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1. 发明授权

US08071324B2 Methods for diagnosing and treating kidney cancer 有权
标题翻译：肾癌诊断和治疗方法
公开(公告)号：US08071324B2
公开(公告)日：2011-12-06
申请号：US12326632
申请日：2008-12-02
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , C07K16/28 , C07K16/3038 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
摘要翻译：公开了用于诊断和治疗肾癌的方法，试剂和试剂盒。用于检测肾癌的免疫测定是基于尿液或血液中CELSR1蛋白与正常组织相比的相对变化。与正常组织相比，用于检测肾癌的免疫组织化学测定是基于与癌组织结合的标记抗体相对不存在的。

2. 发明授权

US07488584B2 Methods for diagnosing and treating kidney and colorectal cancer 失效
标题翻译：诊断和治疗肾脏和结肠直肠癌的方法
公开(公告)号：US07488584B2
公开(公告)日：2009-02-10
申请号：US11388550
申请日：2006-03-24
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N33/5082 , G01N33/57438 , G01N33/57492
摘要： Methods, reagents and kits for diagnosing and treating cancer such as kidney or colorectal cancer are disclosed. An immunoassay for detecting kidney or colorectal cancer is based on the relative change of the ADAMTSL4 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney or colorectal cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
摘要翻译：公开了用于诊断和治疗诸如肾或结肠直肠癌的癌症的方法，试剂和试剂盒。用于检测肾或结肠直肠癌的免疫测定是基于与正常组织相比，尿液或血液中ADAMTSL4蛋白质的相对变化。用于检测肾或结肠直肠癌的免疫组织化学测定是基于与正常组织相比，与癌组织结合的标记抗体的相对不存在。

3. 发明申请

US20100041126A1 METHODS FOR DIAGNOSING AND TREATING PROSTATE CANCER 审中-公开
标题翻译：用于诊断和治疗前列腺癌的方法
公开(公告)号：US20100041126A1
公开(公告)日：2010-02-18
申请号：US12541824
申请日：2009-08-14
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： C12M1/34
CPC分类号： G01N33/57434
摘要： Devices and methods for diagnosing and treating prostate cancer are disclosed. In practicing the method, a subject's body-fluid sample is assayed for GPC3 protein, and the GPC3 level observed is used in determining whether the subject has an elevated GPC3 level associated with prostate cancer. Patients with such elevated levels may be treated, in accordance with the present disclosure, with a variety of GPC3-related immunotherapy agents.
摘要翻译：公开了用于诊断和治疗前列腺癌的装置和方法。在实施该方法时，测定受试者体液样品的GPC3蛋白，并且观察到的GPC3水平用于确定受试者是否具有与前列腺癌相关的升高的GPC3水平。根据本公开，可以使用各种GPC3相关的免疫治疗剂来治疗具有这种升高水平的患者。

4. 发明授权

US07459280B2 Methods for diagnosing and treating kidney cancer 失效
标题翻译：肾癌诊断和治疗方法
公开(公告)号：US07459280B2
公开(公告)日：2008-12-02
申请号：US11363596
申请日：2006-02-27
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , C07K16/28 , C07K16/3038 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
摘要翻译：公开了用于诊断和治疗肾癌的方法，试剂和试剂盒。用于检测肾癌的免疫测定是基于尿液或血液中CELSR1蛋白与正常组织相比的相对变化。与正常组织相比，用于检测肾癌的免疫组织化学测定是基于与癌组织结合的标记抗体相对不存在的。

5. 发明申请

US20080234213A1 Oncogenic regulatory RNAs for diagnostics and therapeutics 审中-公开
标题翻译：致癌调节RNA用于诊断和治疗
公开(公告)号：US20080234213A1
公开(公告)日：2008-09-25
申请号：US11515263
申请日：2006-09-01
申请人： Matthias Wabl , Bruce Wang
发明人： Matthias Wabl , Bruce Wang
IPC分类号： A61K31/70 , C12Q1/68 , C07H21/00 , A61P43/00
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q2600/106 , C12Q2600/178 , C12Q2525/207
摘要： A method of identifying regulatory RNAs, including miRNAs, using insertional mutagenesis to generate tumors in mice and determining the human orthologs is disclosed. Further, specific miRNA sequences are identified. The causal nature and expression patterns of these regulatory RNAs and miRNAs in human tumors demonstrate their utility in diagnosis and therapy of cancer. Furthermore, a set of co-mutations that act in conjunction with miRNAs in tumor formation is disclosed.
摘要翻译：公开了使用插入诱变在小鼠中产生肿瘤并确定人类直向同源物来鉴定调节性RNA（包括miRNA）的方法。此外，鉴定特异性miRNA序列。这些调节性RNA和miRNA在人类肿瘤中的致病性质和表达模式证明了它们在诊断和治疗癌症中的作用。此外，公开了一组与miRNA在肿瘤形成中联合作用的共突变。

6. 发明申请

US20070202510A1 Methods for diagnosing and treating kidney cancer 失效
标题翻译：肾癌诊断和治疗方法
公开(公告)号：US20070202510A1
公开(公告)日：2007-08-30
申请号：US11363596
申请日：2006-02-27
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： C12Q1/68 , G01N33/574 , C12M3/00 , C07K16/30
CPC分类号： G01N33/57438 , C07K16/28 , C07K16/3038 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
摘要翻译：公开了用于诊断和治疗肾癌的方法，试剂和试剂盒。用于检测肾癌的免疫测定是基于尿液或血液中CELSR1蛋白与正常组织相比的相对变化。与正常组织相比，用于检测肾癌的免疫组织化学测定是基于与癌组织结合的标记抗体的相对不存在的。

