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    • 4. 发明授权
    • Liquid phase process for the preparation of GnRH peptides
    • 用于制备GnRH肽的液相方法
    • US5977302A
    • 1999-11-02
    • US195049
    • 1998-11-18
    • David C. PalmerAhmed Abdel-MagidMichael S. BreslavUrs P. EggmannBruce HarrisMark L. HaslegoKirk L. Sorgi
    • David C. PalmerAhmed Abdel-MagidMichael S. BreslavUrs P. EggmannBruce HarrisMark L. HaslegoKirk L. Sorgi
    • C07K5/09C07K5/103C07K5/107C07K7/23C07K7/06
    • C07K5/0815C07K5/101C07K5/1013C07K5/1016C07K7/23Y02P20/55
    • A liquid phase process for preparing GnRH peptide analogs of the formula:G-AA.sub.1 -(A)D-Phe-AA.sub.3 -AA.sub.4 -(R.sub.2)-AA.sub.5 -AA.sub.6 AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2Formula 1which comprises:(a) reacting a peptide of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -Xwhere T is (P.sub.2)AA4 orP.sub.2 and X is AA.sub.7 --OH or is --OH, with a peptide of the formula:X'-AA.sub.8 -Pro-AA.sub.10 -NH.sub.2or acid-addition salt form thereof, where X' is AA.sub.7 when X is absent and X' selected from P-Ala, Gly, GABA, the D- and L- isomers of Ala, amino isobutyric acid, 6-amino-hexanoic acid, Ser, Thr, His, Tyr, Asn, and Gln' is absent when X is AA.sub.7 --OH;in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula:T-(R.sub.2)AA.sub.5 -AA.sub.6 -AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2(b) removing the P.sub.2 protecting group at the N-terminus, and(c) reacting the product of step (b) or an acid addition salt thereof, with a peptide of the formula:G-AA.sub.1 -(R.sub.1)D-Phe-AA.sub.3 -T'or acid-addition salt form thereof, where T' is AA.sub.4 --OH when T is absent and is absent when T is P2-AA.sub.4, in a liquid reaction medium to obtain a GnRH peptide of the formula:G-AA.sub.1 -(A)D-Phe-AA.sub.3 -AA.sub.4 -(R.sub.2)AA.sub.5 -AA.sub.6 -AA.sub.7 -AA.sub.8 -Pro-AA.sub.10 -NH.sub.2.
    • 用于制备下式的GnRH肽类似物的液相方法:G-AA1-(A)D-Phe-AA3-AA4-(R2)-AA5-AA6AA7-AA8-Pro-AA10-NH2式1,其包含:(a )使下式的肽与下式的肽反应:其中T是(P2)AA4或P2,X是AA7-OH或-OH的式(T-(R2)AA5-AA6-X)肽与下式的肽反应:X'-AA8-Pro -AA10-NH2或其酸加成盐形式,其中当X不存在时X'为AA 7,X'选自P-Ala,Gly,GABA,Ala的D-和L-异构体,氨基异丁酸, 当X是AA7-OH时,氨基己酸,Ser,Thr,His,Tyr,Asn和Gln'不存在; 在液体反应介质中,在肽偶联剂和强有机胺碱的存在下,得到下式的产物:((R 2)AA 5 -A AA 6 -A AA 7 -A AA 8 -Pro-AA 10 -NH 2(b) P2保护基团,和(c)使步骤(b)的产物或其酸加成盐与下式的肽反应:G-AA1-(R1)D-Phe-AA3-T' 或其酸加成盐形式,其中当T不存在时T'为AA4-OH,当T为P2-AA4时不存在,在液体反应介质中得到G-AA1 - (A)的GnRH肽, D-Phe-AA3-AA4-(R2)AA5-AA6-AA7-AA8-Pro-AA10-NH2。
    • 8. 发明授权
    • Methods and apparatus for bursting perforated paper stock
    • 破碎纸板原料的方法和装置
    • US07059794B2
    • 2006-06-13
    • US10878835
    • 2004-06-28
    • David E. WeeksBruce HarrisSteven P. Hilsdorf
    • David E. WeeksBruce HarrisSteven P. Hilsdorf
    • B26F3/00
    • B41J11/70B41J15/005G07B5/02Y10T225/10Y10T225/16Y10T225/20Y10T225/205
    • Methods and apparatus for bursting perforated paper stock are provided. A feed mechanism is provided for feeding perforated paper stock in a feed direction along a paper path in a printer. The perforated paper stock has sections separated by perforations. A loop area is provided in the printer for accumulating one of the sections of the perforated paper stock. A burst element is provided for bursting a perforation of the accumulated section. In order to burst the perforation of the accumulated section, the feed direction is reversed to draw the perforation of the accumulated section against the burst element, thereby separating the section from the perforated paper stock. A paper dispensing mechanism is provided for advancing the separated section out of the loop area and dispensing the section from the printer.
    • 提供了用于破裂多孔纸原料的方法和装置。 提供了一种进给机构,用于沿打印机中的纸路径沿进给方向进给穿孔纸料。 穿孔纸料有穿孔分开的部分。 在打印机中设置有循环区域,用于堆积穿孔纸料的一个部分。 提供突发元件用于破裂累积部分的穿孔。 为了突破累积部分的穿孔,进给方向相反,以将累积部分的穿孔拉到爆裂元件上,从而将该部分与穿孔纸料分离。 提供纸分配机构用于将分离的部分推出环形区域并从打印机分配该部分。