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1. 发明授权

US07935075B2 Self-deploying vascular occlusion device 有权
标题翻译：自体部署血管闭塞装置
公开(公告)号：US07935075B2
公开(公告)日：2011-05-03
申请号：US11115594
申请日：2005-04-26
申请人： Bruce A. Tockman , Scott A Stockmoe , Eric T. Johnson , John S. Greenland , Gary L. Hague , William E. Webler
发明人： Bruce A. Tockman , Scott A Stockmoe , Eric T. Johnson , John S. Greenland , Gary L. Hague , William E. Webler
IPC分类号： A61M1/00
CPC分类号： A61N1/057 , A61N2001/0585
摘要： The present invention provides a cardiac vascular occlusion system which includes inner and outer guide catheters and an occluding member disposed on the inner catheter. The occluding member may be deployed from a compressed to an expanded position to limit retrograde blood flow in a body lumen. The occluding member may be used when injecting a contrast agent into the body lumen.
摘要翻译：本发明提供一种心脏血管闭塞系统，其包括内导管和外引导导管以及设置在内导管上的闭塞构件。闭塞构件可以从压缩展开到展开位置以限制体腔内的逆行血流。当将造影剂注入体腔时，可以使用闭塞构件。

2. 发明申请

US20110184282A1 SELF-DEPLOYING VASCULAR OCCLUSION DEVICE 审中-公开
标题翻译：自体血液灌注装置
公开(公告)号：US20110184282A1
公开(公告)日：2011-07-28
申请号：US13078456
申请日：2011-04-01
申请人： Bruce A. Tockman , Scott A. Stockmoe , Eric T. Johnson , John S. Greenland , Gary L. Hague , William E. Webler
发明人： Bruce A. Tockman , Scott A. Stockmoe , Eric T. Johnson , John S. Greenland , Gary L. Hague , William E. Webler
IPC分类号： A61B6/00
CPC分类号： A61N1/057 , A61N2001/0585
摘要： The present invention provides a cardiac vascular occlusion system which includes inner and outer guide catheters and an occluding member disposed on the inner catheter. The occluding member may be deployed from a compressed to an expanded position to limit retrograde blood flow in a body lumen. The occluding member may be used when injecting a contrast agent into the body lumen.
摘要翻译：本发明提供一种心脏血管闭塞系统，其包括内导管和外引导导管以及设置在内导管上的闭塞构件。闭塞构件可以从压缩展开到展开位置以限制体腔内的逆行血流。当将造影剂注入体腔时，可以使用闭塞构件。

3. 发明授权

US08521262B2 Methods and apparatus for localization, diagnosis, contact or activity detection of bio-electric tissue 有权
标题翻译：生物电组织的定位，诊断，接触或活动检测的方法和装置
公开(公告)号：US08521262B2
公开(公告)日：2013-08-27
申请号：US12482255
申请日：2009-06-10
申请人： William E. Webler
发明人： William E. Webler
IPC分类号： A61B5/0402 , A61B5/04
CPC分类号： A61B5/0428 , A61B5/042 , A61B5/6885
摘要： Methods and apparatus for localization, diagnosis, contact or activity detection of bio-electric tissue providing improved sensitivity to the distance between a sensing electrode and bio-electric tissue and providing the means to measure the impedance of the tissue between a sensing electrode and bio-electric tissue. In accordance with the method, a controlled effective input impedance is provided to the monitor, which input impedance can be set to cause a significant portion of the bio-electric tissue signal to be dropped across the tissue between a sensing electrode and the bio-electric tissue when the two are separated by a predetermined or arbitrary distance. Various illustrative embodiments and forms of construction are disclosed.
摘要翻译：生物电组织的定位，诊断，接触或活动检测的方法和装置，提供对感测电极和生物电组织之间距离的敏感性，并提供测量感测电极和生物电组织之间的组织阻抗的装置，电组织。根据该方法，向监视器提供受控的有效输入阻抗，该输入阻抗可被设定为使生物电组织信号的大部分在感测电极和生物电当两者分离预定或任意距离时的组织。公开了各种说明性的实施例和结构形式。

4. 发明授权

US08382674B2 Visualization of a catheter viewed under ultrasound imaging 失效
公开(公告)号：US08382674B2
公开(公告)日：2013-02-26
申请号：US12044704
申请日：2008-03-07
申请人： William E. Webler
发明人： William E. Webler
IPC分类号： A61B8/14
CPC分类号： A61M25/0127 , A61B1/00165 , A61B5/04 , A61B8/0833 , A61B90/36 , A61B2017/00924 , A61B2090/3782 , A61B2090/3925 , A61M25/0009 , A61M25/0045 , A61M25/0052 , A61M25/0068 , A61M25/0084 , A61M25/0108 , A61M25/0147 , A61M2025/0089 , Y10T29/49826
摘要： A catheter for use in a patient's body lumen, having a shaft section configured to minimize ultrasonic image artifacts and the direct ultrasonic image brightness of the shaft surface and its internal components, and to produce its image at a wide range of imaging angles, preferably with an intensity not substantially different than surrounding tissue of the body lumen under ultrasound visualization. The shaft section is operative for the desired use of the catheter, yet is also configured to facilitate accurately imaging the shape and location of the shaft section, and easily differentiate it from the surrounding anatomy without unduly obscuring the images of the adjacent anatomy using an ultrasound imaging system.