7. 发明授权

US07723043B2 Methods for screening for prostate cancer 有权
标题翻译：筛查前列腺癌的方法
公开(公告)号：US07723043B2
公开(公告)日：2010-05-25
申请号：US11325847
申请日：2006-01-04
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： G01N33/53 , G01N33/567 , G01N33/574 , C07K16/00
CPC分类号： G01N33/57434
摘要： Methods for diagnosing and treating prostate cancer are disclosed. In practicing the method, a subject's body-fluid sample is assayed for GPC3 protein, and the GPC3 level observed is used in determining whether the subject has an elevated GPC3 level associated with prostate cancer. Patients with such elevated levels may be treated, in accordance with the invention, with a variety of GPC3-related immunotherapy agents.
摘要翻译：公开了诊断和治疗前列腺癌的方法。在实施该方法时，测定受试者体液样品的GPC3蛋白，并且观察到的GPC3水平用于确定受试者是否具有与前列腺癌相关的升高的GPC3水平。具有这种升高水平的患者可根据本发明用各种GPC3相关的免疫治疗剂进行治疗。

8. 发明申请

US20090220501A1 Anti-CD19 Antibody, Immunotoxin and Treatment Method 审中-公开
标题翻译：抗CD19抗体，免疫毒素和治疗方法
公开(公告)号：US20090220501A1
公开(公告)日：2009-09-03
申请号：US12175368
申请日：2008-07-17
申请人： Georg H. Fey , Matthias Peipp , Michael Schwemmlein , Bruce Wang , Matthias Wabl
发明人： Georg H. Fey , Matthias Peipp , Michael Schwemmlein , Bruce Wang , Matthias Wabl
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2803 , A61K47/6829 , A61K47/6849 , C07K2317/56 , C07K2319/04 , C12N2799/026
摘要： Provided is an immunotoxin including (a) an anti-CD19 antibody lacking an Fc fragment, (b) a modified exotoxin A protein having both Domains II and III, but lacking Domain I, and (c) a peptide linker joining the C-terminal end of the antibody to the N-terminal end of the modified exotoxin A protein. The linker is substantially resistant to extracellular cleavage. The modified exotoxin A protein may be further modified to include a C-terminal KDEL sequence (SEQ ID NO: 6) that promotes transport of the protein to the endoplasmic reticulum of cells that have taken up the immunotoxin. Also provided is an anti-CD19 antibody having enhanced binding activity, antibody-dependent cellular cytotoxicity (ADCC) and methods for using the antibody to treat a disease state associated with B-lineage cells that express CD19. The antibody variable light and variable heavy chains have unique sequences in their J region relative to known anti-CD19 antibody sequences.
摘要翻译：本发明提供一种免疫毒素，其包括（a）缺少Fc片段的抗CD19抗体，（b）具有两个结构域II和III的修饰的外毒素A蛋白，但缺少结构域I，和（c）连接C-端的肽接头抗体结合到修饰的外毒素A蛋白的N末端。接头基本上抗细胞外切割。修饰的外毒素A蛋白可以被进一步修饰以包括促进蛋白质转运到已经吸收免疫毒素的细胞的内质网的C-末端KDEL序列（SEQ ID NO：6）。还提供了具有增强的结合活性，抗体依赖性细胞毒性（ADCC）的抗CD19抗体以及使用该抗体治疗与表达CD19的B系细胞相关的疾病状态的方法。抗体可变轻链和可变重链相对于已知的抗CD19抗体序列在其J区具有独特的序列。

9. 发明申请

US20090123484A1 Methods for Diagnosing and Treating Kidney Cancer 有权
标题翻译：诊断和治疗肾癌的方法
公开(公告)号：US20090123484A1
公开(公告)日：2009-05-14
申请号：US12326632
申请日：2008-12-02
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： A61K39/395 , C07K16/30 , C12M1/34 , A61P35/00 , C12Q1/68
CPC分类号： G01N33/57438 , C07K16/28 , C07K16/3038 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
摘要翻译：公开了用于诊断和治疗肾癌的方法，试剂和试剂盒。用于检测肾癌的免疫测定是基于尿液或血液中CELSR1蛋白与正常组织相比的相对变化。与正常组织相比，用于检测肾癌的免疫组织化学测定是基于与癌组织结合的标记抗体相对不存在的。

10. 发明申请

US20070224600A1 Methods for diagnosing and treating kidney and colorectal cancer 失效
标题翻译：诊断和治疗肾脏和结肠直肠癌的方法
公开(公告)号：US20070224600A1
公开(公告)日：2007-09-27
申请号：US11388550
申请日：2006-03-24
申请人： Bruce Wang , Matthias Wabl
发明人： Bruce Wang , Matthias Wabl
IPC分类号： C12Q1/68 , G01N33/574 , C12M3/00
CPC分类号： G01N33/57419 , G01N33/5082 , G01N33/57438 , G01N33/57492
摘要： Methods, reagents and kits for diagnosing and treating cancer such as kidney or colorectal cancer are disclosed. An immunoassay for detecting kidney or colorectal cancer is based on the relative change of the ADAMTSL4 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney or colorectal cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
摘要翻译：公开了用于诊断和治疗诸如肾或结肠直肠癌的癌症的方法，试剂和试剂盒。用于检测肾或结肠直肠癌的免疫测定是基于与正常组织相比，尿液或血液中ADAMTSL4蛋白质的相对变化。用于检测肾或结肠直肠癌的免疫组织化学测定是基于与正常组织相比，与癌组织结合的标记抗体的相对不存在。

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