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1. 发明授权

US08029511B2 Multi-stage biomaterial injection system for spinal implants 失效
标题翻译：用于脊柱植入物的多级生物材料注射系统
公开(公告)号：US08029511B2
公开(公告)日：2011-10-04
申请号：US10984493
申请日：2004-11-09
申请人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
发明人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.
摘要翻译：一种用于将包含可流动的生物材料的容器流体耦合到模具的方法和装置。根据第一操作参数控制可流动的生物材料流入模具的流动。至少监测一个注射条件。响应于达到阈值水平的一个或多个注入条件，可流动生物材料的流动根据第二操作参数来控制。在可流动的生物材料的固化的至少一部分期间维持第二操作参数。在一些实施例中，第二操作参数可以可选地包括允许可流动的生物材料的一部分从模具中排出。

2. 发明申请

US20090076518A1 METHOD AND SYSTEM FOR STABILIZING ADJACENT VERTEBRAE 审中-公开
标题翻译：用于稳定相邻VERTEBRAE的方法和系统
公开(公告)号：US20090076518A1
公开(公告)日：2009-03-19
申请号：US12266301
申请日：2008-11-06
申请人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
发明人： Bruce R. Bowman , Rob Kohler , Erik Martz , Dan Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Garryl Hudgins
IPC分类号： A61B17/58 , A61B19/00
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method of stabilizing adjacent vertebrae including the steps of forming at least one annulotomy in an annulus. At least a portion of the nucleus material is removed through the annulotomy to form a cavity in an intervertebral disc space between the adjacent vertebrae. A reservoir containing a flowable biomaterial is fluidly coupled to the intervertebral disc space. A flowable biomaterial is delivered to the cavity. The delivery of the flowable biomaterial into the intervertebral disc space is controlled in accordance with at least a first operating parameter. The biomaterial is at least partially cured to stabilize the adjacent vertebrae.
摘要翻译：一种稳定相邻椎骨的方法，包括在环空中形成至少一个瓣膜切开术的步骤。至少一部分细胞核材料通过瓣膜切开术去除以在相邻椎骨之间的椎间盘间隙中形成空腔。包含可流动的生物材料的储存器流体耦合到椎间盘空间。可流动的生物材料被输送到空腔。根据至少第一操作参数控制可流动的生物材料输送到椎间盘空间中。生物材料至少部分固化以稳定相邻的椎骨。

3. 发明申请

US20050209602A1 Multi-stage biomaterial injection system for spinal implants 审中-公开
标题翻译：用于脊柱植入物的多级生物材料注射系统
公开(公告)号：US20050209602A1
公开(公告)日：2005-09-22
申请号：US10984566
申请日：2004-11-09
申请人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
发明人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
IPC分类号： A61B17/88 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.
摘要翻译：一种用于将包含可流动的生物材料的容器流体耦合到模具的方法和装置。根据第一操作参数控制可流动的生物材料流入模具的流动。至少监测一个注射条件。响应于达到阈值水平的一个或多个注入条件，可流动生物材料的流动根据第二操作参数来控制。在可流动的生物材料的固化的至少一部分期间维持第二操作参数。在一些实施例中，第二操作参数可以可选地包括允许可流动的生物材料的一部分从模具中排出。

4. 发明申请

US20050209601A1 Multi-stage biomaterial injection system for spinal implants 失效
公开(公告)号：US20050209601A1
公开(公告)日：2005-09-22
申请号：US10984493
申请日：2004-11-09
申请人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
发明人： Bruce Bowman , Robert Kohler , Erik Martz , Daniel Melink , Khin Myint , Michael Ahrens , Jean-Charles Lehuec , John Sherman , Scott Hook , Dennis Johnson , Qi-Bin Bao , Robert Hudgins
IPC分类号： A61B17/88 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61B17/8805 , A61B17/8827 , A61B17/8836 , A61B2090/064 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30583 , A61F2002/4627 , A61F2002/465 , A61F2002/4663 , A61F2002/467 , A61F2002/4677 , A61F2002/4688 , A61F2002/4693 , A61F2002/4694 , A61F2210/0004 , A61F2210/0085 , A61F2250/0098
摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.