5. 发明授权

US08303509B2 Echogenic needle catheter configured to produce an improved ultrasound image 有权
标题翻译：构造为产生改善的超声图像的生殖针导管
公开(公告)号：US08303509B2
公开(公告)日：2012-11-06
申请号：US12882156
申请日：2010-09-14
申请人： William E. Webler , Mina Chow
发明人： William E. Webler , Mina Chow
IPC分类号： A61B8/14
CPC分类号： A61M25/0068 , A61B8/0841 , A61B90/36 , A61B2090/3782 , A61M25/0009 , A61M25/0045 , A61M25/0052 , A61M25/0069 , A61M25/0084 , A61M25/0108 , A61M25/0147 , A61M2025/0089
摘要： An echogenic medical device, such as a needle catheter, which produces an improved ultrasonic image of the device, and a method of performing a medical procedure using a device of the invention. One aspect is directed to a catheter which reduces artifacts in the ultrasound image of the catheter. In one embodiment, the catheter has a spherical distal tip. Another aspect of the invention is directed to an echogenic catheter with echogenic portions arranged in an array to facilitate determination by ultrasonic imaging of the rotational orientation of the catheter relative to a desired location within the patient.
摘要翻译：产生设备的改进的超声波图像的回声医疗装置，例如针导管，以及使用本发明的装置执行医疗程序的方法。一个方面涉及导管，其减少导管的超声图像中的伪像。在一个实施例中，导管具有球形远端尖端。本发明的另一方面涉及一种具有排列成阵列的回声部分的回声导管，以有助于通过超声波成像来确定导管相对于患者内的期望位置的旋转取向。

6. 发明授权

US07981152B1 Vascular delivery system for accessing and delivering devices into coronary sinus and other vascular sites 有权
标题翻译：用于进入和输送装置进入冠状窦和其他血管部位的血管输送系统
公开(公告)号：US07981152B1
公开(公告)日：2011-07-19
申请号：US11008902
申请日：2004-12-10
申请人： William E. Webler , Neil Becker , Gregory M. Hyde
发明人： William E. Webler , Neil Becker , Gregory M. Hyde
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61F2/2451 , A61F2250/0039 , A61F2250/0065
摘要： A method for placing a device into a target vasculature. The method comprises accessing the target vasculature with an access guide catheter to sub-select a proximal portion of the target vasculature. A rail catheter is tracked into the access guide catheter to place the rail catheter more distally and into a distal portion of the target vasculature. The access guide catheter is removed. A delivery catheter is tracked over the rail catheter. The rail catheter is then removed. A device catheter having the device is placed into the delivery catheter and positioned at a desired location within the distal portion of the target vasculature.
摘要翻译：将装置放置在目标脉管系统中的方法。该方法包括用导入导管接近目标脉管，以选择目标脉管系统的近端部分。轨道导管被跟踪到进入导管中以将轨道导管更远侧地放置到目标脉管系统的远端部分中。取出导管导管。输送导管在轨道导管上追踪。然后取出导轨导管。具有该装置的装置导管被放置在输送导管中并且定位在目标脉管系统的远端部分内的期望位置处。

7. 发明授权

US07674240B2 Method and apparatus for controlled vessel occlusion 有权
标题翻译：用于控制血管闭塞的方法和装置
公开(公告)号：US07674240B2
公开(公告)日：2010-03-09
申请号：US11313477
申请日：2005-12-20
申请人： William E. Webler , August R. Yambao
发明人： William E. Webler , August R. Yambao
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/1204 , A61M25/0021 , A61M25/1002 , A61M25/10182 , A61M25/10188 , A61M25/1027 , A61M2025/1052
摘要： A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter to incremental equal increases in inflation volume.
摘要翻译：一种受控体积的充气 - 放气装置，用于通过拨打锁定在旋转位置处的手柄来使气囊膨胀以封闭血管，以将柱塞定位在充气 - 放气装置的注射器内的等间隔位置处。充气 - 放气装置包括可释放的闩锁，以将近端和远端壳体锁定在一起以将柱塞保持在前方用于闭塞，并且分离并保持近端和远端壳体以缩回柱塞用于灌注。当充气 - 放气装置返回到锁定位置时，将气囊重新膨胀至其先前的闭塞直径。此外，可以使用由较高模量的内部材料共挤出并可与较高模量的内部材料混合的由较低模量外部材料制成的延伸管。球囊可以具有锥形端部和圆柱形中心部分，使得其在外径中增加更多相等的增量以增加充气体积的增加。

