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1. 发明授权

US06800609B1 Isolated peptide of the horny layer and user thereof 有权
标题翻译：角质层的分离肽及其用户
公开(公告)号：US06800609B1
公开(公告)日：2004-10-05
申请号：US10031403
申请日：2002-07-24
申请人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
发明人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
IPC分类号： A61K3816
CPC分类号： C07K14/4728 , A61K8/64 , A61K38/00 , A61K47/42 , A61K48/00 , A61K2800/86 , A61Q19/00 , Y10S514/863
摘要： The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.
摘要翻译：本发明涉及钙固定蛋白家族的分离的多肽，衍生自分离的多肽的蛋白水解的多肽的混合物，含有它们的组合物，所述多肽的用途和用于干性皮肤，角化过度，角化不全的化妆品处理方法，牛皮癣，鱼鳞病，瘤形成。本发明还涉及编码所述多肽的脱氧核糖核酸序列和所述脱氧核糖核酸序列的用途。

2. 发明申请

US20060009380A1 Isolated polypeptide of the stratum corneum and its use 有权
标题翻译：孤立的角质层多肽及其用途
公开(公告)号：US20060009380A1
公开(公告)日：2006-01-12
申请号：US10879056
申请日：2004-06-30
申请人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
发明人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
IPC分类号： A61K38/17 , C07K14/47 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4728 , A61K8/64 , A61K38/00 , A61K47/42 , A61K48/00 , A61K2800/86 , A61Q19/00 , Y10S514/863
摘要： The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, and neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.
摘要翻译：本发明涉及钙固定蛋白家族的分离的多肽，衍生自分离的多肽的蛋白水解的多肽的混合物，含有它们的组合物，所述多肽的用途和用于干性皮肤，角化过度，角化不全的化妆品处理方法，牛皮癣，鱼鳞病和瘤形成。本发明还涉及编码所述多肽的脱氧核糖核酸序列和所述脱氧核糖核酸序列的用途。

3. 发明授权

US07098004B2 Isolated polypeptide of the stratum corneum and its use 有权
公开(公告)号：US07098004B2
公开(公告)日：2006-08-29
申请号：US10879056
申请日：2004-06-30
申请人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
发明人： Bruno Mehul , Dominique Bernard , Lucie Simonetti
IPC分类号： C12P21/02 , A61K31/711 , C07H21/04
CPC分类号： C07K14/4728 , A61K8/64 , A61K38/00 , A61K47/42 , A61K48/00 , A61K2800/86 , A61Q19/00 , Y10S514/863
摘要： The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, and neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.

4. 发明申请

US20110091439A1 COSMETIC USE OF ACID CERAMIDASE TYPE PROTEINS 审中-公开
标题翻译：酸性蛋白酶类型蛋白质的化学使用
公开(公告)号：US20110091439A1
公开(公告)日：2011-04-21
申请号：US12809428
申请日：2008-12-18
申请人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
发明人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
IPC分类号： A61K38/46 , A61K38/00 , G01N33/53 , C12Q1/68 , C12N5/071 , A61Q19/00 , A61Q19/08
CPC分类号： A61K38/50 , A61K8/64 , A61K8/66 , A61Q19/08
摘要： A method for preventing and/or treating the signs of skin aging comprises administering as an agent into an individual in need thereof an effective amount of acid ceramidase, polypeptides derived from this protein or analogues thereof, a nucleic sequence encoding such a polypeptide, or an agent for modulating the expression or the biological or biochemical activity of such a polypeptide. A methods for characterizing a state of an epithelium comprises determining a content of acid ceramidase, polypeptides derived from this protein or analogues thereof, or a nucleic sequence encoding such a polypeptide in an epidermis sample.
摘要翻译：用于预防和/或治疗皮肤老化症状的方法包括将有效量的酸性神经酰胺酶，衍生自该蛋白质或其类似物的多肽，编码这种多肽的核酸序列，或用于调节这种多肽的表达或生物或生物化学活性的试剂。用于表征上皮状态的方法包括确定酸性神经酰胺酶的含量，源自该蛋白质的多肽或其类似物，或在表皮样品中编码这种多肽的核酸序列。

5. 发明授权

US09295711B2 Cosmetic and therapeutic use of proteins of DJ-1 type for treating skin dryness 有权
标题翻译： DJ-1型蛋白质的化妆和治疗用途，用于治疗皮肤干燥
公开(公告)号：US09295711B2
公开(公告)日：2016-03-29
申请号：US13130710
申请日：2009-11-19
申请人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
发明人： Dominique Bernard , Lucie Simonetti , Isabelle Castiel
IPC分类号： A61K38/00 , A61K38/17 , A61K8/64 , A61Q19/00
CPC分类号： A61K38/1709 , A61K8/64 , A61Q19/007
摘要： The present invention relates to the use, especially the cosmetic and/or therapeutic use, of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof, of a nucleic acid sequence coding for such a polypeptide or of a modulator of the activity, stability or expression of such a polypeptide, especially for preventing and/or treating the signs of skin dryness. The invention also relates to the use of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof or of a nucleic acid sequence coding for such a polypeptide, as a marker for evaluating the state of dryness of an epithelium.
摘要翻译：本发明涉及编码这种多肽或调节剂的核酸序列的衍生自该蛋白质或其类似物的多肽的蛋白质DJ-1的使用，特别是化妆品和/或治疗用途这种多肽的活性，稳定性或表达，特别是用于预防和/或治疗皮肤干燥症状。本发明还涉及蛋白质DJ-1来自该蛋白质或其类似物的多肽或编码这种多肽的核酸序列作为评价上皮干燥状态的标记物的用途。