5. 发明申请

US20060265076A1 Catheter holder for spinal implant 审中-公开
标题翻译：导管支架用于脊柱植入
公开(公告)号：US20060265076A1
公开(公告)日：2006-11-23
申请号：US11268876
申请日：2005-11-08
申请人： Benjamin Carter , Erik Martz , Scott Hook , Mark Rydell , Ronald Burke , Robert Kohler , Steven Healy , Bruce Bowman , John Sherman , Jean-Charles Lehuec
发明人： Benjamin Carter , Erik Martz , Scott Hook , Mark Rydell , Ronald Burke , Robert Kohler , Steven Healy , Bruce Bowman , John Sherman , Jean-Charles Lehuec
IPC分类号： A61F2/44
CPC分类号： A61F2/4611 , A61B1/3135 , A61B17/3415 , A61B90/50 , A61B2017/00261 , A61B2017/3405 , A61B2017/3445 , A61B2017/3447 , A61B2017/3488 , A61F2/441 , A61F2002/4627 , A61M25/04 , A61M25/0662
摘要： A catheter holder designed to deliver a curable biomaterial to an intervertebral disc space. By securing the catheter to the catheter holder, the depth of insertion of the catheter into the disc space can be accurately controlled. The catheter holder optionally helps with insertion of a optional mold through the annulotomy and into the disc space created by the nuclectomy. The catheter holder helps keep the mold from being drawn too far into the disc space or pushed too far out of the disc space during polymer injection.
摘要翻译：设计用于将可固化生物材料递送到椎间盘空间的导管支架。通过将导管固定到导管支架上，可以精确地控制导管插入椎间盘空间的深度。导管支架可选择地有助于插入可选模具通过瓣膜切开术并进入由切除切割术产生的椎间盘空间。在聚合物注射期间，导管支架有助于保持模具不被太吸引到盘片空间中或被推到太远的盘片空间。

6. 发明申请

US20060253198A1 Multi-lumen mold for intervertebral prosthesis and method of using same 审中-公开
标题翻译：用于椎间假体的多腔模具及其使用方法
公开(公告)号：US20060253198A1
公开(公告)日：2006-11-09
申请号：US11268786
申请日：2005-11-08
申请人： Khin Myint , Erik Martz , Benjamin Carter , Ronald Burke
发明人： Khin Myint , Erik Martz , Benjamin Carter , Ronald Burke
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2002/30062 , A61F2002/30578 , A61F2002/30583 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2210/0004 , A61F2210/0085
摘要： A multi-lumen mold is for the in situ formation of a prosthesis in an annulus located in an intervertebral disc space of a patient. The annulus has at least two openings formed by minimally invasive techniques and at least a portion of the nucleus pulposus is removed to form a nuclear cavity. The multi-lumen mold includes a mold adapted to be located in the nuclear cavity. A first lumen having a distal end is fluidly coupled to a flexible mold at a first location. At least a second lumen having a distal end fluidly coupled to the flexible mold at a second location. The first and second lumens are adapted to extend out through the openings in the annulus when the mold is positioned in the nuclear cavity. One or more securing members can be used to secure the mold in the intervertebral disc space. The securing members can engage with the annulus, the end plates, and/or another surface of a vertebrate.
摘要翻译：多腔模具用于在位于患者的椎间盘空间中的环中原位形成假体。所述环具有通过微创技术形成的至少两个开口，并且去除髓核的至少一部分以形成核腔。多腔模具包括适于位于核腔内的模具。具有远端的第一管腔在第一位置处流体地联接到柔性模具。至少第二内腔具有在第二位置处与柔性模具流体耦合的远端。当模具定位在核腔中时，第一和第二内腔适于延伸穿过环形空间中的开口。可以使用一个或多个固定构件将模具固定在椎间盘空间中。固定构件可与环形物，端板和/或脊椎动物的另一表面接合。

7. 发明申请

US20060135959A1 Nuclectomy method and apparatus 审中-公开
标题翻译：核结肠切除术方法和装置
公开(公告)号：US20060135959A1
公开(公告)日：2006-06-22
申请号：US11304053
申请日：2005-12-15
申请人： Hansen Yuan , Scott Hook , Erik Martz
发明人： Hansen Yuan , Scott Hook , Erik Martz
IPC分类号： A61B17/88 , A61F2/44
CPC分类号： A61B17/1606 , A61B34/10 , A61B2017/00261
摘要： A nuclectomy method for creating a nuclear cavity in an annulus located in an intervertebral disc space and for preparing the nuclear cavity to receive an intervertebral prosthesis. An annulotomy is formed in the annulus along an annular axis to provide access to a nucleus. A portion of the nucleus is removed in a first region surrounding the annular axis using at least a first surgical tool. Another portion of the nucleus is removed from a second region using at least a second surgical tool. An evaluation mold is positioned in the nuclear cavity and a fluid is delivered to the evaluation mold so that the mold substantially fills the nuclear cavity. The amount of nucleus removed from the annulus is estimated. One or more of the removing steps are optionally repeated as necessary until an adequate amount of the nucleus is removed from the annulus.
摘要翻译：一种用于在位于椎间盘空间中的环中产生核腔并用于准备核腔以接收椎间假体的核切除术方法。在环形环中沿环形轴线形成瓣膜切开术以提供对细胞核的接近。至少使用第一外科手术工具，在包围环形轴的第一区域中移除核的一部分。使用至少第二外科手术工具从第二区域移除细胞核的另一部分。评估模具定位在核腔中，并将流体输送到评估模具，使得模具基本上填充核腔。估计从环带移除的核的量。根据需要可选地重复一个或多个除去步骤，直到从环空中除去足够量的细胞核。

