，同步处理器可以使用计算设备或应用专用电路来实现。

8. 发明申请

US20170249932A1 CONFINEMENT OR MOVEMENT OF AN OBJECT USING FOCUSED ULTRASOUND WAVES TO GENERATE ANULTRASOUND INTENSITY WELL 审中-公开
公开(公告)号：US20170249932A1
公开(公告)日：2017-08-31
申请号：US15508841
申请日：2015-08-26
申请人： Oleg A. SAPOZHNIKOV , Wayne KREIDER , Michael R. BAILEY , University of Washington
发明人： Adam D. Maxwell , Oleg A. Sapozhnikov , Wayne Kreider , Michael R. Bailey
IPC分类号： G10K11/00 , G10K11/30 , H03H9/64 , G10K11/20 , G10K11/24
CPC分类号： G10K11/008 , A61B17/225 , A61B17/2255 , A61B2017/22028 , G10K11/20 , G10K11/24 , G10K11/30 , G10K11/346 , G10K15/00 , H03H9/6483
摘要： A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.

9. 发明申请

US20120259250A1 METHODS OF SOFT TISSUE EMULSIFICATION USING A MECHANISM OF ULTRASONIC ATOMIZATION INSIDE GAS OR VAPOR CAVITIES AND ASSOCIATED SYSTEMS AND DEVICES 有权
标题翻译：使用机体在气体或蒸气密度和相关系统和设备中的超声原子化机制进行软组织模拟的方法
公开(公告)号：US20120259250A1
公开(公告)日：2012-10-11
申请号：US13444466
申请日：2012-04-11
申请人： Oleg A. Sapozhnikov , Michael R. Bailey , Lawrence A. Crum , Tatiana D. Khokhlova , Vera A. Khokhlova , Julianna C. Simon , Yak-Nam Wang
发明人： Oleg A. Sapozhnikov , Michael R. Bailey , Lawrence A. Crum , Tatiana D. Khokhlova , Vera A. Khokhlova , Julianna C. Simon , Yak-Nam Wang
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B8/00 , A61N2007/0039
摘要： The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue.
摘要翻译：本技术涉及使用在气体或蒸气腔内的超声雾化机理以及相关系统和装置的软组织乳化方法。在几个实施例中，例如，非侵入性治疗组织的方法包括将来自超声源的超声能量脉冲到组织中的靶位点。超声波源被配置为发射高强度聚焦超声（HIFU）波。靶位置包括位于组织内的气体或气体腔的压力释放界面。该方法继续通过在组织中产生冲击波以在靶位点处的组织中引起损伤。该方法还包括基于组织的机械或热消融中的至少一个程度来表征病变。

10. 发明申请

US20110251528A1 METHODS AND SYSTEMS FOR NON-INVASIVE TREATMENT OF TISSUE USING HIGH INTENSITY FOCUSED ULTRASOUND THERAPY 有权
标题翻译：使用高强度聚焦超声治疗非组织治疗组织的方法和系统
公开(公告)号：US20110251528A1
公开(公告)日：2011-10-13
申请号：US13085368
申请日：2011-04-12
申请人： Michael S. Canney , Michael R. Bailey , Lawrence A. Crum , Vera A. Khokhlova , Tatiana D. Khokhlova , Wayne Kreider , Joo Ha Hwang , Oleg A. Sapozhnikov
发明人： Michael S. Canney , Michael R. Bailey , Lawrence A. Crum , Vera A. Khokhlova , Tatiana D. Khokhlova , Wayne Kreider , Joo Ha Hwang , Oleg A. Sapozhnikov
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2018/00005 , A61B2090/374 , A61B2090/378
摘要： Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
摘要翻译：使用高强度聚焦超声（“HIFU”）治疗非侵入性治疗组织的方法和系统。例如，根据本技术的实施例的非侵入性治疗组织的方法可以包括将超声源的焦平面定位在组织中的目标部位。超声波源可被配置为发射HIFU波。该方法还可以包括将来自超声源的超声能量脉冲向目标部位，并在组织内产生冲击波，以在毫秒内诱导目标部位的组织沸腾。组织的沸腾至少基本上乳化组织。

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