6. 发明授权

US08173144B2 Administration of urea compounds for combating signs of cutaneous aging 有权
标题翻译：管理尿素化合物，防止皮肤老化迹象
公开(公告)号：US08173144B2
公开(公告)日：2012-05-08
申请号：US11260139
申请日：2005-10-28
申请人： Dominique Bernard , Lucie Simonetti
发明人： Dominique Bernard , Lucie Simonetti
IPC分类号： A61K8/02
CPC分类号： A61Q19/08 , A61K8/42
摘要： Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.
摘要翻译：防止和/或减少皮肤和/或粘膜老化的迹象，通过向需要这种治疗的个体施用化妆品/药物组合物来刺激角质层蛋白水解酶的活性其包含如此有效量的至少一种具有下式（I）的羟基化脲化合物：其中：可以相同或不同的基团R 1，R 2，R 3和R 4各自为氢原子，C1- C4烷基或可含有1至5个羟基的C 2 -C 6羟烷基，其中至少一个R 1至R 4基团表示配制成其生理学上可接受的介质的羟烷基或其盐，溶剂化物或异构体。

7. 发明授权

US07999008B2 Urea compounds that promote desquamation 有权
标题翻译：促进脱屑的尿素化合物
公开(公告)号：US07999008B2
公开(公告)日：2011-08-16
申请号：US11485506
申请日：2006-07-13
申请人： Dominique Bernard , Lucie Simonetti , Pascale Pelletier
发明人： Dominique Bernard , Lucie Simonetti , Pascale Pelletier
IPC分类号： A61K8/02 , A61K31/17 , A01N47/28
CPC分类号： A61Q19/00 , A61K8/42 , A61K8/66 , A61K31/17 , A61K2800/28 , A61K2800/88 , A61Q5/006
摘要： The invention relates to the use of at least one urea derivative of the following formula (I) in a composition containing a physiologically acceptable medium, as agent intended for stimulating desquamation of the skin and/or the mucous membranes. It also relates to a method of cosmetic treatment and cosmetic agents containing it.
摘要翻译：本发明涉及至少一种下述式（I）的尿素衍生物在含有生理学上可接受的培养基的组合物中作为用于刺激皮肤和/或粘膜脱屑的试剂。它还涉及一种美容治疗方法和含有它的美容剂。

8. 发明申请

US20100216707A1 COSMETIC USE OF APOLIPOPROTEIN D TYPE PROTEINS 有权
标题翻译：化学应用APOLIPOPROTEIN D型蛋白质
公开(公告)号：US20100216707A1
公开(公告)日：2010-08-26
申请号：US12602246
申请日：2008-06-20
申请人： Dominique Bernard , Isabelle Castiel , Lucie Simonetti
发明人： Dominique Bernard , Isabelle Castiel , Lucie Simonetti
IPC分类号： A61K8/64 , A61K8/60 , A61K8/63 , A61K8/36 , A61K8/49 , G01N33/68 , C12Q1/02 , A61Q19/00
CPC分类号： G01N33/92 , A61K8/64 , A61K38/1709 , A61Q17/00 , A61Q19/08 , C07K14/775 , G01N2500/04 , G01N2500/10
摘要： The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation. The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis.
摘要翻译：本发明的主题是使用来自该蛋白质或其类似物的多肽的载脂蛋白D的化妆品和/或治疗用途，编码这种多肽的核酸序列或调节活性或这种多肽的表达，特别是用于刺激末端上皮分化。本发明还涉及来自该蛋白质或其类似物的多肽的蛋白质载脂蛋白D或编码这种多肽的核酸序列作为评估表皮状态的标记物的用途。

9. 发明申请

US20070232574A1 2-Oxothiazolidine 4-Carboxylic acid compounds for promoting desquamation of the skin 审中-公开
标题翻译：用于促进皮肤脱屑的2-氧代噻唑烷4-羧酸化合物
公开(公告)号：US20070232574A1
公开(公告)日：2007-10-04
申请号：US11806218
申请日：2007-05-30
申请人： Jean-Baptiste Galey , Dominique Bernard , Lucie Simonetti
发明人： Jean-Baptiste Galey , Dominique Bernard , Lucie Simonetti
IPC分类号： A61K31/426 , A61K31/60 , A61K31/65 , A61P17/00
CPC分类号： A61Q19/00 , A61K8/49 , A61K2800/28 , A61Q19/08
摘要： 2-oxothiazolidine-4-carboxylic acid compounds having the structural formula (I): are suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating aging of the skin.
摘要翻译：具有结构式（I）的2-氧代噻唑烷-4-羧酸化合物：适于促进皮肤脱皮和/或刺激表皮更新和/或抵抗皮肤老化。

10. 发明申请

US20070134183A1 Aminosulfonic acid compounds for promoting desquamation of the skin 审中-公开
标题翻译：用于促进皮肤脱屑的氨基磺酸化合物
公开(公告)号：US20070134183A1
公开(公告)日：2007-06-14
申请号：US11702164
申请日：2007-02-05
申请人： Jean-Baptiste Galey , Dominique Bernard , Lucie Simonetti
发明人： Jean-Baptiste Galey , Dominique Bernard , Lucie Simonetti
IPC分类号： A61K31/5375 , A61K31/495 , A61K8/49
CPC分类号： A61K31/535 , A61K8/49 , A61K8/494 , A61K31/495 , A61K31/5375 , A61K45/06 , A61K2800/28 , A61Q19/00 , A61Q19/08 , A61K31/00 , A61K2300/00
摘要： Aminosulfonic acid compounds having the structural formula (I): are suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating aging of the skin.
摘要翻译：具有结构式（I）的氨基磺酸化合物：适于促进皮肤脱皮和/或刺激表皮更新和/或抵抗皮肤老化。

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