8. 发明申请

US20060095043A1 Adjustable instrumentation for spinal implant insertion 有权
标题翻译：用于脊柱植入物插入的可调节仪器
公开(公告)号：US20060095043A1
公开(公告)日：2006-05-04
申请号：US11253410
申请日：2005-10-19
申请人： Erik Martz , Jo-Wen Lin , David Chow , Daniel Rosenthal
发明人： Erik Martz , Jo-Wen Lin , David Chow , Daniel Rosenthal
IPC分类号： A61B17/58
CPC分类号： A61F2/4611 , A61B17/1604 , A61B17/1606 , A61B17/1659 , A61B17/1671 , A61B17/320016 , A61B90/50 , A61B2017/00261 , A61B2017/00464 , A61B2017/0256 , A61B2017/2904 , A61B2017/2931 , A61F2/442 , A61F2/4455 , A61F2002/30538 , A61F2002/30795 , A61F2002/4624 , A61F2002/4627 , A61F2002/4628 , A61F2002/4629 , A61F2002/4679 , A61F2250/0006
摘要： A plurality of differently configured bone spinal implants for insertion in a spine have a cylindrical bore for receiving an insertion head stud. A plurality of instruments are disclosed each of which have a first connection element which is either a male or female member such as e.g., a ball and socket, a cylinder and socket and so on for forming either a stationary or articulating interchangeable joint for a plurality of disc processing heads or implant insertion heads. The plurality of disc space processing heads or implant insertion heads have a complementary second joint member for interchangeable attachment to the first connection element. The implant insertion heads or disc processing heads have different configurations for different shaped implants. Different instrument insertion or disc processing heads such as implant inserters, impactors, rasps, distractors, curettes, rongeur, and so on are disclosed as being interchangeable with a common instrument in which articulating or fixed joints are provided the interchangeable heads.
摘要翻译：用于插入脊椎的多个不同构造的骨脊椎植入物具有用于接收插入头钉的圆柱形孔。公开了多个仪器，每个仪器具有第一连接元件，该第一连接元件是阳或阴构件，例如球窝，气缸和插座等，用于形成用于多个的静止或可铰接的可互换接头的盘处理头或植入物插入头。多个盘空间处理头或植入物插入头具有用于可互换连接到第一连接元件的互补的第二关节构件。植入物插入头或椎间盘处理头具有不同形状的植入物的不同构型。公开了不同的仪器插入或盘处理头，例如植入物插入器，冲击器，锉刀，牵引器，刮刀，护腿等，其可与可互换的头部提供关节或固定接头的通用仪器互换。