8. 发明申请

US20100057037A1 Agent Delivery Catheters 有权
标题翻译：代理输送导管
公开(公告)号：US20100057037A1
公开(公告)日：2010-03-04
申请号：US12553036
申请日：2009-09-02
申请人： William E. Webler
发明人： William E. Webler
IPC分类号： A61M25/092
CPC分类号： A61M25/0054 , A61M25/0052 , A61M2025/0089
摘要： An agent delivery catheter that includes an anti-whipping feature, improved assembly of distal parts and/or accuracy/repeatability of needle delivery to a target tissue. Additional features include fitting a catheter with a pneumatic delivery device for delivery of a therapeutic agent without using a needle.
摘要翻译：一种药剂递送导管，其包括抗鞭打特征，改善远端部分的组装和/或针向目标组织递送的精确/可重复性。另外的特征包括使用气动输送装置安装导管，用于递送治疗剂而不使用针头。

9. 发明申请

US20090105644A1 INTRAVASCULAR MEDICAL DEVICE HAVING A READILY COLLAPSIBLE COVERED FRAME 审中-公开
标题翻译：具有可立即覆盖的框架的血管内装置
公开(公告)号：US20090105644A1
公开(公告)日：2009-04-23
申请号：US11876555
申请日：2007-10-22
申请人： Michael J. Leonard , William E. Webler
发明人： Michael J. Leonard , William E. Webler
IPC分类号： A61M29/00 , A61M25/00
CPC分类号： A61M25/0662 , A61F2/013 , A61F2002/011 , A61F2002/016 , A61F2230/0076 , A61F2230/008
摘要： An elongated intravascular device having a frame configured for reversibly expanding in a patient's body lumen, which has a sleeve secured to the frame, and at least one sleeve-folding strut configured to fold the sleeve inwardly as the frame radially collapses in the patient's body lumen. Additional aspects of the invention are directed to methods of recovering such expanded frame type devices, and a recovery catheter configured for collapsing an expanded frame. The devices and methods of the invention facilitate the collapse of expanded frame devices, for repositioning or removal from the patient's body lumen.
摘要翻译：一种细长的血管内装置，其具有被构造用于在患者的体腔中可逆地扩张的框架，所述框架具有固定到所述框架的套筒以及至少一个套筒折叠支柱，所述至少一个套筒折叠支柱构造成当所述框架在患者的体腔内径向塌陷时向内折叠。本发明的另外的方面涉及恢复这种扩展的框架型装置的方法，以及被配置用于塌缩扩展框架的回收导管。本发明的装置和方法有助于扩大的框架装置的塌陷，用于重新定位或从患者体腔移除。

10. 发明申请

US20080027350A1 Methods and apparatus for localization, diagnosis, contact or activity detection of bio-electric tissue 审中-公开
标题翻译：生物电组织的定位，诊断，接触或活动检测的方法和装置
公开(公告)号：US20080027350A1
公开(公告)日：2008-01-31
申请号：US11486828
申请日：2006-07-13
申请人： William E. Webler
发明人： William E. Webler
IPC分类号： A61B5/05
CPC分类号： A61B5/0428 , A61B5/042 , A61B5/6885
摘要： Methods and apparatus for localization, diagnosis, contact or activity detection of bio-electric tissue providing improved sensitivity to the distance between a sensing electrode and bio-electric tissue and providing the means to measure the impedance of the tissue between a sensing electrode and bio-electric tissue. In accordance with the method, a controlled effective input impedance is provided to the monitor, which input impedance can be set to cause a significant portion of the bio-electric tissue signal to be dropped across the tissue between a sensing electrode and the bio-electric tissue when the two are separated by a predetermined or arbitrary distance. Various illustrative embodiments and forms of construction are disclosed.
摘要翻译：生物电组织的定位，诊断，接触或活动检测的方法和装置，提供对感测电极和生物电组织之间距离的敏感性，并提供测量感测电极和生物电组织之间的组织阻抗的装置，电组织。根据该方法，向监视器提供受控的有效输入阻抗，该输入阻抗可被设定为使生物电组织信号的大部分在感测电极和生物电当两者分离预定或任意距离时的组织。公开了各种说明性的实施例和结构形式。

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