9. 发明授权

US06706067B2 Spinal intervertebral implant and method of making 有权
标题翻译：脊柱椎间植入物及其制备方法
公开(公告)号：US06706067B2
公开(公告)日：2004-03-16
申请号：US10008279
申请日：2001-11-05
申请人： Lawrence A. Shimp , Steven Annunziato , Erik Martz , David R. Kaes
发明人： Lawrence A. Shimp , Steven Annunziato , Erik Martz , David R. Kaes
IPC分类号： A61F244
CPC分类号： A61F2/4455 , A61F2/30965 , A61F2/442 , A61F2/4465 , A61F2/4611 , A61F2002/2835 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/3023 , A61F2002/30235 , A61F2002/30293 , A61F2002/30462 , A61F2002/30492 , A61F2002/30507 , A61F2002/30551 , A61F2002/30604 , A61F2002/30677 , A61F2002/3082 , A61F2002/30879 , A61F2002/30892 , A61F2002/30904 , A61F2002/30957 , A61F2002/4475 , A61F2210/0004 , A61F2220/0025 , A61F2220/0075 , A61F2230/0013 , A61F2230/0019 , A61F2230/0069 , A61F2230/0091 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179
摘要： A C-shaped or ring shaped implant formed of cortical bone has its C-shaped or inner channel filled with a bone promoting material which is preferably demineralized bone fibers formed as a flexible wet sheet or may be cancellous bone, pressed bone fibers formed from demineralized cortical bone chips soaked in acid, or a flex material formed of demineralized bone growth promoting bone fibers. The discrete bone filler element may be secured by a bonding agent, pins or screws, metal, polymer or bone material. The bone filler material is preferably bonded by filling a section of a long bone medullary cavity with wet bone fibers and then drying the fibers to bond them to the outer bone. A filled bone ring may be sliced to form annular filled sections which are then divided into mirror image C-shaped halves each forming an implant. Flex material of compressed bone fibers may be formed with an opening shaped to receive a cortical bone implant element having a C-shaped channel. The flex material surrounds the cortical bone element and fills its channel. Other embodiments are disclosed.
摘要翻译：由皮质骨形成的C形或环形植入体具有填充有骨促进材料的C形或内部通道，其优选为柔性湿片形成的软化骨纤维，或可为松质骨，由软化骨形成的压制骨纤维浸入酸中的皮质骨碎片，或由去矿质骨生长促进骨纤维形成的柔软材料。离散的骨填充元件可以通过粘合剂，销或螺钉，金属，聚合物或骨材料固定。骨填充材料优选通过用湿骨纤维填充长骨髓腔的一部分然后干燥纤维以将它们结合到外骨上来结合。填充的骨环可以被切片以形成环形填充部分，然后将其分成镜像C形半部，每个形成植入物。压缩骨纤维的柔性材料可以形成为具有形状以容纳具有C形通道的皮质骨植入元件的开口。柔性材料围绕皮质骨元素并填充其通道。公开了其他实施例。

10. 发明申请

US20050251146A1 Chisels and procedure for insertion of spinal implant in a spinal disc space 有权
标题翻译：将脊柱植入物插入椎间盘空间的凿子和程序
公开(公告)号：US20050251146A1
公开(公告)日：2005-11-10
申请号：US10520794
申请日：2003-07-16
申请人： Erik Martz , David Chow
发明人： Erik Martz , David Chow
IPC分类号： A61B17/16 , A61F2/00 , A61F2/28 , A61F2/44 , A61F2/46
CPC分类号： A61F2/4684 , A61B17/1604 , A61B17/1671 , A61F2/28 , A61F2/4455 , A61F2002/30131 , A61F2002/448 , A61F2230/0013 , A61F2310/00359
摘要： A chisel with U.V-shaped, saw tooth or other shaped opposing blades is used to form channels in adjacent vertebrae. The chisel has a projection extending from at least one of the top and bottom surfaces to limit depth of penetration into the vertebrae. A guide member may be attached to the forward tip of the chisel to guide the chisel into the disc space to uniformly chisel both adjacent vertebrae simultaneously to form a channel in the vertebrae. The so formed channels serve as sa guide for a second chisel having no guide member. The second chisel, which may be a box chisel, is used to complete the channels to the desired depth to receive an associated implant, typically of cortical bone. Other embodiments are disclosed in which a two step box chisel has a retractable guide member for initially guiding the chisel as it forms partial channels in the vertebrae disc space. The guide member is then retracted and the channels formed to the desired depth. The chisels include guide member pins which serve to both limit the extension and retraction of the guide member and also to serve to limit the depth of penetration of the chisel, physically and visually. The guide member may be retracted with a rotatable knob and a threaded engaged rod or with an axially displaceable pin and rod assembly attached to the guide member. A procedure for using the chisels is also disclosed.
摘要翻译：使用具有U.V形锯齿或其他形状相对的刀片的凿子在相邻椎骨中形成通道。凿子具有从顶表面和底表面中的至少一个延伸的突起，以限制穿入椎骨的深度。引导构件可以附接到凿子的前端，以将凿子引导到椎间盘空间中，以均匀地同时凿孔两个相邻的椎骨以在椎骨中形成通道。这样形成的通道用作没有引导构件的第二凿子的引导件。可以使用第二凿子，其可以是盒式凿子，以将通道完成到期望的深度以接收通常为皮层骨的相关植入物。公开了其他实施例，其中两台凿子具有可缩回的引导构件，用于在椎骨盘空间中形成部分通道时最初引导凿子。然后引导构件缩回并且通道形成到期望的深度。凿子包括引导构件销，其用于限制引导构件的延伸和缩回，并且还用于在物理和视觉上限制凿子的穿透深度。引导构件可以用可旋转的旋钮和螺纹接合的杆或与安装在引导构件上的可轴向移位的销和杆组件缩回。还公开了使用凿子的方法。

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